Gene Gene information from NCBI Gene database.
Entrez ID 79924
Gene name Adrenomedullin 2
Gene symbol ADM2
Synonyms (NCBI Gene)
AM2dJ579N16.4
Chromosome 22
Chromosome location 22q13.33
Summary This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water i
miRNA miRNA information provided by mirtarbase database.
394
miRTarBase ID miRNA Experiments Reference
MIRT662322 hsa-miR-1245a HITS-CLIP 23824327
MIRT662321 hsa-miR-8079 HITS-CLIP 23824327
MIRT662320 hsa-miR-6513-3p HITS-CLIP 23824327
MIRT662319 hsa-miR-6840-3p HITS-CLIP 23824327
MIRT662318 hsa-miR-1915-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IDA 20596610
GO:0003073 Process Regulation of systemic arterial blood pressure IBA
GO:0005179 Function Hormone activity IDA 32296767
GO:0005179 Function Hormone activity IEA
GO:0005576 Component Extracellular region IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608682 28898 ENSG00000128165
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q7Z4H4
Protein name Protein ADM2 (Intermedin) [Cleaved into: Adrenomedullin-2 (AM2) (Intermedin-long) (IMDL); Intermedin-short (IMDS)]
Protein function Intermedin/ADM2 is a peptide hormone that plays a role as physiological regulator of gastrointestinal and cardiovascular bioactivities mediated by the CALCRL-RAMPs receptor complexes (PubMed:14615490). Activates the cAMP-dependent pathway throug
PDB 6D1U , 6UVA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00214 Calc_CGRP_IAPP 45 148 Calcitonin / CGRP / IAPP family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary. {ECO:0000269|
Sequence
Sequence length 148
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
  G alpha (s) signalling events
Calcitonin-like ligand receptors
ADORA2B mediated anti-inflammatory cytokines production
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Malignant tumor of urinary bladder Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
VASCULAR DISEASES CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute pancreatitis Pancreatitis BEFREE 21786034
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Neoplasms Adrenal neoplasia BEFREE 18460550
★☆☆☆☆
Found in Text Mining only
Aortic Aneurysm, Abdominal Aortic Aneurysm BEFREE 27634835, 29943223
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 29146892
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 29146892
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular Diseases BEFREE 21786034, 31408662, 31466304
★☆☆☆☆
Found in Text Mining only
Cerebrovascular Disorders Cerebrovascular Disorders BEFREE 29128104
★☆☆☆☆
Found in Text Mining only
Chronic heart failure Heart Failure BEFREE 24531032
★☆☆☆☆
Found in Text Mining only
Chronic Kidney Diseases Kidney Disease BEFREE 26880455
★☆☆☆☆
Found in Text Mining only
Congestive heart failure Congestive Heart Failure BEFREE 24531032, 28627670
★☆☆☆☆
Found in Text Mining only