Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79892
Gene name	Minichromosome maintenance complex binding protein
Gene symbol	MCMBP
Synonyms (NCBI Gene)	C10orf119MCM-BP
Chromosome	10
Chromosome location	10q26.11
Summary	This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided

178

Show/Hide all (178)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019649	hsa-miR-340-5p	Sequencing	20371350
MIRT025386	hsa-miR-34a-5p	Proteomics	21566225
MIRT029372	hsa-miR-26b-5p	Microarray	19088304
MIRT044035	hsa-miR-365a-3p	CLASH	23622248
MIRT042503	hsa-miR-423-3p	CLASH	23622248
MIRT040523	hsa-miR-551b-3p	CLASH	23622248
MIRT038205	hsa-miR-342-5p	CLASH	23622248
MIRT722727	hsa-miR-5197-5p	HITS-CLIP	19536157
MIRT722726	hsa-miR-7852-3p	HITS-CLIP	19536157
MIRT722725	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT722724	hsa-miR-15b-3p	HITS-CLIP	19536157
MIRT722723	hsa-miR-31-5p	HITS-CLIP	19536157
MIRT722722	hsa-miR-6809-5p	HITS-CLIP	19536157
MIRT722721	hsa-miR-1257	HITS-CLIP	19536157
MIRT536051	hsa-miR-548n	PAR-CLIP	22012620
MIRT536050	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT536049	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT536048	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT536047	hsa-miR-548ag	PAR-CLIP	22012620
MIRT536046	hsa-miR-548ai	PAR-CLIP	22012620
MIRT536045	hsa-miR-548ba	PAR-CLIP	22012620
MIRT536044	hsa-miR-570-5p	PAR-CLIP	22012620
MIRT536043	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT536042	hsa-miR-154-3p	PAR-CLIP	22012620
MIRT536041	hsa-miR-487a-3p	PAR-CLIP	22012620
MIRT536040	hsa-miR-545-5p	PAR-CLIP	22012620
MIRT536039	hsa-miR-4427	PAR-CLIP	22012620
MIRT722727	hsa-miR-5197-5p	HITS-CLIP	19536157
MIRT722726	hsa-miR-7852-3p	HITS-CLIP	19536157
MIRT722725	hsa-miR-3607-5p	HITS-CLIP	19536157
MIRT722724	hsa-miR-15b-3p	HITS-CLIP	19536157
MIRT722723	hsa-miR-31-5p	HITS-CLIP	19536157
MIRT722722	hsa-miR-6809-5p	HITS-CLIP	19536157
MIRT722721	hsa-miR-1257	HITS-CLIP	19536157
MIRT536051	hsa-miR-548n	PAR-CLIP	22012620
MIRT536050	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT536049	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT536048	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT536047	hsa-miR-548ag	PAR-CLIP	22012620
MIRT536046	hsa-miR-548ai	PAR-CLIP	22012620
MIRT536045	hsa-miR-548ba	PAR-CLIP	22012620
MIRT536044	hsa-miR-570-5p	PAR-CLIP	22012620
MIRT536043	hsa-miR-4724-5p	PAR-CLIP	22012620
MIRT536042	hsa-miR-154-3p	PAR-CLIP	22012620
MIRT536041	hsa-miR-487a-3p	PAR-CLIP	22012620
MIRT536040	hsa-miR-545-5p	PAR-CLIP	22012620
MIRT536039	hsa-miR-4427	PAR-CLIP	22012620
MIRT1137871	hsa-miR-10a	CLIP-seq
MIRT1137872	hsa-miR-10b	CLIP-seq
MIRT1137873	hsa-miR-1184	CLIP-seq
MIRT1137874	hsa-miR-1205	CLIP-seq
MIRT1137875	hsa-miR-1245b-5p	CLIP-seq
MIRT1137876	hsa-miR-1248	CLIP-seq
MIRT1137877	hsa-miR-1271	CLIP-seq
MIRT1137878	hsa-miR-1295	CLIP-seq
MIRT1137879	hsa-miR-136	CLIP-seq
MIRT1137880	hsa-miR-146a	CLIP-seq
MIRT1137881	hsa-miR-146b-5p	CLIP-seq
MIRT1137882	hsa-miR-1825	CLIP-seq
MIRT1137883	hsa-miR-199a-5p	CLIP-seq
MIRT1137884	hsa-miR-199b-5p	CLIP-seq
MIRT1137885	hsa-miR-205	CLIP-seq
MIRT1137886	hsa-miR-3142	CLIP-seq
MIRT1137887	hsa-miR-3148	CLIP-seq
MIRT1137888	hsa-miR-3153	CLIP-seq
MIRT1137889	hsa-miR-3158-5p	CLIP-seq
MIRT1137890	hsa-miR-3189-3p	CLIP-seq
MIRT1137891	hsa-miR-3192	CLIP-seq
MIRT1137892	hsa-miR-3614-3p	CLIP-seq
MIRT1137893	hsa-miR-3919	CLIP-seq
MIRT1137894	hsa-miR-3922-5p	CLIP-seq
MIRT1137895	hsa-miR-3925-5p	CLIP-seq
MIRT1137896	hsa-miR-3926	CLIP-seq
MIRT1137897	hsa-miR-3929	CLIP-seq
MIRT1137898	hsa-miR-4314	CLIP-seq
MIRT1137899	hsa-miR-4419b	CLIP-seq
MIRT1137900	hsa-miR-4475	CLIP-seq
MIRT1137901	hsa-miR-4478	CLIP-seq
MIRT1137902	hsa-miR-4496	CLIP-seq
MIRT1137903	hsa-miR-4645-3p	CLIP-seq
MIRT1137904	hsa-miR-4646-5p	CLIP-seq
MIRT1137905	hsa-miR-4668-5p	CLIP-seq
MIRT1137906	hsa-miR-4671-5p	CLIP-seq
MIRT1137907	hsa-miR-4713-3p	CLIP-seq
MIRT1137908	hsa-miR-4719	CLIP-seq
MIRT1137909	hsa-miR-4725-5p	CLIP-seq
MIRT1137910	hsa-miR-4735-5p	CLIP-seq
MIRT1137911	hsa-miR-4738-3p	CLIP-seq
MIRT1137912	hsa-miR-4772-3p	CLIP-seq
MIRT1137913	hsa-miR-4778-3p	CLIP-seq
MIRT1137914	hsa-miR-4786-3p	CLIP-seq
MIRT1137915	hsa-miR-4793-3p	CLIP-seq
MIRT1137916	hsa-miR-4803	CLIP-seq
MIRT1137917	hsa-miR-499-3p	CLIP-seq
MIRT1137918	hsa-miR-499a-3p	CLIP-seq
MIRT1137919	hsa-miR-502-5p	CLIP-seq
MIRT1137920	hsa-miR-504	CLIP-seq
MIRT1137921	hsa-miR-544	CLIP-seq
MIRT1137922	hsa-miR-548s	CLIP-seq
MIRT1137923	hsa-miR-570	CLIP-seq
MIRT1137924	hsa-miR-579	CLIP-seq
MIRT1137925	hsa-miR-875-3p	CLIP-seq
MIRT1137926	hsa-miR-96	CLIP-seq
MIRT2039129	hsa-miR-1207-3p	CLIP-seq
MIRT2039130	hsa-miR-127-5p	CLIP-seq
MIRT2039131	hsa-miR-1305	CLIP-seq
MIRT2039132	hsa-miR-3163	CLIP-seq
MIRT2039133	hsa-miR-331-5p	CLIP-seq
MIRT2039134	hsa-miR-345	CLIP-seq
MIRT2039135	hsa-miR-3646	CLIP-seq
MIRT2039136	hsa-miR-3682-5p	CLIP-seq
MIRT1137894	hsa-miR-3922-5p	CLIP-seq
MIRT2039137	hsa-miR-4277	CLIP-seq
MIRT2039138	hsa-miR-4452	CLIP-seq
MIRT2039139	hsa-miR-4521	CLIP-seq
MIRT1137904	hsa-miR-4646-5p	CLIP-seq
MIRT1137910	hsa-miR-4735-5p	CLIP-seq
MIRT2039140	hsa-miR-498	CLIP-seq
MIRT1137919	hsa-miR-502-5p	CLIP-seq
MIRT2039141	hsa-miR-512-5p	CLIP-seq
MIRT2039142	hsa-miR-522	CLIP-seq
MIRT2039143	hsa-miR-545	CLIP-seq
MIRT2039144	hsa-miR-548t	CLIP-seq
MIRT1137923	hsa-miR-570	CLIP-seq
MIRT2039145	hsa-miR-935	CLIP-seq
MIRT2269190	hsa-miR-125a-3p	CLIP-seq
MIRT2269191	hsa-miR-3934	CLIP-seq
MIRT2269192	hsa-miR-4694-5p	CLIP-seq
MIRT2269193	hsa-miR-487a	CLIP-seq
MIRT2269194	hsa-miR-764	CLIP-seq
MIRT2568426	hsa-miR-101	CLIP-seq
MIRT2039129	hsa-miR-1207-3p	CLIP-seq
MIRT2039130	hsa-miR-127-5p	CLIP-seq
MIRT2568427	hsa-miR-1281	CLIP-seq
MIRT2568428	hsa-miR-139-5p	CLIP-seq
MIRT2568429	hsa-miR-299-3p	CLIP-seq
MIRT2568430	hsa-miR-31	CLIP-seq
MIRT2039132	hsa-miR-3163	CLIP-seq
MIRT2568431	hsa-miR-3200-5p	CLIP-seq
MIRT2039135	hsa-miR-3646	CLIP-seq
MIRT2568432	hsa-miR-3689a-5p	CLIP-seq
MIRT2568433	hsa-miR-3689b	CLIP-seq
MIRT2568434	hsa-miR-3689e	CLIP-seq
MIRT2568435	hsa-miR-3689f	CLIP-seq
MIRT2568436	hsa-miR-4474-3p	CLIP-seq
MIRT2568437	hsa-miR-4491	CLIP-seq
MIRT2039139	hsa-miR-4521	CLIP-seq
MIRT2568438	hsa-miR-4536	CLIP-seq
MIRT1137903	hsa-miR-4645-3p	CLIP-seq
MIRT2568439	hsa-miR-4657	CLIP-seq
MIRT2568440	hsa-miR-4680-3p	CLIP-seq
MIRT2039141	hsa-miR-512-5p	CLIP-seq
MIRT2039142	hsa-miR-522	CLIP-seq
MIRT2568441	hsa-miR-548v	CLIP-seq
MIRT2568442	hsa-miR-582-5p	CLIP-seq
MIRT2568443	hsa-miR-590-3p	CLIP-seq
MIRT2568444	hsa-miR-668	CLIP-seq
MIRT2568445	hsa-miR-758	CLIP-seq
MIRT2568428	hsa-miR-139-5p	CLIP-seq
MIRT2568429	hsa-miR-299-3p	CLIP-seq
MIRT2039132	hsa-miR-3163	CLIP-seq
MIRT2568431	hsa-miR-3200-5p	CLIP-seq
MIRT2039135	hsa-miR-3646	CLIP-seq
MIRT2568432	hsa-miR-3689a-5p	CLIP-seq
MIRT2568433	hsa-miR-3689b	CLIP-seq
MIRT2568434	hsa-miR-3689e	CLIP-seq
MIRT2568435	hsa-miR-3689f	CLIP-seq
MIRT2568436	hsa-miR-4474-3p	CLIP-seq
MIRT2568437	hsa-miR-4491	CLIP-seq
MIRT2568438	hsa-miR-4536	CLIP-seq
MIRT2684745	hsa-miR-4641	CLIP-seq
MIRT2568439	hsa-miR-4657	CLIP-seq
MIRT2568440	hsa-miR-4680-3p	CLIP-seq
MIRT2568441	hsa-miR-548v	CLIP-seq
MIRT2568442	hsa-miR-582-5p	CLIP-seq
MIRT2568443	hsa-miR-590-3p	CLIP-seq
MIRT2568444	hsa-miR-668	CLIP-seq
MIRT2568445	hsa-miR-758	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	17296731
GO:0005515	Function	Protein binding	IPI	17296731, 22540012, 24299456, 25036637, 25416956, 26871637, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	17296731
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006260	Process	DNA replication	IEA
GO:0006261	Process	DNA-templated DNA replication	IBA
GO:0006261	Process	DNA-templated DNA replication	IMP	21196493
GO:0007062	Process	Sister chromatid cohesion	IMP	20090939
GO:0030054	Component	Cell junction	IDA
GO:0042555	Component	MCM complex	IDA	17296731
GO:0051301	Process	Cell division	IEA

MIM	HGNC	e!Ensembl
610909	25782	ENSG00000197771

Q9BTE3

Protein name

Mini-chromosome maintenance complex-binding protein (MCM-BP) (MCM-binding protein)

Protein function

Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replicatio

PDB

4KG9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09739	MCM_bind	36 → 631	Mini-chromosome maintenance replisome factor	Family

Sequence

MPCGEDWLSHPLGIVQGFFAQNGVNPDWEKKVIEYFKEKLKENNAPKWVPSLNEVPLHYL
KPNSFVKFRCMIQDMFDPEFYMGVYETVNQNTKAHVLHFGKYRDVAECGPQQELDLNSPR
NTTLERQTFYCVPVPGESTWVKEAYVNANQARVSPSTSYTPSRHKRSYEDDDDMDLQPNK
QKDQHAGARQAGSVGGLQWCGEPKRLETEASTGQQLNSLNLSSPFDLNFPLPGEKGPACL
VKVYEDWDCFKVNDILELYGILSVDPVLSILNNDERDASALLDPMECTDTAEEQRVHSPP
ASLVPRIHVILAQKLQHINPLLPACLNKEESKTCKFVSSFMSELSPVRAELLGFLTHALL
GDSLAAEYLILHLISTVYTRRDVLPLGKFTVNLSGCPRNSTFTEHLYRIIQHLVPASFRL
QMTIENMNHLKFIPHKDYTANRLVSGLLQLPSNTSLVIDETLLEQGQLDTPGVHNVTALS
NLITWQKVDYDFSYHQMEFPCNINVFITSEGRSLLPADCQIHLQPQLIPPNMEEYMNSLL
SAVLPSVLNKFRIYLTLLRFLEYSISDEITKAVEDDFVEMRKNDPQSITADDLHQLLVVA
RCLSLSAGQTTLSRERWLRAKQLESLRRTRLQQQKCVNGNEL

Sequence length

642

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25246271	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

MCMBP (minichromosome maintenance complex binding protein)