Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79949
Gene name	Pleckstrin homology domain containing S1
Gene symbol	PLEKHS1
Synonyms (NCBI Gene)	C10orf81HEL185
Chromosome	10
Chromosome location	10q25.3

139

Show/Hide all (139)

miRTarBase ID	miRNA	Experiments	Reference
MIRT671937	hsa-miR-5197-5p	HITS-CLIP	23313552
MIRT671936	hsa-miR-130a-3p	HITS-CLIP	23313552
MIRT671935	hsa-miR-130b-3p	HITS-CLIP	23313552
MIRT671934	hsa-miR-301a-3p	HITS-CLIP	23313552
MIRT671933	hsa-miR-301b-3p	HITS-CLIP	23313552
MIRT671932	hsa-miR-3666	HITS-CLIP	23313552
MIRT671931	hsa-miR-4295	HITS-CLIP	23313552
MIRT671930	hsa-miR-454-3p	HITS-CLIP	23313552
MIRT693712	hsa-miR-877-3p	HITS-CLIP	23313552
MIRT671927	hsa-miR-3135b	HITS-CLIP	23313552
MIRT671926	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT671925	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT671924	hsa-miR-3622b-5p	HITS-CLIP	23313552
MIRT671923	hsa-miR-4284	HITS-CLIP	23313552
MIRT671922	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT671921	hsa-miR-3652	HITS-CLIP	23313552
MIRT671920	hsa-miR-4430	HITS-CLIP	23313552
MIRT671919	hsa-miR-6501-5p	HITS-CLIP	23313552
MIRT671918	hsa-miR-4423-5p	HITS-CLIP	23313552
MIRT693711	hsa-miR-7111-3p	HITS-CLIP	23313552
MIRT693709	hsa-miR-6780a-3p	HITS-CLIP	23313552
MIRT693710	hsa-miR-6881-3p	HITS-CLIP	23313552
MIRT671917	hsa-miR-106a-3p	HITS-CLIP	23313552
MIRT671916	hsa-miR-8057	HITS-CLIP	23313552
MIRT671915	hsa-miR-744-3p	HITS-CLIP	23313552
MIRT693708	hsa-miR-670-3p	HITS-CLIP	23313552
MIRT693707	hsa-miR-1238-3p	HITS-CLIP	23313552
MIRT671937	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT671936	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT671935	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT671934	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT671933	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT671932	hsa-miR-3666	HITS-CLIP	23824327
MIRT671931	hsa-miR-4295	HITS-CLIP	23824327
MIRT671930	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT671929	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT671928	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT671927	hsa-miR-3135b	HITS-CLIP	23824327
MIRT671926	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT671925	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT671924	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT671923	hsa-miR-4284	HITS-CLIP	23824327
MIRT671922	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671921	hsa-miR-3652	HITS-CLIP	23824327
MIRT671920	hsa-miR-4430	HITS-CLIP	23824327
MIRT671919	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT671918	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT671917	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT671916	hsa-miR-8057	HITS-CLIP	23824327
MIRT671915	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT516892	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT516890	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516891	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT516889	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516890	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516888	hsa-miR-3149	PAR-CLIP	23446348
MIRT671917	hsa-miR-106a-3p	PAR-CLIP	27292025
MIRT671925	hsa-miR-122-5p	PAR-CLIP	27292025
MIRT693707	hsa-miR-1238-3p	PAR-CLIP	27292025
MIRT671936	hsa-miR-130a-3p	PAR-CLIP	27292025
MIRT671935	hsa-miR-130b-3p	PAR-CLIP	27292025
MIRT671922	hsa-miR-24-3p	PAR-CLIP	27292025
MIRT671934	hsa-miR-301a-3p	PAR-CLIP	27292025
MIRT671933	hsa-miR-301b-3p	PAR-CLIP	27292025
MIRT671927	hsa-miR-3135b	PAR-CLIP	27292025
MIRT671924	hsa-miR-3622b-5p	PAR-CLIP	27292025
MIRT671921	hsa-miR-3652	PAR-CLIP	27292025
MIRT671932	hsa-miR-3666	PAR-CLIP	27292025
MIRT671923	hsa-miR-4284	PAR-CLIP	27292025
MIRT671931	hsa-miR-4295	PAR-CLIP	27292025
MIRT671918	hsa-miR-4423-5p	PAR-CLIP	27292025
MIRT671920	hsa-miR-4430	PAR-CLIP	27292025
MIRT671930	hsa-miR-454-3p	PAR-CLIP	27292025
MIRT671926	hsa-miR-504-3p	PAR-CLIP	27292025
MIRT671937	hsa-miR-5197-5p	PAR-CLIP	27292025
MIRT671919	hsa-miR-6501-5p	PAR-CLIP	27292025
MIRT693708	hsa-miR-670-3p	PAR-CLIP	27292025
MIRT693709	hsa-miR-6780a-3p	PAR-CLIP	27292025
MIRT693710	hsa-miR-6881-3p	PAR-CLIP	27292025
MIRT693711	hsa-miR-7111-3p	PAR-CLIP	27292025
MIRT671915	hsa-miR-744-3p	PAR-CLIP	27292025
MIRT671916	hsa-miR-8057	PAR-CLIP	27292025
MIRT693712	hsa-miR-877-3p	PAR-CLIP	27292025
MIRT671937	hsa-miR-5197-5p	HITS-CLIP	23313552
MIRT671936	hsa-miR-130a-3p	HITS-CLIP	23313552
MIRT671935	hsa-miR-130b-3p	HITS-CLIP	23313552
MIRT671934	hsa-miR-301a-3p	HITS-CLIP	23313552
MIRT671933	hsa-miR-301b-3p	HITS-CLIP	23313552
MIRT671932	hsa-miR-3666	HITS-CLIP	23313552
MIRT671931	hsa-miR-4295	HITS-CLIP	23313552
MIRT671930	hsa-miR-454-3p	HITS-CLIP	23313552
MIRT693712	hsa-miR-877-3p	HITS-CLIP	23313552
MIRT671927	hsa-miR-3135b	HITS-CLIP	23313552
MIRT671926	hsa-miR-504-3p	HITS-CLIP	23313552
MIRT671925	hsa-miR-122-5p	HITS-CLIP	23313552
MIRT671924	hsa-miR-3622b-5p	HITS-CLIP	23313552
MIRT671923	hsa-miR-4284	HITS-CLIP	23313552
MIRT671922	hsa-miR-24-3p	HITS-CLIP	23313552
MIRT671921	hsa-miR-3652	HITS-CLIP	23313552
MIRT671920	hsa-miR-4430	HITS-CLIP	23313552
MIRT671919	hsa-miR-6501-5p	HITS-CLIP	23313552
MIRT671918	hsa-miR-4423-5p	HITS-CLIP	23313552
MIRT693711	hsa-miR-7111-3p	HITS-CLIP	23313552
MIRT693709	hsa-miR-6780a-3p	HITS-CLIP	23313552
MIRT693710	hsa-miR-6881-3p	HITS-CLIP	23313552
MIRT671917	hsa-miR-106a-3p	HITS-CLIP	23313552
MIRT671916	hsa-miR-8057	HITS-CLIP	23313552
MIRT671915	hsa-miR-744-3p	HITS-CLIP	23313552
MIRT693708	hsa-miR-670-3p	HITS-CLIP	23313552
MIRT693707	hsa-miR-1238-3p	HITS-CLIP	23313552
MIRT671937	hsa-miR-5197-5p	HITS-CLIP	23824327
MIRT671936	hsa-miR-130a-3p	HITS-CLIP	23824327
MIRT671935	hsa-miR-130b-3p	HITS-CLIP	23824327
MIRT671934	hsa-miR-301a-3p	HITS-CLIP	23824327
MIRT671933	hsa-miR-301b-3p	HITS-CLIP	23824327
MIRT671932	hsa-miR-3666	HITS-CLIP	23824327
MIRT671931	hsa-miR-4295	HITS-CLIP	23824327
MIRT671930	hsa-miR-454-3p	HITS-CLIP	23824327
MIRT671929	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT671928	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT671927	hsa-miR-3135b	HITS-CLIP	23824327
MIRT671926	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT671925	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT671924	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT671923	hsa-miR-4284	HITS-CLIP	23824327
MIRT671922	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT671921	hsa-miR-3652	HITS-CLIP	23824327
MIRT671920	hsa-miR-4430	HITS-CLIP	23824327
MIRT671919	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT671918	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT671917	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT671916	hsa-miR-8057	HITS-CLIP	23824327
MIRT671915	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT516892	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT516890	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516891	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT516889	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516890	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516888	hsa-miR-3149	PAR-CLIP	23446348

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25814554, 28514442, 32296183, 32814053, 33961781

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q5SXH7

Protein name

Pleckstrin homology domain-containing family S member 1 (PH domain-containing family S member 1) (Epididymis luminal protein 185) (hEL185)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00169	PH	15 → 127	PH domain	Domain

Sequence

MAGGKQFTFSYENEVCKQDYFIKSPPSQLFSSVTSWKKRFFILSKAGEKSFSLSYYKDHH
HRGSIEIDQNSSVEVGISSQEKMQSVQKMFKCHPDEVMSIRTTNREYFLIGHDREKIKDW
VSFMSSFRQDIKATQQNTEEELSLGNKRTLFYSSPLLGPSSTSEAVGSSSPRNGLQDKHL
MEQSSPGFRQTHLQDLSEATQDVKEENHYLTPRSVLLELDNIIASSDSGESIETDGPDQV
SGRIECHYEPMESSFFKETSHESVDSSKEEPQTLPETQDGDLHLQEQGSGIDWCLSPADV
EAQTTNDQKGNIPDESQVEKLNVFLSPPDVINYLALTEATGRICVSQWEGPPRLGCIFCH
GDHLLAVNDLKPQSLEEVSLFLTRSIQKEDSFRILSYQVAFGEGTELRDRAPGFRTSDRH
DVAKRACMESDWCRDSKTAPSTNLCLSFLFCKIMTNDGAGCWIIK

Sequence length

465

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Benign Neoplasm	Benign Neoplasm	CTD_human_DG	25261935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31828095	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	CTD_human_DG	25261935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	CTD_human_DG	25261935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	33450964	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	32878427, 35446856, 37978443	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	30578357, 36658180	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PLEKHS1 (pleckstrin homology domain containing S1)