DOK3 (docking protein 3)

Gene

• Entrez ID: 79930
• Gene name: Docking protein 3
• Gene symbol: DOK3
• Synonyms (NCBI Gene): DOKL
• Chromosome: 5
• Chromosome location: 5q35.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044507	hsa-miR-320a	CLASH	23622248
MIRT044507	hsa-miR-320a	CLASH	23622248
MIRT943095	hsa-miR-3202	CLIP-seq
MIRT943096	hsa-miR-3925-5p	CLIP-seq
MIRT943097	hsa-miR-4271	CLIP-seq
MIRT943098	hsa-miR-4475	CLIP-seq
MIRT943099	hsa-miR-4716-3p	CLIP-seq
MIRT943100	hsa-miR-4725-3p	CLIP-seq
MIRT943101	hsa-miR-4747-5p	CLIP-seq
MIRT943102	hsa-miR-4773	CLIP-seq
MIRT943103	hsa-miR-625	CLIP-seq
MIRT943104	hsa-miR-3134	CLIP-seq
MIRT943105	hsa-miR-3185	CLIP-seq
MIRT943106	hsa-miR-4476	CLIP-seq
MIRT943107	hsa-miR-3130-3p	CLIP-seq
MIRT943108	hsa-miR-433	CLIP-seq
MIRT943109	hsa-miR-4677-3p	CLIP-seq
MIRT943110	hsa-miR-4679	CLIP-seq
MIRT943111	hsa-miR-4793-3p	CLIP-seq
MIRT943112	hsa-miR-627	CLIP-seq
MIRT943113	hsa-miR-664	CLIP-seq
MIRT943114	hsa-miR-924	CLIP-seq
MIRT1979249	hsa-miR-3144-5p	CLIP-seq
MIRT1979250	hsa-miR-3191	CLIP-seq
MIRT1979251	hsa-miR-4652-5p	CLIP-seq
MIRT2214402	hsa-miR-3194-3p	CLIP-seq
MIRT2214403	hsa-miR-3921	CLIP-seq
MIRT2214404	hsa-miR-4303	CLIP-seq
MIRT2214405	hsa-miR-4653-5p	CLIP-seq
MIRT943109	hsa-miR-4677-3p	CLIP-seq
MIRT943110	hsa-miR-4679	CLIP-seq
MIRT2214406	hsa-miR-4795-3p	CLIP-seq
MIRT2387072	hsa-miR-1183	CLIP-seq
MIRT2387073	hsa-miR-3125	CLIP-seq
MIRT943105	hsa-miR-3185	CLIP-seq
MIRT2387074	hsa-miR-3916	CLIP-seq
MIRT2387075	hsa-miR-3919	CLIP-seq
MIRT2387076	hsa-miR-3928	CLIP-seq
MIRT2387077	hsa-miR-4257	CLIP-seq
MIRT943106	hsa-miR-4476	CLIP-seq
MIRT2387078	hsa-miR-4709-3p	CLIP-seq
MIRT2448475	hsa-miR-1294	CLIP-seq
MIRT2448476	hsa-miR-2355-5p	CLIP-seq
MIRT2448477	hsa-miR-3679-3p	CLIP-seq
MIRT2448478	hsa-miR-4316	CLIP-seq
MIRT2448479	hsa-miR-4633-5p	CLIP-seq
MIRT943109	hsa-miR-4677-3p	CLIP-seq
MIRT2448480	hsa-miR-532-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17290227, 25416956, 25814554, 27956147, 31515488, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007265	Process	Ras protein signal transduction	IBA
GO:0016020	Component	Membrane	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS

Other IDs

• MIM: 611435
• HGNC: 24583
• e!Ensembl: ENSG00000146094

Protein

• UniProt ID: Q7L591
• Protein name: Docking protein 3 (Downstream of tyrosine kinase 3)
• Protein function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02174	IRS	213 → 312	PTB domain (IRS-1 type)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in spleen. {ECO:0000269|PubMed:12595900}.
• Sequence:

  MTRGARLRSDARAQLNQLSLDGGTGSGQKGKCEEFPSSLSSVSPGLEAAALLLAVTMDPL
  ETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPG
  RRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFP
  GTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVL
  GPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAFSTPCAPDLC
  RAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEP
  GPQSLPLLLGPEPNDLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEG
  PGSRSPTTSPIYHNGQDLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKAKLVT
  LLSRERRKGPAPCDRP

• Sequence length: 496

Pathways

Reactome:

Neutrophil degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	34872567, 37235715	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	27354594		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	20970032	Associate	★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	29212778		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung Neoplasms	Lung Neoplasms	BEFREE	20139980		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung Neoplasms	Lung Neoplasms	CTD_human_DG	20139980		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung Neoplasms	Lung neoplasms	Pubtator	36028467	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	37235715	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	CTD_human_DG	20139980		★☆☆☆☆ Found in Text Mining only
Osteopenia	Osteopenia	BEFREE	29548825		★☆☆☆☆ Found in Text Mining only
Respiratory Distress Syndrome, Adult	Respiratory Distress Syndrome	BEFREE	28590889		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	36210538	Associate	★☆☆☆☆ Found in Text Mining only