SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1)

Gene

• Entrez ID: 79987
• Gene name: Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
• Gene symbol: SVEP1
• Synonyms (NCBI Gene): C9orf13, CCP22, POLYDOM, SEL-OB, SELOB
• Chromosome: 9
• Chromosome location: 9q31.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT652968	hsa-miR-3156-5p	HITS-CLIP	23824327
MIRT652967	hsa-miR-6888-5p	HITS-CLIP	23824327
MIRT652966	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT652965	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT652964	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT652963	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT652962	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT652961	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT652960	hsa-miR-544a	HITS-CLIP	23824327
MIRT652959	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT652968	hsa-miR-3156-5p	HITS-CLIP	23824327
MIRT652967	hsa-miR-6888-5p	HITS-CLIP	23824327
MIRT652966	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT652965	hsa-miR-5196-3p	HITS-CLIP	23824327
MIRT652964	hsa-miR-4793-5p	HITS-CLIP	23824327
MIRT652963	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT652962	hsa-miR-20a-3p	HITS-CLIP	23824327
MIRT652961	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT652960	hsa-miR-544a	HITS-CLIP	23824327
MIRT652959	hsa-miR-6738-3p	HITS-CLIP	23824327
MIRT1404623	hsa-miR-150	CLIP-seq
MIRT1404624	hsa-miR-155	CLIP-seq
MIRT1404625	hsa-miR-2113	CLIP-seq
MIRT1404626	hsa-miR-3127-3p	CLIP-seq
MIRT1404627	hsa-miR-338-3p	CLIP-seq
MIRT1404628	hsa-miR-3646	CLIP-seq
MIRT1404629	hsa-miR-365	CLIP-seq
MIRT1404630	hsa-miR-3667-3p	CLIP-seq
MIRT1404631	hsa-miR-3920	CLIP-seq
MIRT1404632	hsa-miR-3921	CLIP-seq
MIRT1404633	hsa-miR-4530	CLIP-seq
MIRT1404634	hsa-miR-4653-5p	CLIP-seq
MIRT1404635	hsa-miR-4670-3p	CLIP-seq
MIRT1404636	hsa-miR-4691-5p	CLIP-seq
MIRT1404637	hsa-miR-4795-3p	CLIP-seq
MIRT1404638	hsa-miR-545	CLIP-seq
MIRT1404639	hsa-miR-548p	CLIP-seq
MIRT1404640	hsa-miR-569	CLIP-seq
MIRT1404641	hsa-miR-656	CLIP-seq
MIRT1404642	hsa-miR-758	CLIP-seq
MIRT1404643	hsa-miR-922	CLIP-seq
MIRT2121408	hsa-miR-1237	CLIP-seq
MIRT2121409	hsa-miR-1248	CLIP-seq
MIRT2121410	hsa-miR-544	CLIP-seq
MIRT2121411	hsa-miR-942	CLIP-seq
MIRT2343365	hsa-miR-4446-5p	CLIP-seq
MIRT2433750	hsa-miR-3074-3p	CLIP-seq
MIRT2433751	hsa-miR-4457	CLIP-seq
MIRT2433752	hsa-miR-4719	CLIP-seq
MIRT2433753	hsa-miR-495	CLIP-seq
MIRT2433754	hsa-miR-513b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001945	Process	Lymph vessel development	IEA
GO:0003013	Process	Circulatory system process	IEA
GO:0003017	Process	Lymph circulation	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0005178	Function	Integrin binding	IDA	35802072
GO:0005178	Function	Integrin binding	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	35802072, 36792666
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	ISS
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IDA	27892606
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	27892606
GO:0005737	Component	Cytoplasm	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007160	Process	Cell-matrix adhesion	IEA
GO:0008544	Process	Epidermis development	IBA
GO:0008544	Process	Epidermis development	IEA
GO:0010467	Process	Gene expression	IEA
GO:0010572	Process	Positive regulation of platelet activation	IEA
GO:0010572	Process	Positive regulation of platelet activation	IMP	36792666
GO:0016020	Component	Membrane	IEA
GO:0036303	Process	Lymph vessel morphogenesis	IBA
GO:0036303	Process	Lymph vessel morphogenesis	IEA
GO:0045906	Process	Negative regulation of vasoconstriction	IMP	35802072
GO:0048014	Process	Tie signaling pathway	IEA
GO:0051241	Process	Negative regulation of multicellular organismal process	IEA
GO:0098640	Function	Integrin binding involved in cell-matrix adhesion	IEA
GO:0098640	Function	Integrin binding involved in cell-matrix adhesion	ISS
GO:0120193	Process	Tight junction organization	IEA

Other IDs

• MIM: 611691
• HGNC: 15985
• e!Ensembl: ENSG00000165124

Protein

• UniProt ID: Q4LDE5
• Protein name: Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (CCP module-containing protein 22) (Polydom) (Selectin-like osteoblast-derived protein) (SEL-OB) (Serologically defined breast cancer antigen NY-BR-38)
• Protein function: Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription (By similarity
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00092	VWA	83 → 258	von Willebrand factor type A domain	Domain
  PF07699	Ephrin_rec_like	310 → 360	Putative ephrin-receptor like	Family
  PF00084	Sushi	378 → 433	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	438 → 493	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	498 → 559	Sushi repeat (SCR repeat)	Domain
  PF02494	HYR	560 → 642	HYR domain	Domain
  PF02494	HYR	643 → 722	HYR domain	Domain
  PF07699	Ephrin_rec_like	1005 → 1052	Putative ephrin-receptor like	Family
  PF07699	Ephrin_rec_like	1059 → 1106	Putative ephrin-receptor like	Family
  PF07699	Ephrin_rec_like	1113 → 1160	Putative ephrin-receptor like	Family
  PF00008	EGF	1197 → 1227	EGF-like domain	Domain
  PF00008	EGF	1235 → 1265	EGF-like domain	Domain
  PF00008	EGF	1273 → 1303	EGF-like domain	Domain
  PF12661	hEGF	1316 → 1337	Human growth factor-like EGF	Domain
  PF00008	EGF	1349 → 1379	EGF-like domain	Domain
  PF00008	EGF	1387 → 1417	EGF-like domain	Domain
  PF00354	Pentaxin	1429 → 1623	Pentaxin family	Domain
  PF00084	Sushi	1628 → 1685	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	1690 → 1743	Sushi repeat (SCR repeat)	Domain
  PF07645	EGF_CA	1745 → 1783	Calcium-binding EGF domain	Domain
  PF00084	Sushi	1789 → 1842	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	1847 → 1900	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	1905 → 1958	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	1963 → 2016	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2021 → 2078	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2083 → 2141	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2146 → 2199	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2204 → 2259	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2264 → 2318	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2323 → 2376	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2381 → 2435	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2440 → 2493	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2498 → 2551	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2556 → 2608	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2658 → 2712	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2717 → 2770	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2775 → 2828	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2833 → 2886	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2891 → 2944	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	2949 → 3002	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	3007 → 3059	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	3064 → 3117	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	3122 → 3176	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	3181 → 3236	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	3241 → 3294	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	3299 → 3352	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	3357 → 3411	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	3416 → 3468	Sushi repeat (SCR repeat)	Domain
  PF00008	EGF	3502 → 3530	EGF-like domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in mesenchymal cells (at protein level) (PubMed:16206243). Expressed in vascular smooth muscle cells (at protein level) (PubMed:35802072). Expressed throughout the epidermis, expression is most prominent in the basal and lowe
• Sequence:

  MWPRLAFCCWGLALVSGWATFQQMSPSRNFSFRLFPETAPGAPGSIPAPPAPGDEAAGSR
  VERLGQAFRRRVRLLRELSERLELVFLVDDSSSVGEVNFRSELMFVRKLLSDFPVVPTAT
  RVAIVTFSSKNYVVPRVDYISTRRARQHKCALLLQEIPAISYRGGGTYTKGAFQQAAQIL
  LHARENSTKVVFLITDGYSNGGDPRPIAASLRDSGVEIFTFGIWQGNIRELNDMASTPKE
  EHCYLLHSFEEFEALARRALHEDLPSGSFIQDDMVHCSYLCDEGKDCCDRMGSCKCGTHT
  GHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGSTSPEDC
  VCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCHPGFDLVGSSIILC
  LPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTC
  QGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSGVKE
  MLRCTTSGKWNVGVQAAVCKDVEAPQINCPKDIEAKTLEQQDSANVTWQIPTAKDNSGEK
  VSVHVHPAFTPPYLFPIGDVAIVYTATDLSGNQASCIFHIKVIDAEPPVIDWCRSPPPVQ
  VSEKVHAASWDEPQFSDNSGAELVITRSHTQGDLFPQGETIVQYTATDPSGNNRTCDIHI
  VIKGSPCEIPFTPVNGDFICTPDNTGVNCTLTCLEGYDFTEGSTDKYYCAYEDGVWKPTY
  TTEWPDCAKKRFANHGFKSFEMFYKAARCDDTDLMKKFSEAFETTLGKMVPSFCSDAEDI
  DCRLEENLTKKYCLEYNYDYENGFAIGPGGWGAANRLDYSYDDFLDTVQETATSIGNAKS
  SRIKRSAPLSDYKIKLIFNITASVPLPDERNDTLEWENQQRLLQTLETITNKLKRTLNKD
  PMYSFQLASEILIADSNSLETKKASPFCRPGSVLRGRMCVNCPLGTYYNLEHFTCESCRI
  GSYQDEEGQLECKLCPSGMYTEYIHSRNISDCKAQCKQGTYSYSGLETCESCPLGTYQPK
  FGSRSCLSCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAGKAFC
  LACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHECFFN
  PCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICECPSG
  YTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNA
  VCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAAGFTGSHC
  ELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCETEQSTGFNLDFEVSGIYGYVM
  LDGMLPSLHALTCTFWMKSSDDMNYGTPISYAVDNGSDNTLLLTDYNGWVLYVNGREKIT
  NCPSVNDGRWHHIAITWTSANGIWKVYIDGKLSDGGAGLSVGLPIPGGGALVLGQEQDKK
  GEGFSPAESFVGSISQLNLWDYVLSPQQVKSLATSCPEELSKGNVLAWPDFLSGIVGKVK
  IDSKSIFCSDCPRLGGSVPHLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQ
  PLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVS
  PSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHS
  SGEIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIEE
  LAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVKCSSPENINNGKYILSG
  LTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIKDAVITGNNFT
  FRNTVTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLFG
  DIAFYYCSDGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKA
  KFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGS
  NYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENGFLEHTTG
  RIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENF
  EVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTT
  EVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVLCTPPPLISFGVPIPSSALHF
  GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLS
  TALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHYGQTV
  TYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGADYSYGAIIIY
  SCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDCGLPPHIDFGDCTKLKDDQGYFEQEDDM
  MEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTMVSYTCNPGYELLGNPVLICQ
  EDGTWNGSAPSCISIECDLPTAPENGFLRFTETSMGSAVQYSCKPGHILAGSDLRLCLEN
  RKWSGASPRCEAISCKKPNPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQDDKN
  WDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWS
  GATPDCVPVRCATPPQLANGVTEGLDYGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAE
  IPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSP
  SCLPCRCSTPVIEYGTVNGTDFDCGKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCE
  HTSCGSLPMIPNAFISETSSWKENVITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPL
  SCGSPPSVANAVATGEAHTYESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPKK
  CPLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVS
  CGKPESPEHGFVVGSKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCE
  TPLEFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCKPNPCPVP
  FVIPENALLSEKEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKISCGPPA
  HVENAIARGVHYQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGG
  ICQRPNACSCPEGWMGRLCEEPICILPCLNGGRCVAPYQCDCPPGWTGSRCHTAVCQSPC
  LNGGKCVRPNRCHCLSSWTGHNCSRKRRTGF

• Sequence length: 3571

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	37118015	Associate	★☆☆☆☆ Found in Text Mining only
Arrhythmias Cardiac	Cardiac arrhythmias	Pubtator	27529678	Associate	★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial fibrillation	Pubtator	37967346	Associate	★☆☆☆☆ Found in Text Mining only
Atrophy	Atrophy	Pubtator	37118015	Associate	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	27529678		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar disorder	Pubtator	27529678	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bladder Exstrophy	Bladder exstrophy	Pubtator	37509153	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	17139625		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	23317273, 39379897	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	39379897	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31272500	Associate	★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	GWASCAT_DG	30595370		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	40026415	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	26934567		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	Pubtator	26934567, 34131117, 37100352	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	28714975, 29212778		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Disease	Coronary artery disease	Pubtator	26934567	Associate	★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	GWASDB_DG	23364394		★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	26934567		★☆☆☆☆ Found in Text Mining only
Deafness	Deafness	Pubtator	35248088	Associate	★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	37118015	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	26975253, 40026415	Associate	★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	Pubtator	27529678	Associate	★☆☆☆☆ Found in Text Mining only
Hearing Loss	Hearing loss	Pubtator	35248088	Associate	★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	38225249	Associate	★☆☆☆☆ Found in Text Mining only
Hepatitis B Chronic	Hepatitis b	Pubtator	36002595	Stimulate	★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung Disease	BEFREE	20361209		★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung disease	Pubtator	20361209	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	27529678	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertensive disease	Hypertension	BEFREE	27529678		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	32678854	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of liver	Liver Cancer	BEFREE	31272500		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17139625		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	35915456	Associate	★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	26975253		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	26975253	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	34308747	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	29178884	Associate	★☆☆☆☆ Found in Text Mining only