Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	81532
Gene name	MOB kinase activator 2
Gene symbol	MOB2
Synonyms (NCBI Gene)	HCCA2
Chromosome	11
Chromosome location	11p15.5

Show/Hide all (94)

miRTarBase ID	miRNA	Experiments
MIRT1154173	hsa-miR-1228	CLIP-seq
MIRT1154174	hsa-miR-1245b-3p	CLIP-seq
MIRT1154175	hsa-miR-1827	CLIP-seq
MIRT1154176	hsa-miR-185	CLIP-seq
MIRT1154177	hsa-miR-214	CLIP-seq
MIRT1154178	hsa-miR-2276	CLIP-seq
MIRT1154179	hsa-miR-3179	CLIP-seq
MIRT1154180	hsa-miR-3202	CLIP-seq
MIRT1154181	hsa-miR-329	CLIP-seq
MIRT1154182	hsa-miR-3612	CLIP-seq
MIRT1154183	hsa-miR-3614-3p	CLIP-seq
MIRT1154184	hsa-miR-3619-5p	CLIP-seq
MIRT1154185	hsa-miR-3621	CLIP-seq
MIRT1154186	hsa-miR-362-3p	CLIP-seq
MIRT1154187	hsa-miR-3925-5p	CLIP-seq
MIRT1154188	hsa-miR-3936	CLIP-seq
MIRT1154189	hsa-miR-4297	CLIP-seq
MIRT1154190	hsa-miR-4306	CLIP-seq
MIRT1154191	hsa-miR-4476	CLIP-seq
MIRT1154192	hsa-miR-4644	CLIP-seq
MIRT1154193	hsa-miR-4695-5p	CLIP-seq
MIRT1154194	hsa-miR-4722-5p	CLIP-seq
MIRT1154195	hsa-miR-4768-3p	CLIP-seq
MIRT1154196	hsa-miR-4772-3p	CLIP-seq
MIRT1154197	hsa-miR-4802-5p	CLIP-seq
MIRT1154198	hsa-miR-548ag	CLIP-seq
MIRT1154199	hsa-miR-548ai	CLIP-seq
MIRT1154200	hsa-miR-556-3p	CLIP-seq
MIRT1154201	hsa-miR-572	CLIP-seq
MIRT1154202	hsa-miR-650	CLIP-seq
MIRT1154203	hsa-miR-761	CLIP-seq
MIRT1154204	hsa-miR-765	CLIP-seq
MIRT2044108	hsa-miR-3944-5p	CLIP-seq
MIRT2431226	hsa-miR-1304	CLIP-seq
MIRT2431227	hsa-miR-15a	CLIP-seq
MIRT2431228	hsa-miR-15b	CLIP-seq
MIRT2431229	hsa-miR-16	CLIP-seq
MIRT2431230	hsa-miR-195	CLIP-seq
MIRT2431231	hsa-miR-3065-3p	CLIP-seq
MIRT2431232	hsa-miR-424	CLIP-seq
MIRT2431233	hsa-miR-4419a	CLIP-seq
MIRT2431234	hsa-miR-4510	CLIP-seq
MIRT2431235	hsa-miR-4530	CLIP-seq
MIRT2431236	hsa-miR-497	CLIP-seq
MIRT1154175	hsa-miR-1827	CLIP-seq
MIRT1154177	hsa-miR-214	CLIP-seq
MIRT1154179	hsa-miR-3179	CLIP-seq
MIRT1154180	hsa-miR-3202	CLIP-seq
MIRT1154182	hsa-miR-3612	CLIP-seq
MIRT1154184	hsa-miR-3619-5p	CLIP-seq
MIRT1154188	hsa-miR-3936	CLIP-seq
MIRT1154191	hsa-miR-4476	CLIP-seq
MIRT1154193	hsa-miR-4695-5p	CLIP-seq
MIRT2438777	hsa-miR-542-3p	CLIP-seq
MIRT1154202	hsa-miR-650	CLIP-seq
MIRT1154203	hsa-miR-761	CLIP-seq
MIRT2572308	hsa-miR-1182	CLIP-seq
MIRT2572309	hsa-miR-1224-3p	CLIP-seq
MIRT1154173	hsa-miR-1228	CLIP-seq
MIRT2572310	hsa-miR-140-3p	CLIP-seq
MIRT2572311	hsa-miR-22	CLIP-seq
MIRT2572312	hsa-miR-3160-3p	CLIP-seq
MIRT2572313	hsa-miR-3173-3p	CLIP-seq
MIRT2572314	hsa-miR-361-3p	CLIP-seq
MIRT2572315	hsa-miR-3921	CLIP-seq
MIRT2572316	hsa-miR-4303	CLIP-seq
MIRT2572317	hsa-miR-4432	CLIP-seq
MIRT2572318	hsa-miR-4487	CLIP-seq
MIRT2572319	hsa-miR-4533	CLIP-seq
MIRT2572320	hsa-miR-4650-5p	CLIP-seq
MIRT2572321	hsa-miR-4653-5p	CLIP-seq
MIRT2572322	hsa-miR-4677-3p	CLIP-seq
MIRT2572323	hsa-miR-4679	CLIP-seq
MIRT2572324	hsa-miR-4747-5p	CLIP-seq
MIRT2572325	hsa-miR-4779	CLIP-seq
MIRT2572326	hsa-miR-558	CLIP-seq
MIRT2572327	hsa-miR-593	CLIP-seq
MIRT2572309	hsa-miR-1224-3p	CLIP-seq
MIRT1154173	hsa-miR-1228	CLIP-seq
MIRT2572310	hsa-miR-140-3p	CLIP-seq
MIRT2572311	hsa-miR-22	CLIP-seq
MIRT2572312	hsa-miR-3160-3p	CLIP-seq
MIRT2572313	hsa-miR-3173-3p	CLIP-seq
MIRT2572314	hsa-miR-361-3p	CLIP-seq
MIRT2572315	hsa-miR-3921	CLIP-seq
MIRT2572316	hsa-miR-4303	CLIP-seq
MIRT2572317	hsa-miR-4432	CLIP-seq
MIRT2572318	hsa-miR-4487	CLIP-seq
MIRT2572319	hsa-miR-4533	CLIP-seq
MIRT2572320	hsa-miR-4650-5p	CLIP-seq
MIRT2572321	hsa-miR-4653-5p	CLIP-seq
MIRT2572324	hsa-miR-4747-5p	CLIP-seq
MIRT2572325	hsa-miR-4779	CLIP-seq
MIRT2572326	hsa-miR-558	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24366813, 25852190, 28514442, 30108113, 32296183, 32707033, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0007165	Process	Signal transduction	IBA
GO:0030295	Function	Protein kinase activator activity	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

MIM	HGNC	e!Ensembl
611969	24904	ENSG00000182208

Q70IA6

Protein name

MOB kinase activator 2 (HCCA2) (Mob2 homolog) (Mps one binder kinase activator-like 2)

Protein function

Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03637	Mob1_phocein	32 → 200	Mob1/phocein family	Family

Sequence

MDWLMGKSKAKPNGKKPAAEERKAYLEPEHTKARITDFQFKELVVLPREIDLNEWLASNT
TTFFHHINLQYSTISEFCTGETCQTMAVCNTQYYWYDERGKKVKCTAPQYVDFVMSSVQK
LVTDEDVFPTKYGREFPSSFESLVRKICRHLFHVLAHIYWAHFKETLALELHGHLNTLYV
HFILFAREFNLLDPKETAIMDDLTEVLCSGAGGVHSGGSGDGAGSGGPGAQNHVKER

Sequence length

237

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER, FAMILIAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	23326134	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	23630301	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	23630301		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	11710830		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Neoplasms	Liver neoplasm	Pubtator	23326134	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	11710830		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11710830		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34363951	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Periventricular Nodular Heterotopia	Periventricular Nodular Heterotopia	BEFREE	29593499		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate cancer, familial	Prostate cancer	CTD_human_DG	29892016		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER, HEREDITARY, 1	Prostate Cancer, Hereditary	CTD_human_DG	29892016		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	GWASCAT_DG	29892016		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

MOB2 (MOB kinase activator 2)