Gene Gene information from NCBI Gene database.
Entrez ID 8019
Gene name Bromodomain containing 3
Gene symbol BRD3
Synonyms (NCBI Gene)
FSHRG2ORFXRING3L
Chromosome 9
Chromosome location 9q34.2
Summary This gene was identified based on its homology to the gene encoding the RING3 protein, a serine/threonine kinase. The gene localizes to 9q34, a region which contains several major histocompatibility complex (MHC) genes. The function of the encoded protein
miRNA miRNA information provided by mirtarbase database.
1081
miRTarBase ID miRNA Experiments Reference
MIRT003279 hsa-miR-141-3p Luciferase reporter assayWestern blot 20053927
MIRT003279 hsa-miR-141-3p Luciferase reporter assayWestern blot 20053927
MIRT004162 hsa-miR-192-5p Microarray 16822819
MIRT003279 hsa-miR-141-3p Reporter assay;Western blot;Other 20053927
MIRT029195 hsa-miR-26b-5p Microarray 19088304
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
BRD7 Activation 12600283
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin IBA
GO:0000785 Component Chromatin IDA 32895492
GO:0003682 Function Chromatin binding IBA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0005515 Function Protein binding IPI 20195357, 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601541 1104 ENSG00000169925
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15059
Protein name Bromodomain-containing protein 3 (RING3-like protein)
Protein function Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coac
PDB 2E7N , 2NXB , 2OO1 , 2YW5 , 3S91 , 3S92 , 5A7C , 5HFR , 5HJC , 6BGG , 6BGH , 6I41 , 6I5P , 6I68 , 6I7A , 6QJU , 6U4A , 6ULP , 7JMY , 7JQ8 , 7JYN , 7JYZ , 7L72 , 7L9L , 7LAY , 7LAZ , 7LB4 , 7LBT , 7R8R , 7RJK , 7RJL , 7RJM , 7RJN , 7S3P , 7TO7 , 7TO8 , 7TO9 , 7TOA , 7UG5 , 8B5A , 8CV5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00439 Bromodomain 42 128 Bromodomain Domain
PF00439 Bromodomain 315 403 Bromodomain Domain
PF17035 BET 571 635 Bromodomain extra-terminal - transcription regulation Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9373153}.
Sequence
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFY
QPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTD
DIVLMAQA
LEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPA
TPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKK
GVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQ
HAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLST
VKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARK
LQDVFEMRFAKMPDEPV
EAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAAL
SQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKA
NSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQ
SREPSLRDSNPDEIEIDFETLKPTTLRELERYVKS
CLQKKQRKPFSASGKKQAAKSKEEL
AQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSS
DSSDSE
Sequence length 726
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MEDULLOBLASTOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OVARIAN FAILURE, PREMATURE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adrenocortical Carcinoma Adrenocortical carcinoma Pubtator 36793283 Associate
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma CTD_human_DG 24231268
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis 4, Juvenile Amyotrophic lateral sclerosis BEFREE 11085590
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 24874954
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 25001387, 31551256, 34813359 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Pancreatic ductal carcinoma Pubtator 34313325 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 24875858 Associate
★☆☆☆☆
Found in Text Mining only
Childhood Medulloblastoma Medulloblastoma CTD_human_DG 24231268
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Desmoplastic Medulloblastoma Medulloblastoma CTD_human_DG 24231268
★☆☆☆☆
Found in Text Mining only