TAS1R2 (taste 1 receptor member 2)

Gene

• Entrez ID: 80834
• Gene name: Taste 1 receptor member 2
• Gene symbol: TAS1R2
• Synonyms (NCBI Gene): GPR71, T1R2, TR2
• Chromosome: 1
• Chromosome location: 1p36.13

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001582	Process	Detection of chemical stimulus involved in sensory perception of sweet taste	IDA	16720576
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IC	16720576
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0008527	Function	Taste receptor activity	IDA	16720576
GO:0008527	Function	Taste receptor activity	IEA
GO:0008527	Function	Taste receptor activity	IPI	11917125
GO:0016020	Component	Membrane	IC	11917125
GO:0016020	Component	Membrane	IEA
GO:0032467	Process	Positive regulation of cytokinesis	IMP	22888021
GO:0033041	Function	Sweet taste receptor activity	IBA
GO:0033041	Function	Sweet taste receptor activity	IDA	16720576
GO:0033041	Function	Sweet taste receptor activity	IEA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0050909	Process	Sensory perception of taste	IEA
GO:0050916	Process	Sensory perception of sweet taste	IBA
GO:0050916	Process	Sensory perception of sweet taste	IDA	11917125
GO:0050916	Process	Sensory perception of sweet taste	IEA
GO:0050916	Process	Sensory perception of sweet taste	IEA
GO:1903767	Component	Sweet taste receptor complex	IBA
GO:1903767	Component	Sweet taste receptor complex	IDA	16720576

Other IDs

• MIM: 606226
• HGNC: 14905
• e!Ensembl: ENSG00000179002

Protein

• UniProt ID: Q8TE23
• Protein name: Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2)
• Protein function: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01094	ANF_receptor	70 → 457	Receptor family ligand binding region	Family
  PF07562	NCD3G	491 → 544	Nine Cysteines Domain of family 3 GPCR	Family
  PF00003	7tm_3	577 → 814	7 transmembrane sweet-taste receptor of 3 GCPR	Family

• Sequence:

  MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCK
  EYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDN
  LLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPAL
  LRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETL
  PTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIA
  SESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCN
  QECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQL
  LEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQD
  ISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPN
  NEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAG
  GPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFK
  MASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSC
  NPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFM
  SAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD

• Sequence length: 839

Pathways

KEGG:

Taste transduction
Carbohydrate digestion and absorption

Reactome:

G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Dental Caries	Dental caries	Pubtator	20858777, 31261961, 36335309, 36609159	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	23761104, 35466133	Stimulate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	19039089		★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	Pubtator	23761104	Associate	★☆☆☆☆ Found in Text Mining only
Hypertriglyceridemia	Hypertriglyceridemia	Pubtator	26907331	Associate	★☆☆☆☆ Found in Text Mining only
Myotonic Dystrophy	Myotonic dystrophy	Pubtator	28977211	Associate	★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	20943793, 35510485	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	16805794		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pulmonary Arterial Hypertension	Pulmonary arterial hypertension	Pubtator	28977211	Associate	★☆☆☆☆ Found in Text Mining only