MAGED4B (MAGE family member D4B)

Gene

• Entrez ID: 81557
• Gene name: MAGE family member D4B
• Gene symbol: MAGED4B
• Synonyms (NCBI Gene): -
• Chromosome: X
• Chromosome location: Xp11.22
• Summary: This gene is a member of the MAGED gene family. It is expressed only in brain and ovary, and some transcript variants of this gene are specifically expressed in glioma cells. This gene is clustered with other MAGED genes on chromosome Xp11. Alternatively

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017566	hsa-miR-335-5p	Microarray	18185580
MIRT440294	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440294	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1125750	hsa-miR-4311	CLIP-seq
MIRT2565316	hsa-miR-1252	CLIP-seq
MIRT2565317	hsa-miR-149	CLIP-seq
MIRT2565318	hsa-miR-3064-5p	CLIP-seq
MIRT2565319	hsa-miR-3135	CLIP-seq
MIRT2565320	hsa-miR-3185	CLIP-seq
MIRT2565321	hsa-miR-3197	CLIP-seq
MIRT2565322	hsa-miR-3200-5p	CLIP-seq
MIRT2565323	hsa-miR-4251	CLIP-seq
MIRT2565324	hsa-miR-4329	CLIP-seq
MIRT2565325	hsa-miR-4695-5p	CLIP-seq
MIRT2565326	hsa-miR-4794	CLIP-seq
MIRT2565316	hsa-miR-1252	CLIP-seq
MIRT2565317	hsa-miR-149	CLIP-seq
MIRT2565318	hsa-miR-3064-5p	CLIP-seq
MIRT2565319	hsa-miR-3135	CLIP-seq
MIRT2565320	hsa-miR-3185	CLIP-seq
MIRT2565321	hsa-miR-3197	CLIP-seq
MIRT2565322	hsa-miR-3200-5p	CLIP-seq
MIRT2565323	hsa-miR-4251	CLIP-seq
MIRT2565324	hsa-miR-4329	CLIP-seq
MIRT2565325	hsa-miR-4695-5p	CLIP-seq
MIRT2565326	hsa-miR-4794	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA

Other IDs

• MIM: 300765
• HGNC: 22880
• e!Ensembl: ENSG00000187243

Interactions View interactions

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ARTERITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma	Adenocarcinoma	BEFREE	16225959, 8550240		★☆☆☆☆ Found in Text Mining only
Bile duct carcinoma	Bile duct carcinoma	BEFREE	10873083		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	8548758		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	30193086	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	22459352	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	10868457, 11289403, 7559092, 9121149		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	12133624		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	20423514		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	10873083		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	26060332	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	7656275		★☆☆☆☆ Found in Text Mining only
Cutaneous Melanoma	Melanoma	BEFREE	8647642		★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	24147998		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	24147998		★☆☆☆☆ Found in Text Mining only
Germ cell tumor	Tumor	BEFREE	10197872		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	11406556, 11436353, 15256472		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	35986882	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	11406556, 11436353, 15256472, 22534618		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	11406556, 24966945, 29541180		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35986882	Associate	★☆☆☆☆ Found in Text Mining only
Head and Neck Carcinoma	Head And Neck Carcinoma	BEFREE	12133624, 16475205		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	7656275, 8217804		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	10576668, 10592101, 10782910, 11776148, 11857021, 12150730, 14672620, 15237429, 20731022, 24068544		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	9247253		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	8119772		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	22459352	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Head and Neck Neoplasm	Head and neck cancer	BEFREE	12133624		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	8548758		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	24147998		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	12150730		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	10704737, 12133624		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	20423514		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of testis	Malignant Neoplasm Of Testis	BEFREE	10704737, 11397121, 15237429, 22294213		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10515601, 11289403, 11782385, 12133624, 15908320, 16225959, 17151793, 7511051, 8119772, 8647642, 9131385		★☆☆☆☆ Found in Text Mining only
Melanocytic nevus	Melanocytic nevus	BEFREE	10215777		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	10187808, 10215777, 10446460, 10465576, 10754339, 10811863, 11604998, 1402688, 15223957, 15665821, 21073635, 22710665, 7511051, 7519125, 7522162, 7557134, 7591261, 8302824, 8416750, 8513199, 8647642, 8900375, 8917707, 8921424, 9378539, 9618514, 9816095		★☆☆☆☆ Found in Text Mining only
Mouth Neoplasms	Mouth neoplasm	Pubtator	25483651	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	10741395		★☆☆☆☆ Found in Text Mining only
Myelomonocytic leukemia	Myelomonocytic Leukemia	BEFREE	7656275		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10446460, 10472332, 10811863, 11776148, 12150730, 1402688, 14672620, 15127237, 16225959, 16773189, 18357396, 20423514, 22664239, 24068544, 7511051, 7519125, 7591235, 7665250, 7980533, 8039421, 8119772, 8513199, 8548758, 8692960, 8757382, 8900370, 8900375, 8917707, 9066537, 9121149, 9209667, 9247253, 9415308, 9441743, 9711530, 9816095		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	10472332, 8900370, 8900375		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	16225959, 8119772		★☆☆☆☆ Found in Text Mining only
Nongerminomatous Germ Cell Tumor	Nongerminomatous Tumor	BEFREE	10197872		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	20423514		★☆☆☆☆ Found in Text Mining only
Rectal Carcinoma	Rectal Carcinoma	BEFREE	30193086		★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	34307667	Associate	★☆☆☆☆ Found in Text Mining only
Small cell carcinoma of lung	Lung carcinoma	BEFREE	9415308		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	24147998, 25951896, 31704827		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	22459352, 25483651	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	30193086	Stimulate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	30193086		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	9121149		★☆☆☆☆ Found in Text Mining only