CAB39L (calcium binding protein 39 like)

Gene

• Entrez ID: 81617
• Gene name: Calcium binding protein 39 like
• Gene symbol: CAB39L
• Synonyms (NCBI Gene): MLAA-34, MO25-BETA, MO2L, bA103J18.3
• Chromosome: 13
• Chromosome location: 13q14.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020525	hsa-miR-155-5p	Proteomics	18668040
MIRT026134	hsa-miR-192-5p	Microarray	19074876
MIRT028849	hsa-miR-26b-5p	Microarray	19088304
MIRT047664	hsa-miR-10a-5p	CLASH	23622248
MIRT437697	hsa-miR-27a-3p	Microarray, qRT-PCR	22815788
MIRT437706	hsa-miR-27b-3p	Microarray, qRT-PCR	22815788
MIRT856913	hsa-miR-1321	CLIP-seq
MIRT856914	hsa-miR-193a-3p	CLIP-seq
MIRT856915	hsa-miR-193b	CLIP-seq
MIRT856916	hsa-miR-2276	CLIP-seq
MIRT856917	hsa-miR-377	CLIP-seq
MIRT856918	hsa-miR-4270	CLIP-seq
MIRT856919	hsa-miR-4435	CLIP-seq
MIRT856920	hsa-miR-4441	CLIP-seq
MIRT856921	hsa-miR-4643	CLIP-seq
MIRT856922	hsa-miR-4708-3p	CLIP-seq
MIRT856923	hsa-miR-4739	CLIP-seq
MIRT856924	hsa-miR-4756-5p	CLIP-seq
MIRT856925	hsa-miR-5096	CLIP-seq
MIRT856926	hsa-miR-580	CLIP-seq
MIRT856927	hsa-miR-106a	CLIP-seq
MIRT856928	hsa-miR-106b	CLIP-seq
MIRT856929	hsa-miR-1285	CLIP-seq
MIRT856930	hsa-miR-130a	CLIP-seq
MIRT856931	hsa-miR-130b	CLIP-seq
MIRT856932	hsa-miR-17	CLIP-seq
MIRT856933	hsa-miR-203	CLIP-seq
MIRT856934	hsa-miR-20a	CLIP-seq
MIRT856935	hsa-miR-20b	CLIP-seq
MIRT856936	hsa-miR-2113	CLIP-seq
MIRT856937	hsa-miR-218	CLIP-seq
MIRT856938	hsa-miR-301a	CLIP-seq
MIRT856939	hsa-miR-301b	CLIP-seq
MIRT856940	hsa-miR-3140-3p	CLIP-seq
MIRT856941	hsa-miR-3156-3p	CLIP-seq
MIRT856942	hsa-miR-3187-5p	CLIP-seq
MIRT856943	hsa-miR-324-5p	CLIP-seq
MIRT856944	hsa-miR-34b	CLIP-seq
MIRT856945	hsa-miR-34c-3p	CLIP-seq
MIRT856946	hsa-miR-3666	CLIP-seq
MIRT856947	hsa-miR-3667-3p	CLIP-seq
MIRT856948	hsa-miR-370	CLIP-seq
MIRT856949	hsa-miR-3945	CLIP-seq
MIRT856950	hsa-miR-4253	CLIP-seq
MIRT856951	hsa-miR-4279	CLIP-seq
MIRT856952	hsa-miR-4295	CLIP-seq
MIRT856953	hsa-miR-4301	CLIP-seq
MIRT856954	hsa-miR-4517	CLIP-seq
MIRT856955	hsa-miR-454	CLIP-seq
MIRT856956	hsa-miR-4729	CLIP-seq
MIRT856957	hsa-miR-4731-5p	CLIP-seq
MIRT856958	hsa-miR-4763-5p	CLIP-seq
MIRT856959	hsa-miR-519a	CLIP-seq
MIRT856960	hsa-miR-519b-3p	CLIP-seq
MIRT856961	hsa-miR-519c-3p	CLIP-seq
MIRT856962	hsa-miR-519d	CLIP-seq
MIRT856963	hsa-miR-548t	CLIP-seq
MIRT856964	hsa-miR-550a	CLIP-seq
MIRT856965	hsa-miR-579	CLIP-seq
MIRT856966	hsa-miR-612	CLIP-seq
MIRT856967	hsa-miR-622	CLIP-seq
MIRT856968	hsa-miR-636	CLIP-seq
MIRT856969	hsa-miR-93	CLIP-seq
MIRT1954490	hsa-miR-329	CLIP-seq
MIRT1954491	hsa-miR-362-3p	CLIP-seq
MIRT2192093	hsa-miR-1251	CLIP-seq
MIRT2192094	hsa-miR-1264	CLIP-seq
MIRT2192095	hsa-miR-128	CLIP-seq
MIRT2192096	hsa-miR-1915	CLIP-seq
MIRT2192097	hsa-miR-2117	CLIP-seq
MIRT856916	hsa-miR-2276	CLIP-seq
MIRT2192098	hsa-miR-27a	CLIP-seq
MIRT2192099	hsa-miR-27b	CLIP-seq
MIRT2192100	hsa-miR-3065-5p	CLIP-seq
MIRT856940	hsa-miR-3140-3p	CLIP-seq
MIRT2192101	hsa-miR-3622a-5p	CLIP-seq
MIRT2192102	hsa-miR-4275	CLIP-seq
MIRT2192103	hsa-miR-4277	CLIP-seq
MIRT2192104	hsa-miR-4283	CLIP-seq
MIRT2192105	hsa-miR-4284	CLIP-seq
MIRT2192106	hsa-miR-4289	CLIP-seq
MIRT2192107	hsa-miR-4423-3p	CLIP-seq
MIRT2192108	hsa-miR-4437	CLIP-seq
MIRT2192109	hsa-miR-4457	CLIP-seq
MIRT2192110	hsa-miR-4487	CLIP-seq
MIRT2192111	hsa-miR-451b	CLIP-seq
MIRT2192112	hsa-miR-455-3p	CLIP-seq
MIRT2192113	hsa-miR-4666-3p	CLIP-seq
MIRT2192114	hsa-miR-4684-5p	CLIP-seq
MIRT2192115	hsa-miR-4772-3p	CLIP-seq
MIRT2192116	hsa-miR-4793-5p	CLIP-seq
MIRT2192117	hsa-miR-513a-5p	CLIP-seq
MIRT2192118	hsa-miR-513b	CLIP-seq
MIRT2385435	hsa-miR-1228	CLIP-seq
MIRT2385436	hsa-miR-2861	CLIP-seq
MIRT1954490	hsa-miR-329	CLIP-seq
MIRT1954491	hsa-miR-362-3p	CLIP-seq
MIRT2192100	hsa-miR-3065-5p	CLIP-seq
MIRT2445998	hsa-miR-3942-3p	CLIP-seq
MIRT2495561	hsa-miR-1	CLIP-seq
MIRT2495562	hsa-miR-1237	CLIP-seq
MIRT2495563	hsa-miR-125a-5p	CLIP-seq
MIRT2495564	hsa-miR-125b	CLIP-seq
MIRT2495565	hsa-miR-1286	CLIP-seq
MIRT2495566	hsa-miR-129-5p	CLIP-seq
MIRT2495567	hsa-miR-146b-3p	CLIP-seq
MIRT2495568	hsa-miR-148a	CLIP-seq
MIRT2495569	hsa-miR-148b	CLIP-seq
MIRT2495570	hsa-miR-152	CLIP-seq
MIRT2495571	hsa-miR-185	CLIP-seq
MIRT2495572	hsa-miR-206	CLIP-seq
MIRT2495573	hsa-miR-28-5p	CLIP-seq
MIRT2495574	hsa-miR-3139	CLIP-seq
MIRT2495575	hsa-miR-3150b-3p	CLIP-seq
MIRT2495576	hsa-miR-3160-3p	CLIP-seq
MIRT2495577	hsa-miR-3173-5p	CLIP-seq
MIRT2495578	hsa-miR-3175	CLIP-seq
MIRT2495579	hsa-miR-3192	CLIP-seq
MIRT2495580	hsa-miR-330-3p	CLIP-seq
MIRT2495581	hsa-miR-3618	CLIP-seq
MIRT2495582	hsa-miR-3673	CLIP-seq
MIRT2495583	hsa-miR-371b-3p	CLIP-seq
MIRT2495584	hsa-miR-4264	CLIP-seq
MIRT856918	hsa-miR-4270	CLIP-seq
MIRT2495585	hsa-miR-4306	CLIP-seq
MIRT2495586	hsa-miR-4314	CLIP-seq
MIRT2495587	hsa-miR-4319	CLIP-seq
MIRT2495588	hsa-miR-4419a	CLIP-seq
MIRT2495589	hsa-miR-4422	CLIP-seq
MIRT2495590	hsa-miR-4436a	CLIP-seq
MIRT856920	hsa-miR-4441	CLIP-seq
MIRT2192110	hsa-miR-4487	CLIP-seq
MIRT2495591	hsa-miR-4499	CLIP-seq
MIRT2495592	hsa-miR-450b-3p	CLIP-seq
MIRT2495593	hsa-miR-450b-5p	CLIP-seq
MIRT2495594	hsa-miR-4510	CLIP-seq
MIRT2495595	hsa-miR-4644	CLIP-seq
MIRT2495596	hsa-miR-4646-5p	CLIP-seq
MIRT2495597	hsa-miR-4663	CLIP-seq
MIRT2495598	hsa-miR-4689	CLIP-seq
MIRT2495599	hsa-miR-4711-3p	CLIP-seq
MIRT2495600	hsa-miR-4713-3p	CLIP-seq
MIRT2495601	hsa-miR-4722-5p	CLIP-seq
MIRT2495602	hsa-miR-4724-3p	CLIP-seq
MIRT2495603	hsa-miR-4728-3p	CLIP-seq
MIRT2495604	hsa-miR-4784	CLIP-seq
MIRT2495605	hsa-miR-4797-3p	CLIP-seq
MIRT2495606	hsa-miR-507	CLIP-seq
MIRT2495607	hsa-miR-557	CLIP-seq
MIRT2495608	hsa-miR-558	CLIP-seq
MIRT2495609	hsa-miR-570	CLIP-seq
MIRT2495610	hsa-miR-613	CLIP-seq
MIRT2495611	hsa-miR-638	CLIP-seq
MIRT2495612	hsa-miR-708	CLIP-seq
MIRT2495613	hsa-miR-769-3p	CLIP-seq
MIRT2495614	hsa-miR-874	CLIP-seq
MIRT2495615	hsa-miR-934	CLIP-seq
MIRT2495561	hsa-miR-1	CLIP-seq
MIRT2495562	hsa-miR-1237	CLIP-seq
MIRT2495563	hsa-miR-125a-5p	CLIP-seq
MIRT2495564	hsa-miR-125b	CLIP-seq
MIRT2495565	hsa-miR-1286	CLIP-seq
MIRT2495566	hsa-miR-129-5p	CLIP-seq
MIRT2495567	hsa-miR-146b-3p	CLIP-seq
MIRT2495568	hsa-miR-148a	CLIP-seq
MIRT2495569	hsa-miR-148b	CLIP-seq
MIRT2495570	hsa-miR-152	CLIP-seq
MIRT2677193	hsa-miR-154	CLIP-seq
MIRT2495571	hsa-miR-185	CLIP-seq
MIRT2495572	hsa-miR-206	CLIP-seq
MIRT2677194	hsa-miR-23a	CLIP-seq
MIRT2677195	hsa-miR-23b	CLIP-seq
MIRT2677196	hsa-miR-23c	CLIP-seq
MIRT2495573	hsa-miR-28-5p	CLIP-seq
MIRT2495574	hsa-miR-3139	CLIP-seq
MIRT2495575	hsa-miR-3150b-3p	CLIP-seq
MIRT2495576	hsa-miR-3160-3p	CLIP-seq
MIRT2495577	hsa-miR-3173-5p	CLIP-seq
MIRT2495578	hsa-miR-3175	CLIP-seq
MIRT2495579	hsa-miR-3192	CLIP-seq
MIRT2495580	hsa-miR-330-3p	CLIP-seq
MIRT856944	hsa-miR-34b	CLIP-seq
MIRT2495581	hsa-miR-3618	CLIP-seq
MIRT2677197	hsa-miR-3620	CLIP-seq
MIRT2677198	hsa-miR-3646	CLIP-seq
MIRT2677199	hsa-miR-3662	CLIP-seq
MIRT2495582	hsa-miR-3673	CLIP-seq
MIRT2495583	hsa-miR-371b-3p	CLIP-seq
MIRT2495584	hsa-miR-4264	CLIP-seq
MIRT856918	hsa-miR-4270	CLIP-seq
MIRT2495585	hsa-miR-4306	CLIP-seq
MIRT2495586	hsa-miR-4314	CLIP-seq
MIRT2495587	hsa-miR-4319	CLIP-seq
MIRT2495588	hsa-miR-4419a	CLIP-seq
MIRT2495589	hsa-miR-4422	CLIP-seq
MIRT2495590	hsa-miR-4436a	CLIP-seq
MIRT856920	hsa-miR-4441	CLIP-seq
MIRT2192110	hsa-miR-4487	CLIP-seq
MIRT2495591	hsa-miR-4499	CLIP-seq
MIRT2495592	hsa-miR-450b-3p	CLIP-seq
MIRT2495593	hsa-miR-450b-5p	CLIP-seq
MIRT2495594	hsa-miR-4510	CLIP-seq
MIRT2495595	hsa-miR-4644	CLIP-seq
MIRT2495596	hsa-miR-4646-5p	CLIP-seq
MIRT2495597	hsa-miR-4663	CLIP-seq
MIRT2192113	hsa-miR-4666-3p	CLIP-seq
MIRT2495598	hsa-miR-4689	CLIP-seq
MIRT2495599	hsa-miR-4711-3p	CLIP-seq
MIRT2495600	hsa-miR-4713-3p	CLIP-seq
MIRT2495601	hsa-miR-4722-5p	CLIP-seq
MIRT2495602	hsa-miR-4724-3p	CLIP-seq
MIRT2495603	hsa-miR-4728-3p	CLIP-seq
MIRT2677200	hsa-miR-4753-3p	CLIP-seq
MIRT2677201	hsa-miR-4775	CLIP-seq
MIRT2495604	hsa-miR-4784	CLIP-seq
MIRT2677202	hsa-miR-4795-3p	CLIP-seq
MIRT2495605	hsa-miR-4797-3p	CLIP-seq
MIRT2677203	hsa-miR-499a-5p	CLIP-seq
MIRT2495606	hsa-miR-507	CLIP-seq
MIRT2495607	hsa-miR-557	CLIP-seq
MIRT2495608	hsa-miR-558	CLIP-seq
MIRT2495609	hsa-miR-570	CLIP-seq
MIRT2677204	hsa-miR-590-3p	CLIP-seq
MIRT2495610	hsa-miR-613	CLIP-seq
MIRT2495611	hsa-miR-638	CLIP-seq
MIRT2677205	hsa-miR-656	CLIP-seq
MIRT2495612	hsa-miR-708	CLIP-seq
MIRT2495613	hsa-miR-769-3p	CLIP-seq
MIRT2495614	hsa-miR-874	CLIP-seq
MIRT2495615	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183, 32814053
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0043539	Function	Protein serine/threonine kinase activator activity	IBA
GO:1902554	Component	Serine/threonine protein kinase complex	ISS

Other IDs

• MIM: 612175
• HGNC: 20290
• e!Ensembl: ENSG00000102547

Protein

• UniProt ID: Q9H9S4
• Protein name: Calcium-binding protein 39-like (Antigen MLAA-34) (MO25beta) (Mo25-like protein)
• Protein function: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).
• PDB: 3ZHP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08569	Mo25	5 → 333	Mo25-like	Family

• Sequence:

  MKKMPLFSKSHKNPAEIVKILKDNLAILEKQDKKTDKASEEVSKSLQAMKEILCGTNEKE
  PPTEAVAQLAQELYSSGLLVTLIADLQLIDFEGKKDVTQIFNNILRRQIGTRSPTVEYIS
  AHPHILFMLLKGYEAPQIALRCGIMLRECIRHEPLAKIILFSNQFRDFFKYVELSTFDIA
  SDAFATFKDLLTRHKVLVADFLEQNYDTIFEDYEKLLQSENYVTKRQSLKLLGELILDRH
  NFAIMTKYISKPENLKLMMNLLRDKSPNIQFEAFHVFKVFVASPHKTQPIVEILLKNQPK
  LIEFLSSFQKERTDDEQFADEKNYLIKQIRDLKKTAP

• Sequence length: 337

Pathways

KEGG:

mTOR signaling pathway
AMPK signaling pathway

Reactome:

Energy dependent regulation of mTOR by LKB1-AMPK

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	18592235, 29059232		★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	LHGDN	18592235		★☆☆☆☆ Found in Text Mining only
Autonomic Nervous System Diseases	Autonomic nervous system disease	Pubtator	34994165	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	37109674	Associate	★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	BEFREE	25296917		★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	25296917	Associate	★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	29059232		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30054562		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30054562		★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	GWASCAT_DG	28892059		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Parkinson Disease	Parkinson disease	Pubtator	34994165	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30054562		★☆☆☆☆ Found in Text Mining only