GPR157 (G protein-coupled receptor 157)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 80045
Gene name G protein-coupled receptor 157
Gene symbol GPR157
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1p36.22
miRNA miRNA information provided by mirtarbase database.
195
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (195)
miRTarBase ID miRNA Experiments Reference
MIRT019724 hsa-miR-375 Microarray 20215506
MIRT051114 hsa-miR-16-5p CLASH 23622248
MIRT050327 hsa-miR-25-3p CLASH 23622248
MIRT692275 hsa-miR-548as-3p HITS-CLIP 23313552
MIRT692274 hsa-miR-4724-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (20)
GO ID Ontology Definition Evidence Reference
GO:0004888 Function Transmembrane signaling receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0004930 Function G protein-coupled receptor activity ISS
GO:0005886 Component Plasma membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
620860 23687 ENSG00000180758
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5UAW9
Protein name G-protein coupled receptor 157
Protein function Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger. {ECO:0000250|UniProtKB:Q8C206}
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00002 7tm_2 13 → 274 7 transmembrane receptor (Secretin family) Family
Sequence
Sequence length 335
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
IDIOPATHIC PULMONARY FIBROSIS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (1)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Corneal Dystrophy Crystalline of Schnyder Corneal dystrophy Pubtator 16163269 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only