Gene Gene information from NCBI Gene database.
Entrez ID 8030
Gene name Coiled-coil domain containing 6
Gene symbol CCDC6
Synonyms (NCBI Gene)
D10S170H4PTCPTC1TPCTST1
Chromosome 10
Chromosome location 10q21.2
Summary This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and
miRNA miRNA information provided by mirtarbase database.
973
miRTarBase ID miRNA Experiments Reference
MIRT021879 hsa-miR-128-3p Microarray 17612493
MIRT025091 hsa-miR-181a-5p Microarray 17612493
MIRT048991 hsa-miR-92a-3p CLASH 23622248
MIRT048602 hsa-miR-99a-5p CLASH 23622248
MIRT043723 hsa-miR-342-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0005200 Function Structural constituent of cytoskeleton TAS 8058316
GO:0005515 Function Protein binding IPI 23108047, 28514442, 31980649, 32203420, 32296183, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IDA
GO:0005856 Component Cytoskeleton IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601985 18782 ENSG00000108091
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q16204
Protein name Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09755 DUF2046 42 337 Uncharacterized conserved protein H4 (DUF2046) Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed.
Sequence
Sequence length 474
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Pathways in cancer
Thyroid cancer
 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMERS DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIFFERENTIATED THYROID CARCINOMA Orphanet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
THYROID CANCER, PAPILLARY CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 22327623
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 23154560, 23578175
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of pancreas Pancreatic adenocarcinoma BEFREE 28261999
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Oxyphilic Adenocarcinoma BEFREE 24559275, 28816539
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Tubular Adenocarcinoma BEFREE 30349383
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 10646882, 15126554, 17639054
★☆☆☆☆
Found in Text Mining only
Adenomatous Polyposis Coli Multiple polyposis syndrome BEFREE 24702198, 27623068, 28314770, 30482542, 9841749
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 31850206
★☆☆☆☆
Found in Text Mining only
Anaplasia Anaplasia BEFREE 19809427, 25260367
★☆☆☆☆
Found in Text Mining only
Anaplastic carcinoma Anaplastic Carcinoma BEFREE 10934169
★☆☆☆☆
Found in Text Mining only