Gene Gene information from NCBI Gene database.
Entrez ID 80830
Gene name Apolipoprotein L6
Gene symbol APOL6
Synonyms (NCBI Gene)
APOL-VIAPOLVI
Chromosome 22
Chromosome location 22q12.3
Summary This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
1600
miRTarBase ID miRNA Experiments Reference
MIRT709203 hsa-miR-4742-3p HITS-CLIP 19536157
MIRT716744 hsa-miR-4778-3p HITS-CLIP 19536157
MIRT709202 hsa-miR-630 HITS-CLIP 19536157
MIRT709201 hsa-miR-943 HITS-CLIP 19536157
MIRT716743 hsa-miR-4659a-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005576 Component Extracellular region IEA
GO:0005737 Component Cytoplasm IEA
GO:0006869 Process Lipid transport IEA
GO:0008289 Function Lipid binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607256 14870 ENSG00000221963
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BWW8
Protein name Apolipoprotein L6 (Apolipoprotein L-VI) (ApoL-VI)
Protein function May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05461 ApoL 14 292 Apolipoprotein L Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed; highly expressed in the uterus, fetal brain and spinal cord, also detected in heart, liver, lung, colon, spleen, thymus, prostate, placenta, adrenal gland, salivary and mammary gland.
Sequence
Sequence length 343
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLONIC NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arteriosclerosis Arteriosclerosis BEFREE 21646352
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 21646352
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 21646352 Associate
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular Diseases BEFREE 21646352
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular disease Pubtator 21646352 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 38387508 Associate
★☆☆☆☆
Found in Text Mining only
Metabolic Syndrome X Metabolic Syndrome BEFREE 23911300
★☆☆☆☆
Found in Text Mining only
Osteoarthritis Osteoarthritis Pubtator 37443790 Associate
★☆☆☆☆
Found in Text Mining only
Pancreatic Neoplasms Pancreatic neoplasm Pubtator 36979348 Associate
★☆☆☆☆
Found in Text Mining only
Parkinson Disease Parkinson disease Pubtator 37107677 Associate
★☆☆☆☆
Found in Text Mining only