Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	81543
Gene name	Leucine rich repeat containing 3
Gene symbol	LRRC3
Synonyms (NCBI Gene)	C21orf102C21orf30LRRC3DN
Chromosome	21
Chromosome location	21q22.3

118

Show/Hide all (118)

miRTarBase ID	miRNA	Experiments
MIRT1119506	hsa-miR-1299	CLIP-seq
MIRT1119507	hsa-miR-1304	CLIP-seq
MIRT1119508	hsa-miR-2355-5p	CLIP-seq
MIRT1119509	hsa-miR-24	CLIP-seq
MIRT1119510	hsa-miR-3122	CLIP-seq
MIRT1119511	hsa-miR-3140-5p	CLIP-seq
MIRT1119512	hsa-miR-3178	CLIP-seq
MIRT1119513	hsa-miR-3194-3p	CLIP-seq
MIRT1119514	hsa-miR-3197	CLIP-seq
MIRT1119515	hsa-miR-3611	CLIP-seq
MIRT1119516	hsa-miR-3614-5p	CLIP-seq
MIRT1119517	hsa-miR-3689a-3p	CLIP-seq
MIRT1119518	hsa-miR-3689c	CLIP-seq
MIRT1119519	hsa-miR-3689d	CLIP-seq
MIRT1119520	hsa-miR-3913-5p	CLIP-seq
MIRT1119521	hsa-miR-3929	CLIP-seq
MIRT1119522	hsa-miR-4261	CLIP-seq
MIRT1119523	hsa-miR-4284	CLIP-seq
MIRT1119524	hsa-miR-4419b	CLIP-seq
MIRT1119525	hsa-miR-4478	CLIP-seq
MIRT1119526	hsa-miR-4649-3p	CLIP-seq
MIRT1119527	hsa-miR-4662a-5p	CLIP-seq
MIRT1119528	hsa-miR-4676-5p	CLIP-seq
MIRT1119529	hsa-miR-4712-5p	CLIP-seq
MIRT1119530	hsa-miR-4728-5p	CLIP-seq
MIRT1119531	hsa-miR-4755-3p	CLIP-seq
MIRT1119532	hsa-miR-4767	CLIP-seq
MIRT1119533	hsa-miR-485-5p	CLIP-seq
MIRT1119534	hsa-miR-487a	CLIP-seq
MIRT1119535	hsa-miR-490-3p	CLIP-seq
MIRT1119536	hsa-miR-575	CLIP-seq
MIRT1119537	hsa-miR-593	CLIP-seq
MIRT1119538	hsa-miR-649	CLIP-seq
MIRT1119539	hsa-miR-770-5p	CLIP-seq
MIRT1119540	hsa-miR-875-3p	CLIP-seq
MIRT2033767	hsa-miR-1271	CLIP-seq
MIRT2033768	hsa-miR-1321	CLIP-seq
MIRT2033769	hsa-miR-1323	CLIP-seq
MIRT2033770	hsa-miR-182	CLIP-seq
MIRT2033771	hsa-miR-1827	CLIP-seq
MIRT1119509	hsa-miR-24	CLIP-seq
MIRT2033772	hsa-miR-3162-5p	CLIP-seq
MIRT1119514	hsa-miR-3197	CLIP-seq
MIRT1119517	hsa-miR-3689a-3p	CLIP-seq
MIRT1119518	hsa-miR-3689c	CLIP-seq
MIRT2033773	hsa-miR-371b-5p	CLIP-seq
MIRT1119521	hsa-miR-3929	CLIP-seq
MIRT2033774	hsa-miR-4267	CLIP-seq
MIRT1119523	hsa-miR-4284	CLIP-seq
MIRT1119524	hsa-miR-4419b	CLIP-seq
MIRT1119525	hsa-miR-4478	CLIP-seq
MIRT1119526	hsa-miR-4649-3p	CLIP-seq
MIRT1119527	hsa-miR-4662a-5p	CLIP-seq
MIRT1119528	hsa-miR-4676-5p	CLIP-seq
MIRT2033775	hsa-miR-4726-3p	CLIP-seq
MIRT1119530	hsa-miR-4728-5p	CLIP-seq
MIRT2033776	hsa-miR-4729	CLIP-seq
MIRT2033777	hsa-miR-4739	CLIP-seq
MIRT1119531	hsa-miR-4755-3p	CLIP-seq
MIRT2033778	hsa-miR-4756-5p	CLIP-seq
MIRT1119533	hsa-miR-485-5p	CLIP-seq
MIRT2033779	hsa-miR-495	CLIP-seq
MIRT2033780	hsa-miR-548o	CLIP-seq
MIRT1119536	hsa-miR-575	CLIP-seq
MIRT2033781	hsa-miR-580	CLIP-seq
MIRT2033782	hsa-miR-888	CLIP-seq
MIRT2033783	hsa-miR-96	CLIP-seq
MIRT2264203	hsa-miR-4325	CLIP-seq
MIRT1119507	hsa-miR-1304	CLIP-seq
MIRT2390340	hsa-miR-4709-5p	CLIP-seq
MIRT2453351	hsa-miR-1205	CLIP-seq
MIRT2453352	hsa-miR-1909	CLIP-seq
MIRT2453353	hsa-miR-448	CLIP-seq
MIRT1119527	hsa-miR-4662a-5p	CLIP-seq
MIRT1119528	hsa-miR-4676-5p	CLIP-seq
MIRT2453354	hsa-miR-4684-5p	CLIP-seq
MIRT1119531	hsa-miR-4755-3p	CLIP-seq
MIRT2453355	hsa-miR-548c-3p	CLIP-seq
MIRT1119536	hsa-miR-575	CLIP-seq
MIRT2453356	hsa-miR-596	CLIP-seq
MIRT1119507	hsa-miR-1304	CLIP-seq
MIRT2563320	hsa-miR-1910	CLIP-seq
MIRT1119509	hsa-miR-24	CLIP-seq
MIRT1119510	hsa-miR-3122	CLIP-seq
MIRT1119514	hsa-miR-3197	CLIP-seq
MIRT1119516	hsa-miR-3614-5p	CLIP-seq
MIRT1119517	hsa-miR-3689a-3p	CLIP-seq
MIRT1119518	hsa-miR-3689c	CLIP-seq
MIRT1119520	hsa-miR-3913-5p	CLIP-seq
MIRT1119521	hsa-miR-3929	CLIP-seq
MIRT2033774	hsa-miR-4267	CLIP-seq
MIRT1119523	hsa-miR-4284	CLIP-seq
MIRT1119524	hsa-miR-4419b	CLIP-seq
MIRT1119525	hsa-miR-4478	CLIP-seq
MIRT2563321	hsa-miR-455-3p	CLIP-seq
MIRT1119526	hsa-miR-4649-3p	CLIP-seq
MIRT2453354	hsa-miR-4684-5p	CLIP-seq
MIRT1119530	hsa-miR-4728-5p	CLIP-seq
MIRT1119532	hsa-miR-4767	CLIP-seq
MIRT1119533	hsa-miR-485-5p	CLIP-seq
MIRT2453355	hsa-miR-548c-3p	CLIP-seq
MIRT1119507	hsa-miR-1304	CLIP-seq
MIRT1119510	hsa-miR-3122	CLIP-seq
MIRT1119514	hsa-miR-3197	CLIP-seq
MIRT1119516	hsa-miR-3614-5p	CLIP-seq
MIRT1119517	hsa-miR-3689a-3p	CLIP-seq
MIRT1119518	hsa-miR-3689c	CLIP-seq
MIRT1119520	hsa-miR-3913-5p	CLIP-seq
MIRT1119521	hsa-miR-3929	CLIP-seq
MIRT1119524	hsa-miR-4419b	CLIP-seq
MIRT1119525	hsa-miR-4478	CLIP-seq
MIRT1119526	hsa-miR-4649-3p	CLIP-seq
MIRT1119527	hsa-miR-4662a-5p	CLIP-seq
MIRT2453354	hsa-miR-4684-5p	CLIP-seq
MIRT1119530	hsa-miR-4728-5p	CLIP-seq
MIRT1119532	hsa-miR-4767	CLIP-seq
MIRT1119533	hsa-miR-485-5p	CLIP-seq
MIRT2453355	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17474147
GO:0005886	Component	Plasma membrane	IBA
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
617620	14965	ENSG00000160233

Q9BY71

Protein name

Leucine-rich repeat-containing protein 3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01462	LRRNT	32 → 63	Leucine rich repeat N-terminal domain	Family
PF13855	LRR_8	65 → 113	Leucine rich repeat	Repeat
PF00560	LRR_1	114 → 136	Leucine Rich Repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Widely expressed; detected in testis, lung, small intestine, breast, brain, heart, bone marrow, placenta, colon, fetal brain, liver, fetal liver, thymus, salivary gland, spinal cord, spleen, trachea and adrenal gland.

Sequence

MGTVRPPRPSLLLVSTRESCLFLLFCLHLGAACPQPCRCPDHAGAVAVFCSLRGLQEVPE
DIPANTVLLKLDANKISHLPDGAFQHLHRLRELDLSHNAIEAIGSATFAGLAGGLRLLDL
SYNRIQRIPKDALGKLSAKIRLSHNPLHCECALQEALWELKLDPDSVDEIACHTSVQEEF
VGKPLVQALDAGASLCSVPHRTTDVAMLVTMFGWFAMVIAYVVYYVRHNQEDARRHLEYL
KSLPSAPASKDPIGPGP

Sequence length

257

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BRAIN ANEURYSM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Intracranial Aneurysm	Intracranial Aneurysm	GWASCAT_DG	30823506		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycythemia Vera	Polycythemia vera	Pubtator	28427458	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

LRRC3 (leucine rich repeat containing 3)