Gene Gene information from NCBI Gene database.
Entrez ID 80228
Gene name ORAI calcium release-activated calcium modulator 2
Gene symbol ORAI2
Synonyms (NCBI Gene)
C7orf19CBCIP2MEM142BTMEM142B
Chromosome 7
Chromosome location 7q22.1
miRNA miRNA information provided by mirtarbase database.
1809
miRTarBase ID miRNA Experiments Reference
MIRT052447 hsa-let-7a-5p CLASH 23622248
MIRT051095 hsa-miR-16-5p CLASH 23622248
MIRT047579 hsa-miR-10a-5p CLASH 23622248
MIRT047449 hsa-miR-10b-5p CLASH 23622248
MIRT044701 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0002115 Process Store-operated calcium entry IBA
GO:0002115 Process Store-operated calcium entry IDA 19182790, 32415068
GO:0002115 Process Store-operated calcium entry IEA
GO:0005262 Function Calcium channel activity IEA
GO:0005515 Function Protein binding IPI 17442569, 20418871, 32415068
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610929 21667 ENSG00000160991
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96SN7
Protein name Protein orai-2 (CAP-binding protein complex-interacting protein 2) (Transmembrane protein 142B)
Protein function Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles with ORAI1 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07856 Orai-1 45 228 Mediator of CRAC channel activity Family
Sequence
Sequence length 254
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Calcium signaling pathway  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 34857756, 36809524 Associate
★☆☆☆☆
Found in Text Mining only
Cognition Disorders Cognition disorder Pubtator 34857756 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 1 Diabetes mellitus, type 1 Pubtator 30543678 Associate
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma BEFREE 31772693
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 31772693 Stimulate
★☆☆☆☆
Found in Text Mining only
Glioblastoma Multiforme Glioblastoma BEFREE 31772693
★☆☆☆☆
Found in Text Mining only
Glioma Glioma BEFREE 31772693
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 31772693 Associate
★☆☆☆☆
Found in Text Mining only
Hypoxia Hypoxia Pubtator 29351410 Stimulate
★☆☆☆☆
Found in Text Mining only
Polycystic Ovary Syndrome Polycystic ovary syndrome Pubtator 35669690 Stimulate
★☆☆☆☆
Found in Text Mining only