NOL10 (nucleolar protein 10)

Gene

• Entrez ID: 79954
• Gene name: Nucleolar protein 10
• Gene symbol: NOL10
• Synonyms (NCBI Gene): PQBP5
• Chromosome: 2
• Chromosome location: 2p25.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019297	hsa-miR-148b-3p	Microarray	17612493
MIRT022386	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT036650	hsa-miR-935	CLASH	23622248
MIRT637401	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT637400	hsa-miR-4422	HITS-CLIP	23824327
MIRT629619	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT629618	hsa-miR-622	HITS-CLIP	23824327
MIRT629617	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT629616	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT629615	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT629614	hsa-miR-4264	HITS-CLIP	23824327
MIRT629613	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT629612	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629611	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT629610	hsa-miR-1976	HITS-CLIP	23824327
MIRT629609	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT629608	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT629607	hsa-miR-4279	HITS-CLIP	23824327
MIRT495111	hsa-miR-4480	PAR-CLIP	23708386
MIRT495110	hsa-miR-1227-3p	PAR-CLIP	23708386
MIRT495109	hsa-miR-550b-2-5p	PAR-CLIP	23708386
MIRT457446	hsa-miR-4428	PAR-CLIP	23592263
MIRT457445	hsa-miR-1321	PAR-CLIP	23592263
MIRT457444	hsa-miR-4739	PAR-CLIP	23592263
MIRT457443	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT457442	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT457441	hsa-miR-7515	PAR-CLIP	23592263
MIRT457440	hsa-miR-4419a	PAR-CLIP	23592263
MIRT457439	hsa-miR-4510	PAR-CLIP	23592263
MIRT457438	hsa-miR-6127	PAR-CLIP	23592263
MIRT457437	hsa-miR-6129	PAR-CLIP	23592263
MIRT457436	hsa-miR-6130	PAR-CLIP	23592263
MIRT457435	hsa-miR-6133	PAR-CLIP	23592263
MIRT457434	hsa-miR-3202	PAR-CLIP	23592263
MIRT457433	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT457432	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT457431	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT457430	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT457429	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT457427	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT457428	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT457426	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT457425	hsa-miR-4271	PAR-CLIP	23592263
MIRT457424	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT457423	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT637401	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT637400	hsa-miR-4422	HITS-CLIP	23824327
MIRT629619	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT629618	hsa-miR-622	HITS-CLIP	23824327
MIRT629617	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT629616	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT629615	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT629614	hsa-miR-4264	HITS-CLIP	23824327
MIRT629613	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT629612	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT629611	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT629610	hsa-miR-1976	HITS-CLIP	23824327
MIRT629609	hsa-miR-520a-5p	HITS-CLIP	23824327
MIRT629608	hsa-miR-525-5p	HITS-CLIP	23824327
MIRT629607	hsa-miR-4279	HITS-CLIP	23824327
MIRT495111	hsa-miR-4480	PAR-CLIP	23708386
MIRT495110	hsa-miR-1227-3p	PAR-CLIP	23708386
MIRT495109	hsa-miR-550b-2-5p	PAR-CLIP	23708386
MIRT457446	hsa-miR-4428	PAR-CLIP	23592263
MIRT457445	hsa-miR-1321	PAR-CLIP	23592263
MIRT457444	hsa-miR-4739	PAR-CLIP	23592263
MIRT457443	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT457442	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT457441	hsa-miR-7515	PAR-CLIP	23592263
MIRT457440	hsa-miR-4419a	PAR-CLIP	23592263
MIRT457439	hsa-miR-4510	PAR-CLIP	23592263
MIRT457438	hsa-miR-6127	PAR-CLIP	23592263
MIRT457437	hsa-miR-6129	PAR-CLIP	23592263
MIRT457436	hsa-miR-6130	PAR-CLIP	23592263
MIRT457435	hsa-miR-6133	PAR-CLIP	23592263
MIRT457434	hsa-miR-3202	PAR-CLIP	23592263
MIRT457433	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT457432	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT457431	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT457430	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT457429	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT457427	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT457428	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT457426	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT457425	hsa-miR-4271	PAR-CLIP	23592263
MIRT457424	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT457423	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT1188377	hsa-miR-124	CLIP-seq
MIRT1188378	hsa-miR-1254	CLIP-seq
MIRT1188379	hsa-miR-1302	CLIP-seq
MIRT1188380	hsa-miR-130a	CLIP-seq
MIRT1188381	hsa-miR-130b	CLIP-seq
MIRT1188382	hsa-miR-134	CLIP-seq
MIRT1188383	hsa-miR-147b	CLIP-seq
MIRT1188384	hsa-miR-148a	CLIP-seq
MIRT1188385	hsa-miR-148b	CLIP-seq
MIRT1188386	hsa-miR-152	CLIP-seq
MIRT1188387	hsa-miR-1908	CLIP-seq
MIRT1188388	hsa-miR-1912	CLIP-seq
MIRT1188389	hsa-miR-196a	CLIP-seq
MIRT1188390	hsa-miR-196b	CLIP-seq
MIRT1188391	hsa-miR-203	CLIP-seq
MIRT1188392	hsa-miR-301a	CLIP-seq
MIRT1188393	hsa-miR-301b	CLIP-seq
MIRT1188394	hsa-miR-3116	CLIP-seq
MIRT1188395	hsa-miR-3118	CLIP-seq
MIRT1188396	hsa-miR-3122	CLIP-seq
MIRT1188397	hsa-miR-3128	CLIP-seq
MIRT1188398	hsa-miR-3130-5p	CLIP-seq
MIRT1188399	hsa-miR-3136-5p	CLIP-seq
MIRT1188400	hsa-miR-3168	CLIP-seq
MIRT1188401	hsa-miR-3200-5p	CLIP-seq
MIRT1188402	hsa-miR-331-3p	CLIP-seq
MIRT1188403	hsa-miR-340	CLIP-seq
MIRT1188404	hsa-miR-3649	CLIP-seq
MIRT1188405	hsa-miR-3666	CLIP-seq
MIRT1188406	hsa-miR-3679-3p	CLIP-seq
MIRT1188407	hsa-miR-3689d	CLIP-seq
MIRT1188408	hsa-miR-3913-5p	CLIP-seq
MIRT1188409	hsa-miR-3973	CLIP-seq
MIRT1188410	hsa-miR-4254	CLIP-seq
MIRT1188411	hsa-miR-4274	CLIP-seq
MIRT1188412	hsa-miR-4275	CLIP-seq
MIRT1188413	hsa-miR-4283	CLIP-seq
MIRT1188414	hsa-miR-4292	CLIP-seq
MIRT1188415	hsa-miR-4295	CLIP-seq
MIRT1188416	hsa-miR-4298	CLIP-seq
MIRT1188417	hsa-miR-4439	CLIP-seq
MIRT1188418	hsa-miR-4457	CLIP-seq
MIRT1188419	hsa-miR-4482	CLIP-seq
MIRT1188420	hsa-miR-4488	CLIP-seq
MIRT1188421	hsa-miR-4489	CLIP-seq
MIRT1188422	hsa-miR-4513	CLIP-seq
MIRT1188423	hsa-miR-4519	CLIP-seq
MIRT1188424	hsa-miR-454	CLIP-seq
MIRT1188425	hsa-miR-4640-5p	CLIP-seq
MIRT1188426	hsa-miR-4675	CLIP-seq
MIRT1188427	hsa-miR-4677-3p	CLIP-seq
MIRT1188428	hsa-miR-4696	CLIP-seq
MIRT1188429	hsa-miR-4697-5p	CLIP-seq
MIRT1188430	hsa-miR-4720-5p	CLIP-seq
MIRT1188431	hsa-miR-4726-5p	CLIP-seq
MIRT1188432	hsa-miR-4741	CLIP-seq
MIRT1188433	hsa-miR-4766-5p	CLIP-seq
MIRT1188434	hsa-miR-4771	CLIP-seq
MIRT1188435	hsa-miR-4773	CLIP-seq
MIRT1188436	hsa-miR-4799-3p	CLIP-seq
MIRT1188437	hsa-miR-486-3p	CLIP-seq
MIRT1188438	hsa-miR-494	CLIP-seq
MIRT1188439	hsa-miR-499a-5p	CLIP-seq
MIRT1188440	hsa-miR-506	CLIP-seq
MIRT1188441	hsa-miR-520g	CLIP-seq
MIRT1188442	hsa-miR-520h	CLIP-seq
MIRT1188443	hsa-miR-577	CLIP-seq
MIRT1188444	hsa-miR-617	CLIP-seq
MIRT1188445	hsa-miR-663	CLIP-seq
MIRT1188446	hsa-miR-744	CLIP-seq
MIRT1188382	hsa-miR-134	CLIP-seq
MIRT1188395	hsa-miR-3118	CLIP-seq
MIRT1188399	hsa-miR-3136-5p	CLIP-seq
MIRT1188407	hsa-miR-3689d	CLIP-seq
MIRT1188417	hsa-miR-4439	CLIP-seq
MIRT1188422	hsa-miR-4513	CLIP-seq
MIRT1188438	hsa-miR-494	CLIP-seq
MIRT1188382	hsa-miR-134	CLIP-seq
MIRT1188395	hsa-miR-3118	CLIP-seq
MIRT1188399	hsa-miR-3136-5p	CLIP-seq
MIRT1188407	hsa-miR-3689d	CLIP-seq
MIRT1188417	hsa-miR-4439	CLIP-seq
MIRT1188422	hsa-miR-4513	CLIP-seq
MIRT1188438	hsa-miR-494	CLIP-seq
MIRT1188382	hsa-miR-134	CLIP-seq
MIRT1188395	hsa-miR-3118	CLIP-seq
MIRT1188399	hsa-miR-3136-5p	CLIP-seq
MIRT2054557	hsa-miR-3152-3p	CLIP-seq
MIRT2054558	hsa-miR-3174	CLIP-seq
MIRT2054559	hsa-miR-3177-5p	CLIP-seq
MIRT2054560	hsa-miR-338-5p	CLIP-seq
MIRT2054561	hsa-miR-3606	CLIP-seq
MIRT1188406	hsa-miR-3679-3p	CLIP-seq
MIRT1188407	hsa-miR-3689d	CLIP-seq
MIRT1188417	hsa-miR-4439	CLIP-seq
MIRT1188420	hsa-miR-4488	CLIP-seq
MIRT1188422	hsa-miR-4513	CLIP-seq
MIRT1188429	hsa-miR-4697-5p	CLIP-seq
MIRT1188434	hsa-miR-4771	CLIP-seq
MIRT2054562	hsa-miR-4778-5p	CLIP-seq
MIRT1188437	hsa-miR-486-3p	CLIP-seq
MIRT1188438	hsa-miR-494	CLIP-seq
MIRT1188439	hsa-miR-499a-5p	CLIP-seq
MIRT2054563	hsa-miR-513b	CLIP-seq
MIRT1188444	hsa-miR-617	CLIP-seq
MIRT2054564	hsa-miR-921	CLIP-seq
MIRT1188382	hsa-miR-134	CLIP-seq
MIRT2283686	hsa-miR-190	CLIP-seq
MIRT2283687	hsa-miR-190b	CLIP-seq
MIRT2283688	hsa-miR-1915	CLIP-seq
MIRT2283689	hsa-miR-2115	CLIP-seq
MIRT2283690	hsa-miR-216a	CLIP-seq
MIRT1188395	hsa-miR-3118	CLIP-seq
MIRT1188399	hsa-miR-3136-5p	CLIP-seq
MIRT2283691	hsa-miR-3657	CLIP-seq
MIRT1188407	hsa-miR-3689d	CLIP-seq
MIRT2283692	hsa-miR-3918	CLIP-seq
MIRT2283693	hsa-miR-4286	CLIP-seq
MIRT1188417	hsa-miR-4439	CLIP-seq
MIRT2283694	hsa-miR-4512	CLIP-seq
MIRT1188422	hsa-miR-4513	CLIP-seq
MIRT2283695	hsa-miR-4669	CLIP-seq
MIRT2283696	hsa-miR-4672	CLIP-seq
MIRT2283697	hsa-miR-4685-5p	CLIP-seq
MIRT2283698	hsa-miR-4719	CLIP-seq
MIRT2283699	hsa-miR-4726-3p	CLIP-seq
MIRT2283700	hsa-miR-4762-5p	CLIP-seq
MIRT1188438	hsa-miR-494	CLIP-seq
MIRT2283701	hsa-miR-508-3p	CLIP-seq
MIRT2283702	hsa-miR-516a-3p	CLIP-seq
MIRT2283703	hsa-miR-584	CLIP-seq
MIRT1188382	hsa-miR-134	CLIP-seq
MIRT1188395	hsa-miR-3118	CLIP-seq
MIRT1188399	hsa-miR-3136-5p	CLIP-seq
MIRT1188407	hsa-miR-3689d	CLIP-seq
MIRT1188417	hsa-miR-4439	CLIP-seq
MIRT1188422	hsa-miR-4513	CLIP-seq
MIRT1188438	hsa-miR-494	CLIP-seq
MIRT2581848	hsa-miR-1913	CLIP-seq
MIRT2581849	hsa-miR-3121-5p	CLIP-seq
MIRT2581850	hsa-miR-3157-3p	CLIP-seq
MIRT2054559	hsa-miR-3177-5p	CLIP-seq
MIRT2581851	hsa-miR-324-3p	CLIP-seq
MIRT2581852	hsa-miR-4290	CLIP-seq
MIRT2581853	hsa-miR-4667-3p	CLIP-seq
MIRT2581854	hsa-miR-4749-3p	CLIP-seq
MIRT2054563	hsa-miR-513b	CLIP-seq
MIRT2581855	hsa-miR-579	CLIP-seq
MIRT2581856	hsa-miR-874	CLIP-seq
MIRT2581848	hsa-miR-1913	CLIP-seq
MIRT2581849	hsa-miR-3121-5p	CLIP-seq
MIRT2581850	hsa-miR-3157-3p	CLIP-seq
MIRT2054559	hsa-miR-3177-5p	CLIP-seq
MIRT2581851	hsa-miR-324-3p	CLIP-seq
MIRT2581852	hsa-miR-4290	CLIP-seq
MIRT2581853	hsa-miR-4667-3p	CLIP-seq
MIRT2581854	hsa-miR-4749-3p	CLIP-seq
MIRT2054563	hsa-miR-513b	CLIP-seq
MIRT2581855	hsa-miR-579	CLIP-seq
MIRT2581856	hsa-miR-874	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000462	Process	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0032040	Component	Small-subunit processome	IBA

Other IDs

• MIM: 616197
• HGNC: 25862
• e!Ensembl: ENSG00000115761

Protein

• UniProt ID: Q9BSC4
• Protein name: Nucleolar protein 10
• PDB: 7MQ8, 7MQ9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08159	NUC153	482 → 509	NUC153 domain	Domain

• Sequence:

  MQVSSLNEVKIYSLSCGKSLPEWLSDRKKRALQKKDVDVRRRIELIQDFEMPTVCTTIKV
  SKDGQYILATGTYKPRVRCYDTYQLSLKFERCLDSEVVTFEILSDDYSKIVFLHNDRYIE
  FHSQSGFYYKTRIPKFGRDFSYHYPSCDLYFVGASSEVYRLNLEQGRYLNPLQTDAAENN
  VCDINSVHGLFATGTIEGRVECWDPRTRNRVGLLDCALNSVTADSEINSLPTISALKFNG
  ALTMAVGTTTGQVLLYDLRSDKPLLVKDHQYGLPIKSVHFQDSLDLILSADSRIVKMWNK
  NSGKIFTSLEPEHDLNDVCLYPNSGMLLTANETPKMGIYYIPVLGPAPRWCSFLDNLTEE
  LEENPESTVYDDYKFVTKKDLENLGLTHLIGSPFLRAYMHGFFMDIRLYHKVKLMVNPFA
  YEEYRKDKIRQKIEETRAQRVQLKKLPKVNKELALKLIEEEEEKQKSTWKKKVKSLPNIL
  TDDRFKVMFENPDFQVDEESEEFRLLNPLVSKISEKRKKKLRLLEQQELREKEEEEEPEG
  KPSDAESSESSDDEKAWVEEVRKQRRLLQQEEKVKRQERLKEDQQTVLKPQFYEIKAGEE
  FRSFKDSATKQKLMNKTLEDRLKIEAKNGTLSVSDTTVGSKQLTFTLKRSEQQKKQQEAE
  KLHRQERKRLRRSAGHLKSRHKRGRSFH

• Sequence length: 688

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	33161513	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	33161513	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36524514	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	30693177		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37587156	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	35035657	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	30693177		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	33161513	Associate	★☆☆☆☆ Found in Text Mining only