Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	80760
Gene name	Inter-alpha-trypsin inhibitor heavy chain 5
Gene symbol	ITIH5
Synonyms (NCBI Gene)	ITI-HC5PP14776
Chromosome	10
Chromosome location	10p14
Summary	This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasm

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Show/Hide all (294)

miRTarBase ID	miRNA	Experiments	Reference
MIRT006553	hsa-miR-29a-3p	Luciferase reporter assay	20566844
MIRT667810	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT667809	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT667808	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT667807	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667806	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT667805	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT667804	hsa-miR-640	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT667810	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT667809	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT667808	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT667807	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT667806	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT667805	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT667804	hsa-miR-640	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609664	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT609663	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT609662	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT609661	hsa-miR-586	HITS-CLIP	23824327
MIRT609660	hsa-miR-2117	HITS-CLIP	23824327
MIRT609659	hsa-miR-340-5p	HITS-CLIP	23824327
MIRT609658	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT609657	hsa-miR-491-3p	HITS-CLIP	23824327
MIRT609656	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT1074383	hsa-miR-1251	CLIP-seq
MIRT1074384	hsa-miR-125a-3p	CLIP-seq
MIRT1074385	hsa-miR-1306	CLIP-seq
MIRT1074386	hsa-miR-1343	CLIP-seq
MIRT1074387	hsa-miR-15a	CLIP-seq
MIRT1074388	hsa-miR-15b	CLIP-seq
MIRT1074389	hsa-miR-16	CLIP-seq
MIRT1074390	hsa-miR-195	CLIP-seq
MIRT1074391	hsa-miR-197	CLIP-seq
MIRT1074392	hsa-miR-1976	CLIP-seq
MIRT1074393	hsa-miR-3170	CLIP-seq
MIRT1074394	hsa-miR-3180-5p	CLIP-seq
MIRT1074395	hsa-miR-3187-3p	CLIP-seq
MIRT1074396	hsa-miR-3605-5p	CLIP-seq
MIRT1074397	hsa-miR-3663-5p	CLIP-seq
MIRT1074398	hsa-miR-3675-3p	CLIP-seq
MIRT1074399	hsa-miR-369-3p	CLIP-seq
MIRT1074400	hsa-miR-374a	CLIP-seq
MIRT1074401	hsa-miR-374b	CLIP-seq
MIRT1074402	hsa-miR-3934	CLIP-seq
MIRT1074403	hsa-miR-424	CLIP-seq
MIRT1074404	hsa-miR-4279	CLIP-seq
MIRT1074405	hsa-miR-4435	CLIP-seq
MIRT1074406	hsa-miR-4438	CLIP-seq
MIRT1074407	hsa-miR-4701-5p	CLIP-seq
MIRT1074408	hsa-miR-4722-3p	CLIP-seq
MIRT1074409	hsa-miR-4755-3p	CLIP-seq
MIRT1074410	hsa-miR-497	CLIP-seq
MIRT1074411	hsa-miR-498	CLIP-seq
MIRT1074412	hsa-miR-5095	CLIP-seq
MIRT1074413	hsa-miR-5096	CLIP-seq
MIRT1074414	hsa-miR-520a-5p	CLIP-seq
MIRT1074415	hsa-miR-525-5p	CLIP-seq
MIRT1074416	hsa-miR-548an	CLIP-seq
MIRT1074417	hsa-miR-548s	CLIP-seq
MIRT1074418	hsa-miR-588	CLIP-seq
MIRT1074419	hsa-miR-617	CLIP-seq
MIRT1074420	hsa-miR-764	CLIP-seq
MIRT1074421	hsa-miR-922	CLIP-seq
MIRT1074422	hsa-miR-1193	CLIP-seq
MIRT1074423	hsa-miR-1234	CLIP-seq
MIRT1074424	hsa-miR-1297	CLIP-seq
MIRT1074425	hsa-miR-1307	CLIP-seq
MIRT1074426	hsa-miR-136	CLIP-seq
MIRT1074427	hsa-miR-150	CLIP-seq
MIRT1074428	hsa-miR-185	CLIP-seq
MIRT1074392	hsa-miR-1976	CLIP-seq
MIRT1074429	hsa-miR-2392	CLIP-seq
MIRT1074430	hsa-miR-26a	CLIP-seq
MIRT1074431	hsa-miR-26b	CLIP-seq
MIRT1074432	hsa-miR-3135b	CLIP-seq
MIRT1074433	hsa-miR-3652	CLIP-seq
MIRT1074434	hsa-miR-3691-3p	CLIP-seq
MIRT1074435	hsa-miR-4306	CLIP-seq
MIRT1074436	hsa-miR-433	CLIP-seq
MIRT1074437	hsa-miR-4430	CLIP-seq
MIRT1074438	hsa-miR-4465	CLIP-seq
MIRT1074439	hsa-miR-4644	CLIP-seq
MIRT1074440	hsa-miR-4698	CLIP-seq
MIRT1074441	hsa-miR-4711-5p	CLIP-seq
MIRT1074442	hsa-miR-4760-5p	CLIP-seq
MIRT1550338	hsa-miR-4425	CLIP-seq
MIRT1074426	hsa-miR-136	CLIP-seq
MIRT1074392	hsa-miR-1976	CLIP-seq
MIRT1074436	hsa-miR-433	CLIP-seq
MIRT2018377	hsa-miR-106a	CLIP-seq
MIRT2018378	hsa-miR-106b	CLIP-seq
MIRT1074423	hsa-miR-1234	CLIP-seq
MIRT1074384	hsa-miR-125a-3p	CLIP-seq
MIRT2018379	hsa-miR-17	CLIP-seq
MIRT2018380	hsa-miR-20a	CLIP-seq
MIRT2018381	hsa-miR-20b	CLIP-seq
MIRT2018382	hsa-miR-302a	CLIP-seq
MIRT2018383	hsa-miR-302b	CLIP-seq
MIRT2018384	hsa-miR-302c	CLIP-seq
MIRT2018385	hsa-miR-302d	CLIP-seq
MIRT2018386	hsa-miR-302e	CLIP-seq
MIRT2018387	hsa-miR-371-5p	CLIP-seq
MIRT2018388	hsa-miR-371b-5p	CLIP-seq
MIRT2018389	hsa-miR-372	CLIP-seq
MIRT2018390	hsa-miR-373	CLIP-seq
MIRT1074402	hsa-miR-3934	CLIP-seq
MIRT2018391	hsa-miR-3973	CLIP-seq
MIRT2018392	hsa-miR-4757-5p	CLIP-seq
MIRT2018393	hsa-miR-519d	CLIP-seq
MIRT2018394	hsa-miR-520a-3p	CLIP-seq
MIRT2018395	hsa-miR-520b	CLIP-seq
MIRT2018396	hsa-miR-520c-3p	CLIP-seq
MIRT2018397	hsa-miR-520d-3p	CLIP-seq
MIRT2018398	hsa-miR-520e	CLIP-seq
MIRT2018399	hsa-miR-520g	CLIP-seq
MIRT2018400	hsa-miR-520h	CLIP-seq
MIRT1074420	hsa-miR-764	CLIP-seq
MIRT2018401	hsa-miR-93	CLIP-seq
MIRT2250252	hsa-miR-516b	CLIP-seq
MIRT1074406	hsa-miR-4438	CLIP-seq
MIRT2250253	hsa-miR-4735-5p	CLIP-seq
MIRT2250254	hsa-miR-4775	CLIP-seq
MIRT1074412	hsa-miR-5095	CLIP-seq
MIRT2465494	hsa-miR-3149	CLIP-seq
MIRT2465495	hsa-miR-3622a-5p	CLIP-seq
MIRT2465496	hsa-miR-411	CLIP-seq
MIRT2250253	hsa-miR-4735-5p	CLIP-seq
MIRT2250254	hsa-miR-4775	CLIP-seq
MIRT2465497	hsa-miR-590-3p	CLIP-seq
MIRT2553910	hsa-miR-1254	CLIP-seq
MIRT1074391	hsa-miR-197	CLIP-seq
MIRT1074392	hsa-miR-1976	CLIP-seq
MIRT2553911	hsa-miR-3116	CLIP-seq
MIRT2465494	hsa-miR-3149	CLIP-seq
MIRT2553912	hsa-miR-3155	CLIP-seq
MIRT2553913	hsa-miR-3155b	CLIP-seq
MIRT2553914	hsa-miR-3162-3p	CLIP-seq
MIRT1074395	hsa-miR-3187-3p	CLIP-seq
MIRT2465495	hsa-miR-3622a-5p	CLIP-seq
MIRT2465496	hsa-miR-411	CLIP-seq
MIRT2553915	hsa-miR-4258	CLIP-seq
MIRT2553916	hsa-miR-4269	CLIP-seq
MIRT1074404	hsa-miR-4279	CLIP-seq
MIRT2553917	hsa-miR-4325	CLIP-seq
MIRT1074405	hsa-miR-4435	CLIP-seq
MIRT1074406	hsa-miR-4438	CLIP-seq
MIRT1074407	hsa-miR-4701-5p	CLIP-seq
MIRT2553918	hsa-miR-4716-5p	CLIP-seq
MIRT1074408	hsa-miR-4722-3p	CLIP-seq
MIRT2250253	hsa-miR-4735-5p	CLIP-seq
MIRT2250254	hsa-miR-4775	CLIP-seq
MIRT2553919	hsa-miR-4781-3p	CLIP-seq
MIRT2553920	hsa-miR-484	CLIP-seq
MIRT1074411	hsa-miR-498	CLIP-seq
MIRT2553921	hsa-miR-507	CLIP-seq
MIRT1074412	hsa-miR-5095	CLIP-seq
MIRT1074413	hsa-miR-5096	CLIP-seq
MIRT2553922	hsa-miR-510	CLIP-seq
MIRT1074417	hsa-miR-548s	CLIP-seq
MIRT2553923	hsa-miR-557	CLIP-seq
MIRT1074418	hsa-miR-588	CLIP-seq
MIRT2465497	hsa-miR-590-3p	CLIP-seq
MIRT2553924	hsa-miR-661	CLIP-seq
MIRT2553910	hsa-miR-1254	CLIP-seq
MIRT1074391	hsa-miR-197	CLIP-seq
MIRT2553911	hsa-miR-3116	CLIP-seq
MIRT2465494	hsa-miR-3149	CLIP-seq
MIRT2682992	hsa-miR-3152-5p	CLIP-seq
MIRT2553914	hsa-miR-3162-3p	CLIP-seq
MIRT1074395	hsa-miR-3187-3p	CLIP-seq
MIRT2465495	hsa-miR-3622a-5p	CLIP-seq
MIRT2682993	hsa-miR-3690	CLIP-seq
MIRT2682994	hsa-miR-378	CLIP-seq
MIRT2682995	hsa-miR-378b	CLIP-seq
MIRT2682996	hsa-miR-378c	CLIP-seq
MIRT2682997	hsa-miR-378d	CLIP-seq
MIRT2682998	hsa-miR-378e	CLIP-seq
MIRT2682999	hsa-miR-378f	CLIP-seq
MIRT2683000	hsa-miR-378h	CLIP-seq
MIRT2683001	hsa-miR-378i	CLIP-seq
MIRT2465496	hsa-miR-411	CLIP-seq
MIRT2683002	hsa-miR-422a	CLIP-seq
MIRT2553915	hsa-miR-4258	CLIP-seq
MIRT1074405	hsa-miR-4435	CLIP-seq
MIRT1074407	hsa-miR-4701-5p	CLIP-seq
MIRT2553918	hsa-miR-4716-5p	CLIP-seq
MIRT2250253	hsa-miR-4735-5p	CLIP-seq
MIRT2683003	hsa-miR-4774-3p	CLIP-seq
MIRT2250254	hsa-miR-4775	CLIP-seq
MIRT2553919	hsa-miR-4781-3p	CLIP-seq
MIRT2683004	hsa-miR-509-3p	CLIP-seq
MIRT1074413	hsa-miR-5096	CLIP-seq
MIRT1074417	hsa-miR-548s	CLIP-seq
MIRT1074418	hsa-miR-588	CLIP-seq
MIRT2465497	hsa-miR-590-3p	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004867	Function	Serine-type endopeptidase inhibitor activity	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0030212	Process	Hyaluronan metabolic process	IEA
GO:0030414	Function	Peptidase inhibitor activity	IEA
GO:0031012	Component	Extracellular matrix	HDA	25037231, 28675934

MIM	HGNC	e!Ensembl
609783	21449	ENSG00000123243

Q86UX2

Protein name

Inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5) (ITI-HC5) (Inter-alpha-inhibitor heavy chain 5)

Protein function

May act as a tumor suppressor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08487	VIT	51 → 159	Vault protein inter-alpha-trypsin domain	Family
PF00092	VWA	295 → 476	von Willebrand factor type A domain	Domain
PF06668	ITI_HC_C	715 → 909	Inter-alpha-trypsin inhibitor heavy chain C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression is barely detectable levels in all other tissues tested. {ECO:0000269|PubMed:14744536}.

Sequence

MLLLLGLCLGLSLCVGSQEEAQSWGHSSEQDGLRVPRQVRLLQRLKTKPLMTEFSVKSTI
ISRYAFTTVSCRMLNRASEDQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITEREKKSGD
RVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFLSYEELLQRRLGKYEHSISVRPQQ
LSGRLSVDVNILESAGIASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFANIIFK
PTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQVLNGYFVHYFAPKDLPPLPKNVVFVL
DSSASMVGTKLRQTKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTPDSIRDGKV
YIHHMSPTGGTDINGALQRAIRLLNKYVAHSGIGDRSVSLIVFLTDGKPTVGETHTLKIL
NNTREAARGQVCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAGSQLIGFYDEIRT
PLLSDIRIDYPPSSVVQATKTLFPNYFNGSEIIIAGKLVDRKLDHLHVEVTASNSKKFII
LKTDVPVRPQKAGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELLSSWLQSDDEPEKER
LRQRAQALAVSYRFLTPFTSMKLRGPVPRMDGLEEAHGMSAAMGPEPVVQSVRGAGTQPG
PLLKKPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNIDGQPGDILRLVSDHRDSGVTV
NGELIGAPAPPNGHKKQRTYLRTITILINKPERSYLEITPSRVILDGGDRLVLPCNQSVV
VGSWGLEVSVSANANVTVTIQGSIAFVILIHLYKKPAPFQRHHLGFYIANSEGLSSNCHG
LLGQFLNQDARLTEDPAGPSQNLTHPLLLQVGEGPEAVLTVKGHQVPVVWKQRKIYNGEE
QIDCWFARNNAAKLIDGEYKDYLAFHPFDTGMTLGQGMSREL

Sequence length

942

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (47)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	26252352		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	26252352		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	28289921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	40123161	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	24265292		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	14744536, 17653090, 28231808, 28940371		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23320751	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	17653090		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	24265292		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	26252352		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	28059468		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	28059468		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	38475675	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	25093535		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	25093535		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	25093535	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24516561	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25093535	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	25809190		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ductal Carcinoma	Ductal Carcinoma	LHGDN	14744536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung Disease	BEFREE	29626357		★★★★★ ★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	14744536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	26252352	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	35870194	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	14744536, 17653090, 28231808, 28940371		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	26252352		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	28289921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	24913813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	24265292		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24265292, 24913813, 28231808		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of cervix	Cervical Tumor	BEFREE	28059468		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	25093535		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	14744536, 17653090, 28940371		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	LHGDN	14744536, 17653090		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17653090, 24265292, 25093535, 26252352, 28059468, 28231808, 28940371		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	26252352		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	21852814		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	21852814	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	25853553	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	28289921, 28940371		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	24913813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid cancer follicular	Follicular thyroid cancer	Pubtator	24099521	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	19809427		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	19809427	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	32046186	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	33924987	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
von Willebrand Disease	von Willebrand disorder	BEFREE	14744536, 24913813		★★★★★ ★☆☆☆☆ Found in Text Mining only

ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5)