Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	8079
Gene name	Myeloid leukemia factor 2
Gene symbol	MLF2
Synonyms (NCBI Gene)	NTN4
Chromosome	12
Chromosome location	12p13.31

186

Show/Hide all (186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051088	hsa-miR-16-5p	CLASH	23622248
MIRT049518	hsa-miR-92a-3p	CLASH	23622248
MIRT038370	hsa-miR-296-3p	CLASH	23622248
MIRT037535	hsa-miR-744-5p	CLASH	23622248
MIRT655716	hsa-miR-4282	HITS-CLIP	23824327
MIRT655715	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT655714	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT655713	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT655712	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT655711	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT655710	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT655716	hsa-miR-4282	HITS-CLIP	23824327
MIRT655715	hsa-miR-6507-3p	HITS-CLIP	23824327
MIRT655714	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT655713	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT655712	hsa-miR-4662a-5p	HITS-CLIP	23824327
MIRT655711	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT655710	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT1150968	hsa-miR-122	CLIP-seq
MIRT1150969	hsa-miR-1252	CLIP-seq
MIRT1150970	hsa-miR-147	CLIP-seq
MIRT1150971	hsa-miR-185	CLIP-seq
MIRT1150972	hsa-miR-186	CLIP-seq
MIRT1150973	hsa-miR-2110	CLIP-seq
MIRT1150974	hsa-miR-3125	CLIP-seq
MIRT1150975	hsa-miR-3126-5p	CLIP-seq
MIRT1150976	hsa-miR-3127-5p	CLIP-seq
MIRT1150977	hsa-miR-3148	CLIP-seq
MIRT1150978	hsa-miR-3150a-3p	CLIP-seq
MIRT1150979	hsa-miR-3154	CLIP-seq
MIRT1150980	hsa-miR-3184	CLIP-seq
MIRT1150981	hsa-miR-3613-3p	CLIP-seq
MIRT1150982	hsa-miR-3714	CLIP-seq
MIRT1150983	hsa-miR-3911	CLIP-seq
MIRT1150984	hsa-miR-3916	CLIP-seq
MIRT1150985	hsa-miR-3919	CLIP-seq
MIRT1150986	hsa-miR-4279	CLIP-seq
MIRT1150987	hsa-miR-4433	CLIP-seq
MIRT1150988	hsa-miR-4450	CLIP-seq
MIRT1150989	hsa-miR-4484	CLIP-seq
MIRT1150990	hsa-miR-4685-5p	CLIP-seq
MIRT1150991	hsa-miR-4719	CLIP-seq
MIRT1150992	hsa-miR-4802-5p	CLIP-seq
MIRT1150993	hsa-miR-486-5p	CLIP-seq
MIRT1150994	hsa-miR-541	CLIP-seq
MIRT1150995	hsa-miR-548an	CLIP-seq
MIRT1150996	hsa-miR-587	CLIP-seq
MIRT1150997	hsa-miR-644	CLIP-seq
MIRT1150998	hsa-miR-654-5p	CLIP-seq
MIRT1150973	hsa-miR-2110	CLIP-seq
MIRT1150974	hsa-miR-3125	CLIP-seq
MIRT1150975	hsa-miR-3126-5p	CLIP-seq
MIRT1150976	hsa-miR-3127-5p	CLIP-seq
MIRT1150977	hsa-miR-3148	CLIP-seq
MIRT1150978	hsa-miR-3150a-3p	CLIP-seq
MIRT2043062	hsa-miR-3915	CLIP-seq
MIRT1150984	hsa-miR-3916	CLIP-seq
MIRT2043063	hsa-miR-3921	CLIP-seq
MIRT2043064	hsa-miR-3928	CLIP-seq
MIRT1150986	hsa-miR-4279	CLIP-seq
MIRT2043065	hsa-miR-4283	CLIP-seq
MIRT2043066	hsa-miR-4447	CLIP-seq
MIRT1150988	hsa-miR-4450	CLIP-seq
MIRT2043067	hsa-miR-4472	CLIP-seq
MIRT2043068	hsa-miR-4488	CLIP-seq
MIRT2043069	hsa-miR-4649-3p	CLIP-seq
MIRT2043070	hsa-miR-4653-5p	CLIP-seq
MIRT1150990	hsa-miR-4685-5p	CLIP-seq
MIRT2043071	hsa-miR-4697-5p	CLIP-seq
MIRT2043072	hsa-miR-4749-3p	CLIP-seq
MIRT1150992	hsa-miR-4802-5p	CLIP-seq
MIRT1150994	hsa-miR-541	CLIP-seq
MIRT1150996	hsa-miR-587	CLIP-seq
MIRT1150998	hsa-miR-654-5p	CLIP-seq
MIRT2043073	hsa-miR-760	CLIP-seq
MIRT2043074	hsa-miR-889	CLIP-seq
MIRT1150969	hsa-miR-1252	CLIP-seq
MIRT1150970	hsa-miR-147	CLIP-seq
MIRT1150971	hsa-miR-185	CLIP-seq
MIRT1150972	hsa-miR-186	CLIP-seq
MIRT1150975	hsa-miR-3126-5p	CLIP-seq
MIRT1150979	hsa-miR-3154	CLIP-seq
MIRT2272555	hsa-miR-33a	CLIP-seq
MIRT2272556	hsa-miR-33b	CLIP-seq
MIRT1150981	hsa-miR-3613-3p	CLIP-seq
MIRT2272557	hsa-miR-3670	CLIP-seq
MIRT1150982	hsa-miR-3714	CLIP-seq
MIRT1150983	hsa-miR-3911	CLIP-seq
MIRT2043062	hsa-miR-3915	CLIP-seq
MIRT1150985	hsa-miR-3919	CLIP-seq
MIRT2043063	hsa-miR-3921	CLIP-seq
MIRT2043064	hsa-miR-3928	CLIP-seq
MIRT2043065	hsa-miR-4283	CLIP-seq
MIRT1150987	hsa-miR-4433	CLIP-seq
MIRT2043066	hsa-miR-4447	CLIP-seq
MIRT2043067	hsa-miR-4472	CLIP-seq
MIRT1150989	hsa-miR-4484	CLIP-seq
MIRT2043068	hsa-miR-4488	CLIP-seq
MIRT2043069	hsa-miR-4649-3p	CLIP-seq
MIRT2043070	hsa-miR-4653-5p	CLIP-seq
MIRT1150990	hsa-miR-4685-5p	CLIP-seq
MIRT2043071	hsa-miR-4697-5p	CLIP-seq
MIRT2272558	hsa-miR-4698	CLIP-seq
MIRT1150991	hsa-miR-4719	CLIP-seq
MIRT2272559	hsa-miR-4725-5p	CLIP-seq
MIRT1150992	hsa-miR-4802-5p	CLIP-seq
MIRT1150993	hsa-miR-486-5p	CLIP-seq
MIRT2272560	hsa-miR-488	CLIP-seq
MIRT2272561	hsa-miR-504	CLIP-seq
MIRT1150994	hsa-miR-541	CLIP-seq
MIRT1150995	hsa-miR-548an	CLIP-seq
MIRT2272562	hsa-miR-586	CLIP-seq
MIRT2272563	hsa-miR-622	CLIP-seq
MIRT1150997	hsa-miR-644	CLIP-seq
MIRT1150998	hsa-miR-654-5p	CLIP-seq
MIRT2043073	hsa-miR-760	CLIP-seq
MIRT1150979	hsa-miR-3154	CLIP-seq
MIRT1150981	hsa-miR-3613-3p	CLIP-seq
MIRT1150982	hsa-miR-3714	CLIP-seq
MIRT1150985	hsa-miR-3919	CLIP-seq
MIRT1150989	hsa-miR-4484	CLIP-seq
MIRT1150991	hsa-miR-4719	CLIP-seq
MIRT1150995	hsa-miR-548an	CLIP-seq
MIRT2454181	hsa-miR-1915	CLIP-seq
MIRT2454182	hsa-miR-361-3p	CLIP-seq
MIRT2454183	hsa-miR-4270	CLIP-seq
MIRT2454184	hsa-miR-4324	CLIP-seq
MIRT2454185	hsa-miR-4329	CLIP-seq
MIRT2454186	hsa-miR-4441	CLIP-seq
MIRT2043066	hsa-miR-4447	CLIP-seq
MIRT2043067	hsa-miR-4472	CLIP-seq
MIRT2454187	hsa-miR-4786-5p	CLIP-seq
MIRT2454188	hsa-miR-769-5p	CLIP-seq
MIRT1150968	hsa-miR-122	CLIP-seq
MIRT2454181	hsa-miR-1915	CLIP-seq
MIRT2571454	hsa-miR-2053	CLIP-seq
MIRT1150973	hsa-miR-2110	CLIP-seq
MIRT1150974	hsa-miR-3125	CLIP-seq
MIRT1150976	hsa-miR-3127-5p	CLIP-seq
MIRT1150977	hsa-miR-3148	CLIP-seq
MIRT1150978	hsa-miR-3150a-3p	CLIP-seq
MIRT1150980	hsa-miR-3184	CLIP-seq
MIRT2454182	hsa-miR-361-3p	CLIP-seq
MIRT1150984	hsa-miR-3916	CLIP-seq
MIRT2454183	hsa-miR-4270	CLIP-seq
MIRT1150987	hsa-miR-4433	CLIP-seq
MIRT2454186	hsa-miR-4441	CLIP-seq
MIRT2043066	hsa-miR-4447	CLIP-seq
MIRT1150988	hsa-miR-4450	CLIP-seq
MIRT2043067	hsa-miR-4472	CLIP-seq
MIRT2043068	hsa-miR-4488	CLIP-seq
MIRT2043071	hsa-miR-4697-5p	CLIP-seq
MIRT2272559	hsa-miR-4725-5p	CLIP-seq
MIRT2571455	hsa-miR-4775	CLIP-seq
MIRT2454187	hsa-miR-4786-5p	CLIP-seq
MIRT2272561	hsa-miR-504	CLIP-seq
MIRT2571456	hsa-miR-569	CLIP-seq
MIRT2454188	hsa-miR-769-5p	CLIP-seq
MIRT2043074	hsa-miR-889	CLIP-seq
MIRT1150968	hsa-miR-122	CLIP-seq
MIRT2454181	hsa-miR-1915	CLIP-seq
MIRT2571454	hsa-miR-2053	CLIP-seq
MIRT1150973	hsa-miR-2110	CLIP-seq
MIRT1150974	hsa-miR-3125	CLIP-seq
MIRT1150976	hsa-miR-3127-5p	CLIP-seq
MIRT1150977	hsa-miR-3148	CLIP-seq
MIRT1150978	hsa-miR-3150a-3p	CLIP-seq
MIRT1150980	hsa-miR-3184	CLIP-seq
MIRT2454182	hsa-miR-361-3p	CLIP-seq
MIRT1150984	hsa-miR-3916	CLIP-seq
MIRT2454183	hsa-miR-4270	CLIP-seq
MIRT1150987	hsa-miR-4433	CLIP-seq
MIRT2454186	hsa-miR-4441	CLIP-seq
MIRT2043066	hsa-miR-4447	CLIP-seq
MIRT1150988	hsa-miR-4450	CLIP-seq
MIRT2043067	hsa-miR-4472	CLIP-seq
MIRT2043068	hsa-miR-4488	CLIP-seq
MIRT1150990	hsa-miR-4685-5p	CLIP-seq
MIRT2043071	hsa-miR-4697-5p	CLIP-seq
MIRT2272559	hsa-miR-4725-5p	CLIP-seq
MIRT2571455	hsa-miR-4775	CLIP-seq
MIRT2454187	hsa-miR-4786-5p	CLIP-seq
MIRT2272561	hsa-miR-504	CLIP-seq
MIRT2571456	hsa-miR-569	CLIP-seq
MIRT2454188	hsa-miR-769-5p	CLIP-seq
MIRT2043074	hsa-miR-889	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23414517, 25036637, 26496610, 32707033, 33961781, 37045861
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0016020	Component	Membrane	HDA	19946888
GO:0045202	Component	Synapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
601401	7126	ENSG00000089693

Q15773

Protein name

Myeloid leukemia factor 2 (Myelodysplasia-myeloid leukemia factor 2)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10248	Mlf1IP	15 → 199	Myelodysplasia-myeloid leukemia factor 1-interacting protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed.

Sequence

MFRFMRDVEPEDPMFLMDPFAIHRQHMSRMLSGGFGYSPFLSITDGNMPGTRPASRRMQQ
AGAVSPFGMLGMSGGFMDMFGMMNDMIGNMEHMTAGGNCQTFSSSTVISYSNTGDGAPKV
YQETSEMRSAPGGIRETRRTVRDSDSGLEQMSIGHHIRDRAHILQRSRNHRTGDQEERQD
YINLDESEAAAFDDEWRRETSRFRQQRPLEFRRLESSGAGGRRAEGPPRLAIQGPEDSPS
RQSRRYDW

Sequence length

248

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute leukemia	Leukemia	BEFREE	8661158		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blister	Blister	Pubtator	32342107	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	24876273		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31388936	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	36042172	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	34557292	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	24876273		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	31831854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24876273		★★★★★ ★☆☆☆☆ Found in Text Mining only

MLF2 (myeloid leukemia factor 2)