Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	80728
Gene name	Rho GTPase activating protein 39
Gene symbol	ARHGAP39
Synonyms (NCBI Gene)	CrGAPVilse
Chromosome	8
Chromosome location	8q24.3

Show/Hide all (91)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045251	hsa-miR-186-5p	CLASH	23622248
MIRT455083	hsa-miR-4428	PAR-CLIP	23592263
MIRT455081	hsa-miR-9500	PAR-CLIP	23592263
MIRT455082	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT455080	hsa-miR-3131	PAR-CLIP	23592263
MIRT455079	hsa-miR-611	PAR-CLIP	23592263
MIRT455078	hsa-miR-5681a	PAR-CLIP	23592263
MIRT455077	hsa-miR-5004-5p	PAR-CLIP	23592263
MIRT455076	hsa-miR-4533	PAR-CLIP	23592263
MIRT455075	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT455074	hsa-miR-4306	PAR-CLIP	23592263
MIRT455073	hsa-miR-4644	PAR-CLIP	23592263
MIRT455072	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT455071	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT455070	hsa-miR-3121-3p	PAR-CLIP	23592263
MIRT455069	hsa-miR-577	PAR-CLIP	23592263
MIRT455068	hsa-miR-1179	PAR-CLIP	23592263
MIRT455067	hsa-miR-3919	PAR-CLIP	23592263
MIRT455066	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT455065	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT455064	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT455063	hsa-miR-92b-5p	PAR-CLIP	23592263
MIRT455062	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT455083	hsa-miR-4428	PAR-CLIP	23592263
MIRT455081	hsa-miR-9500	PAR-CLIP	23592263
MIRT455082	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT455080	hsa-miR-3131	PAR-CLIP	23592263
MIRT455079	hsa-miR-611	PAR-CLIP	23592263
MIRT455078	hsa-miR-5681a	PAR-CLIP	23592263
MIRT455077	hsa-miR-5004-5p	PAR-CLIP	23592263
MIRT455076	hsa-miR-4533	PAR-CLIP	23592263
MIRT455075	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT455074	hsa-miR-4306	PAR-CLIP	23592263
MIRT455073	hsa-miR-4644	PAR-CLIP	23592263
MIRT455072	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT455071	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT455070	hsa-miR-3121-3p	PAR-CLIP	23592263
MIRT455069	hsa-miR-577	PAR-CLIP	23592263
MIRT455068	hsa-miR-1179	PAR-CLIP	23592263
MIRT455067	hsa-miR-3919	PAR-CLIP	23592263
MIRT455066	hsa-miR-4756-3p	PAR-CLIP	23592263
MIRT455065	hsa-miR-7154-3p	PAR-CLIP	23592263
MIRT455064	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT455063	hsa-miR-92b-5p	PAR-CLIP	23592263
MIRT455062	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT794845	hsa-miR-1275	CLIP-seq
MIRT794846	hsa-miR-1280	CLIP-seq
MIRT794847	hsa-miR-154	CLIP-seq
MIRT794848	hsa-miR-24	CLIP-seq
MIRT794849	hsa-miR-296-5p	CLIP-seq
MIRT794850	hsa-miR-3130-3p	CLIP-seq
MIRT794851	hsa-miR-3176	CLIP-seq
MIRT794852	hsa-miR-3177-3p	CLIP-seq
MIRT794853	hsa-miR-3191	CLIP-seq
MIRT794854	hsa-miR-3194-3p	CLIP-seq
MIRT794855	hsa-miR-361-3p	CLIP-seq
MIRT794856	hsa-miR-3620	CLIP-seq
MIRT794857	hsa-miR-3922-3p	CLIP-seq
MIRT794858	hsa-miR-4260	CLIP-seq
MIRT794859	hsa-miR-4449	CLIP-seq
MIRT794860	hsa-miR-4488	CLIP-seq
MIRT794861	hsa-miR-4523	CLIP-seq
MIRT794862	hsa-miR-4530	CLIP-seq
MIRT794863	hsa-miR-4532	CLIP-seq
MIRT794864	hsa-miR-4660	CLIP-seq
MIRT794865	hsa-miR-4665-5p	CLIP-seq
MIRT794866	hsa-miR-4697-5p	CLIP-seq
MIRT794867	hsa-miR-4722-3p	CLIP-seq
MIRT794868	hsa-miR-4740-3p	CLIP-seq
MIRT794869	hsa-miR-4746-5p	CLIP-seq
MIRT794870	hsa-miR-4749-3p	CLIP-seq
MIRT794871	hsa-miR-4755-3p	CLIP-seq
MIRT794872	hsa-miR-4763-5p	CLIP-seq
MIRT794873	hsa-miR-4793-3p	CLIP-seq
MIRT794874	hsa-miR-582-5p	CLIP-seq
MIRT794875	hsa-miR-596	CLIP-seq
MIRT794876	hsa-miR-646	CLIP-seq
MIRT794877	hsa-miR-659	CLIP-seq
MIRT794878	hsa-miR-9	CLIP-seq
MIRT794879	hsa-miR-935	CLIP-seq
MIRT794847	hsa-miR-154	CLIP-seq
MIRT1934708	hsa-miR-4453	CLIP-seq
MIRT1934709	hsa-miR-4538	CLIP-seq
MIRT2174431	hsa-miR-4505	CLIP-seq
MIRT2174432	hsa-miR-4646-5p	CLIP-seq
MIRT2384421	hsa-miR-4325	CLIP-seq
MIRT2384422	hsa-miR-4716-5p	CLIP-seq
MIRT794870	hsa-miR-4749-3p	CLIP-seq
MIRT794851	hsa-miR-3176	CLIP-seq
MIRT794857	hsa-miR-3922-3p	CLIP-seq
MIRT794870	hsa-miR-4749-3p	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0098978	Component	Glutamatergic synapse	IDA	24656827
GO:0098978	Component	Glutamatergic synapse	IMP	24656827
GO:0099173	Process	Postsynapse organization	IDA	24656827
GO:0099173	Process	Postsynapse organization	IMP	24656827

MIM	HGNC	e!Ensembl
615880	29351	ENSG00000147799

Q9C0H5

Protein name

Rho GTPase-activating protein 39

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00784	MyTH4	764 → 878	MyTH4 domain	Family
PF00620	RhoGAP	909 → 1054	RhoGAP domain	Domain

Sequence

MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
GVAISTYAKYCYHKLQKAALTGAKKGLKKPNVEEIRHAKNAVFSPSMFGSALQEVMGMQR
ERYPERQLPWVQTRLSEEVLALNGDQTEGIFRVPGDIDEVNALKLQVDQWKVPTGLEDPH
VPASLLKLWYRELEEPLIPHEFYEQCIAHYDSPEAAVAVVHALPRINRMVLCYLIRFLQV
FVQPANVAVTKMDVSNLAMVMAPNCLRCQSDDPRVIFENTRKEMSFLRVLIQHLDTSFME
GVL

Sequence length

1083

Interactions

View interactions

	Reactome
			Rho GTPase cycle

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM MALFORMATION	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	37189064	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	37189064	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37059586	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37059586	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ARHGAP39 (Rho GTPase activating protein 39)