ITFG1 (integrin alpha FG-GAP repeat containing 1)

Gene

• Entrez ID: 81533
• Gene name: Integrin alpha FG-GAP repeat containing 1
• Gene symbol: ITFG1
• Synonyms (NCBI Gene): 2310047C21Rik, CDA08, LINKIN, LNKN-1, TIP
• Chromosome: 16
• Chromosome location: 16q12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT028851	hsa-miR-26b-5p	Microarray	19088304
MIRT046353	hsa-miR-23b-3p	CLASH	23622248
MIRT1073311	hsa-miR-1305	CLIP-seq
MIRT1073312	hsa-miR-141	CLIP-seq
MIRT1073313	hsa-miR-200a	CLIP-seq
MIRT1073314	hsa-miR-3129-3p	CLIP-seq
MIRT1073315	hsa-miR-323b-3p	CLIP-seq
MIRT1073316	hsa-miR-340	CLIP-seq
MIRT1073317	hsa-miR-4729	CLIP-seq
MIRT1073318	hsa-miR-4731-3p	CLIP-seq
MIRT1073319	hsa-miR-4801	CLIP-seq
MIRT1073320	hsa-miR-498	CLIP-seq
MIRT1073321	hsa-miR-499-3p	CLIP-seq
MIRT1073322	hsa-miR-499a-3p	CLIP-seq
MIRT1073323	hsa-miR-599	CLIP-seq
MIRT1073315	hsa-miR-323b-3p	CLIP-seq
MIRT2249919	hsa-miR-3692	CLIP-seq
MIRT1073317	hsa-miR-4729	CLIP-seq
MIRT1073321	hsa-miR-499-3p	CLIP-seq
MIRT1073322	hsa-miR-499a-3p	CLIP-seq
MIRT1073315	hsa-miR-323b-3p	CLIP-seq
MIRT2553386	hsa-miR-4272	CLIP-seq
MIRT1073321	hsa-miR-499-3p	CLIP-seq
MIRT1073322	hsa-miR-499a-3p	CLIP-seq
MIRT1073315	hsa-miR-323b-3p	CLIP-seq
MIRT2553386	hsa-miR-4272	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145

Other IDs

• MIM: 611803
• HGNC: 30697
• e!Ensembl: ENSG00000129636

Protein

• UniProt ID: Q8TB96
• Protein name: T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin)
• Protein function: Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13517	VCBS	35 → 118	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	Repeat

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed.
• Sequence:

  MAAAGRLPSSWALFSPLLAGLALLGVGPVPARALHNVTAELFGAEAWGTLAAFGDLNSDK
  QTDLFVLRERNDLIVFLADQNAPYFKPKVKVSFKNHSALITSVVPGDYDGDSQMDVLLTY
  LPKNYAKSELGAVIFWGQNQTLDPNNMTILNRTFQDEPLIMDFNGDLIPDIFGITNESNQ
  PQILLGGNLSWHPALTTTSKMRIPHSHAFIDLTEDFTADLFLTTLNATTSTFQFEIWENL
  DGNFSVSTILEKPQNMMVVGQSAFADFDGDGHMDHLLPGCEDKNCQKSTIYLVRSGMKQW
  VPVLQDFSNKGTLWGFVPFVDEQQPTEIPIPITLHIGDYNMDGYPDALVILKNTSGSNQQ
  AFLLENVPCNNASCEEARRMFKVYWELTDLNQIKDAMVATFFDIYEDGILDIVVLSKGYT
  KNDFAIHTLKNNFEADAYFVKVIVLSGLCSNDCPRKITPFGVNQPGPYIMYTTVDANGYL
  KNGSAGQLSQSAHLALQLPYNVLGLGRSANFLDHLYVGIPRPSGEKSIRKQEWTAIIPNS
  QLIVIPYPHNVPRSWSAKLYLTPSNIVLLTAIALIGVCVFILAIIGILHWQEKKADDREK
  RQEAHRFHFDAM

• Sequence length: 612

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	28341484		★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	28643178		★☆☆☆☆ Found in Text Mining only
Familial aplasia of the vermis	Cerebellar vermis agenesis	BEFREE	31412255		★☆☆☆☆ Found in Text Mining only
Graft-vs-Host Disease	Graft-Vs-Host Disease	BEFREE	12598909		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28341484		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30154154		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	25310526		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30154154		★☆☆☆☆ Found in Text Mining only
Otitis Media	Otitis media	BEFREE	31202036		★☆☆☆☆ Found in Text Mining only
Teratoma	Teratoma	BEFREE	30296502		★☆☆☆☆ Found in Text Mining only