Gene Gene information from NCBI Gene database.
Entrez ID 80143
Gene name Suppressor of IKBKE 1
Gene symbol SIKE1
Synonyms (NCBI Gene)
SIKE
Chromosome 1
Chromosome location 1p13.2
Summary SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
1532
miRTarBase ID miRNA Experiments Reference
MIRT052225 hsa-let-7b-5p CLASH 23622248
MIRT438057 hsa-miR-146a-5p Luciferase reporter assayqRT-PCRMicroarray 23963696
MIRT438057 hsa-miR-146a-5p Luciferase reporter assayqRT-PCRMicroarray 23963696
MIRT438057 hsa-miR-146a-5p Luciferase reporter assayqRT-PCRMicroarray 23963696
MIRT438057 hsa-miR-146a-5p Luciferase reporter assayqRT-PCRMicroarray 23963696
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18782753, 26496610, 30622739, 32296183, 33961781
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol TAS
GO:0019901 Function Protein kinase binding IPI 25743393
GO:0030674 Function Protein-macromolecule adaptor activity IDA 30622739
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611656 26119 ENSG00000052723
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BRV8
Protein name Suppressor of IKBKE 1 (Suppressor of IKK-epsilon)
Protein function Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disruptin
PDB 6AKK , 6AKL , 6AKM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05769 SIKE 2 187 SIKE family Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level). {ECO:0000269|PubMed:16281057}.
Sequence
Sequence length 207
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  RIG-I-like receptor signaling pathway   TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Pseudohyperkalemia Cardiff Pseudohyperkalemia Cardiff BEFREE 20714117
★☆☆☆☆
Found in Text Mining only
Stomach Neoplasms Stomach neoplasms Pubtator 30487159 Associate
★☆☆☆☆
Found in Text Mining only