Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	7982
Gene name	Suppression of tumorigenicity 7
Gene symbol	ST7
Synonyms (NCBI Gene)	ETS7qFAM4AFAM4A1HELGRAY1SEN4TSG7
Chromosome	7
Chromosome location	7q31.2
Summary	The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutation

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miRTarBase ID	miRNA	Experiments
MIRT1393806	hsa-miR-1273f	CLIP-seq
MIRT1393807	hsa-miR-1294	CLIP-seq
MIRT1393808	hsa-miR-3656	CLIP-seq
MIRT1393809	hsa-miR-3960	CLIP-seq
MIRT1393810	hsa-miR-4710	CLIP-seq
MIRT1393811	hsa-miR-885-3p	CLIP-seq
MIRT1393812	hsa-miR-124	CLIP-seq
MIRT1393813	hsa-miR-19a	CLIP-seq
MIRT1393814	hsa-miR-19b	CLIP-seq
MIRT1393815	hsa-miR-4708-3p	CLIP-seq
MIRT1393816	hsa-miR-4729	CLIP-seq
MIRT1393817	hsa-miR-506	CLIP-seq
MIRT1393818	hsa-miR-518a-5p	CLIP-seq
MIRT1393819	hsa-miR-527	CLIP-seq
MIRT1393820	hsa-miR-556-5p	CLIP-seq
MIRT1393821	hsa-miR-570	CLIP-seq
MIRT1393813	hsa-miR-19a	CLIP-seq
MIRT1393814	hsa-miR-19b	CLIP-seq
MIRT2395262	hsa-miR-3179	CLIP-seq
MIRT2395263	hsa-miR-4761-3p	CLIP-seq
MIRT2433622	hsa-miR-3150a-3p	CLIP-seq
MIRT2634122	hsa-miR-1180	CLIP-seq
MIRT2634123	hsa-miR-1193	CLIP-seq
MIRT2634124	hsa-miR-186	CLIP-seq
MIRT2634125	hsa-miR-299-3p	CLIP-seq
MIRT2634126	hsa-miR-3133	CLIP-seq
MIRT2433622	hsa-miR-3150a-3p	CLIP-seq
MIRT2634127	hsa-miR-3151	CLIP-seq
MIRT2634128	hsa-miR-3163	CLIP-seq
MIRT2634129	hsa-miR-3165	CLIP-seq
MIRT2634130	hsa-miR-3175	CLIP-seq
MIRT2634131	hsa-miR-3202	CLIP-seq
MIRT2634132	hsa-miR-320a	CLIP-seq
MIRT2634133	hsa-miR-320b	CLIP-seq
MIRT2634134	hsa-miR-320c	CLIP-seq
MIRT2634135	hsa-miR-320d	CLIP-seq
MIRT2634136	hsa-miR-3611	CLIP-seq
MIRT2634137	hsa-miR-3691-5p	CLIP-seq
MIRT2634138	hsa-miR-411	CLIP-seq
MIRT2634139	hsa-miR-4429	CLIP-seq
MIRT2634140	hsa-miR-4446-3p	CLIP-seq
MIRT2634141	hsa-miR-4447	CLIP-seq
MIRT2634142	hsa-miR-4472	CLIP-seq
MIRT2634143	hsa-miR-4493	CLIP-seq
MIRT2634144	hsa-miR-4511	CLIP-seq
MIRT2634145	hsa-miR-4533	CLIP-seq
MIRT2634146	hsa-miR-4651	CLIP-seq
MIRT2634147	hsa-miR-4664-3p	CLIP-seq
MIRT2634148	hsa-miR-4709-3p	CLIP-seq
MIRT2634149	hsa-miR-4730	CLIP-seq
MIRT2634150	hsa-miR-4764-5p	CLIP-seq
MIRT2634151	hsa-miR-491-5p	CLIP-seq
MIRT2634152	hsa-miR-496	CLIP-seq
MIRT2634153	hsa-miR-512-5p	CLIP-seq
MIRT2634154	hsa-miR-608	CLIP-seq
MIRT2634155	hsa-miR-658	CLIP-seq
MIRT2634156	hsa-miR-939	CLIP-seq
MIRT2634122	hsa-miR-1180	CLIP-seq
MIRT2634123	hsa-miR-1193	CLIP-seq
MIRT2692133	hsa-miR-1255a	CLIP-seq
MIRT2692134	hsa-miR-1255b	CLIP-seq
MIRT2692135	hsa-miR-1293	CLIP-seq
MIRT2634124	hsa-miR-186	CLIP-seq
MIRT2634125	hsa-miR-299-3p	CLIP-seq
MIRT2692136	hsa-miR-3120-3p	CLIP-seq
MIRT2634126	hsa-miR-3133	CLIP-seq
MIRT2433622	hsa-miR-3150a-3p	CLIP-seq
MIRT2634127	hsa-miR-3151	CLIP-seq
MIRT2634128	hsa-miR-3163	CLIP-seq
MIRT2634129	hsa-miR-3165	CLIP-seq
MIRT2634130	hsa-miR-3175	CLIP-seq
MIRT2395262	hsa-miR-3179	CLIP-seq
MIRT2634131	hsa-miR-3202	CLIP-seq
MIRT2634132	hsa-miR-320a	CLIP-seq
MIRT2634133	hsa-miR-320b	CLIP-seq
MIRT2634134	hsa-miR-320c	CLIP-seq
MIRT2634135	hsa-miR-320d	CLIP-seq
MIRT2634136	hsa-miR-3611	CLIP-seq
MIRT2692137	hsa-miR-3681	CLIP-seq
MIRT2634137	hsa-miR-3691-5p	CLIP-seq
MIRT2634138	hsa-miR-411	CLIP-seq
MIRT2634139	hsa-miR-4429	CLIP-seq
MIRT2634140	hsa-miR-4446-3p	CLIP-seq
MIRT2634141	hsa-miR-4447	CLIP-seq
MIRT2692138	hsa-miR-4468	CLIP-seq
MIRT2634142	hsa-miR-4472	CLIP-seq
MIRT2692139	hsa-miR-4483	CLIP-seq
MIRT2634143	hsa-miR-4493	CLIP-seq
MIRT2634144	hsa-miR-4511	CLIP-seq
MIRT2634145	hsa-miR-4533	CLIP-seq
MIRT2692140	hsa-miR-4645-3p	CLIP-seq
MIRT2634146	hsa-miR-4651	CLIP-seq
MIRT2634147	hsa-miR-4664-3p	CLIP-seq
MIRT2634148	hsa-miR-4709-3p	CLIP-seq
MIRT2395263	hsa-miR-4761-3p	CLIP-seq
MIRT2634150	hsa-miR-4764-5p	CLIP-seq
MIRT2634151	hsa-miR-491-5p	CLIP-seq
MIRT2634152	hsa-miR-496	CLIP-seq
MIRT2634153	hsa-miR-512-5p	CLIP-seq
MIRT2692141	hsa-miR-542-3p	CLIP-seq
MIRT2692142	hsa-miR-545	CLIP-seq
MIRT2634154	hsa-miR-608	CLIP-seq
MIRT2634156	hsa-miR-939	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	30945288
GO:0016020	Component	Membrane	IEA
GO:0030198	Process	Extracellular matrix organization	NAS	16474848
GO:0045595	Process	Regulation of cell differentiation	NAS	16474848

MIM	HGNC	e!Ensembl
600833	11351	ENSG00000004866

Q9NRC1

Protein name

Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG)

Protein function

May act as a tumor suppressor.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04184	ST7	17 → 562	ST7 protein	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in heart, liver and pancreas. {ECO:0000269|PubMed:10889047, ECO:0000269|PubMed:11279520}.

Sequence

MAEAATGFLEQLKSCIVWSWTYLWTVWFFIVLFLVYILRVPLKINDNLSTVSMFLNTLTP
KFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSN
GDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDS
DHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCAT
AYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKR
RLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDD
ISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYL
LEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKG
HLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELM
GVFAKAMIDIFCSAEFRDWNCKSIFMRVEDELEIPPAPQSQHFQN

Sequence length

585

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Brain atrophy	Likely pathogenic	rs550492993	RCV000162112	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Global developmental delay	Likely pathogenic	rs550492993	RCV000162112	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Intractable seizure	Likely pathogenic	rs550492993	RCV000162112	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (23)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DUPUYTREN CONTRACTURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EARLY INFANTILE EPILEPTIC ENCEPHALOPATHY WITH SUPPRESSION BURSTS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GENETIC DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEIZURES, INTRACTABLE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ST7-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ST7 (suppression of tumorigenicity 7)