CCDC33 (coiled-coil domain containing 33)

Gene

• Entrez ID: 80125
• Gene name: Coiled-coil domain containing 33
• Gene symbol: CCDC33
• Synonyms (NCBI Gene): CC2D3, CT61, HP11097
• Chromosome: 15
• Chromosome location: 15q24.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT495943	hsa-miR-4735-5p	PAR-CLIP	22291592
MIRT495944	hsa-miR-6822-3p	PAR-CLIP	22291592
MIRT495942	hsa-miR-580-3p	PAR-CLIP	22291592
MIRT495943	hsa-miR-4735-5p	PAR-CLIP	22291592
MIRT495944	hsa-miR-6822-3p	PAR-CLIP	22291592
MIRT495942	hsa-miR-580-3p	PAR-CLIP	22291592
MIRT868827	hsa-miR-1296	CLIP-seq
MIRT868828	hsa-miR-27a	CLIP-seq
MIRT868829	hsa-miR-27b	CLIP-seq
MIRT868830	hsa-miR-3065-3p	CLIP-seq
MIRT868831	hsa-miR-3127-5p	CLIP-seq
MIRT868832	hsa-miR-3184	CLIP-seq
MIRT868833	hsa-miR-3545-3p	CLIP-seq
MIRT868834	hsa-miR-423-5p	CLIP-seq
MIRT868835	hsa-miR-4320	CLIP-seq
MIRT868836	hsa-miR-4468	CLIP-seq
MIRT868837	hsa-miR-4512	CLIP-seq
MIRT868838	hsa-miR-4688	CLIP-seq
MIRT868839	hsa-miR-486-3p	CLIP-seq
MIRT868840	hsa-miR-513a-5p	CLIP-seq
MIRT1957818	hsa-miR-4793-5p	CLIP-seq
MIRT2194845	hsa-miR-4650-5p	CLIP-seq
MIRT2194846	hsa-miR-759	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 25910212, 27229929, 31515488
GO:0005777	Component	Peroxisome	IBA

Other IDs

• MIM: 618525
• HGNC: 26552
• e!Ensembl: ENSG00000140481

Protein

• UniProt ID: Q8N5R6
• Protein name: Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	238 → 335	C2 domain	Domain

• Sequence:

  MAFRGPEPWVSASLLRQRLKAEEKTLDLEFEVLSVGFNEAGRYALRLSAENPLQVGSGAG
  VQLQVNDGDPFPACSAITDVIEQQEPGQSLTLTRSKFIFTLPKGFCKNDGQHDAQLHVEA
  LRLDEPLGRAAQRVGEAIFPIYPRPDQPRMNPKAQDHEDLYRYCGNLALLRASTDPTARH
  CGSLAYSVAFHVHRGPQPPVSDSPPRAGQPELMSPEEPLIASQSTEPEIGHLSPSKKETI
  MVTLHGATNLPACKDGSEPWPYVVVKSTSEEKNNQSSKAVTSVTSEPTRAPIWGDTVNVE
  IQAEDAGQEDVILKVVDNRKKQELLSYKIPIKYLRVFHPYHFELVKPTESGKADEATAKT
  QLYATVVRKSSFIPRYIGCNHMALEIFLRGVNEPLANNPNPIVVIARVVPNYKEFKVSQA
  NRDLASVGLPITPLSFPIPSMMNFDVPRVSQNGCPQLSKPGGPPEQPLWNQSFLFQGRDG
  ATSFSEDTALVLEYYSSTSMKGSQPWTLNQPLGISVLPLKSRLYQKMLTGKGLDGLHVER
  LPIMDTSLKTINDEAPTVALSFQLLSSERPENFLTPNNSKALPTLDPKILDKKLRTIQES
  WSKDTVSSTMDLSTSTPREAEEEPLVPEMSHDTEMNNYRRAMQKMAEDILSLRRQASILE
  GENRILRSRLAQQEEEEGQGKASEAQNTVSMKQKLLLSELDMKKLRDRVQHLQNELIRKN
  DREKELLLLYQAQQPQAALLKQYQGKLQKMKALEETVRHQEKVIEKMERVLEDRLQDRSK
  PPPLNRQQGKPYTGFPMLSASGLPLGSMGENLPVELYSVLLAENAKLRTELDKNRHQQAP
  IILQQQALPDLLSGTSDKFNLLAKLEHAQSRILSLESQLEDSARRWGREKQDLATRLQEQ
  EKGFRHPSNSIIIEQPSALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT

• Sequence length: 958

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CCDC33-related disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	GWASCAT_DG	25918132		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Azoospermia Nonobstructive	Nonobstructive azoospermia	Pubtator	36259570	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22606018, 29445914	Associate	★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	BEFREE	15496203		★☆☆☆☆ Found in Text Mining only
Osteoarthritis of hip	Osteoarthritis Of Hip	GWASCAT_DG	30664745		★☆☆☆☆ Found in Text Mining only
Osteoarthritis, Knee	Knee osteoarthritis	GWASCAT_DG	30664745		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	28639886	Associate	★☆☆☆☆ Found in Text Mining only