PLEKHH3 (pleckstrin homology, MyTH4 and FERM domain containing H3)

Gene

• Entrez ID: 79990
• Gene name: Pleckstrin homology, MyTH4 and FERM domain containing H3
• Gene symbol: PLEKHH3
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17q21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018704	hsa-miR-335-5p	Microarray	18185580
MIRT049030	hsa-miR-92a-3p	CLASH	23622248
MIRT1242352	hsa-miR-3647-3p	CLIP-seq
MIRT1242353	hsa-miR-3653	CLIP-seq
MIRT1242354	hsa-miR-3658	CLIP-seq
MIRT1242355	hsa-miR-495	CLIP-seq
MIRT2071393	hsa-miR-1205	CLIP-seq
MIRT2071394	hsa-miR-1236	CLIP-seq
MIRT2071395	hsa-miR-146b-3p	CLIP-seq
MIRT2071396	hsa-miR-1909	CLIP-seq
MIRT2071397	hsa-miR-3173-5p	CLIP-seq
MIRT2071398	hsa-miR-339-5p	CLIP-seq
MIRT2071399	hsa-miR-3918	CLIP-seq
MIRT2071400	hsa-miR-3926	CLIP-seq
MIRT2071401	hsa-miR-4716-5p	CLIP-seq
MIRT2071402	hsa-miR-874	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005856	Component	Cytoskeleton	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q7Z736
• Protein name: Pleckstrin homology domain-containing family H member 3 (PH domain-containing family H member 3)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00784	MyTH4	285 → 398	MyTH4 domain	Family
  PF00788	RA	406 → 493	Ras association (RalGDS/AF-6) domain	Domain
  PF00373	FERM_M	506 → 664	FERM central domain	Domain

• Sequence:

  MPLPGGLWWLLCCRRGFTLLHRDYGDGELSGDGDEDEDEETFELRTPSPAGGGRGPLEVT
  LTQPVRSGPVSNRLQSWEETWSLIPEKGLPEDDPDIVVKGWLYREPRGGGARPWLPPRRA
  WFVLTRDSLDQFSSSGKGARRLGSLVLTSLCSVTGPERRRKETGLWSVTVSGRKHSVRLC
  SPRQAEAERWGVALREVIASKAPLETPTQLLLRDIQESCGDPEAVALIYLRNPILRHTSG
  ALYAPLLPLPYGVSAPGPGYAPLREEAVRLFLALQALEGARRPGPLMQGVLQTCRDLPAL
  RDELFLQLAKQTSGPAGPPGLPATQDPAALRYWQLLTCMSCTFRPGGAVRGHLLGHLERT
  EQALPDSELAEYARFIRKALGRTRGRELVPSLAEISALSQRQELLCTVHCPGAGACAVAI
  DSHTTAGEVARELVGRLGLARSRNAFALYEQRGAQERALAGGTLVADVLTRFENLAAEEA
  GLEDSPDSGWRLCLRLHGPLHPEGLSPDGHELPFLFEQAHALLLRGRPPPPDDTLRALAA
  LRLQSLQRDFSPRVPLPRLDRLLPPPAPPREDPPRPTPRPPPSAALLAGALWSPGLAKRR
  AERARRGGAGRTAGSIAREGGGGAGTAAAVLGGWKRLRGMGRAEAMAAYLALAAQCPGFG
  AARYDVLELSTEPGRGAPQKLCLGLGAKAMSLSRPGETEPIHSVSYGHVAACQLMGPHTL
  ALRVGESQLLLQSPQVEEIMQLVNAYLANPSPERPCSSSSPPCQDLPDTSPPSQRPGLDE
  PQGQSGCLGQLQD

• Sequence length: 793

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CATARACT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TONSILLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Malignant neoplasm of prostate	Prostate cancer	BEFREE	26585945		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	26585945		★☆☆☆☆ Found in Text Mining only
Sleep Apnea Obstructive	Sleep apnea	Pubtator	28520763	Associate	★☆☆☆☆ Found in Text Mining only