PIP4K2C (phosphatidylinositol-5-phosphate 4-kinase type 2 gamma)

Gene

• Entrez ID: 79837
• Gene name: Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
• Gene symbol: PIP4K2C
• Synonyms (NCBI Gene): PIP5K2C
• Chromosome: 12
• Chromosome location: 12q13.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016341	hsa-miR-193b-3p	Proteomics	21512034
MIRT045985	hsa-miR-125b-5p	CLASH	23622248
MIRT036860	hsa-miR-877-3p	CLASH	23622248
MIRT066182	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT066166	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT066180	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT555602	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT066175	hsa-miR-3174	PAR-CLIP	21572407
MIRT066165	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT066177	hsa-miR-3617-3p	PAR-CLIP	21572407
MIRT066169	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT135785	hsa-miR-6828-5p	PAR-CLIP	21572407
MIRT066171	hsa-miR-921	PAR-CLIP	21572407
MIRT066168	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT555601	hsa-miR-361-5p	PAR-CLIP	21572407
MIRT066181	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT066167	hsa-miR-374a-3p	PAR-CLIP	21572407
MIRT449859	hsa-miR-3137	PAR-CLIP	22100165
MIRT449858	hsa-miR-20b-3p	PAR-CLIP	22100165
MIRT449857	hsa-miR-574-5p	PAR-CLIP	22100165
MIRT449856	hsa-miR-3659	PAR-CLIP	22100165
MIRT449855	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT449854	hsa-miR-1238-5p	PAR-CLIP	22100165
MIRT449853	hsa-miR-4758-5p	PAR-CLIP	22100165
MIRT449852	hsa-miR-4658	PAR-CLIP	22100165
MIRT449851	hsa-miR-6790-5p	PAR-CLIP	22100165
MIRT135718	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT135706	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT135718	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT135705	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT135724	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT135707	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT135733	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT135706	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT135785	hsa-miR-6828-5p	PAR-CLIP	26701625
MIRT066169	hsa-miR-545-3p	PAR-CLIP	27292025
MIRT066182	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT066166	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT066180	hsa-miR-548at-5p	PAR-CLIP	21572407
MIRT555602	hsa-miR-561-3p	PAR-CLIP	21572407
MIRT066175	hsa-miR-3174	PAR-CLIP	21572407
MIRT066165	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT066177	hsa-miR-3617-3p	PAR-CLIP	21572407
MIRT066169	hsa-miR-545-3p	PAR-CLIP	21572407
MIRT135785	hsa-miR-6828-5p	PAR-CLIP	21572407
MIRT066171	hsa-miR-921	PAR-CLIP	21572407
MIRT066168	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT555601	hsa-miR-361-5p	PAR-CLIP	21572407
MIRT066181	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT066167	hsa-miR-374a-3p	PAR-CLIP	21572407
MIRT449859	hsa-miR-3137	PAR-CLIP	22100165
MIRT449858	hsa-miR-20b-3p	PAR-CLIP	22100165
MIRT449857	hsa-miR-574-5p	PAR-CLIP	22100165
MIRT449856	hsa-miR-3659	PAR-CLIP	22100165
MIRT449855	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT449854	hsa-miR-1238-5p	PAR-CLIP	22100165
MIRT449853	hsa-miR-4758-5p	PAR-CLIP	22100165
MIRT449852	hsa-miR-4658	PAR-CLIP	22100165
MIRT449851	hsa-miR-6790-5p	PAR-CLIP	22100165
MIRT1235734	hsa-miR-106a	CLIP-seq
MIRT1235735	hsa-miR-106b	CLIP-seq
MIRT1235736	hsa-miR-1273f	CLIP-seq
MIRT1235737	hsa-miR-17	CLIP-seq
MIRT1235738	hsa-miR-20a	CLIP-seq
MIRT1235739	hsa-miR-20b	CLIP-seq
MIRT1235740	hsa-miR-3127-3p	CLIP-seq
MIRT1235741	hsa-miR-3153	CLIP-seq
MIRT1235742	hsa-miR-324-5p	CLIP-seq
MIRT1235743	hsa-miR-340	CLIP-seq
MIRT1235744	hsa-miR-4640-3p	CLIP-seq
MIRT1235745	hsa-miR-4787-5p	CLIP-seq
MIRT1235746	hsa-miR-519a	CLIP-seq
MIRT1235747	hsa-miR-519b-3p	CLIP-seq
MIRT1235748	hsa-miR-519c-3p	CLIP-seq
MIRT1235749	hsa-miR-519d	CLIP-seq
MIRT1235750	hsa-miR-520a-5p	CLIP-seq
MIRT1235751	hsa-miR-520g	CLIP-seq
MIRT1235752	hsa-miR-520h	CLIP-seq
MIRT1235753	hsa-miR-525-5p	CLIP-seq
MIRT1235754	hsa-miR-545	CLIP-seq
MIRT1235755	hsa-miR-548p	CLIP-seq
MIRT1235756	hsa-miR-561	CLIP-seq
MIRT1235757	hsa-miR-625	CLIP-seq
MIRT1235758	hsa-miR-93	CLIP-seq
MIRT1235759	hsa-miR-330-3p	CLIP-seq
MIRT1235760	hsa-miR-4330	CLIP-seq
MIRT1235761	hsa-miR-4797-5p	CLIP-seq
MIRT1235762	hsa-miR-646	CLIP-seq
MIRT1235763	hsa-miR-137	CLIP-seq
MIRT1235764	hsa-miR-185	CLIP-seq
MIRT1235765	hsa-miR-200b	CLIP-seq
MIRT1235766	hsa-miR-200c	CLIP-seq
MIRT1235767	hsa-miR-25	CLIP-seq
MIRT1235768	hsa-miR-3065-5p	CLIP-seq
MIRT1235769	hsa-miR-3143	CLIP-seq
MIRT1235770	hsa-miR-3150a-3p	CLIP-seq
MIRT1235741	hsa-miR-3153	CLIP-seq
MIRT1235771	hsa-miR-3175	CLIP-seq
MIRT1235772	hsa-miR-32	CLIP-seq
MIRT1235773	hsa-miR-33a	CLIP-seq
MIRT1235774	hsa-miR-33b	CLIP-seq
MIRT1235775	hsa-miR-3614-5p	CLIP-seq
MIRT1235776	hsa-miR-363	CLIP-seq
MIRT1235777	hsa-miR-367	CLIP-seq
MIRT1235778	hsa-miR-3689a-3p	CLIP-seq
MIRT1235779	hsa-miR-3689c	CLIP-seq
MIRT1235780	hsa-miR-429	CLIP-seq
MIRT1235781	hsa-miR-4306	CLIP-seq
MIRT1235782	hsa-miR-4644	CLIP-seq
MIRT1235783	hsa-miR-4771	CLIP-seq
MIRT1235745	hsa-miR-4787-5p	CLIP-seq
MIRT1235784	hsa-miR-499a-5p	CLIP-seq
MIRT1235785	hsa-miR-505	CLIP-seq
MIRT1235786	hsa-miR-543	CLIP-seq
MIRT1235787	hsa-miR-576-5p	CLIP-seq
MIRT1235757	hsa-miR-625	CLIP-seq
MIRT1235788	hsa-miR-92a	CLIP-seq
MIRT1235789	hsa-miR-92b	CLIP-seq
MIRT1235790	hsa-miR-939	CLIP-seq
MIRT2069391	hsa-miR-3179	CLIP-seq
MIRT1235759	hsa-miR-330-3p	CLIP-seq
MIRT1235743	hsa-miR-340	CLIP-seq
MIRT2069392	hsa-miR-3617	CLIP-seq
MIRT2069393	hsa-miR-3675-5p	CLIP-seq
MIRT2069394	hsa-miR-641	CLIP-seq
MIRT2069395	hsa-miR-3140-5p	CLIP-seq
MIRT1235734	hsa-miR-106a	CLIP-seq
MIRT1235735	hsa-miR-106b	CLIP-seq
MIRT2296743	hsa-miR-1184	CLIP-seq
MIRT2296744	hsa-miR-1224-3p	CLIP-seq
MIRT2296745	hsa-miR-1244	CLIP-seq
MIRT2296746	hsa-miR-1260	CLIP-seq
MIRT2296747	hsa-miR-1260b	CLIP-seq
MIRT2296748	hsa-miR-1273e	CLIP-seq
MIRT2296749	hsa-miR-1294	CLIP-seq
MIRT1235763	hsa-miR-137	CLIP-seq
MIRT2296750	hsa-miR-138	CLIP-seq
MIRT2296751	hsa-miR-140-3p	CLIP-seq
MIRT2296752	hsa-miR-145	CLIP-seq
MIRT2296753	hsa-miR-15a	CLIP-seq
MIRT2296754	hsa-miR-15b	CLIP-seq
MIRT2296755	hsa-miR-16	CLIP-seq
MIRT1235737	hsa-miR-17	CLIP-seq
MIRT1235764	hsa-miR-185	CLIP-seq
MIRT2296756	hsa-miR-1915	CLIP-seq
MIRT2296757	hsa-miR-195	CLIP-seq
MIRT2296758	hsa-miR-1972	CLIP-seq
MIRT1235765	hsa-miR-200b	CLIP-seq
MIRT1235766	hsa-miR-200c	CLIP-seq
MIRT1235738	hsa-miR-20a	CLIP-seq
MIRT1235739	hsa-miR-20b	CLIP-seq
MIRT2296759	hsa-miR-2278	CLIP-seq
MIRT1235767	hsa-miR-25	CLIP-seq
MIRT2296760	hsa-miR-2682	CLIP-seq
MIRT1235768	hsa-miR-3065-5p	CLIP-seq
MIRT2069395	hsa-miR-3140-5p	CLIP-seq
MIRT1235769	hsa-miR-3143	CLIP-seq
MIRT1235772	hsa-miR-32	CLIP-seq
MIRT1235742	hsa-miR-324-5p	CLIP-seq
MIRT1235775	hsa-miR-3614-5p	CLIP-seq
MIRT2069392	hsa-miR-3617	CLIP-seq
MIRT1235776	hsa-miR-363	CLIP-seq
MIRT1235777	hsa-miR-367	CLIP-seq
MIRT1235778	hsa-miR-3689a-3p	CLIP-seq
MIRT1235779	hsa-miR-3689c	CLIP-seq
MIRT2296761	hsa-miR-377	CLIP-seq
MIRT2296762	hsa-miR-3919	CLIP-seq
MIRT2296763	hsa-miR-3925-5p	CLIP-seq
MIRT2296764	hsa-miR-3942-5p	CLIP-seq
MIRT2296765	hsa-miR-424	CLIP-seq
MIRT1235780	hsa-miR-429	CLIP-seq
MIRT2296766	hsa-miR-4293	CLIP-seq
MIRT2296767	hsa-miR-4299	CLIP-seq
MIRT1235781	hsa-miR-4306	CLIP-seq
MIRT2296768	hsa-miR-4316	CLIP-seq
MIRT2296769	hsa-miR-4456	CLIP-seq
MIRT2296770	hsa-miR-449c	CLIP-seq
MIRT2296771	hsa-miR-4514	CLIP-seq
MIRT1235782	hsa-miR-4644	CLIP-seq
MIRT2296772	hsa-miR-4645-5p	CLIP-seq
MIRT2296773	hsa-miR-4651	CLIP-seq
MIRT2296774	hsa-miR-4673	CLIP-seq
MIRT2296775	hsa-miR-4680-3p	CLIP-seq
MIRT2296776	hsa-miR-4692	CLIP-seq
MIRT2296777	hsa-miR-4703-3p	CLIP-seq
MIRT2296778	hsa-miR-4703-5p	CLIP-seq
MIRT2296779	hsa-miR-4709-3p	CLIP-seq
MIRT2296780	hsa-miR-4726-3p	CLIP-seq
MIRT2296781	hsa-miR-4756-3p	CLIP-seq
MIRT2296782	hsa-miR-4768-3p	CLIP-seq
MIRT1235783	hsa-miR-4771	CLIP-seq
MIRT1235761	hsa-miR-4797-5p	CLIP-seq
MIRT2296783	hsa-miR-497	CLIP-seq
MIRT1235784	hsa-miR-499a-5p	CLIP-seq
MIRT1235785	hsa-miR-505	CLIP-seq
MIRT1235746	hsa-miR-519a	CLIP-seq
MIRT1235747	hsa-miR-519b-3p	CLIP-seq
MIRT1235748	hsa-miR-519c-3p	CLIP-seq
MIRT1235749	hsa-miR-519d	CLIP-seq
MIRT1235750	hsa-miR-520a-5p	CLIP-seq
MIRT1235751	hsa-miR-520g	CLIP-seq
MIRT1235752	hsa-miR-520h	CLIP-seq
MIRT1235753	hsa-miR-525-5p	CLIP-seq
MIRT1235786	hsa-miR-543	CLIP-seq
MIRT1235754	hsa-miR-545	CLIP-seq
MIRT1235755	hsa-miR-548p	CLIP-seq
MIRT2296784	hsa-miR-548q	CLIP-seq
MIRT1235787	hsa-miR-576-5p	CLIP-seq
MIRT2296785	hsa-miR-589	CLIP-seq
MIRT2296786	hsa-miR-596	CLIP-seq
MIRT2296787	hsa-miR-597	CLIP-seq
MIRT2296788	hsa-miR-608	CLIP-seq
MIRT2296789	hsa-miR-628-5p	CLIP-seq
MIRT2069394	hsa-miR-641	CLIP-seq
MIRT2296790	hsa-miR-654-3p	CLIP-seq
MIRT2296791	hsa-miR-665	CLIP-seq
MIRT1235788	hsa-miR-92a	CLIP-seq
MIRT1235789	hsa-miR-92b	CLIP-seq
MIRT1235758	hsa-miR-93	CLIP-seq
MIRT2456526	hsa-miR-298	CLIP-seq
MIRT1235771	hsa-miR-3175	CLIP-seq
MIRT2069391	hsa-miR-3179	CLIP-seq
MIRT2456527	hsa-miR-4468	CLIP-seq
MIRT2296744	hsa-miR-1224-3p	CLIP-seq
MIRT2594182	hsa-miR-1225-5p	CLIP-seq
MIRT2296746	hsa-miR-1260	CLIP-seq
MIRT2296747	hsa-miR-1260b	CLIP-seq
MIRT2594183	hsa-miR-1280	CLIP-seq
MIRT2296749	hsa-miR-1294	CLIP-seq
MIRT2594184	hsa-miR-135a	CLIP-seq
MIRT2594185	hsa-miR-135b	CLIP-seq
MIRT1235764	hsa-miR-185	CLIP-seq
MIRT2594186	hsa-miR-1910	CLIP-seq
MIRT2594187	hsa-miR-197	CLIP-seq
MIRT2456526	hsa-miR-298	CLIP-seq
MIRT2594188	hsa-miR-3130-3p	CLIP-seq
MIRT1235771	hsa-miR-3175	CLIP-seq
MIRT2069391	hsa-miR-3179	CLIP-seq
MIRT2594189	hsa-miR-3183	CLIP-seq
MIRT2594190	hsa-miR-3187-3p	CLIP-seq
MIRT2594191	hsa-miR-326	CLIP-seq
MIRT1235759	hsa-miR-330-3p	CLIP-seq
MIRT2594192	hsa-miR-330-5p	CLIP-seq
MIRT2069393	hsa-miR-3675-5p	CLIP-seq
MIRT2594193	hsa-miR-3909	CLIP-seq
MIRT2594194	hsa-miR-4283	CLIP-seq
MIRT2594195	hsa-miR-4287	CLIP-seq
MIRT2594196	hsa-miR-4300	CLIP-seq
MIRT1235781	hsa-miR-4306	CLIP-seq
MIRT2296768	hsa-miR-4316	CLIP-seq
MIRT2594197	hsa-miR-4419a	CLIP-seq
MIRT2456527	hsa-miR-4468	CLIP-seq
MIRT2594198	hsa-miR-4469	CLIP-seq
MIRT2594199	hsa-miR-4488	CLIP-seq
MIRT2594200	hsa-miR-4493	CLIP-seq
MIRT2594201	hsa-miR-4510	CLIP-seq
MIRT2594202	hsa-miR-4529-5p	CLIP-seq
MIRT2594203	hsa-miR-455-3p	CLIP-seq
MIRT2594204	hsa-miR-4639-3p	CLIP-seq
MIRT1235782	hsa-miR-4644	CLIP-seq
MIRT2296773	hsa-miR-4651	CLIP-seq
MIRT2594205	hsa-miR-4667-5p	CLIP-seq
MIRT2594206	hsa-miR-4677-3p	CLIP-seq
MIRT2594207	hsa-miR-4679	CLIP-seq
MIRT2594208	hsa-miR-4684-5p	CLIP-seq
MIRT2594209	hsa-miR-4685-3p	CLIP-seq
MIRT2594210	hsa-miR-4693-3p	CLIP-seq
MIRT2594211	hsa-miR-4697-5p	CLIP-seq
MIRT2594212	hsa-miR-4699-5p	CLIP-seq
MIRT2594213	hsa-miR-4700-5p	CLIP-seq
MIRT2594214	hsa-miR-4711-5p	CLIP-seq
MIRT2594215	hsa-miR-4713-5p	CLIP-seq
MIRT2594216	hsa-miR-4723-3p	CLIP-seq
MIRT2594217	hsa-miR-4753-5p	CLIP-seq
MIRT2594218	hsa-miR-4755-3p	CLIP-seq
MIRT2594219	hsa-miR-4757-5p	CLIP-seq
MIRT2594220	hsa-miR-4763-5p	CLIP-seq
MIRT1235761	hsa-miR-4797-5p	CLIP-seq
MIRT2594221	hsa-miR-578	CLIP-seq
MIRT2594222	hsa-miR-581	CLIP-seq
MIRT2594223	hsa-miR-582-3p	CLIP-seq
MIRT2296788	hsa-miR-608	CLIP-seq
MIRT2296789	hsa-miR-628-5p	CLIP-seq
MIRT2594224	hsa-miR-637	CLIP-seq
MIRT1235762	hsa-miR-646	CLIP-seq
MIRT2594225	hsa-miR-920	CLIP-seq
MIRT2296744	hsa-miR-1224-3p	CLIP-seq
MIRT2296744	hsa-miR-1224-3p	CLIP-seq
MIRT2594182	hsa-miR-1225-5p	CLIP-seq
MIRT2296746	hsa-miR-1260	CLIP-seq
MIRT2296747	hsa-miR-1260b	CLIP-seq
MIRT2594183	hsa-miR-1280	CLIP-seq
MIRT2296749	hsa-miR-1294	CLIP-seq
MIRT2594186	hsa-miR-1910	CLIP-seq
MIRT2456526	hsa-miR-298	CLIP-seq
MIRT2594188	hsa-miR-3130-3p	CLIP-seq
MIRT1235771	hsa-miR-3175	CLIP-seq
MIRT2069391	hsa-miR-3179	CLIP-seq
MIRT2594190	hsa-miR-3187-3p	CLIP-seq
MIRT1235759	hsa-miR-330-3p	CLIP-seq
MIRT2069393	hsa-miR-3675-5p	CLIP-seq
MIRT2594193	hsa-miR-3909	CLIP-seq
MIRT2594194	hsa-miR-4283	CLIP-seq
MIRT2594195	hsa-miR-4287	CLIP-seq
MIRT2594196	hsa-miR-4300	CLIP-seq
MIRT2296768	hsa-miR-4316	CLIP-seq
MIRT1235760	hsa-miR-4330	CLIP-seq
MIRT2594197	hsa-miR-4419a	CLIP-seq
MIRT2456527	hsa-miR-4468	CLIP-seq
MIRT2594198	hsa-miR-4469	CLIP-seq
MIRT2594199	hsa-miR-4488	CLIP-seq
MIRT2594201	hsa-miR-4510	CLIP-seq
MIRT2594202	hsa-miR-4529-5p	CLIP-seq
MIRT2594203	hsa-miR-455-3p	CLIP-seq
MIRT2594204	hsa-miR-4639-3p	CLIP-seq
MIRT2594206	hsa-miR-4677-3p	CLIP-seq
MIRT2594207	hsa-miR-4679	CLIP-seq
MIRT2594208	hsa-miR-4684-5p	CLIP-seq
MIRT2594209	hsa-miR-4685-3p	CLIP-seq
MIRT2594211	hsa-miR-4697-5p	CLIP-seq
MIRT2594215	hsa-miR-4713-5p	CLIP-seq
MIRT2594218	hsa-miR-4755-3p	CLIP-seq
MIRT2594219	hsa-miR-4757-5p	CLIP-seq
MIRT2594220	hsa-miR-4763-5p	CLIP-seq
MIRT1235761	hsa-miR-4797-5p	CLIP-seq
MIRT2687936	hsa-miR-526b	CLIP-seq
MIRT2594223	hsa-miR-582-3p	CLIP-seq
MIRT2296789	hsa-miR-628-5p	CLIP-seq
MIRT2594225	hsa-miR-920	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	31091439
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005776	Component	Autophagosome	IEA
GO:0005776	Component	Autophagosome	IMP	25578879
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0010506	Process	Regulation of autophagy	IMP	25578879
GO:0016301	Function	Kinase activity	IEA
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA	26774281
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	IEA
GO:0016309	Function	1-phosphatidylinositol-5-phosphate 4-kinase activity	IBA
GO:0016309	Function	1-phosphatidylinositol-5-phosphate 4-kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	18255255
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA	30718367
GO:0046488	Process	Phosphatidylinositol metabolic process	IEA
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IEA
GO:0046627	Process	Negative regulation of insulin receptor signaling pathway	IMP	31091439
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IBA
GO:0052742	Function	Phosphatidylinositol kinase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	18570454, 19056867
GO:1902635	Process	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	IDA	26774281
GO:1902635	Process	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	IEA
GO:2000786	Process	Positive regulation of autophagosome assembly	IEA
GO:2000786	Process	Positive regulation of autophagosome assembly	IMP	25578879

Other IDs

• MIM: 617104
• HGNC: 23786
• e!Ensembl: ENSG00000166908

Protein

• UniProt ID: Q8TBX8
• Protein name: Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)
• Protein function: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent
• PDB: 2GK9, 7QIE, 7QPN, 8BQ4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01504	PIP5K	128 → 419	Phosphatidylinositol-4-phosphate 5-Kinase	Family

• Sequence:

  MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSIN
  ELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQ
  DYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNT
  LLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTL
  KDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEA
  PVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAE
  GAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIF
  A

• Sequence length: 421

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Regulation of actin cytoskeleton

Reactome:

Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BIPOLAR DISORDER	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autoimmune Diseases	Autoimmune disease	Pubtator	34312224	Associate	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	PSYGENET_DG	16094259		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Carcinoma	Breast Carcinoma	BEFREE	29851245, 30104711		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26070530	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	34006268	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	19110536		★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Hematologic Neoplasms	BEFREE	31109595		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	38069220	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	31109595		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29851245, 30104711		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31109595, 31804920		★☆☆☆☆ Found in Text Mining only
Polycystic Kidney Diseases	Polycystic kidney disease	BEFREE	30321068		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	16094259, 16801950, 17555944, 18545987, 19644675, 25548108		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	16094259, 16801950		★★☆☆☆ Found in Text Mining + Unknown/Other Associations