TRABD (TraB domain containing)

Gene

• Entrez ID: 80305
• Gene name: TraB domain containing
• Gene symbol: TRABD
• Synonyms (NCBI Gene): LP6054, PP2447
• Chromosome: 22
• Chromosome location: 22q13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005240	hsa-let-7b-5p	pSILAC	18668040
MIRT005240	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT005240	hsa-let-7b-5p	CLASH	23622248
MIRT050774	hsa-miR-17-3p	CLASH	23622248
MIRT1450648	hsa-miR-1197	CLIP-seq
MIRT1450649	hsa-miR-1207-5p	CLIP-seq
MIRT1450650	hsa-miR-3617	CLIP-seq
MIRT1450651	hsa-miR-3682-5p	CLIP-seq
MIRT1450652	hsa-miR-3688-5p	CLIP-seq
MIRT1450653	hsa-miR-3921	CLIP-seq
MIRT1450654	hsa-miR-4282	CLIP-seq
MIRT1450655	hsa-miR-4328	CLIP-seq
MIRT1450656	hsa-miR-4476	CLIP-seq
MIRT1450657	hsa-miR-4533	CLIP-seq
MIRT1450658	hsa-miR-4653-5p	CLIP-seq
MIRT1450659	hsa-miR-4699-3p	CLIP-seq
MIRT1450660	hsa-miR-4736	CLIP-seq
MIRT1450661	hsa-miR-4763-3p	CLIP-seq
MIRT1450662	hsa-miR-4766-5p	CLIP-seq
MIRT1450663	hsa-miR-4768-5p	CLIP-seq
MIRT1450664	hsa-miR-574-5p	CLIP-seq
MIRT1450665	hsa-miR-641	CLIP-seq
MIRT1450666	hsa-miR-644	CLIP-seq
MIRT1450649	hsa-miR-1207-5p	CLIP-seq
MIRT2134711	hsa-miR-1321	CLIP-seq
MIRT2134712	hsa-miR-1909	CLIP-seq
MIRT2134713	hsa-miR-3689d	CLIP-seq
MIRT2134714	hsa-miR-4270	CLIP-seq
MIRT2134715	hsa-miR-4441	CLIP-seq
MIRT2134716	hsa-miR-4467	CLIP-seq
MIRT1450660	hsa-miR-4736	CLIP-seq
MIRT2134717	hsa-miR-4739	CLIP-seq
MIRT2134718	hsa-miR-4755-3p	CLIP-seq
MIRT2134719	hsa-miR-4756-5p	CLIP-seq
MIRT1450661	hsa-miR-4763-3p	CLIP-seq
MIRT2134720	hsa-miR-665	CLIP-seq
MIRT2355991	hsa-miR-1275	CLIP-seq
MIRT2355992	hsa-miR-1293	CLIP-seq
MIRT2355993	hsa-miR-134	CLIP-seq
MIRT2355994	hsa-miR-1587	CLIP-seq
MIRT2355995	hsa-miR-193a-3p	CLIP-seq
MIRT2355996	hsa-miR-193b	CLIP-seq
MIRT2355997	hsa-miR-3118	CLIP-seq
MIRT2355998	hsa-miR-3136-3p	CLIP-seq
MIRT2355999	hsa-miR-4417	CLIP-seq
MIRT2356000	hsa-miR-4483	CLIP-seq
MIRT2356001	hsa-miR-4492	CLIP-seq
MIRT2356002	hsa-miR-4498	CLIP-seq
MIRT2356003	hsa-miR-4505	CLIP-seq
MIRT2356004	hsa-miR-4525	CLIP-seq
MIRT2356005	hsa-miR-4656	CLIP-seq
MIRT2356006	hsa-miR-4665-5p	CLIP-seq
MIRT2356007	hsa-miR-4675	CLIP-seq
MIRT2356008	hsa-miR-4723-5p	CLIP-seq
MIRT2356009	hsa-miR-4728-5p	CLIP-seq
MIRT2356010	hsa-miR-4731-5p	CLIP-seq
MIRT2356011	hsa-miR-4741	CLIP-seq
MIRT2356012	hsa-miR-541	CLIP-seq
MIRT2356013	hsa-miR-604	CLIP-seq
MIRT2356014	hsa-miR-625	CLIP-seq
MIRT2356015	hsa-miR-637	CLIP-seq
MIRT2356016	hsa-miR-647	CLIP-seq
MIRT2356017	hsa-miR-654-5p	CLIP-seq
MIRT2356018	hsa-miR-762	CLIP-seq
MIRT1450656	hsa-miR-4476	CLIP-seq
MIRT2442766	hsa-miR-1273f	CLIP-seq
MIRT2442767	hsa-miR-4283	CLIP-seq
MIRT2442768	hsa-miR-4489	CLIP-seq
MIRT2356003	hsa-miR-4505	CLIP-seq
MIRT2442769	hsa-miR-4645-5p	CLIP-seq
MIRT2442770	hsa-miR-4673	CLIP-seq
MIRT2356010	hsa-miR-4731-5p	CLIP-seq
MIRT2442771	hsa-miR-4756-3p	CLIP-seq
MIRT2442772	hsa-miR-661	CLIP-seq
MIRT2442766	hsa-miR-1273f	CLIP-seq
MIRT2134711	hsa-miR-1321	CLIP-seq
MIRT2462251	hsa-miR-3177-3p	CLIP-seq
MIRT2462252	hsa-miR-3657	CLIP-seq
MIRT2462253	hsa-miR-3690	CLIP-seq
MIRT2462254	hsa-miR-4254	CLIP-seq
MIRT2442767	hsa-miR-4283	CLIP-seq
MIRT2462255	hsa-miR-4419a	CLIP-seq
MIRT2462256	hsa-miR-4459	CLIP-seq
MIRT2442768	hsa-miR-4489	CLIP-seq
MIRT2356003	hsa-miR-4505	CLIP-seq
MIRT2462257	hsa-miR-4510	CLIP-seq
MIRT2462258	hsa-miR-4520a-3p	CLIP-seq
MIRT2462259	hsa-miR-4638-3p	CLIP-seq
MIRT2442769	hsa-miR-4645-5p	CLIP-seq
MIRT2462260	hsa-miR-4669	CLIP-seq
MIRT2442770	hsa-miR-4673	CLIP-seq
MIRT2356007	hsa-miR-4675	CLIP-seq
MIRT2356010	hsa-miR-4731-5p	CLIP-seq
MIRT2134717	hsa-miR-4739	CLIP-seq
MIRT2356011	hsa-miR-4741	CLIP-seq
MIRT2442771	hsa-miR-4756-3p	CLIP-seq
MIRT2134719	hsa-miR-4756-5p	CLIP-seq
MIRT2462261	hsa-miR-4779	CLIP-seq
MIRT2442772	hsa-miR-661	CLIP-seq
MIRT2134720	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005741	Component	Mitochondrial outer membrane	IDA	38843396
GO:0008053	Process	Mitochondrial fusion	IMP	38843396
GO:0160204	Function	Mitochondrion-mitochondrion outer membrane tether activity	IMP	38843396

Other IDs

• MIM: 621246
• HGNC: 28805
• e!Ensembl: ENSG00000170638

Protein

• UniProt ID: Q9H4I3
• Protein name: TraB domain-containing protein (Protein TTG2)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01963	TraB	64 → 311	TraB family	Family

• Sequence:

  MDGEEQQPPHEANVEPVVPSEASEPVPRVLSGDPQNLSDVDAFNLLLEMKLKRRRQRPNL
  PRTVTQLVAEDGSRVYVVGTAHFSDDSKRDVVKTIREVQPDVVVVELCQYRVSMLKMDES
  TLLREAQELSLEKLQQAVRQNGLMSGLMQMLLLKVSAHITEQLGMAPGGEFREAFKEASK
  VPFCKFHLGDRPIPVTFKRAIAALSFWQKVRLAWGLCFLSDPISKDDVERCKQKDLLEQM
  MAEMIGEFPDLHRTIVSERDVYLTYMLRQAARRLELPRASDAEPRKCVPSVVVGVVGMGH
  VPGIEKNWSTDLNIQEIMTVPPPSVSGRVSRLAVKAAFFGLLGYSLYWMGRRTASLVLSL
  PAAQYCLQRVTEARHK

• Sequence length: 376

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	8142620		★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	BEFREE	30023063		★☆☆☆☆ Found in Text Mining only
insulinoma	Insulinoma	BEFREE	29654212		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	1923511		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25173755		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	25173755	Associate	★☆☆☆☆ Found in Text Mining only
Tendinopathy	Tendinopathy	BEFREE	21710445		★☆☆☆☆ Found in Text Mining only