Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	81285
Gene name	Olfactory receptor family 51 subfamily E member 2
Gene symbol	OR51E2
Synonyms (NCBI Gene)	HPRAJOR51E3POR52A2PSGR
Chromosome	11
Chromosome location	11p15.4
Summary	Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from sing

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miRTarBase ID	miRNA	Experiments	Reference
MIRT035900	hsa-miR-1303	CLASH	23622248
MIRT691562	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT691561	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT691560	hsa-miR-5588-3p	HITS-CLIP	23313552
MIRT691559	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT691558	hsa-miR-5690	HITS-CLIP	23313552
MIRT691557	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691556	hsa-miR-554	HITS-CLIP	23313552
MIRT691555	hsa-miR-1827	HITS-CLIP	23313552
MIRT691554	hsa-miR-298	HITS-CLIP	23313552
MIRT691553	hsa-miR-3682-5p	HITS-CLIP	23313552
MIRT691552	hsa-miR-7977	HITS-CLIP	23313552
MIRT691551	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT662275	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT662274	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT662273	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT662272	hsa-miR-1292-3p	HITS-CLIP	23824327
MIRT662271	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT662270	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT662269	hsa-miR-4299	HITS-CLIP	23824327
MIRT662268	hsa-miR-4252	HITS-CLIP	23824327
MIRT662267	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT662266	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT662265	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT662264	hsa-miR-7703	HITS-CLIP	23824327
MIRT662274	hsa-miR-1273g-3p	PAR-CLIP	27292025
MIRT662272	hsa-miR-1292-3p	PAR-CLIP	27292025
MIRT662268	hsa-miR-4252	PAR-CLIP	27292025
MIRT662269	hsa-miR-4299	PAR-CLIP	27292025
MIRT662270	hsa-miR-4793-3p	PAR-CLIP	27292025
MIRT662275	hsa-miR-508-5p	PAR-CLIP	27292025
MIRT662267	hsa-miR-542-3p	PAR-CLIP	27292025
MIRT662266	hsa-miR-6512-3p	PAR-CLIP	27292025
MIRT662265	hsa-miR-6720-5p	PAR-CLIP	27292025
MIRT662273	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT662271	hsa-miR-766-3p	PAR-CLIP	27292025
MIRT662264	hsa-miR-7703	PAR-CLIP	27292025
MIRT691562	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT691561	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT691560	hsa-miR-5588-3p	HITS-CLIP	23313552
MIRT691559	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT691558	hsa-miR-5690	HITS-CLIP	23313552
MIRT691557	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT691556	hsa-miR-554	HITS-CLIP	23313552
MIRT691555	hsa-miR-1827	HITS-CLIP	23313552
MIRT691554	hsa-miR-298	HITS-CLIP	23313552
MIRT691553	hsa-miR-3682-5p	HITS-CLIP	23313552
MIRT691552	hsa-miR-7977	HITS-CLIP	23313552
MIRT691551	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT662275	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT662274	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT662273	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT662272	hsa-miR-1292-3p	HITS-CLIP	23824327
MIRT662271	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT662270	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT662269	hsa-miR-4299	HITS-CLIP	23824327
MIRT662268	hsa-miR-4252	HITS-CLIP	23824327
MIRT662267	hsa-miR-542-3p	HITS-CLIP	23824327
MIRT662266	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT662265	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT662264	hsa-miR-7703	HITS-CLIP	23824327
MIRT1204712	hsa-miR-1224-3p	CLIP-seq
MIRT1204713	hsa-miR-1228	CLIP-seq
MIRT1204714	hsa-miR-1260	CLIP-seq
MIRT1204715	hsa-miR-1260b	CLIP-seq
MIRT1204716	hsa-miR-1280	CLIP-seq
MIRT1204717	hsa-miR-150	CLIP-seq
MIRT1204718	hsa-miR-3122	CLIP-seq
MIRT1204719	hsa-miR-3165	CLIP-seq
MIRT1204720	hsa-miR-3197	CLIP-seq
MIRT1204721	hsa-miR-3656	CLIP-seq
MIRT1204722	hsa-miR-3689a-3p	CLIP-seq
MIRT1204723	hsa-miR-3689c	CLIP-seq
MIRT1204724	hsa-miR-3690	CLIP-seq
MIRT1204725	hsa-miR-371-5p	CLIP-seq
MIRT1204726	hsa-miR-378	CLIP-seq
MIRT1204727	hsa-miR-378b	CLIP-seq
MIRT1204728	hsa-miR-378c	CLIP-seq
MIRT1204729	hsa-miR-378d	CLIP-seq
MIRT1204730	hsa-miR-378e	CLIP-seq
MIRT1204731	hsa-miR-378f	CLIP-seq
MIRT1204732	hsa-miR-378h	CLIP-seq
MIRT1204733	hsa-miR-378i	CLIP-seq
MIRT1204734	hsa-miR-3913-5p	CLIP-seq
MIRT1204735	hsa-miR-3926	CLIP-seq
MIRT1204736	hsa-miR-3929	CLIP-seq
MIRT1204737	hsa-miR-3974	CLIP-seq
MIRT1204738	hsa-miR-422a	CLIP-seq
MIRT1204739	hsa-miR-4254	CLIP-seq
MIRT1204740	hsa-miR-4311	CLIP-seq
MIRT1204741	hsa-miR-4419b	CLIP-seq
MIRT1204742	hsa-miR-4433	CLIP-seq
MIRT1204743	hsa-miR-4457	CLIP-seq
MIRT1204744	hsa-miR-4459	CLIP-seq
MIRT1204745	hsa-miR-4478	CLIP-seq
MIRT1204746	hsa-miR-4649-3p	CLIP-seq
MIRT1204747	hsa-miR-4683	CLIP-seq
MIRT1204748	hsa-miR-4713-5p	CLIP-seq
MIRT1204749	hsa-miR-4728-5p	CLIP-seq
MIRT1204750	hsa-miR-4733-5p	CLIP-seq
MIRT1204751	hsa-miR-4768-3p	CLIP-seq
MIRT1204752	hsa-miR-4786-5p	CLIP-seq
MIRT1204753	hsa-miR-4793-5p	CLIP-seq
MIRT1204754	hsa-miR-485-5p	CLIP-seq
MIRT1204755	hsa-miR-513b	CLIP-seq
MIRT1204756	hsa-miR-532-3p	CLIP-seq
MIRT1204757	hsa-miR-548s	CLIP-seq
MIRT1204758	hsa-miR-624	CLIP-seq
MIRT1204759	hsa-miR-766	CLIP-seq
MIRT2059034	hsa-miR-122	CLIP-seq
MIRT2059035	hsa-miR-140-5p	CLIP-seq
MIRT2059036	hsa-miR-142-3p	CLIP-seq
MIRT2059037	hsa-miR-3135b	CLIP-seq
MIRT1204719	hsa-miR-3165	CLIP-seq
MIRT1204720	hsa-miR-3197	CLIP-seq
MIRT2059038	hsa-miR-3545-5p	CLIP-seq
MIRT2059039	hsa-miR-3652	CLIP-seq
MIRT1204721	hsa-miR-3656	CLIP-seq
MIRT1204722	hsa-miR-3689a-3p	CLIP-seq
MIRT1204723	hsa-miR-3689c	CLIP-seq
MIRT1204735	hsa-miR-3926	CLIP-seq
MIRT1204736	hsa-miR-3929	CLIP-seq
MIRT1204737	hsa-miR-3974	CLIP-seq
MIRT2059040	hsa-miR-4280	CLIP-seq
MIRT1204741	hsa-miR-4419b	CLIP-seq
MIRT2059041	hsa-miR-4423-5p	CLIP-seq
MIRT2059042	hsa-miR-4430	CLIP-seq
MIRT1204742	hsa-miR-4433	CLIP-seq
MIRT1204743	hsa-miR-4457	CLIP-seq
MIRT1204744	hsa-miR-4459	CLIP-seq
MIRT2059043	hsa-miR-4460	CLIP-seq
MIRT1204745	hsa-miR-4478	CLIP-seq
MIRT1204746	hsa-miR-4649-3p	CLIP-seq
MIRT1204747	hsa-miR-4683	CLIP-seq
MIRT1204749	hsa-miR-4728-5p	CLIP-seq
MIRT1204751	hsa-miR-4768-3p	CLIP-seq
MIRT1204752	hsa-miR-4786-5p	CLIP-seq
MIRT1204753	hsa-miR-4793-5p	CLIP-seq
MIRT1204754	hsa-miR-485-5p	CLIP-seq
MIRT1204755	hsa-miR-513b	CLIP-seq
MIRT1204757	hsa-miR-548s	CLIP-seq
MIRT1204758	hsa-miR-624	CLIP-seq
MIRT1204759	hsa-miR-766	CLIP-seq
MIRT2059034	hsa-miR-122	CLIP-seq
MIRT1204713	hsa-miR-1228	CLIP-seq
MIRT2287175	hsa-miR-128	CLIP-seq
MIRT2059035	hsa-miR-140-5p	CLIP-seq
MIRT2059036	hsa-miR-142-3p	CLIP-seq
MIRT2287176	hsa-miR-3120-5p	CLIP-seq
MIRT1204718	hsa-miR-3122	CLIP-seq
MIRT2059037	hsa-miR-3135b	CLIP-seq
MIRT1204719	hsa-miR-3165	CLIP-seq
MIRT1204720	hsa-miR-3197	CLIP-seq
MIRT2059038	hsa-miR-3545-5p	CLIP-seq
MIRT2059039	hsa-miR-3652	CLIP-seq
MIRT1204721	hsa-miR-3656	CLIP-seq
MIRT2287177	hsa-miR-3664-5p	CLIP-seq
MIRT1204722	hsa-miR-3689a-3p	CLIP-seq
MIRT1204723	hsa-miR-3689c	CLIP-seq
MIRT1204724	hsa-miR-3690	CLIP-seq
MIRT1204725	hsa-miR-371-5p	CLIP-seq
MIRT2287178	hsa-miR-377	CLIP-seq
MIRT1204726	hsa-miR-378	CLIP-seq
MIRT1204727	hsa-miR-378b	CLIP-seq
MIRT1204728	hsa-miR-378c	CLIP-seq
MIRT1204729	hsa-miR-378d	CLIP-seq
MIRT1204730	hsa-miR-378e	CLIP-seq
MIRT1204731	hsa-miR-378f	CLIP-seq
MIRT1204732	hsa-miR-378h	CLIP-seq
MIRT1204733	hsa-miR-378i	CLIP-seq
MIRT1204734	hsa-miR-3913-5p	CLIP-seq
MIRT1204735	hsa-miR-3926	CLIP-seq
MIRT1204736	hsa-miR-3929	CLIP-seq
MIRT1204737	hsa-miR-3974	CLIP-seq
MIRT1204738	hsa-miR-422a	CLIP-seq
MIRT1204739	hsa-miR-4254	CLIP-seq
MIRT2059040	hsa-miR-4280	CLIP-seq
MIRT1204741	hsa-miR-4419b	CLIP-seq
MIRT2059041	hsa-miR-4423-5p	CLIP-seq
MIRT2059042	hsa-miR-4430	CLIP-seq
MIRT1204742	hsa-miR-4433	CLIP-seq
MIRT1204743	hsa-miR-4457	CLIP-seq
MIRT1204744	hsa-miR-4459	CLIP-seq
MIRT2059043	hsa-miR-4460	CLIP-seq
MIRT1204745	hsa-miR-4478	CLIP-seq
MIRT1204746	hsa-miR-4649-3p	CLIP-seq
MIRT2287179	hsa-miR-4672	CLIP-seq
MIRT1204747	hsa-miR-4683	CLIP-seq
MIRT2287180	hsa-miR-4684-5p	CLIP-seq
MIRT1204749	hsa-miR-4728-5p	CLIP-seq
MIRT2287181	hsa-miR-4738-3p	CLIP-seq
MIRT1204751	hsa-miR-4768-3p	CLIP-seq
MIRT1204752	hsa-miR-4786-5p	CLIP-seq
MIRT1204753	hsa-miR-4793-5p	CLIP-seq
MIRT1204754	hsa-miR-485-5p	CLIP-seq
MIRT1204755	hsa-miR-513b	CLIP-seq
MIRT1204757	hsa-miR-548s	CLIP-seq
MIRT2287182	hsa-miR-593	CLIP-seq
MIRT1204758	hsa-miR-624	CLIP-seq
MIRT1204759	hsa-miR-766	CLIP-seq
MIRT2059035	hsa-miR-140-5p	CLIP-seq
MIRT2455665	hsa-miR-1182	CLIP-seq
MIRT2059034	hsa-miR-122	CLIP-seq
MIRT1204713	hsa-miR-1228	CLIP-seq
MIRT2455666	hsa-miR-1267	CLIP-seq
MIRT2455667	hsa-miR-193a-5p	CLIP-seq
MIRT2287176	hsa-miR-3120-5p	CLIP-seq
MIRT1204718	hsa-miR-3122	CLIP-seq
MIRT2059037	hsa-miR-3135b	CLIP-seq
MIRT1204719	hsa-miR-3165	CLIP-seq
MIRT2455668	hsa-miR-3194-3p	CLIP-seq
MIRT1204720	hsa-miR-3197	CLIP-seq
MIRT2059039	hsa-miR-3652	CLIP-seq
MIRT1204721	hsa-miR-3656	CLIP-seq
MIRT2287177	hsa-miR-3664-5p	CLIP-seq
MIRT1204722	hsa-miR-3689a-3p	CLIP-seq
MIRT1204723	hsa-miR-3689c	CLIP-seq
MIRT1204734	hsa-miR-3913-5p	CLIP-seq
MIRT1204736	hsa-miR-3929	CLIP-seq
MIRT2059040	hsa-miR-4280	CLIP-seq
MIRT2455669	hsa-miR-431	CLIP-seq
MIRT1204741	hsa-miR-4419b	CLIP-seq
MIRT2059041	hsa-miR-4423-5p	CLIP-seq
MIRT2059042	hsa-miR-4430	CLIP-seq
MIRT1204745	hsa-miR-4478	CLIP-seq
MIRT1204746	hsa-miR-4649-3p	CLIP-seq
MIRT2287180	hsa-miR-4684-5p	CLIP-seq
MIRT1204749	hsa-miR-4728-5p	CLIP-seq
MIRT1204750	hsa-miR-4733-5p	CLIP-seq
MIRT2287181	hsa-miR-4738-3p	CLIP-seq
MIRT1204754	hsa-miR-485-5p	CLIP-seq
MIRT2287182	hsa-miR-593	CLIP-seq
MIRT2455665	hsa-miR-1182	CLIP-seq
MIRT2059034	hsa-miR-122	CLIP-seq
MIRT2455666	hsa-miR-1267	CLIP-seq
MIRT2455667	hsa-miR-193a-5p	CLIP-seq
MIRT2059037	hsa-miR-3135b	CLIP-seq
MIRT2455668	hsa-miR-3194-3p	CLIP-seq
MIRT2059039	hsa-miR-3652	CLIP-seq
MIRT2059040	hsa-miR-4280	CLIP-seq
MIRT2455669	hsa-miR-431	CLIP-seq
MIRT2059041	hsa-miR-4423-5p	CLIP-seq
MIRT2059042	hsa-miR-4430	CLIP-seq
MIRT2455665	hsa-miR-1182	CLIP-seq
MIRT2059034	hsa-miR-122	CLIP-seq
MIRT1204713	hsa-miR-1228	CLIP-seq
MIRT2455666	hsa-miR-1267	CLIP-seq
MIRT2059036	hsa-miR-142-3p	CLIP-seq
MIRT2455667	hsa-miR-193a-5p	CLIP-seq
MIRT2287176	hsa-miR-3120-5p	CLIP-seq
MIRT1204718	hsa-miR-3122	CLIP-seq
MIRT2059037	hsa-miR-3135b	CLIP-seq
MIRT1204719	hsa-miR-3165	CLIP-seq
MIRT2455668	hsa-miR-3194-3p	CLIP-seq
MIRT1204720	hsa-miR-3197	CLIP-seq
MIRT2059039	hsa-miR-3652	CLIP-seq
MIRT1204721	hsa-miR-3656	CLIP-seq
MIRT2287177	hsa-miR-3664-5p	CLIP-seq
MIRT1204722	hsa-miR-3689a-3p	CLIP-seq
MIRT1204723	hsa-miR-3689c	CLIP-seq
MIRT1204734	hsa-miR-3913-5p	CLIP-seq
MIRT1204735	hsa-miR-3926	CLIP-seq
MIRT1204736	hsa-miR-3929	CLIP-seq
MIRT2059040	hsa-miR-4280	CLIP-seq
MIRT2455669	hsa-miR-431	CLIP-seq
MIRT1204741	hsa-miR-4419b	CLIP-seq
MIRT2059041	hsa-miR-4423-5p	CLIP-seq
MIRT2059042	hsa-miR-4430	CLIP-seq
MIRT1204745	hsa-miR-4478	CLIP-seq
MIRT2585425	hsa-miR-4537	CLIP-seq
MIRT1204746	hsa-miR-4649-3p	CLIP-seq
MIRT2287180	hsa-miR-4684-5p	CLIP-seq
MIRT1204749	hsa-miR-4728-5p	CLIP-seq
MIRT1204750	hsa-miR-4733-5p	CLIP-seq
MIRT2287181	hsa-miR-4738-3p	CLIP-seq
MIRT1204752	hsa-miR-4786-5p	CLIP-seq
MIRT1204753	hsa-miR-4793-5p	CLIP-seq
MIRT1204754	hsa-miR-485-5p	CLIP-seq
MIRT1204757	hsa-miR-548s	CLIP-seq
MIRT2287182	hsa-miR-593	CLIP-seq
MIRT1204759	hsa-miR-766	CLIP-seq
MIRT2455665	hsa-miR-1182	CLIP-seq
MIRT2059034	hsa-miR-122	CLIP-seq
MIRT1204713	hsa-miR-1228	CLIP-seq
MIRT2455666	hsa-miR-1267	CLIP-seq
MIRT2455667	hsa-miR-193a-5p	CLIP-seq
MIRT2287176	hsa-miR-3120-5p	CLIP-seq
MIRT1204718	hsa-miR-3122	CLIP-seq
MIRT2059037	hsa-miR-3135b	CLIP-seq
MIRT1204719	hsa-miR-3165	CLIP-seq
MIRT2455668	hsa-miR-3194-3p	CLIP-seq
MIRT1204720	hsa-miR-3197	CLIP-seq
MIRT2059039	hsa-miR-3652	CLIP-seq
MIRT1204721	hsa-miR-3656	CLIP-seq
MIRT2287177	hsa-miR-3664-5p	CLIP-seq
MIRT1204722	hsa-miR-3689a-3p	CLIP-seq
MIRT1204723	hsa-miR-3689c	CLIP-seq
MIRT1204734	hsa-miR-3913-5p	CLIP-seq
MIRT1204735	hsa-miR-3926	CLIP-seq
MIRT1204736	hsa-miR-3929	CLIP-seq
MIRT2059040	hsa-miR-4280	CLIP-seq
MIRT2455669	hsa-miR-431	CLIP-seq
MIRT1204741	hsa-miR-4419b	CLIP-seq
MIRT2059041	hsa-miR-4423-5p	CLIP-seq
MIRT2059042	hsa-miR-4430	CLIP-seq
MIRT1204745	hsa-miR-4478	CLIP-seq
MIRT1204746	hsa-miR-4649-3p	CLIP-seq
MIRT2287180	hsa-miR-4684-5p	CLIP-seq
MIRT1204749	hsa-miR-4728-5p	CLIP-seq
MIRT1204750	hsa-miR-4733-5p	CLIP-seq
MIRT2287181	hsa-miR-4738-3p	CLIP-seq
MIRT1204752	hsa-miR-4786-5p	CLIP-seq
MIRT1204753	hsa-miR-4793-5p	CLIP-seq
MIRT1204754	hsa-miR-485-5p	CLIP-seq
MIRT1204757	hsa-miR-548s	CLIP-seq
MIRT2287182	hsa-miR-593	CLIP-seq

Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003008	Process	System process	IEA
GO:0003707	Function	Nuclear steroid receptor activity	IDA	19389702
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004984	Function	Olfactory receptor activity	IBA
GO:0004984	Function	Olfactory receptor activity	IDA	19389702
GO:0004984	Function	Olfactory receptor activity	IEA
GO:0004984	Function	Olfactory receptor activity	IMP	29249973
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	23401498, 27226631, 29249973
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP	29249973
GO:0007608	Process	Sensory perception of smell	IEA
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IMP	29249973
GO:0030318	Process	Melanocyte differentiation	IMP	27226631
GO:0030518	Process	Nuclear receptor-mediated steroid hormone signaling pathway	IEA
GO:0031901	Component	Early endosome membrane	IDA	27226631
GO:0031901	Component	Early endosome membrane	IEA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0038023	Function	Signaling receptor activity	ISS
GO:0043229	Component	Intracellular organelle	IDA	29249973
GO:0043401	Process	Steroid hormone receptor signaling pathway	IDA	19389702
GO:0045777	Process	Positive regulation of blood pressure	IEA
GO:0045777	Process	Positive regulation of blood pressure	ISS
GO:0050911	Process	Detection of chemical stimulus involved in sensory perception of smell	IEA
GO:0071396	Process	Cellular response to lipid	IEA
GO:0071398	Process	Cellular response to fatty acid	IEA
GO:0071398	Process	Cellular response to fatty acid	ISS
GO:0097325	Process	Melanocyte proliferation	IMP	27226631
GO:1900135	Process	Positive regulation of renin secretion into blood stream	IEA
GO:1900135	Process	Positive regulation of renin secretion into blood stream	ISS

MIM	HGNC	e!Ensembl
611268	15195	ENSG00000167332

Q9H255

Protein name

Olfactory receptor 51E2 (HPRAJ) (Olfactory receptor OR11-16) (Prostate-specific G-protein coupled receptor)

Protein function

Olfactory receptor (PubMed:27226631, PubMed:29249973). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:19389702, PubMed:27226631, PubMed:29249973). The activity of this receptor is probably mediated by G-proteins leading to

PDB

8F76

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13853	7tm_4	30 → 309	Olfactory receptor	Family

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the prostate (PubMed:11707321). Also expressed in spleen, liver, olfactory epithelium, retinal pigment epithelium and medulla oblongata (PubMed:11707321, PubMed:16491480, PubMed:29249973). In the retinal pigment epi

Sequence

MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYL
FLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFD
RYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVH
QDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTC
VSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRT
RVLAMFKISCDKDLQAVGGK

Sequence length

320

Interactions

View interactions

	KEGG		Reactome
	Olfactory transduction		Olfactory Signaling Pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	17166409		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cap Myopathy	Cap myopathy	Pubtator	17166409	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	11118034, 11593396, 15499628, 16149059, 16206286, 16231015, 16491480, 17166409, 19389702, 20672322, 24517338, 25219547, 26028029, 27280498, 30928381		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16491480		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	28191688		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11118034, 16231015, 26028029		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	11118034, 11593396, 15499628, 16149059, 16231015, 16491480, 17166409, 19389702, 20672322, 24517338, 25219547, 26028029, 27280498, 30928381		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Hyperplasia	Prostatic hyperplasia	Pubtator	17166409	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Intraepithelial Neoplasia	Prostatic intraepithelial neoplasia	Pubtator	26582057	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Intraepithelial Neoplasias	Prostatic Neoplasms	BEFREE	15499628, 16149059		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	BEFREE	15499628, 16149059, 26028029		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	LHGDN	15499628, 16231015, 16491480		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	19389702, 24517338, 26582057, 27374083, 28910345, 37245085, 37270661	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	33640452	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

OR51E2 (olfactory receptor family 51 subfamily E member 2)