GFOD2 (Gfo/Idh/MocA-like oxidoreductase domain containing 2)

Gene

• Entrez ID: 81577
• Gene name: Gfo/Idh/MocA-like oxidoreductase domain containing 2
• Gene symbol: GFOD2
• Synonyms (NCBI Gene): -
• Chromosome: 16
• Chromosome location: 16q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029015	hsa-miR-26b-5p	Microarray	19088304
MIRT039383	hsa-miR-421	CLASH	23622248
MIRT1016852	hsa-miR-10a	CLIP-seq
MIRT1016853	hsa-miR-10b	CLIP-seq
MIRT1016854	hsa-miR-1229	CLIP-seq
MIRT1016855	hsa-miR-1258	CLIP-seq
MIRT1016856	hsa-miR-1288	CLIP-seq
MIRT1016857	hsa-miR-1972	CLIP-seq
MIRT1016858	hsa-miR-3117-3p	CLIP-seq
MIRT1016859	hsa-miR-3169	CLIP-seq
MIRT1016860	hsa-miR-3620	CLIP-seq
MIRT1016861	hsa-miR-4487	CLIP-seq
MIRT1016862	hsa-miR-4650-5p	CLIP-seq
MIRT1016863	hsa-miR-4759	CLIP-seq
MIRT2000946	hsa-miR-1231	CLIP-seq
MIRT2000947	hsa-miR-149	CLIP-seq
MIRT2000948	hsa-miR-3064-5p	CLIP-seq
MIRT2000949	hsa-miR-4794	CLIP-seq
MIRT2000950	hsa-miR-654-3p	CLIP-seq
MIRT2234383	hsa-miR-3616-3p	CLIP-seq
MIRT2234384	hsa-miR-3689a-3p	CLIP-seq
MIRT2234385	hsa-miR-3689c	CLIP-seq
MIRT2234386	hsa-miR-4436b-3p	CLIP-seq
MIRT2234387	hsa-miR-4717-3p	CLIP-seq
MIRT2234388	hsa-miR-4728-5p	CLIP-seq
MIRT2234389	hsa-miR-4736	CLIP-seq
MIRT2000946	hsa-miR-1231	CLIP-seq
MIRT2538463	hsa-miR-1296	CLIP-seq
MIRT2000947	hsa-miR-149	CLIP-seq
MIRT2538464	hsa-miR-2114	CLIP-seq
MIRT2000948	hsa-miR-3064-5p	CLIP-seq
MIRT2538465	hsa-miR-339-5p	CLIP-seq
MIRT2538466	hsa-miR-3691-3p	CLIP-seq
MIRT2538467	hsa-miR-4480	CLIP-seq
MIRT2538468	hsa-miR-4512	CLIP-seq
MIRT2000949	hsa-miR-4794	CLIP-seq
MIRT2538469	hsa-miR-593	CLIP-seq
MIRT2000950	hsa-miR-654-3p	CLIP-seq
MIRT2538463	hsa-miR-1296	CLIP-seq
MIRT2538464	hsa-miR-2114	CLIP-seq
MIRT2538465	hsa-miR-339-5p	CLIP-seq
MIRT2538466	hsa-miR-3691-3p	CLIP-seq
MIRT2538467	hsa-miR-4480	CLIP-seq
MIRT2538468	hsa-miR-4512	CLIP-seq
MIRT2538469	hsa-miR-593	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0031012	Component	Extracellular matrix	IEA

Other IDs

• MIM: 619933
• HGNC: 28159
• e!Ensembl: ENSG00000141098

Protein

• UniProt ID: Q3B7J2
• Protein name: Glucose-fructose oxidoreductase domain-containing protein 2 (EC 1.-.-.-)
• Protein function: Promotes matrix assembly.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01408	GFO_IDH_MocA	6 → 119	Oxidoreductase family, NAD-binding Rossmann fold	Family
  PF02894	GFO_IDH_MocA_C	134 → 284	Oxidoreductase family, C-terminal alpha/beta domain	Domain

• Sequence:

  MKMLPGVGVFGTGSSARVLVPLLRAEGFTVEALWGKTEEEAKQLAEEMNIAFYTSRTDDI
  LLHQDVDLVCISIPPPLTRQISVKALGIGKNVVCEKAATSVDAFRMVTASRYYPQLMSLV
  GNVLRFLPAFVRMKQLISEHYVGAVMICDARIYSGSLLSPSYGWICDELMGGGGLHTMGT
  YIVDLLTHLTGRRAEKVHGLLKTFVRQNAAIRGIRHVTSDDFCFFQMLMGGGVCSTVTLN
  FNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSATQEELLLRDSLAVGAGLPEQGPQDVP
  LLYLKGMVYMVQALRQSFQGQGDRRTWDRTPVSMAASFEDGLYMQSVVDAIKRSSRSGEW
  EAVEVLTEEPDTNQNLCEALQRNNL

• Sequence length: 385

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Hypercholesterolemia	Hypercholesterolemia	BEFREE	24064143		★☆☆☆☆ Found in Text Mining only
Panic Disorder	Panic disorder	Pubtator	35477560	Associate	★☆☆☆☆ Found in Text Mining only