Gene Gene information from NCBI Gene database.
Entrez ID 80777
Gene name Cytochrome b5 type B
Gene symbol CYB5B
Synonyms (NCBI Gene)
CYB5-MCYPB5MOMB5
Chromosome 16
Chromosome location 16q22.1
miRNA miRNA information provided by mirtarbase database.
669
miRTarBase ID miRNA Experiments Reference
MIRT025368 hsa-miR-34a-5p Proteomics 21566225
MIRT025368 hsa-miR-34a-5p Proteomics 21566225
MIRT046142 hsa-miR-30b-5p CLASH 23622248
MIRT038950 hsa-miR-28-3p CLASH 23622248
MIRT036444 hsa-miR-1226-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25616068, 32296183
GO:0005739 Component Mitochondrion IEA
GO:0005741 Component Mitochondrial outer membrane IBA
GO:0005741 Component Mitochondrial outer membrane IEA
GO:0005741 Component Mitochondrial outer membrane TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611964 24374 ENSG00000103018
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43169
Protein name Cytochrome b5 type B (Cytochrome b5 outer mitochondrial membrane isoform)
Protein function Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
PDB 3NER
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00173 Cyt-b5 28 100 Cytochrome b5-like Heme/Steroid binding domain Domain
Sequence
MSGSMATAEASGSDGKGQEVETSVTYYRLEEVAKRNSLKELWLVIHGRVYDVTRFLNEHP
GGEEVLLEQAGVDASESFEDVGHSSDAREMLKQYYIGDIH
PSDLKPESGSKDPSKNDTCK
SCWAYWILPIIGAVLLGFLYRYYTSESKSS
Sequence length 150
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Phase I - Functionalization of compounds
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
14
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CATARACT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHOLELITHIASIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adult Hodgkin Lymphoma Hodgkin Lymphoma BEFREE 20100355
★☆☆☆☆
Found in Text Mining only
Hodgkin Disease Hodgkin Disease BEFREE 20100355
★☆☆☆☆
Found in Text Mining only
Hodgkin Disease Hodgkin disease Pubtator 20100355 Associate
★☆☆☆☆
Found in Text Mining only
Hypertension Hypertension Pubtator 25189868 Associate
★☆☆☆☆
Found in Text Mining only
Mitochondrial Diseases Mitochondrial disease Pubtator 38286121 Associate
★☆☆☆☆
Found in Text Mining only
Narcolepsy Narcolepsy GWASDB_DG 19629137
★☆☆☆☆
Found in Text Mining only