Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79979
Gene name	TRNA methyltransferase 2B
Gene symbol	TRMT2B
Synonyms (NCBI Gene)	CXorf34dJ341D10.3
Chromosome	X
Chromosome location	Xq22.1
Summary	This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028766	hsa-miR-26b-5p	Microarray	19088304
MIRT1456802	hsa-miR-132	CLIP-seq
MIRT1456803	hsa-miR-137	CLIP-seq
MIRT1456804	hsa-miR-212	CLIP-seq
MIRT1456805	hsa-miR-2277-3p	CLIP-seq
MIRT1456806	hsa-miR-3120-3p	CLIP-seq
MIRT1456807	hsa-miR-3613-3p	CLIP-seq
MIRT1456808	hsa-miR-371-5p	CLIP-seq
MIRT1456809	hsa-miR-371b-5p	CLIP-seq
MIRT1456810	hsa-miR-4268	CLIP-seq
MIRT1456811	hsa-miR-4448	CLIP-seq
MIRT1456812	hsa-miR-455-3p	CLIP-seq
MIRT1456813	hsa-miR-548c-3p	CLIP-seq
MIRT1456814	hsa-miR-606	CLIP-seq
MIRT1456815	hsa-miR-143	CLIP-seq
MIRT1456816	hsa-miR-1827	CLIP-seq
MIRT1456817	hsa-miR-3150a-3p	CLIP-seq
MIRT1456818	hsa-miR-3175	CLIP-seq
MIRT1456819	hsa-miR-34b	CLIP-seq
MIRT1456820	hsa-miR-3545-5p	CLIP-seq
MIRT1456821	hsa-miR-3614-5p	CLIP-seq
MIRT1456822	hsa-miR-3622a-5p	CLIP-seq
MIRT1456823	hsa-miR-3664-5p	CLIP-seq
MIRT1456824	hsa-miR-4253	CLIP-seq
MIRT1456825	hsa-miR-4521	CLIP-seq
MIRT1456826	hsa-miR-4639-3p	CLIP-seq
MIRT1456827	hsa-miR-4649-3p	CLIP-seq
MIRT1456828	hsa-miR-4766-5p	CLIP-seq
MIRT1456829	hsa-miR-488	CLIP-seq
MIRT1456830	hsa-miR-491-5p	CLIP-seq
MIRT1456831	hsa-miR-939	CLIP-seq
MIRT1456832	hsa-miR-1285	CLIP-seq
MIRT1456816	hsa-miR-1827	CLIP-seq
MIRT1456833	hsa-miR-31	CLIP-seq
MIRT1456834	hsa-miR-3160-3p	CLIP-seq
MIRT1456835	hsa-miR-3165	CLIP-seq
MIRT1456836	hsa-miR-3187-5p	CLIP-seq
MIRT1456819	hsa-miR-34b	CLIP-seq
MIRT1456821	hsa-miR-3614-5p	CLIP-seq
MIRT1456822	hsa-miR-3622a-5p	CLIP-seq
MIRT1456837	hsa-miR-3656	CLIP-seq
MIRT1456838	hsa-miR-4433	CLIP-seq
MIRT1456839	hsa-miR-4487	CLIP-seq
MIRT1456827	hsa-miR-4649-3p	CLIP-seq
MIRT1456840	hsa-miR-4768-3p	CLIP-seq
MIRT1456841	hsa-miR-612	CLIP-seq
MIRT1456842	hsa-miR-766	CLIP-seq
MIRT1456834	hsa-miR-3160-3p	CLIP-seq
MIRT1456819	hsa-miR-34b	CLIP-seq
MIRT1456821	hsa-miR-3614-5p	CLIP-seq
MIRT1456839	hsa-miR-4487	CLIP-seq
MIRT2136886	hsa-miR-1182	CLIP-seq
MIRT2136887	hsa-miR-122	CLIP-seq
MIRT1456832	hsa-miR-1285	CLIP-seq
MIRT2136888	hsa-miR-1915	CLIP-seq
MIRT1456833	hsa-miR-31	CLIP-seq
MIRT2136889	hsa-miR-3135b	CLIP-seq
MIRT1456834	hsa-miR-3160-3p	CLIP-seq
MIRT1456836	hsa-miR-3187-5p	CLIP-seq
MIRT2136890	hsa-miR-323b-3p	CLIP-seq
MIRT1456819	hsa-miR-34b	CLIP-seq
MIRT1456821	hsa-miR-3614-5p	CLIP-seq
MIRT2136891	hsa-miR-3622b-5p	CLIP-seq
MIRT2136892	hsa-miR-3652	CLIP-seq
MIRT1456823	hsa-miR-3664-5p	CLIP-seq
MIRT1456824	hsa-miR-4253	CLIP-seq
MIRT2136893	hsa-miR-4430	CLIP-seq
MIRT1456838	hsa-miR-4433	CLIP-seq
MIRT1456839	hsa-miR-4487	CLIP-seq
MIRT2136894	hsa-miR-4733-3p	CLIP-seq
MIRT2136895	hsa-miR-4740-3p	CLIP-seq
MIRT1456829	hsa-miR-488	CLIP-seq
MIRT2136896	hsa-miR-5095	CLIP-seq
MIRT2136897	hsa-miR-515-5p	CLIP-seq
MIRT2136898	hsa-miR-552	CLIP-seq
MIRT2136899	hsa-miR-564	CLIP-seq
MIRT2136900	hsa-miR-579	CLIP-seq
MIRT1456841	hsa-miR-612	CLIP-seq
MIRT2136901	hsa-miR-764	CLIP-seq
MIRT1456842	hsa-miR-766	CLIP-seq
MIRT2136886	hsa-miR-1182	CLIP-seq
MIRT2136887	hsa-miR-122	CLIP-seq
MIRT1456832	hsa-miR-1285	CLIP-seq
MIRT2357681	hsa-miR-155	CLIP-seq
MIRT1456816	hsa-miR-1827	CLIP-seq
MIRT2136888	hsa-miR-1915	CLIP-seq
MIRT2357682	hsa-miR-204	CLIP-seq
MIRT2357683	hsa-miR-211	CLIP-seq
MIRT2357684	hsa-miR-2276	CLIP-seq
MIRT2136889	hsa-miR-3135b	CLIP-seq
MIRT1456834	hsa-miR-3160-3p	CLIP-seq
MIRT1456835	hsa-miR-3165	CLIP-seq
MIRT1456836	hsa-miR-3187-5p	CLIP-seq
MIRT2357685	hsa-miR-337-3p	CLIP-seq
MIRT1456819	hsa-miR-34b	CLIP-seq
MIRT1456821	hsa-miR-3614-5p	CLIP-seq
MIRT1456822	hsa-miR-3622a-5p	CLIP-seq
MIRT2136892	hsa-miR-3652	CLIP-seq
MIRT1456837	hsa-miR-3656	CLIP-seq
MIRT1456823	hsa-miR-3664-5p	CLIP-seq
MIRT2357686	hsa-miR-3692	CLIP-seq
MIRT2357687	hsa-miR-3926	CLIP-seq
MIRT2136893	hsa-miR-4430	CLIP-seq
MIRT1456838	hsa-miR-4433	CLIP-seq
MIRT2357688	hsa-miR-4436b-5p	CLIP-seq
MIRT2357689	hsa-miR-4446-5p	CLIP-seq
MIRT1456839	hsa-miR-4487	CLIP-seq
MIRT2357690	hsa-miR-4527	CLIP-seq
MIRT1456826	hsa-miR-4639-3p	CLIP-seq
MIRT1456827	hsa-miR-4649-3p	CLIP-seq
MIRT2357691	hsa-miR-4719	CLIP-seq
MIRT2357692	hsa-miR-4722-3p	CLIP-seq
MIRT2357693	hsa-miR-4726-3p	CLIP-seq
MIRT2136894	hsa-miR-4733-3p	CLIP-seq
MIRT2136895	hsa-miR-4740-3p	CLIP-seq
MIRT2357694	hsa-miR-4755-5p	CLIP-seq
MIRT1456828	hsa-miR-4766-5p	CLIP-seq
MIRT1456840	hsa-miR-4768-3p	CLIP-seq
MIRT2357695	hsa-miR-4772-3p	CLIP-seq
MIRT2357696	hsa-miR-4786-5p	CLIP-seq
MIRT2357697	hsa-miR-498	CLIP-seq
MIRT2357698	hsa-miR-509-3p	CLIP-seq
MIRT2136896	hsa-miR-5095	CLIP-seq
MIRT2357699	hsa-miR-513b	CLIP-seq
MIRT2357700	hsa-miR-548s	CLIP-seq
MIRT2136898	hsa-miR-552	CLIP-seq
MIRT1456841	hsa-miR-612	CLIP-seq
MIRT2357701	hsa-miR-623	CLIP-seq
MIRT2136901	hsa-miR-764	CLIP-seq
MIRT1456842	hsa-miR-766	CLIP-seq
MIRT2357702	hsa-miR-769-5p	CLIP-seq
MIRT2136886	hsa-miR-1182	CLIP-seq
MIRT2357682	hsa-miR-204	CLIP-seq
MIRT2357683	hsa-miR-211	CLIP-seq
MIRT1456835	hsa-miR-3165	CLIP-seq
MIRT2136890	hsa-miR-323b-3p	CLIP-seq
MIRT1456821	hsa-miR-3614-5p	CLIP-seq
MIRT1456837	hsa-miR-3656	CLIP-seq
MIRT1456838	hsa-miR-4433	CLIP-seq
MIRT2357689	hsa-miR-4446-5p	CLIP-seq
MIRT2357694	hsa-miR-4755-5p	CLIP-seq
MIRT1456840	hsa-miR-4768-3p	CLIP-seq
MIRT2357696	hsa-miR-4786-5p	CLIP-seq
MIRT2136897	hsa-miR-515-5p	CLIP-seq
MIRT2357701	hsa-miR-623	CLIP-seq
MIRT2357702	hsa-miR-769-5p	CLIP-seq
MIRT2462397	hsa-miR-10a	CLIP-seq
MIRT2462398	hsa-miR-10b	CLIP-seq
MIRT1456835	hsa-miR-3165	CLIP-seq
MIRT2462399	hsa-miR-339-5p	CLIP-seq
MIRT2136891	hsa-miR-3622b-5p	CLIP-seq
MIRT1456837	hsa-miR-3656	CLIP-seq
MIRT1456824	hsa-miR-4253	CLIP-seq
MIRT2462400	hsa-miR-4421	CLIP-seq
MIRT2462401	hsa-miR-4684-5p	CLIP-seq
MIRT2462402	hsa-miR-593	CLIP-seq
MIRT2462397	hsa-miR-10a	CLIP-seq
MIRT2462398	hsa-miR-10b	CLIP-seq
MIRT2462399	hsa-miR-339-5p	CLIP-seq
MIRT2462400	hsa-miR-4421	CLIP-seq
MIRT2462401	hsa-miR-4684-5p	CLIP-seq
MIRT2462402	hsa-miR-593	CLIP-seq
MIRT2462397	hsa-miR-10a	CLIP-seq
MIRT2462398	hsa-miR-10b	CLIP-seq
MIRT1456802	hsa-miR-132	CLIP-seq
MIRT2136888	hsa-miR-1915	CLIP-seq
MIRT2651352	hsa-miR-198	CLIP-seq
MIRT1456804	hsa-miR-212	CLIP-seq
MIRT1456805	hsa-miR-2277-3p	CLIP-seq
MIRT1456833	hsa-miR-31	CLIP-seq
MIRT1456806	hsa-miR-3120-3p	CLIP-seq
MIRT1456817	hsa-miR-3150a-3p	CLIP-seq
MIRT1456835	hsa-miR-3165	CLIP-seq
MIRT1456818	hsa-miR-3175	CLIP-seq
MIRT2462399	hsa-miR-339-5p	CLIP-seq
MIRT1456819	hsa-miR-34b	CLIP-seq
MIRT1456820	hsa-miR-3545-5p	CLIP-seq
MIRT1456807	hsa-miR-3613-3p	CLIP-seq
MIRT1456821	hsa-miR-3614-5p	CLIP-seq
MIRT2136891	hsa-miR-3622b-5p	CLIP-seq
MIRT1456837	hsa-miR-3656	CLIP-seq
MIRT1456808	hsa-miR-371-5p	CLIP-seq
MIRT1456809	hsa-miR-371b-5p	CLIP-seq
MIRT2357687	hsa-miR-3926	CLIP-seq
MIRT1456824	hsa-miR-4253	CLIP-seq
MIRT2462400	hsa-miR-4421	CLIP-seq
MIRT1456838	hsa-miR-4433	CLIP-seq
MIRT2651353	hsa-miR-4481	CLIP-seq
MIRT1456825	hsa-miR-4521	CLIP-seq
MIRT1456812	hsa-miR-455-3p	CLIP-seq
MIRT2462401	hsa-miR-4684-5p	CLIP-seq
MIRT2357692	hsa-miR-4722-3p	CLIP-seq
MIRT2357693	hsa-miR-4726-3p	CLIP-seq
MIRT2136895	hsa-miR-4740-3p	CLIP-seq
MIRT2651354	hsa-miR-4745-5p	CLIP-seq
MIRT1456828	hsa-miR-4766-5p	CLIP-seq
MIRT1456840	hsa-miR-4768-3p	CLIP-seq
MIRT2357696	hsa-miR-4786-5p	CLIP-seq
MIRT1456829	hsa-miR-488	CLIP-seq
MIRT1456830	hsa-miR-491-5p	CLIP-seq
MIRT2357697	hsa-miR-498	CLIP-seq
MIRT1456813	hsa-miR-548c-3p	CLIP-seq
MIRT2357700	hsa-miR-548s	CLIP-seq
MIRT2462402	hsa-miR-593	CLIP-seq
MIRT2651355	hsa-miR-665	CLIP-seq
MIRT2357702	hsa-miR-769-5p	CLIP-seq
MIRT1456831	hsa-miR-939	CLIP-seq
MIRT2462397	hsa-miR-10a	CLIP-seq
MIRT2462398	hsa-miR-10b	CLIP-seq
MIRT1456802	hsa-miR-132	CLIP-seq
MIRT2651352	hsa-miR-198	CLIP-seq
MIRT1456804	hsa-miR-212	CLIP-seq
MIRT1456805	hsa-miR-2277-3p	CLIP-seq
MIRT1456833	hsa-miR-31	CLIP-seq
MIRT1456806	hsa-miR-3120-3p	CLIP-seq
MIRT1456817	hsa-miR-3150a-3p	CLIP-seq
MIRT1456818	hsa-miR-3175	CLIP-seq
MIRT2462399	hsa-miR-339-5p	CLIP-seq
MIRT1456820	hsa-miR-3545-5p	CLIP-seq
MIRT1456807	hsa-miR-3613-3p	CLIP-seq
MIRT1456808	hsa-miR-371-5p	CLIP-seq
MIRT1456809	hsa-miR-371b-5p	CLIP-seq
MIRT1456824	hsa-miR-4253	CLIP-seq
MIRT2462400	hsa-miR-4421	CLIP-seq
MIRT1456838	hsa-miR-4433	CLIP-seq
MIRT2651353	hsa-miR-4481	CLIP-seq
MIRT1456812	hsa-miR-455-3p	CLIP-seq
MIRT2462401	hsa-miR-4684-5p	CLIP-seq
MIRT2651354	hsa-miR-4745-5p	CLIP-seq
MIRT1456830	hsa-miR-491-5p	CLIP-seq
MIRT1456813	hsa-miR-548c-3p	CLIP-seq
MIRT2462402	hsa-miR-593	CLIP-seq
MIRT2651355	hsa-miR-665	CLIP-seq
MIRT1456831	hsa-miR-939	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	31948311
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	27184847
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006396	Process	RNA processing	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008173	Function	RNA methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030697	Function	TRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent	IDA	31948311
GO:0030697	Function	TRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent	IEA
GO:0031167	Process	RRNA methylation	IEA
GO:0032259	Process	Methylation	IEA
GO:0070041	Function	RRNA (uridine-C5-)-methyltransferase activity	IDA	31948311, 34556860
GO:0070041	Function	RRNA (uridine-C5-)-methyltransferase activity	IEA

MIM	HGNC	e!Ensembl
301128	25748	ENSG00000188917

Q96GJ1

Protein name

tRNA (uracil-5-)-methyltransferase homolog B (EC 2.1.1.35) (TRM2 homolog B) (rRNA (uracil-5-)-methyltransferase TRMT2B) (EC 2.1.1.-)

Protein function

Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and 12S rRNA (PubMed:31948311, PubMed:34556860). Catalyzes the methylation of uridine at position 54 (m5U54) in all tRNAs

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05958	tRNA_U5-meth_tr	295 → 504	tRNA (Uracil-5-)-methyltransferase	Family

Sequence

MAGLKRRVPLHSLRYFISMVGLFSKPGLLPWYARNPPGWSQLFLGTVCKGDFTRVIATKC
QKGQKSQKKPSHLGPLDGSWQERLADVVTPLWRLSYEEQLKVKFAAQKKILQRLESYIQM
LNGVSVTTAVPKSERLSCLLHPIIPSPVINGYRNKSTFSVNRGPDGNPKTVGFYLGTWRD
GNVVCVQSNHLKNIPEKHSQVAQYYEVFLRQSPLEPCLVFHEGGYWRELTVRTNSQGHTM
AIITFHPQKLSQEELHVQKEIVKEFFIRGPGAACGLTSLYFQESTMTRCSHQQSPYQLLF
GEPYIFEELLSLKIRISPDAFFQINTAGAEMLYRTVGELTGVNSDTILLDICCGTGVIGL
SLAQHTSRVLGIELLEQAVEDARWTAAFNGITNSEFHTGQAEKILPGLLKSKEDGQSIVA
VVNPARAGLHYKVIQAIRNFRAIHTLVFVSCKLHGESTRNVIELCCPPDPAKKLLGEPFV
LQQAVPVDLFPHTPHCELVLLFTR

Sequence length

504

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

TRMT2B (tRNA methyltransferase 2B)