ARHGAP28 (Rho GTPase activating protein 28)

Gene

• Entrez ID: 79822
• Gene name: Rho GTPase activating protein 28
• Gene symbol: ARHGAP28
• Synonyms (NCBI Gene): -
• Chromosome: 18
• Chromosome location: 18p11.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022171	hsa-miR-124-3p	Microarray	18668037
MIRT026097	hsa-miR-196a-5p	Sequencing	20371350
MIRT027425	hsa-miR-98-5p	Microarray	19088304
MIRT794367	hsa-miR-124	CLIP-seq
MIRT794368	hsa-miR-3161	CLIP-seq
MIRT794369	hsa-miR-3714	CLIP-seq
MIRT794370	hsa-miR-3910	CLIP-seq
MIRT794371	hsa-miR-433	CLIP-seq
MIRT794372	hsa-miR-506	CLIP-seq
MIRT794373	hsa-miR-548l	CLIP-seq
MIRT794374	hsa-miR-548n	CLIP-seq
MIRT794375	hsa-miR-548t	CLIP-seq
MIRT1545482	hsa-let-7a	CLIP-seq
MIRT1545483	hsa-let-7b	CLIP-seq
MIRT1545484	hsa-let-7c	CLIP-seq
MIRT1545485	hsa-let-7d	CLIP-seq
MIRT1545486	hsa-let-7e	CLIP-seq
MIRT1545487	hsa-let-7f	CLIP-seq
MIRT1545488	hsa-let-7g	CLIP-seq
MIRT1545489	hsa-let-7i	CLIP-seq
MIRT1545490	hsa-miR-1183	CLIP-seq
MIRT1545491	hsa-miR-1294	CLIP-seq
MIRT1545492	hsa-miR-196a	CLIP-seq
MIRT1545493	hsa-miR-196b	CLIP-seq
MIRT1545494	hsa-miR-202	CLIP-seq
MIRT1545495	hsa-miR-4446-5p	CLIP-seq
MIRT1545496	hsa-miR-4458	CLIP-seq
MIRT1545497	hsa-miR-4500	CLIP-seq
MIRT1545498	hsa-miR-548an	CLIP-seq
MIRT1545499	hsa-miR-579	CLIP-seq
MIRT1545500	hsa-miR-664	CLIP-seq
MIRT1545501	hsa-miR-98	CLIP-seq
MIRT1934430	hsa-miR-144	CLIP-seq
MIRT1934431	hsa-miR-3662	CLIP-seq
MIRT1545495	hsa-miR-4446-5p	CLIP-seq
MIRT1934432	hsa-miR-4796-5p	CLIP-seq
MIRT1934433	hsa-miR-548a-5p	CLIP-seq
MIRT1934434	hsa-miR-548ab	CLIP-seq
MIRT1934435	hsa-miR-548ak	CLIP-seq
MIRT1934436	hsa-miR-548b-5p	CLIP-seq
MIRT1934437	hsa-miR-548c-5p	CLIP-seq
MIRT1934438	hsa-miR-548d-5p	CLIP-seq
MIRT1934439	hsa-miR-548h	CLIP-seq
MIRT1934440	hsa-miR-548i	CLIP-seq
MIRT1934441	hsa-miR-548j	CLIP-seq
MIRT1934442	hsa-miR-548k	CLIP-seq
MIRT794373	hsa-miR-548l	CLIP-seq
MIRT1934443	hsa-miR-548w	CLIP-seq
MIRT1934444	hsa-miR-548y	CLIP-seq
MIRT1934445	hsa-miR-559	CLIP-seq
MIRT1545499	hsa-miR-579	CLIP-seq
MIRT2174233	hsa-miR-1258	CLIP-seq
MIRT2174234	hsa-miR-3065-3p	CLIP-seq
MIRT2174235	hsa-miR-425	CLIP-seq
MIRT2174236	hsa-miR-4422	CLIP-seq
MIRT2174237	hsa-miR-4496	CLIP-seq
MIRT2174238	hsa-miR-4760-5p	CLIP-seq
MIRT2174239	hsa-miR-495	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030833	Process	Regulation of actin filament polymerization	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051497	Process	Negative regulation of stress fiber assembly	IBA
GO:0051497	Process	Negative regulation of stress fiber assembly	IEA

Other IDs

• MIM: 610592
• HGNC: 25509
• e!Ensembl: ENSG00000088756

Protein

• UniProt ID: Q9P2N2
• Protein name: Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28)
• Protein function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	399 → 552	RhoGAP domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in testis. Expressed at moderate level in kidney and ovary, and weakly expressed in spleen and skeletal muscle. {ECO:0000269|PubMed:10718198}.
• Sequence:

  MEVEDSGGVVLTAYHSYARAQPPNAESRCAPRAAASHPLSRKSIPRCRRINRMLSNESLH
  PPAFSRSNSEASVDSASMEDFWREIESIKDSSMGGQEEPPPAEVTPVDEGELEAEWLQDV
  GLSTLISGDEEEDGKALLSTLTRTQAAAVQKRYHTYTQTMRKKDKQSIRDVRDIFGVSES
  PPRDTCGNHTNQLDGTKEERELPRVIKTSGSMPDDASLNSTTLSDASQDKEGSFAVPRSD
  SVAILETIPVLPVHSNGSPEPGQPVQNAISDDDFLEKNIPPEAEELSFEVSYSEMVTEAL
  KRNKLKKSEIKKEDYVLTKFNVQKTRFGLTEAGDLSAEDMKKIRHLSLIELTAFFDAFGI
  QLKRNKTEKVKGRDNGIFGVPLTVLLDGDRKKDPGVKVPLVLQKFFEKVEESGLESEGIF
  RLSGCTAKVKQYREELDAKFNADKFKWDKMCHREAAVMLKAFFRELPTSLFPVEYIPAFI
  SLMERGPHVKVQFQALHLMVMALPDANRDAAQALMTFFNKVIANESKNRMSLWNISTVMA
  PNLFFSRSKHSDYEELLLANTAAHIIRLMLKYQKILWKVPSFLITQVRRMNEATMLLKKQ
  LPSVRKLLRRKTLERETASPKTSKVLQKSPSARRMSDVPEGVIRVHAPLLSKVSMAIQLN
  NQTKAKDILAKFQYENSHGSSECIKIQNQRLYEIGGNIGEHCLDPDAYILDVYRINPQAE
  WVIKPQQSS

• Sequence length: 729

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ARHGAP28-related disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Endometrioma	Endometrioma	CTD_human_DG	20864642		★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	CTD_human_DG	20864642		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19885562		★☆☆☆☆ Found in Text Mining only