LIMD2 (LIM domain containing 2)

Gene

• Entrez ID: 80774
• Gene name: LIM domain containing 2
• Gene symbol: LIMD2
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020001	hsa-miR-375	Microarray	20215506
MIRT023120	hsa-miR-124-3p	Microarray	18668037
MIRT493329	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT493328	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT493327	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT493326	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT493325	hsa-miR-4458	PAR-CLIP	23592263
MIRT493324	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT493323	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT493322	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT493320	hsa-miR-4500	PAR-CLIP	23592263
MIRT493321	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT493319	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT493317	hsa-miR-6863	PAR-CLIP	23592263
MIRT493318	hsa-miR-6755-5p	PAR-CLIP	23592263
MIRT493316	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT493315	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT493314	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT493313	hsa-miR-3175	PAR-CLIP	23592263
MIRT493312	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT493311	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT493310	hsa-miR-197-5p	PAR-CLIP	23592263
MIRT493309	hsa-miR-3132	PAR-CLIP	23592263
MIRT493308	hsa-miR-4451	PAR-CLIP	23592263
MIRT493307	hsa-miR-6892-5p	PAR-CLIP	23592263
MIRT493306	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT493305	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT450500	hsa-miR-3145-5p	PAR-CLIP	22100165
MIRT450499	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT450498	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT450497	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT450496	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT450495	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT450494	hsa-miR-298	PAR-CLIP	22100165
MIRT450493	hsa-miR-498	PAR-CLIP	22100165
MIRT493329	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT493328	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT493327	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT493326	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT493325	hsa-miR-4458	PAR-CLIP	23592263
MIRT493324	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT493323	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT493322	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT493320	hsa-miR-4500	PAR-CLIP	23592263
MIRT493321	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT493319	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT493317	hsa-miR-6863	PAR-CLIP	23592263
MIRT493318	hsa-miR-6755-5p	PAR-CLIP	23592263
MIRT493316	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT493315	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT493314	hsa-miR-139-3p	PAR-CLIP	23592263
MIRT493313	hsa-miR-3175	PAR-CLIP	23592263
MIRT493312	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT493311	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT493310	hsa-miR-197-5p	PAR-CLIP	23592263
MIRT493309	hsa-miR-3132	PAR-CLIP	23592263
MIRT493308	hsa-miR-4451	PAR-CLIP	23592263
MIRT493307	hsa-miR-6892-5p	PAR-CLIP	23592263
MIRT493306	hsa-miR-3150a-3p	PAR-CLIP	23592263
MIRT493305	hsa-miR-6763-5p	PAR-CLIP	23592263
MIRT450500	hsa-miR-3145-5p	PAR-CLIP	22100165
MIRT450499	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT450498	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT450497	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT450496	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT450495	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT450494	hsa-miR-298	PAR-CLIP	22100165
MIRT450493	hsa-miR-498	PAR-CLIP	22100165
MIRT1109585	hsa-miR-1226	CLIP-seq
MIRT1109586	hsa-miR-1266	CLIP-seq
MIRT1109587	hsa-miR-1272	CLIP-seq
MIRT1109588	hsa-miR-1287	CLIP-seq
MIRT1109589	hsa-miR-1291	CLIP-seq
MIRT1109590	hsa-miR-1293	CLIP-seq
MIRT1109591	hsa-miR-1825	CLIP-seq
MIRT1109592	hsa-miR-1972	CLIP-seq
MIRT1109593	hsa-miR-2467-5p	CLIP-seq
MIRT1109594	hsa-miR-2682	CLIP-seq
MIRT1109595	hsa-miR-297	CLIP-seq
MIRT1109596	hsa-miR-3135b	CLIP-seq
MIRT1109597	hsa-miR-3149	CLIP-seq
MIRT1109598	hsa-miR-3151	CLIP-seq
MIRT1109599	hsa-miR-3188	CLIP-seq
MIRT1109600	hsa-miR-328	CLIP-seq
MIRT1109601	hsa-miR-342-5p	CLIP-seq
MIRT1109602	hsa-miR-345	CLIP-seq
MIRT1109603	hsa-miR-3664-3p	CLIP-seq
MIRT1109604	hsa-miR-3914	CLIP-seq
MIRT1109605	hsa-miR-3929	CLIP-seq
MIRT1109606	hsa-miR-3975	CLIP-seq
MIRT1109607	hsa-miR-412	CLIP-seq
MIRT1109608	hsa-miR-4269	CLIP-seq
MIRT1109609	hsa-miR-4277	CLIP-seq
MIRT1109610	hsa-miR-4290	CLIP-seq
MIRT1109611	hsa-miR-4318	CLIP-seq
MIRT1109612	hsa-miR-4419b	CLIP-seq
MIRT1109613	hsa-miR-4434	CLIP-seq
MIRT1109614	hsa-miR-4455	CLIP-seq
MIRT1109615	hsa-miR-4478	CLIP-seq
MIRT1109616	hsa-miR-4483	CLIP-seq
MIRT1109617	hsa-miR-449c	CLIP-seq
MIRT1109618	hsa-miR-4514	CLIP-seq
MIRT1109619	hsa-miR-4516	CLIP-seq
MIRT1109620	hsa-miR-4518	CLIP-seq
MIRT1109621	hsa-miR-4531	CLIP-seq
MIRT1109622	hsa-miR-4649-3p	CLIP-seq
MIRT1109623	hsa-miR-4650-5p	CLIP-seq
MIRT1109624	hsa-miR-4651	CLIP-seq
MIRT1109625	hsa-miR-4664-5p	CLIP-seq
MIRT1109626	hsa-miR-4692	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT1109628	hsa-miR-4742-5p	CLIP-seq
MIRT1109629	hsa-miR-4757-5p	CLIP-seq
MIRT1109630	hsa-miR-485-5p	CLIP-seq
MIRT1109631	hsa-miR-502-5p	CLIP-seq
MIRT1109632	hsa-miR-510	CLIP-seq
MIRT1109633	hsa-miR-513b	CLIP-seq
MIRT1109634	hsa-miR-515-3p	CLIP-seq
MIRT1109635	hsa-miR-519e	CLIP-seq
MIRT1109636	hsa-miR-541	CLIP-seq
MIRT1109637	hsa-miR-544b	CLIP-seq
MIRT1109638	hsa-miR-548aa	CLIP-seq
MIRT1109639	hsa-miR-548an	CLIP-seq
MIRT1109640	hsa-miR-550a	CLIP-seq
MIRT1109641	hsa-miR-608	CLIP-seq
MIRT1109642	hsa-miR-609	CLIP-seq
MIRT1109643	hsa-miR-628-5p	CLIP-seq
MIRT1109644	hsa-miR-654-5p	CLIP-seq
MIRT1550753	hsa-miR-3173-5p	CLIP-seq
MIRT2030487	hsa-let-7a	CLIP-seq
MIRT2030488	hsa-let-7b	CLIP-seq
MIRT2030489	hsa-let-7c	CLIP-seq
MIRT2030490	hsa-let-7d	CLIP-seq
MIRT2030491	hsa-let-7e	CLIP-seq
MIRT2030492	hsa-let-7f	CLIP-seq
MIRT2030493	hsa-let-7g	CLIP-seq
MIRT2030494	hsa-let-7i	CLIP-seq
MIRT2030495	hsa-miR-1184	CLIP-seq
MIRT1109590	hsa-miR-1293	CLIP-seq
MIRT2030496	hsa-miR-1294	CLIP-seq
MIRT2030497	hsa-miR-1343	CLIP-seq
MIRT2030498	hsa-miR-2467-3p	CLIP-seq
MIRT1109593	hsa-miR-2467-5p	CLIP-seq
MIRT2030499	hsa-miR-3140-3p	CLIP-seq
MIRT2030500	hsa-miR-3144-5p	CLIP-seq
MIRT2030501	hsa-miR-3184	CLIP-seq
MIRT1109599	hsa-miR-3188	CLIP-seq
MIRT2030502	hsa-miR-3191	CLIP-seq
MIRT1109601	hsa-miR-342-5p	CLIP-seq
MIRT2030503	hsa-miR-377	CLIP-seq
MIRT2030504	hsa-miR-3919	CLIP-seq
MIRT1109606	hsa-miR-3975	CLIP-seq
MIRT2030505	hsa-miR-3977	CLIP-seq
MIRT2030506	hsa-miR-423-5p	CLIP-seq
MIRT2030507	hsa-miR-4289	CLIP-seq
MIRT2030508	hsa-miR-4300	CLIP-seq
MIRT2030509	hsa-miR-4446-3p	CLIP-seq
MIRT1109616	hsa-miR-4483	CLIP-seq
MIRT2030510	hsa-miR-4492	CLIP-seq
MIRT2030511	hsa-miR-4498	CLIP-seq
MIRT2030512	hsa-miR-4505	CLIP-seq
MIRT1109622	hsa-miR-4649-3p	CLIP-seq
MIRT1109624	hsa-miR-4651	CLIP-seq
MIRT2030513	hsa-miR-4652-5p	CLIP-seq
MIRT2030514	hsa-miR-4653-3p	CLIP-seq
MIRT1109625	hsa-miR-4664-5p	CLIP-seq
MIRT2030515	hsa-miR-4667-5p	CLIP-seq
MIRT2030516	hsa-miR-4700-5p	CLIP-seq
MIRT2030517	hsa-miR-4710	CLIP-seq
MIRT2030518	hsa-miR-4728-5p	CLIP-seq
MIRT2030519	hsa-miR-4731-5p	CLIP-seq
MIRT2030520	hsa-miR-4756-3p	CLIP-seq
MIRT1109630	hsa-miR-485-5p	CLIP-seq
MIRT1109634	hsa-miR-515-3p	CLIP-seq
MIRT1109635	hsa-miR-519e	CLIP-seq
MIRT2030521	hsa-miR-520f	CLIP-seq
MIRT1109640	hsa-miR-550a	CLIP-seq
MIRT1109641	hsa-miR-608	CLIP-seq
MIRT2030522	hsa-miR-762	CLIP-seq
MIRT2030523	hsa-miR-920	CLIP-seq
MIRT2030524	hsa-miR-939	CLIP-seq
MIRT2030525	hsa-miR-98	CLIP-seq
MIRT2030487	hsa-let-7a	CLIP-seq
MIRT2030488	hsa-let-7b	CLIP-seq
MIRT2030489	hsa-let-7c	CLIP-seq
MIRT2030490	hsa-let-7d	CLIP-seq
MIRT2030491	hsa-let-7e	CLIP-seq
MIRT2030492	hsa-let-7f	CLIP-seq
MIRT2030493	hsa-let-7g	CLIP-seq
MIRT2030494	hsa-let-7i	CLIP-seq
MIRT2030496	hsa-miR-1294	CLIP-seq
MIRT2261273	hsa-miR-3127-5p	CLIP-seq
MIRT1109598	hsa-miR-3151	CLIP-seq
MIRT2030501	hsa-miR-3184	CLIP-seq
MIRT2261274	hsa-miR-3918	CLIP-seq
MIRT2030506	hsa-miR-423-5p	CLIP-seq
MIRT2261275	hsa-miR-4279	CLIP-seq
MIRT2030510	hsa-miR-4492	CLIP-seq
MIRT2030511	hsa-miR-4498	CLIP-seq
MIRT2030514	hsa-miR-4653-3p	CLIP-seq
MIRT2261276	hsa-miR-4685-5p	CLIP-seq
MIRT2030517	hsa-miR-4710	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT2030519	hsa-miR-4731-5p	CLIP-seq
MIRT2030522	hsa-miR-762	CLIP-seq
MIRT2030525	hsa-miR-98	CLIP-seq
MIRT2030496	hsa-miR-1294	CLIP-seq
MIRT2390150	hsa-miR-2355-5p	CLIP-seq
MIRT2030501	hsa-miR-3184	CLIP-seq
MIRT2390151	hsa-miR-361-3p	CLIP-seq
MIRT2030506	hsa-miR-423-5p	CLIP-seq
MIRT2261275	hsa-miR-4279	CLIP-seq
MIRT2030514	hsa-miR-4653-3p	CLIP-seq
MIRT2030517	hsa-miR-4710	CLIP-seq
MIRT2390152	hsa-miR-4781-5p	CLIP-seq
MIRT2453045	hsa-miR-1913	CLIP-seq
MIRT2453046	hsa-miR-1976	CLIP-seq
MIRT2453047	hsa-miR-3127-3p	CLIP-seq
MIRT2453048	hsa-miR-324-3p	CLIP-seq
MIRT2453049	hsa-miR-4267	CLIP-seq
MIRT2453050	hsa-miR-4667-3p	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT2453051	hsa-miR-4749-3p	CLIP-seq
MIRT2453045	hsa-miR-1913	CLIP-seq
MIRT2453046	hsa-miR-1976	CLIP-seq
MIRT2561255	hsa-miR-219-2-3p	CLIP-seq
MIRT2561256	hsa-miR-2964a-3p	CLIP-seq
MIRT2453047	hsa-miR-3127-3p	CLIP-seq
MIRT2453048	hsa-miR-324-3p	CLIP-seq
MIRT2561257	hsa-miR-3691-5p	CLIP-seq
MIRT2561258	hsa-miR-3944-5p	CLIP-seq
MIRT2453049	hsa-miR-4267	CLIP-seq
MIRT2561259	hsa-miR-4427	CLIP-seq
MIRT2453050	hsa-miR-4667-3p	CLIP-seq
MIRT2561260	hsa-miR-4680-3p	CLIP-seq
MIRT2561261	hsa-miR-4711-3p	CLIP-seq
MIRT2561262	hsa-miR-4715-3p	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT2453051	hsa-miR-4749-3p	CLIP-seq
MIRT2561263	hsa-miR-4752	CLIP-seq
MIRT2561264	hsa-miR-517a	CLIP-seq
MIRT2561265	hsa-miR-517b	CLIP-seq
MIRT2561266	hsa-miR-517c	CLIP-seq
MIRT2561267	hsa-miR-654-3p	CLIP-seq
MIRT2453045	hsa-miR-1913	CLIP-seq
MIRT2453046	hsa-miR-1976	CLIP-seq
MIRT2561255	hsa-miR-219-2-3p	CLIP-seq
MIRT2561256	hsa-miR-2964a-3p	CLIP-seq
MIRT2453047	hsa-miR-3127-3p	CLIP-seq
MIRT2453048	hsa-miR-324-3p	CLIP-seq
MIRT2561257	hsa-miR-3691-5p	CLIP-seq
MIRT2561258	hsa-miR-3944-5p	CLIP-seq
MIRT2453049	hsa-miR-4267	CLIP-seq
MIRT2561259	hsa-miR-4427	CLIP-seq
MIRT2453050	hsa-miR-4667-3p	CLIP-seq
MIRT2561260	hsa-miR-4680-3p	CLIP-seq
MIRT2561261	hsa-miR-4711-3p	CLIP-seq
MIRT2561262	hsa-miR-4715-3p	CLIP-seq
MIRT1109627	hsa-miR-4722-3p	CLIP-seq
MIRT2453051	hsa-miR-4749-3p	CLIP-seq
MIRT2561263	hsa-miR-4752	CLIP-seq
MIRT2561264	hsa-miR-517a	CLIP-seq
MIRT2561265	hsa-miR-517b	CLIP-seq
MIRT2561266	hsa-miR-517c	CLIP-seq
MIRT2561267	hsa-miR-654-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051015	Function	Actin filament binding	IBA
GO:0051017	Process	Actin filament bundle assembly	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9BT23
• Protein name: LIM domain-containing protein 2
• Protein function: Acts as an activator of the protein-kinase ILK, thereby regulating cell motility (PubMed:24590809).
• PDB: 2LZU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00412	LIM	40 → 96	LIM domain	Domain

• Sequence:

  MFQAAGAAQATPSHDAKGGGSSTVQRSKSFSLRAQVKETCAACQKTVYPMERLVADKLIF
  HNSCFCCKHCHTKLSLGSYAALHGEFYCKPHFQQLFKSKGNYDEGFGRKQHKELWAHKEV
  DPGTKTA

• Sequence length: 127

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	34713769	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18925433, 20185823		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	18925433		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	38116315	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	26593252		★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	20145149		★☆☆☆☆ Found in Text Mining only
Follicular thyroid carcinoma	Follicular Thyroid Carcinoma	BEFREE	29560564		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18925433, 20185823		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	18925433		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	26593252		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	30221696		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29560564		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	20145149		★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	18925433		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	18925433		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	18925433		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	24590809, 30221696		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17699795, 24590809, 29560564, 31423280		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	30221696, 31423280		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	27564309	Associate	★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	26593252		★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	29560564		★☆☆☆☆ Found in Text Mining only
Pediatric Obesity	Childhood obesity	BEFREE	27564309		★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	17699795, 33238381	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	30221696		★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	24590809		★☆☆☆☆ Found in Text Mining only