PODNL1 (podocan like 1)

Gene

• Entrez ID: 79883
• Gene name: Podocan like 1
• Gene symbol: PODNL1
• Synonyms (NCBI Gene): SLRR5B
• Chromosome: 19
• Chromosome location: 19p13.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029802	hsa-miR-26b-5p	Microarray	19088304
MIRT1246393	hsa-miR-1254	CLIP-seq
MIRT1246394	hsa-miR-129-5p	CLIP-seq
MIRT1246395	hsa-miR-1307	CLIP-seq
MIRT1246396	hsa-miR-3116	CLIP-seq
MIRT1246397	hsa-miR-324-5p	CLIP-seq
MIRT738946	hsa-miR-4254	CLIP-seq
MIRT1246398	hsa-miR-4307	CLIP-seq
MIRT1246399	hsa-miR-4328	CLIP-seq
MIRT1246400	hsa-miR-4527	CLIP-seq
MIRT1246401	hsa-miR-4638-5p	CLIP-seq
MIRT1246402	hsa-miR-4677-3p	CLIP-seq
MIRT1246403	hsa-miR-4679	CLIP-seq
MIRT1246404	hsa-miR-4711-3p	CLIP-seq
MIRT1246405	hsa-miR-4715-3p	CLIP-seq
MIRT1246406	hsa-miR-550a	CLIP-seq
MIRT2299961	hsa-miR-1227	CLIP-seq
MIRT2299962	hsa-miR-1301	CLIP-seq
MIRT2299963	hsa-miR-371-5p	CLIP-seq
MIRT1246398	hsa-miR-4307	CLIP-seq
MIRT2299964	hsa-miR-4317	CLIP-seq
MIRT2299965	hsa-miR-455-5p	CLIP-seq
MIRT1246405	hsa-miR-4715-3p	CLIP-seq
MIRT2299966	hsa-miR-5047	CLIP-seq
MIRT738943	hsa-miR-3612	CLIP-seq
MIRT738946	hsa-miR-4254	CLIP-seq
MIRT738947	hsa-miR-4308	CLIP-seq
MIRT738944	hsa-miR-4443	CLIP-seq
MIRT738941	hsa-miR-4768-3p	CLIP-seq
MIRT738945	hsa-miR-650	CLIP-seq
MIRT738942	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005201	Function	Extracellular matrix structural constituent	HDA	27068509
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0031012	Component	Extracellular matrix	HDA	26998606, 27068509, 32055794
GO:0031012	Component	Extracellular matrix	HDA	33266304

Other IDs

• MIM: 621043
• HGNC: 26275
• e!Ensembl: ENSG00000132000

Protein

• UniProt ID: Q6PEZ8
• Protein name: Podocan-like protein 1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	74 → 136	Leucine rich repeat	Repeat
  PF13855	LRR_8	216 → 278	Leucine rich repeat	Repeat
  PF13855	LRR_8	358 → 420	Leucine rich repeat	Repeat
  PF13855	LRR_8	429 → 483	Leucine rich repeat	Repeat

• Sequence:

  MAESGLAMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDC
  DGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAF
  ESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQ
  LSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQT
  QLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIR
  QVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRL
  RALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQL
  TRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQA
  LQVRHRLVSHTVPRAPPSPCLPCHVPNILVSW

• Sequence length: 512

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Glioma	Glioma	Pubtator	34830454	Associate	★☆☆☆☆ Found in Text Mining only
Retinal Dystrophies	Retinal Dystrophy	GENOMICS_ENGLAND_DG	28041643		★☆☆☆☆ Found in Text Mining only