Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	80213
Gene name	TM2 domain containing 3
Gene symbol	TM2D3
Synonyms (NCBI Gene)	BLP2
Chromosome	15
Chromosome location	15q26.3
Summary	The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, u

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Show/Hide all (182)

miRTarBase ID	miRNA	Experiments
MIRT1427194	hsa-miR-1228	CLIP-seq
MIRT1427195	hsa-miR-127-5p	CLIP-seq
MIRT1427196	hsa-miR-27a	CLIP-seq
MIRT1427197	hsa-miR-27b	CLIP-seq
MIRT1427198	hsa-miR-3074-3p	CLIP-seq
MIRT1427199	hsa-miR-3156-3p	CLIP-seq
MIRT1427200	hsa-miR-3180-5p	CLIP-seq
MIRT1427201	hsa-miR-342-3p	CLIP-seq
MIRT1427202	hsa-miR-34c-3p	CLIP-seq
MIRT1427203	hsa-miR-4269	CLIP-seq
MIRT1427204	hsa-miR-4275	CLIP-seq
MIRT1427205	hsa-miR-4301	CLIP-seq
MIRT1427206	hsa-miR-4477a	CLIP-seq
MIRT1427207	hsa-miR-4514	CLIP-seq
MIRT1427208	hsa-miR-4662a-5p	CLIP-seq
MIRT1427209	hsa-miR-4663	CLIP-seq
MIRT1427210	hsa-miR-4692	CLIP-seq
MIRT1427211	hsa-miR-4724-3p	CLIP-seq
MIRT1427212	hsa-miR-4729	CLIP-seq
MIRT1427213	hsa-miR-4742-5p	CLIP-seq
MIRT1427214	hsa-miR-4775	CLIP-seq
MIRT1427215	hsa-miR-4788	CLIP-seq
MIRT1427216	hsa-miR-5096	CLIP-seq
MIRT1427217	hsa-miR-513a-5p	CLIP-seq
MIRT1427218	hsa-miR-520a-5p	CLIP-seq
MIRT1427219	hsa-miR-525-5p	CLIP-seq
MIRT1427220	hsa-miR-532-3p	CLIP-seq
MIRT1427221	hsa-miR-548ac	CLIP-seq
MIRT1427222	hsa-miR-548ae	CLIP-seq
MIRT1427223	hsa-miR-548aj	CLIP-seq
MIRT1427224	hsa-miR-548am	CLIP-seq
MIRT1427225	hsa-miR-548d-3p	CLIP-seq
MIRT1427226	hsa-miR-548x	CLIP-seq
MIRT1427227	hsa-miR-548z	CLIP-seq
MIRT1427228	hsa-miR-579	CLIP-seq
MIRT1427229	hsa-miR-590-3p	CLIP-seq
MIRT2127965	hsa-miR-1305	CLIP-seq
MIRT2127966	hsa-miR-1587	CLIP-seq
MIRT2127967	hsa-miR-3671	CLIP-seq
MIRT2127968	hsa-miR-4492	CLIP-seq
MIRT2127969	hsa-miR-4498	CLIP-seq
MIRT2127970	hsa-miR-4656	CLIP-seq
MIRT2127971	hsa-miR-4674	CLIP-seq
MIRT2127972	hsa-miR-4675	CLIP-seq
MIRT2127973	hsa-miR-4741	CLIP-seq
MIRT1427215	hsa-miR-4788	CLIP-seq
MIRT2127974	hsa-miR-607	CLIP-seq
MIRT2127975	hsa-miR-762	CLIP-seq
MIRT2349610	hsa-miR-1208	CLIP-seq
MIRT2349611	hsa-miR-1246	CLIP-seq
MIRT2349612	hsa-miR-1290	CLIP-seq
MIRT2127965	hsa-miR-1305	CLIP-seq
MIRT2349613	hsa-miR-3167	CLIP-seq
MIRT2349614	hsa-miR-34b	CLIP-seq
MIRT2349615	hsa-miR-4705	CLIP-seq
MIRT2349616	hsa-miR-568	CLIP-seq
MIRT2349617	hsa-miR-876-5p	CLIP-seq
MIRT2349610	hsa-miR-1208	CLIP-seq
MIRT1427194	hsa-miR-1228	CLIP-seq
MIRT2349611	hsa-miR-1246	CLIP-seq
MIRT2643134	hsa-miR-1270	CLIP-seq
MIRT1427195	hsa-miR-127-5p	CLIP-seq
MIRT2349612	hsa-miR-1290	CLIP-seq
MIRT2127965	hsa-miR-1305	CLIP-seq
MIRT2643135	hsa-miR-140-3p	CLIP-seq
MIRT2127966	hsa-miR-1587	CLIP-seq
MIRT2643136	hsa-miR-300	CLIP-seq
MIRT2643137	hsa-miR-3074-5p	CLIP-seq
MIRT2643138	hsa-miR-3119	CLIP-seq
MIRT2643139	hsa-miR-3120-3p	CLIP-seq
MIRT2643140	hsa-miR-3135b	CLIP-seq
MIRT1427199	hsa-miR-3156-3p	CLIP-seq
MIRT2643141	hsa-miR-3158-3p	CLIP-seq
MIRT2349613	hsa-miR-3167	CLIP-seq
MIRT2643142	hsa-miR-3171	CLIP-seq
MIRT2643143	hsa-miR-3173-5p	CLIP-seq
MIRT2643144	hsa-miR-329	CLIP-seq
MIRT2349614	hsa-miR-34b	CLIP-seq
MIRT2643145	hsa-miR-362-3p	CLIP-seq
MIRT2643146	hsa-miR-3652	CLIP-seq
MIRT2643147	hsa-miR-3714	CLIP-seq
MIRT2643148	hsa-miR-381	CLIP-seq
MIRT2643149	hsa-miR-3922-5p	CLIP-seq
MIRT2643150	hsa-miR-4263	CLIP-seq
MIRT2643151	hsa-miR-4268	CLIP-seq
MIRT1427204	hsa-miR-4275	CLIP-seq
MIRT1427205	hsa-miR-4301	CLIP-seq
MIRT2643152	hsa-miR-4430	CLIP-seq
MIRT2643153	hsa-miR-4448	CLIP-seq
MIRT2127968	hsa-miR-4492	CLIP-seq
MIRT2127969	hsa-miR-4498	CLIP-seq
MIRT2127970	hsa-miR-4656	CLIP-seq
MIRT1427208	hsa-miR-4662a-5p	CLIP-seq
MIRT1427209	hsa-miR-4663	CLIP-seq
MIRT2127971	hsa-miR-4674	CLIP-seq
MIRT2127972	hsa-miR-4675	CLIP-seq
MIRT2643154	hsa-miR-4683	CLIP-seq
MIRT2643155	hsa-miR-4694-3p	CLIP-seq
MIRT2643156	hsa-miR-4703-3p	CLIP-seq
MIRT2643157	hsa-miR-4704-3p	CLIP-seq
MIRT2349615	hsa-miR-4705	CLIP-seq
MIRT2127973	hsa-miR-4741	CLIP-seq
MIRT2643158	hsa-miR-4762-3p	CLIP-seq
MIRT2643159	hsa-miR-4766-5p	CLIP-seq
MIRT2643160	hsa-miR-4771	CLIP-seq
MIRT1427215	hsa-miR-4788	CLIP-seq
MIRT2643161	hsa-miR-498	CLIP-seq
MIRT2643162	hsa-miR-522	CLIP-seq
MIRT1427220	hsa-miR-532-3p	CLIP-seq
MIRT1427221	hsa-miR-548ac	CLIP-seq
MIRT1427222	hsa-miR-548ae	CLIP-seq
MIRT1427223	hsa-miR-548aj	CLIP-seq
MIRT1427224	hsa-miR-548am	CLIP-seq
MIRT1427225	hsa-miR-548d-3p	CLIP-seq
MIRT2643163	hsa-miR-548u	CLIP-seq
MIRT1427226	hsa-miR-548x	CLIP-seq
MIRT1427227	hsa-miR-548z	CLIP-seq
MIRT2349616	hsa-miR-568	CLIP-seq
MIRT2643164	hsa-miR-576-5p	CLIP-seq
MIRT2643165	hsa-miR-620	CLIP-seq
MIRT2643166	hsa-miR-635	CLIP-seq
MIRT2127975	hsa-miR-762	CLIP-seq
MIRT2349617	hsa-miR-876-5p	CLIP-seq
MIRT1427194	hsa-miR-1228	CLIP-seq
MIRT2349611	hsa-miR-1246	CLIP-seq
MIRT2643134	hsa-miR-1270	CLIP-seq
MIRT1427195	hsa-miR-127-5p	CLIP-seq
MIRT2127965	hsa-miR-1305	CLIP-seq
MIRT2643135	hsa-miR-140-3p	CLIP-seq
MIRT2127966	hsa-miR-1587	CLIP-seq
MIRT2643136	hsa-miR-300	CLIP-seq
MIRT2643137	hsa-miR-3074-5p	CLIP-seq
MIRT2643138	hsa-miR-3119	CLIP-seq
MIRT2643139	hsa-miR-3120-3p	CLIP-seq
MIRT2643140	hsa-miR-3135b	CLIP-seq
MIRT1427199	hsa-miR-3156-3p	CLIP-seq
MIRT2643141	hsa-miR-3158-3p	CLIP-seq
MIRT2643142	hsa-miR-3171	CLIP-seq
MIRT2643143	hsa-miR-3173-5p	CLIP-seq
MIRT2643144	hsa-miR-329	CLIP-seq
MIRT2643145	hsa-miR-362-3p	CLIP-seq
MIRT2643146	hsa-miR-3652	CLIP-seq
MIRT2643147	hsa-miR-3714	CLIP-seq
MIRT2643148	hsa-miR-381	CLIP-seq
MIRT2643149	hsa-miR-3922-5p	CLIP-seq
MIRT2643150	hsa-miR-4263	CLIP-seq
MIRT2643151	hsa-miR-4268	CLIP-seq
MIRT1427204	hsa-miR-4275	CLIP-seq
MIRT1427205	hsa-miR-4301	CLIP-seq
MIRT2643152	hsa-miR-4430	CLIP-seq
MIRT2643153	hsa-miR-4448	CLIP-seq
MIRT2127968	hsa-miR-4492	CLIP-seq
MIRT2127969	hsa-miR-4498	CLIP-seq
MIRT2127970	hsa-miR-4656	CLIP-seq
MIRT1427208	hsa-miR-4662a-5p	CLIP-seq
MIRT1427209	hsa-miR-4663	CLIP-seq
MIRT2127971	hsa-miR-4674	CLIP-seq
MIRT2127972	hsa-miR-4675	CLIP-seq
MIRT2643154	hsa-miR-4683	CLIP-seq
MIRT2643155	hsa-miR-4694-3p	CLIP-seq
MIRT2643156	hsa-miR-4703-3p	CLIP-seq
MIRT2643157	hsa-miR-4704-3p	CLIP-seq
MIRT2127973	hsa-miR-4741	CLIP-seq
MIRT2643158	hsa-miR-4762-3p	CLIP-seq
MIRT2643159	hsa-miR-4766-5p	CLIP-seq
MIRT2643160	hsa-miR-4771	CLIP-seq
MIRT1427215	hsa-miR-4788	CLIP-seq
MIRT2643161	hsa-miR-498	CLIP-seq
MIRT2643162	hsa-miR-522	CLIP-seq
MIRT1427220	hsa-miR-532-3p	CLIP-seq
MIRT1427221	hsa-miR-548ac	CLIP-seq
MIRT1427222	hsa-miR-548ae	CLIP-seq
MIRT1427223	hsa-miR-548aj	CLIP-seq
MIRT1427224	hsa-miR-548am	CLIP-seq
MIRT1427225	hsa-miR-548d-3p	CLIP-seq
MIRT2643163	hsa-miR-548u	CLIP-seq
MIRT1427226	hsa-miR-548x	CLIP-seq
MIRT1427227	hsa-miR-548z	CLIP-seq
MIRT2643164	hsa-miR-576-5p	CLIP-seq
MIRT2643165	hsa-miR-620	CLIP-seq
MIRT2643166	hsa-miR-635	CLIP-seq
MIRT2127975	hsa-miR-762	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	ISM	27764101
GO:0016020	Component	Membrane	IEA
GO:0045747	Process	Positive regulation of Notch signaling pathway	ISS
GO:0046331	Process	Lateral inhibition	IGI	27764101
GO:0046331	Process	Lateral inhibition	ISS

MIM	HGNC	e!Ensembl
610014	24128	ENSG00000184277

Q9BRN9

Protein name

TM2 domain-containing protein 3 (Beta-amyloid-binding protein-like protein 2) (BBP-like protein 2)

Protein function

Probable positive regulator of Notch signaling.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05154	TM2	182 → 231	TM2 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11278849}.

Sequence

MAGGVLPLRGLRALCRVLLFLSQFCILSGGEQSQALAQSIKDPGPTRTFTVVPRAAESTE
IPPYVMKCPSNGLCSRLPADCIDCTTNFSCTYGKPVTFDCAVKPSVTCVDQDFKSQKNFI
INMTCRFCWQLPETDYECTNSTSCMTVSCPRQRYPANCTVRDHVHCLGNRTFPKMLYCNW
TGGYKWSTALALSITLGGFGADRFYLGQWREGLGKLFSFGGLGIWTLIDVLLIGVGYVGP
ADGSLYI

Sequence length

247

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease, Late Onset	Alzheimer disease	BEFREE	27764101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	LHGDN	16642435		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	31836585	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26011102, 29446487		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	16642435	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TM2D3 (TM2 domain containing 3)