Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	80852
Gene name	Glutamate receptor interacting protein 2
Gene symbol	GRIP2
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3p25.1

174

Show/Hide all (174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019003	hsa-miR-335-5p	Microarray	18185580
MIRT1034764	hsa-miR-1297	CLIP-seq
MIRT1034765	hsa-miR-1299	CLIP-seq
MIRT1034766	hsa-miR-1301	CLIP-seq
MIRT1034767	hsa-miR-136	CLIP-seq
MIRT1034768	hsa-miR-149	CLIP-seq
MIRT1034769	hsa-miR-1915	CLIP-seq
MIRT1034770	hsa-miR-2355-5p	CLIP-seq
MIRT1034771	hsa-miR-26a	CLIP-seq
MIRT1034772	hsa-miR-26b	CLIP-seq
MIRT1034773	hsa-miR-3173-3p	CLIP-seq
MIRT1034774	hsa-miR-326	CLIP-seq
MIRT1034775	hsa-miR-330-5p	CLIP-seq
MIRT1034776	hsa-miR-331-5p	CLIP-seq
MIRT1034777	hsa-miR-3612	CLIP-seq
MIRT1034778	hsa-miR-3661	CLIP-seq
MIRT1034779	hsa-miR-3679-3p	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034781	hsa-miR-370	CLIP-seq
MIRT1034782	hsa-miR-378	CLIP-seq
MIRT1034783	hsa-miR-378b	CLIP-seq
MIRT1034784	hsa-miR-378c	CLIP-seq
MIRT1034785	hsa-miR-378d	CLIP-seq
MIRT1034786	hsa-miR-378e	CLIP-seq
MIRT1034787	hsa-miR-378f	CLIP-seq
MIRT1034788	hsa-miR-378h	CLIP-seq
MIRT1034789	hsa-miR-378i	CLIP-seq
MIRT1034790	hsa-miR-3922-5p	CLIP-seq
MIRT1034791	hsa-miR-422a	CLIP-seq
MIRT1034792	hsa-miR-4264	CLIP-seq
MIRT1034793	hsa-miR-4267	CLIP-seq
MIRT1034794	hsa-miR-4287	CLIP-seq
MIRT1034795	hsa-miR-4305	CLIP-seq
MIRT1034796	hsa-miR-4328	CLIP-seq
MIRT1034797	hsa-miR-4443	CLIP-seq
MIRT1034798	hsa-miR-4446-5p	CLIP-seq
MIRT1034799	hsa-miR-4465	CLIP-seq
MIRT1034800	hsa-miR-4638-3p	CLIP-seq
MIRT1034801	hsa-miR-4639-3p	CLIP-seq
MIRT1034802	hsa-miR-4660	CLIP-seq
MIRT1034803	hsa-miR-4678	CLIP-seq
MIRT1034804	hsa-miR-4685-3p	CLIP-seq
MIRT1034805	hsa-miR-4695-5p	CLIP-seq
MIRT1034806	hsa-miR-4708-3p	CLIP-seq
MIRT1034807	hsa-miR-4726-3p	CLIP-seq
MIRT1034808	hsa-miR-4729	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT1034810	hsa-miR-4758-3p	CLIP-seq
MIRT1034811	hsa-miR-4780	CLIP-seq
MIRT1034812	hsa-miR-4797-3p	CLIP-seq
MIRT1034813	hsa-miR-4802-5p	CLIP-seq
MIRT1034814	hsa-miR-483-3p	CLIP-seq
MIRT1034815	hsa-miR-485-5p	CLIP-seq
MIRT1034816	hsa-miR-498	CLIP-seq
MIRT1034817	hsa-miR-502-5p	CLIP-seq
MIRT1034818	hsa-miR-5047	CLIP-seq
MIRT1034819	hsa-miR-508-5p	CLIP-seq
MIRT1034820	hsa-miR-513a-3p	CLIP-seq
MIRT1034821	hsa-miR-542-5p	CLIP-seq
MIRT1034822	hsa-miR-548m	CLIP-seq
MIRT1034823	hsa-miR-623	CLIP-seq
MIRT1034824	hsa-miR-631	CLIP-seq
MIRT1034825	hsa-miR-650	CLIP-seq
MIRT1034826	hsa-miR-769-5p	CLIP-seq
MIRT1034827	hsa-miR-875-3p	CLIP-seq
MIRT1034828	hsa-miR-877	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034781	hsa-miR-370	CLIP-seq
MIRT1034790	hsa-miR-3922-5p	CLIP-seq
MIRT1034794	hsa-miR-4287	CLIP-seq
MIRT1549392	hsa-miR-4297	CLIP-seq
MIRT1034804	hsa-miR-4685-3p	CLIP-seq
MIRT1034806	hsa-miR-4708-3p	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT1034811	hsa-miR-4780	CLIP-seq
MIRT1034823	hsa-miR-623	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2006856	hsa-miR-1178	CLIP-seq
MIRT2006857	hsa-miR-1302	CLIP-seq
MIRT2006858	hsa-miR-147	CLIP-seq
MIRT2006859	hsa-miR-3138	CLIP-seq
MIRT1034774	hsa-miR-326	CLIP-seq
MIRT1034775	hsa-miR-330-5p	CLIP-seq
MIRT1034778	hsa-miR-3661	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034781	hsa-miR-370	CLIP-seq
MIRT2006860	hsa-miR-3907	CLIP-seq
MIRT2006861	hsa-miR-3911	CLIP-seq
MIRT1034790	hsa-miR-3922-5p	CLIP-seq
MIRT1034794	hsa-miR-4287	CLIP-seq
MIRT1549392	hsa-miR-4297	CLIP-seq
MIRT2006862	hsa-miR-4298	CLIP-seq
MIRT2006863	hsa-miR-4436b-3p	CLIP-seq
MIRT1034801	hsa-miR-4639-3p	CLIP-seq
MIRT1034804	hsa-miR-4685-3p	CLIP-seq
MIRT2006864	hsa-miR-4685-5p	CLIP-seq
MIRT1034806	hsa-miR-4708-3p	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2006865	hsa-miR-4736	CLIP-seq
MIRT1034811	hsa-miR-4780	CLIP-seq
MIRT2006866	hsa-miR-4800-5p	CLIP-seq
MIRT1034823	hsa-miR-623	CLIP-seq
MIRT1034824	hsa-miR-631	CLIP-seq
MIRT2006867	hsa-miR-635	CLIP-seq
MIRT2006868	hsa-miR-644	CLIP-seq
MIRT1034826	hsa-miR-769-5p	CLIP-seq
MIRT2239345	hsa-miR-1207-5p	CLIP-seq
MIRT2239346	hsa-miR-1238	CLIP-seq
MIRT1034764	hsa-miR-1297	CLIP-seq
MIRT1034771	hsa-miR-26a	CLIP-seq
MIRT1034772	hsa-miR-26b	CLIP-seq
MIRT2239347	hsa-miR-3120-3p	CLIP-seq
MIRT2239348	hsa-miR-3121-5p	CLIP-seq
MIRT2239349	hsa-miR-3143	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT2239350	hsa-miR-377	CLIP-seq
MIRT2006860	hsa-miR-3907	CLIP-seq
MIRT2239351	hsa-miR-4325	CLIP-seq
MIRT1034799	hsa-miR-4465	CLIP-seq
MIRT2239352	hsa-miR-4661-5p	CLIP-seq
MIRT2006864	hsa-miR-4685-5p	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2239353	hsa-miR-4763-3p	CLIP-seq
MIRT1034816	hsa-miR-498	CLIP-seq
MIRT2239354	hsa-miR-507	CLIP-seq
MIRT1034820	hsa-miR-513a-3p	CLIP-seq
MIRT1034821	hsa-miR-542-5p	CLIP-seq
MIRT2239355	hsa-miR-545	CLIP-seq
MIRT2239356	hsa-miR-550a	CLIP-seq
MIRT2239357	hsa-miR-557	CLIP-seq
MIRT2239358	hsa-miR-671-5p	CLIP-seq
MIRT2388782	hsa-miR-1236	CLIP-seq
MIRT1034764	hsa-miR-1297	CLIP-seq
MIRT2006858	hsa-miR-147	CLIP-seq
MIRT1034771	hsa-miR-26a	CLIP-seq
MIRT1034772	hsa-miR-26b	CLIP-seq
MIRT2006859	hsa-miR-3138	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT2006861	hsa-miR-3911	CLIP-seq
MIRT1549392	hsa-miR-4297	CLIP-seq
MIRT1034799	hsa-miR-4465	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2006866	hsa-miR-4800-5p	CLIP-seq
MIRT1034816	hsa-miR-498	CLIP-seq
MIRT1034820	hsa-miR-513a-3p	CLIP-seq
MIRT1034821	hsa-miR-542-5p	CLIP-seq
MIRT2006867	hsa-miR-635	CLIP-seq
MIRT2006868	hsa-miR-644	CLIP-seq
MIRT1034780	hsa-miR-3680	CLIP-seq
MIRT1034809	hsa-miR-4733-3p	CLIP-seq
MIRT2450791	hsa-miR-186	CLIP-seq
MIRT2450792	hsa-miR-3154	CLIP-seq
MIRT2450793	hsa-miR-3656	CLIP-seq
MIRT2006863	hsa-miR-4436b-3p	CLIP-seq
MIRT2450794	hsa-miR-4728-3p	CLIP-seq
MIRT2543175	hsa-miR-1307	CLIP-seq
MIRT2543176	hsa-miR-1324	CLIP-seq
MIRT2239347	hsa-miR-3120-3p	CLIP-seq
MIRT2543177	hsa-miR-3183	CLIP-seq
MIRT2543178	hsa-miR-361-3p	CLIP-seq
MIRT2543179	hsa-miR-3615	CLIP-seq
MIRT2239350	hsa-miR-377	CLIP-seq
MIRT2543180	hsa-miR-3943	CLIP-seq
MIRT2543181	hsa-miR-4279	CLIP-seq
MIRT2543182	hsa-miR-4638-5p	CLIP-seq
MIRT2543183	hsa-miR-4650-5p	CLIP-seq
MIRT2543184	hsa-miR-4723-3p	CLIP-seq
MIRT2543185	hsa-miR-4757-5p	CLIP-seq
MIRT2239355	hsa-miR-545	CLIP-seq
MIRT2543176	hsa-miR-1324	CLIP-seq
MIRT2239347	hsa-miR-3120-3p	CLIP-seq
MIRT2239350	hsa-miR-377	CLIP-seq
MIRT2239355	hsa-miR-545	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0007219	Process	Notch signaling pathway	IEA
GO:0014824	Process	Artery smooth muscle contraction	IEA
GO:0016020	Component	Membrane	IEA
GO:0045777	Process	Positive regulation of blood pressure	IEA
GO:0098887	Process	Neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA
GO:0098887	Process	Neurotransmitter receptor transport, endosome to postsynaptic membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099003	Process	Vesicle-mediated transport in synapse	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q9C0E4

Protein name

Glutamate receptor-interacting protein 2 (GRIP-2)

Protein function

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.

PDB

1V62 , 1X5R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	48 → 128	PDZ domain	Domain
PF00595	PDZ	146 → 231	PDZ domain	Domain
PF00595	PDZ	249 → 329	PDZ domain	Domain
PF17820	PDZ_6	486 → 542	PDZ domain	Domain
PF00595	PDZ	557 → 638	PDZ domain	Domain
PF00595	PDZ	656 → 735	PDZ domain	Domain
PF00595	PDZ	941 → 1020	PDZ domain	Domain

Sequence

MLCGLSRETPGEADDGPYSKGGKDAGGADVSLACRRQSIPEEFRGITVVELIKKEGSTLG
LTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGIHLTRLRHDEIITLLKNVG
ERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGNSFGFVLRGGAHEDGHKSRPLVLTY
VRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALATLRQCSHEALFQVEYDVATPDTV
ANASGPLMVEIVKTPGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSI
DGTSMEHCSLLEATKLLASISEKVRLEILPVPQSQRPLRPSEAVKVQRSEQLHRWDPCVP
SCHSPRPGHCRMPTWATPAGQDQSRSLSSTPFSSPTLNHAFSCNNPSTLPRGSQPMSPRT
TMGRRRQRRREHKSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATET
LSSPPLVCFIEPDSPAERCGLLQVGDRVLSINGIATEDGTMEEANQLLRDAALAHKVVLE
VEFDVAESVIPSSGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTL
EPGDKLLAIDNIRLDNCPMEDAVQILRQCEDLVKLKIRKDEDNSDELETTGAVSYTVELK
RYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAI
HLLQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSV
DSAVESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPA
DESFPEEEEEDDWEPPTSPAPGPAREEGFWRMFGEALEDLESCGQSELLRELEASIMTGT
VQRVALEGRPGHRPWQRGREVRASPAEMEELLLPTPLEMHKVTLHKDPMRHDFGFSVSDG
LLEKGVYVHTVRPDGPAHRGGLQPFDRVLQVNHVRTRDFDCCLAVPLLAEAGDVLELIIS
RKPHTAHSSRAPRSPGPSSPRML

Sequence length

1043

Interactions

View interactions

	Reactome
			Trafficking of GluR2-containing AMPA receptors

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STROKE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	34407845	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	35257412	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	32529991	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GRIP2 (glutamate receptor interacting protein 2)