Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	81614
Gene name	NIPA magnesium transporter 2
Gene symbol	NIPA2
Synonyms (NCBI Gene)	SLC57A2
Chromosome	15
Chromosome location	15q11.2
Summary	This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene a

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SNP ID	Visualize variation	Clinical significance	Consequence
rs371775791	A>G	Likely-pathogenic	Coding sequence variant, missense variant

224

Show/Hide all (224)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040535	hsa-miR-92b-3p	CLASH	23622248
MIRT039066	hsa-miR-769-3p	CLASH	23622248
MIRT052855	hsa-miR-3615	CLASH	23622248
MIRT440111	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT440110	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440111	hsa-miR-205-5p	HITS-CLIP	22473208
MIRT440110	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1185485	hsa-miR-1265	CLIP-seq
MIRT1185486	hsa-miR-214	CLIP-seq
MIRT1185487	hsa-miR-2681	CLIP-seq
MIRT1185488	hsa-miR-300	CLIP-seq
MIRT1185489	hsa-miR-3160-3p	CLIP-seq
MIRT1185490	hsa-miR-3171	CLIP-seq
MIRT1185491	hsa-miR-3174	CLIP-seq
MIRT1185492	hsa-miR-335	CLIP-seq
MIRT1185493	hsa-miR-3591-5p	CLIP-seq
MIRT1185494	hsa-miR-3606	CLIP-seq
MIRT1185495	hsa-miR-3619-5p	CLIP-seq
MIRT1185496	hsa-miR-381	CLIP-seq
MIRT1185497	hsa-miR-4495	CLIP-seq
MIRT1185498	hsa-miR-4514	CLIP-seq
MIRT1185499	hsa-miR-4639-5p	CLIP-seq
MIRT1185500	hsa-miR-4645-5p	CLIP-seq
MIRT1185501	hsa-miR-4673	CLIP-seq
MIRT1185502	hsa-miR-4690-5p	CLIP-seq
MIRT1185503	hsa-miR-4692	CLIP-seq
MIRT1185504	hsa-miR-4753-5p	CLIP-seq
MIRT1185505	hsa-miR-4755-3p	CLIP-seq
MIRT1185506	hsa-miR-4761-5p	CLIP-seq
MIRT1185507	hsa-miR-4764-5p	CLIP-seq
MIRT1185508	hsa-miR-4772-3p	CLIP-seq
MIRT1185509	hsa-miR-548ad	CLIP-seq
MIRT1185510	hsa-miR-548k	CLIP-seq
MIRT1185511	hsa-miR-548n	CLIP-seq
MIRT1185512	hsa-miR-553	CLIP-seq
MIRT1185513	hsa-miR-610	CLIP-seq
MIRT1185514	hsa-miR-761	CLIP-seq
MIRT1185515	hsa-miR-921	CLIP-seq
MIRT1185516	hsa-miR-940	CLIP-seq
MIRT1185517	hsa-miR-1270	CLIP-seq
MIRT1185518	hsa-miR-130a	CLIP-seq
MIRT1185519	hsa-miR-130b	CLIP-seq
MIRT1185487	hsa-miR-2681	CLIP-seq
MIRT1185520	hsa-miR-301a	CLIP-seq
MIRT1185521	hsa-miR-301b	CLIP-seq
MIRT1185522	hsa-miR-3119	CLIP-seq
MIRT1185523	hsa-miR-3140-3p	CLIP-seq
MIRT1185524	hsa-miR-3154	CLIP-seq
MIRT1185525	hsa-miR-3185	CLIP-seq
MIRT1185526	hsa-miR-3666	CLIP-seq
MIRT1185527	hsa-miR-3671	CLIP-seq
MIRT1185528	hsa-miR-4272	CLIP-seq
MIRT1185529	hsa-miR-4295	CLIP-seq
MIRT1185530	hsa-miR-4434	CLIP-seq
MIRT1185531	hsa-miR-4473	CLIP-seq
MIRT1185532	hsa-miR-4516	CLIP-seq
MIRT1185533	hsa-miR-4531	CLIP-seq
MIRT1185534	hsa-miR-454	CLIP-seq
MIRT1185500	hsa-miR-4645-5p	CLIP-seq
MIRT1185535	hsa-miR-4671-3p	CLIP-seq
MIRT1185501	hsa-miR-4673	CLIP-seq
MIRT1185536	hsa-miR-4705	CLIP-seq
MIRT1185506	hsa-miR-4761-5p	CLIP-seq
MIRT1185537	hsa-miR-548a-3p	CLIP-seq
MIRT1185509	hsa-miR-548ad	CLIP-seq
MIRT1185538	hsa-miR-548e	CLIP-seq
MIRT1185539	hsa-miR-548f	CLIP-seq
MIRT1185540	hsa-miR-548g	CLIP-seq
MIRT1185512	hsa-miR-553	CLIP-seq
MIRT1185541	hsa-miR-607	CLIP-seq
MIRT1185542	hsa-miR-616	CLIP-seq
MIRT1185543	hsa-miR-620	CLIP-seq
MIRT1185488	hsa-miR-300	CLIP-seq
MIRT1185491	hsa-miR-3174	CLIP-seq
MIRT1185493	hsa-miR-3591-5p	CLIP-seq
MIRT1185494	hsa-miR-3606	CLIP-seq
MIRT1185544	hsa-miR-3607-5p	CLIP-seq
MIRT1185496	hsa-miR-381	CLIP-seq
MIRT1185500	hsa-miR-4645-5p	CLIP-seq
MIRT1185545	hsa-miR-4663	CLIP-seq
MIRT1185501	hsa-miR-4673	CLIP-seq
MIRT1185506	hsa-miR-4761-5p	CLIP-seq
MIRT1185512	hsa-miR-553	CLIP-seq
MIRT1185515	hsa-miR-921	CLIP-seq
MIRT2053753	hsa-miR-3674	CLIP-seq
MIRT2053754	hsa-miR-1305	CLIP-seq
MIRT1185494	hsa-miR-3606	CLIP-seq
MIRT2053755	hsa-miR-3942-3p	CLIP-seq
MIRT2053756	hsa-miR-4307	CLIP-seq
MIRT2053757	hsa-miR-4494	CLIP-seq
MIRT2053758	hsa-miR-4511	CLIP-seq
MIRT2053759	hsa-miR-4795-3p	CLIP-seq
MIRT2053760	hsa-miR-499a-5p	CLIP-seq
MIRT1185537	hsa-miR-548a-3p	CLIP-seq
MIRT1185538	hsa-miR-548e	CLIP-seq
MIRT1185539	hsa-miR-548f	CLIP-seq
MIRT2053761	hsa-miR-579	CLIP-seq
MIRT1185513	hsa-miR-610	CLIP-seq
MIRT1185485	hsa-miR-1265	CLIP-seq
MIRT1185486	hsa-miR-214	CLIP-seq
MIRT2282943	hsa-miR-3150a-5p	CLIP-seq
MIRT2282944	hsa-miR-3150b-5p	CLIP-seq
MIRT1185495	hsa-miR-3619-5p	CLIP-seq
MIRT1185498	hsa-miR-4514	CLIP-seq
MIRT1185500	hsa-miR-4645-5p	CLIP-seq
MIRT1185501	hsa-miR-4673	CLIP-seq
MIRT1185502	hsa-miR-4690-5p	CLIP-seq
MIRT1185503	hsa-miR-4692	CLIP-seq
MIRT2282945	hsa-miR-4714-3p	CLIP-seq
MIRT2282946	hsa-miR-4722-5p	CLIP-seq
MIRT1185507	hsa-miR-4764-5p	CLIP-seq
MIRT1185514	hsa-miR-761	CLIP-seq
MIRT1185516	hsa-miR-940	CLIP-seq
MIRT1185544	hsa-miR-3607-5p	CLIP-seq
MIRT1185485	hsa-miR-1265	CLIP-seq
MIRT1185517	hsa-miR-1270	CLIP-seq
MIRT2581079	hsa-miR-1283	CLIP-seq
MIRT1185518	hsa-miR-130a	CLIP-seq
MIRT1185519	hsa-miR-130b	CLIP-seq
MIRT2581080	hsa-miR-2053	CLIP-seq
MIRT1185486	hsa-miR-214	CLIP-seq
MIRT1185487	hsa-miR-2681	CLIP-seq
MIRT1185520	hsa-miR-301a	CLIP-seq
MIRT1185521	hsa-miR-301b	CLIP-seq
MIRT1185522	hsa-miR-3119	CLIP-seq
MIRT1185523	hsa-miR-3140-3p	CLIP-seq
MIRT1185524	hsa-miR-3154	CLIP-seq
MIRT1185489	hsa-miR-3160-3p	CLIP-seq
MIRT2581081	hsa-miR-3163	CLIP-seq
MIRT1185490	hsa-miR-3171	CLIP-seq
MIRT1185491	hsa-miR-3174	CLIP-seq
MIRT1185525	hsa-miR-3185	CLIP-seq
MIRT1185492	hsa-miR-335	CLIP-seq
MIRT1185493	hsa-miR-3591-5p	CLIP-seq
MIRT1185494	hsa-miR-3606	CLIP-seq
MIRT1185544	hsa-miR-3607-5p	CLIP-seq
MIRT1185495	hsa-miR-3619-5p	CLIP-seq
MIRT2581082	hsa-miR-3647-3p	CLIP-seq
MIRT2581083	hsa-miR-3662	CLIP-seq
MIRT1185526	hsa-miR-3666	CLIP-seq
MIRT2581084	hsa-miR-3682-5p	CLIP-seq
MIRT1185529	hsa-miR-4295	CLIP-seq
MIRT1185530	hsa-miR-4434	CLIP-seq
MIRT1185531	hsa-miR-4473	CLIP-seq
MIRT1185497	hsa-miR-4495	CLIP-seq
MIRT1185498	hsa-miR-4514	CLIP-seq
MIRT1185532	hsa-miR-4516	CLIP-seq
MIRT1185533	hsa-miR-4531	CLIP-seq
MIRT1185534	hsa-miR-454	CLIP-seq
MIRT1185500	hsa-miR-4645-5p	CLIP-seq
MIRT1185545	hsa-miR-4663	CLIP-seq
MIRT1185535	hsa-miR-4671-3p	CLIP-seq
MIRT1185501	hsa-miR-4673	CLIP-seq
MIRT1185502	hsa-miR-4690-5p	CLIP-seq
MIRT1185503	hsa-miR-4692	CLIP-seq
MIRT1185505	hsa-miR-4755-3p	CLIP-seq
MIRT1185506	hsa-miR-4761-5p	CLIP-seq
MIRT1185507	hsa-miR-4764-5p	CLIP-seq
MIRT1185508	hsa-miR-4772-3p	CLIP-seq
MIRT1185509	hsa-miR-548ad	CLIP-seq
MIRT1185510	hsa-miR-548k	CLIP-seq
MIRT1185511	hsa-miR-548n	CLIP-seq
MIRT1185512	hsa-miR-553	CLIP-seq
MIRT2581085	hsa-miR-569	CLIP-seq
MIRT1185513	hsa-miR-610	CLIP-seq
MIRT1185542	hsa-miR-616	CLIP-seq
MIRT1185543	hsa-miR-620	CLIP-seq
MIRT2581086	hsa-miR-633	CLIP-seq
MIRT1185514	hsa-miR-761	CLIP-seq
MIRT1185515	hsa-miR-921	CLIP-seq
MIRT1185516	hsa-miR-940	CLIP-seq
MIRT1185517	hsa-miR-1270	CLIP-seq
MIRT2581079	hsa-miR-1283	CLIP-seq
MIRT1185518	hsa-miR-130a	CLIP-seq
MIRT1185519	hsa-miR-130b	CLIP-seq
MIRT2581080	hsa-miR-2053	CLIP-seq
MIRT1185486	hsa-miR-214	CLIP-seq
MIRT1185487	hsa-miR-2681	CLIP-seq
MIRT1185520	hsa-miR-301a	CLIP-seq
MIRT1185521	hsa-miR-301b	CLIP-seq
MIRT1185522	hsa-miR-3119	CLIP-seq
MIRT1185523	hsa-miR-3140-3p	CLIP-seq
MIRT1185524	hsa-miR-3154	CLIP-seq
MIRT1185489	hsa-miR-3160-3p	CLIP-seq
MIRT2581081	hsa-miR-3163	CLIP-seq
MIRT1185490	hsa-miR-3171	CLIP-seq
MIRT1185491	hsa-miR-3174	CLIP-seq
MIRT1185525	hsa-miR-3185	CLIP-seq
MIRT1185492	hsa-miR-335	CLIP-seq
MIRT1185493	hsa-miR-3591-5p	CLIP-seq
MIRT1185494	hsa-miR-3606	CLIP-seq
MIRT1185544	hsa-miR-3607-5p	CLIP-seq
MIRT1185495	hsa-miR-3619-5p	CLIP-seq
MIRT2581082	hsa-miR-3647-3p	CLIP-seq
MIRT2581083	hsa-miR-3662	CLIP-seq
MIRT1185526	hsa-miR-3666	CLIP-seq
MIRT2581084	hsa-miR-3682-5p	CLIP-seq
MIRT1185529	hsa-miR-4295	CLIP-seq
MIRT1185530	hsa-miR-4434	CLIP-seq
MIRT1185531	hsa-miR-4473	CLIP-seq
MIRT1185497	hsa-miR-4495	CLIP-seq
MIRT1185532	hsa-miR-4516	CLIP-seq
MIRT1185533	hsa-miR-4531	CLIP-seq
MIRT1185534	hsa-miR-454	CLIP-seq
MIRT1185500	hsa-miR-4645-5p	CLIP-seq
MIRT1185545	hsa-miR-4663	CLIP-seq
MIRT1185535	hsa-miR-4671-3p	CLIP-seq
MIRT1185501	hsa-miR-4673	CLIP-seq
MIRT1185502	hsa-miR-4690-5p	CLIP-seq
MIRT1185505	hsa-miR-4755-3p	CLIP-seq
MIRT1185506	hsa-miR-4761-5p	CLIP-seq
MIRT1185508	hsa-miR-4772-3p	CLIP-seq
MIRT1185509	hsa-miR-548ad	CLIP-seq
MIRT1185510	hsa-miR-548k	CLIP-seq
MIRT1185511	hsa-miR-548n	CLIP-seq
MIRT1185512	hsa-miR-553	CLIP-seq
MIRT2581085	hsa-miR-569	CLIP-seq
MIRT1185513	hsa-miR-610	CLIP-seq
MIRT1185542	hsa-miR-616	CLIP-seq
MIRT1185543	hsa-miR-620	CLIP-seq
MIRT2581086	hsa-miR-633	CLIP-seq
MIRT1185514	hsa-miR-761	CLIP-seq
MIRT1185515	hsa-miR-921	CLIP-seq
MIRT2581079	hsa-miR-1283	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	25347071
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0015095	Function	Magnesium ion transmembrane transporter activity	IEA
GO:0015693	Process	Magnesium ion transport	IBA
GO:0015693	Process	Magnesium ion transport	IEA
GO:0015693	Process	Magnesium ion transport	IMP	25347071
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:1903830	Process	Magnesium ion transmembrane transport	IEA

MIM	HGNC	e!Ensembl
608146	17044	ENSG00000140157

Q8N8Q9

Protein name

Magnesium transporter NIPA2 (Non-imprinted in Prader-Willi/Angelman syndrome region protein 2)

Protein function

Acts as a selective Mg(2+) transporter.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05653	Mg_trans_NIPA	8 → 302	Magnesium transporter NIPA	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:14508708}.

Sequence

MSQGRGKYDFYIGLGLAMSSSIFIGGSFILKKKGLLRLARKGSMRAGQGGHAYLKEWLWW
AGLLSMGAGEVANFAAYAFAPATLVTPLGALSVLVSAILSSYFLNERLNLHGKIGCLLSI
LGSTVMVIHAPKEEEIETLNEMSHKLGDPGFVVFATLVVIVALILIFVVGPRHGQTNILV
YITICSVIGAFSVSCVKGLGIAIKELFAGKPVLRHPLAWILLLSLIVCVSTQINYLNRAL
DIFNTSIVTPIYYVFFTTSVLTCSAILFKEWQDMPVDDVIGTLSGFFTIIVGIFLLHAFK
DVSFSLASLPVSFRKDEKAMNGNLSNMYEVLNNNEESLTCGIEQHTGENVSRRNGNLTAF

Sequence length

360

Interactions

View interactions

	Reactome
			Miscellaneous transport and binding events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
15Q11.2 MICRODELETION SYNDROME	—	Disgenet, Orphanet Disgenet, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIPA2-related disorder	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

NIPA2 (NIPA magnesium transporter 2)