NIPAL2 (NIPA like domain containing 2)

Gene

• Entrez ID: 79815
• Gene name: NIPA like domain containing 2
• Gene symbol: NIPAL2
• Synonyms (NCBI Gene): NPAL2, SLC57A4
• Chromosome: 8
• Chromosome location: 8q22.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT718043	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT718042	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT718041	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT718040	hsa-miR-152-5p	HITS-CLIP	19536157
MIRT718039	hsa-miR-485-3p	HITS-CLIP	19536157
MIRT718038	hsa-miR-539-3p	HITS-CLIP	19536157
MIRT718037	hsa-miR-3686	HITS-CLIP	19536157
MIRT718036	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT718043	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT718042	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT718041	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT718040	hsa-miR-152-5p	HITS-CLIP	19536157
MIRT718039	hsa-miR-485-3p	HITS-CLIP	19536157
MIRT718038	hsa-miR-539-3p	HITS-CLIP	19536157
MIRT718037	hsa-miR-3686	HITS-CLIP	19536157
MIRT718036	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT718043	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT718042	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT718041	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT718040	hsa-miR-152-5p	HITS-CLIP	19536157
MIRT718039	hsa-miR-485-3p	HITS-CLIP	19536157
MIRT718038	hsa-miR-539-3p	HITS-CLIP	19536157
MIRT718037	hsa-miR-3686	HITS-CLIP	19536157
MIRT718036	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT718043	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT718042	hsa-miR-23a-5p	HITS-CLIP	19536157
MIRT718041	hsa-miR-23b-5p	HITS-CLIP	19536157
MIRT718040	hsa-miR-152-5p	HITS-CLIP	19536157
MIRT718039	hsa-miR-485-3p	HITS-CLIP	19536157
MIRT718038	hsa-miR-539-3p	HITS-CLIP	19536157
MIRT718037	hsa-miR-3686	HITS-CLIP	19536157
MIRT718036	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT1185567	hsa-miR-100	CLIP-seq
MIRT1185568	hsa-miR-18a	CLIP-seq
MIRT1185569	hsa-miR-18b	CLIP-seq
MIRT1185570	hsa-miR-19a	CLIP-seq
MIRT1185571	hsa-miR-19b	CLIP-seq
MIRT1185572	hsa-miR-2278	CLIP-seq
MIRT1185573	hsa-miR-297	CLIP-seq
MIRT1185574	hsa-miR-3074-5p	CLIP-seq
MIRT1185575	hsa-miR-3117-5p	CLIP-seq
MIRT1185576	hsa-miR-370	CLIP-seq
MIRT1185577	hsa-miR-3921	CLIP-seq
MIRT1185578	hsa-miR-3926	CLIP-seq
MIRT1185579	hsa-miR-4307	CLIP-seq
MIRT1185580	hsa-miR-433	CLIP-seq
MIRT1185581	hsa-miR-4434	CLIP-seq
MIRT1185582	hsa-miR-4516	CLIP-seq
MIRT1185583	hsa-miR-4652-3p	CLIP-seq
MIRT1185584	hsa-miR-4653-5p	CLIP-seq
MIRT1185585	hsa-miR-4682	CLIP-seq
MIRT1185586	hsa-miR-4719	CLIP-seq
MIRT1185587	hsa-miR-4735-3p	CLIP-seq
MIRT1185588	hsa-miR-4761-5p	CLIP-seq
MIRT1185589	hsa-miR-4775	CLIP-seq
MIRT1185590	hsa-miR-4786-3p	CLIP-seq
MIRT1185591	hsa-miR-543	CLIP-seq
MIRT1185592	hsa-miR-548s	CLIP-seq
MIRT1185593	hsa-miR-567	CLIP-seq
MIRT1185594	hsa-miR-590-3p	CLIP-seq
MIRT1185595	hsa-miR-642b	CLIP-seq
MIRT1185596	hsa-miR-663b	CLIP-seq
MIRT1185597	hsa-miR-760	CLIP-seq
MIRT1185598	hsa-miR-99a	CLIP-seq
MIRT1185599	hsa-miR-99b	CLIP-seq
MIRT1185567	hsa-miR-100	CLIP-seq
MIRT2053771	hsa-miR-1321	CLIP-seq
MIRT1185568	hsa-miR-18a	CLIP-seq
MIRT1185569	hsa-miR-18b	CLIP-seq
MIRT2053772	hsa-miR-1909	CLIP-seq
MIRT1185570	hsa-miR-19a	CLIP-seq
MIRT1185571	hsa-miR-19b	CLIP-seq
MIRT2053773	hsa-miR-2110	CLIP-seq
MIRT2053774	hsa-miR-216a	CLIP-seq
MIRT2053775	hsa-miR-216b	CLIP-seq
MIRT1185572	hsa-miR-2278	CLIP-seq
MIRT1185573	hsa-miR-297	CLIP-seq
MIRT1185574	hsa-miR-3074-5p	CLIP-seq
MIRT1185575	hsa-miR-3117-5p	CLIP-seq
MIRT2053776	hsa-miR-3151	CLIP-seq
MIRT2053777	hsa-miR-3162-5p	CLIP-seq
MIRT2053778	hsa-miR-337-3p	CLIP-seq
MIRT2053779	hsa-miR-33a	CLIP-seq
MIRT2053780	hsa-miR-33b	CLIP-seq
MIRT2053781	hsa-miR-34b	CLIP-seq
MIRT2053782	hsa-miR-34c-3p	CLIP-seq
MIRT1185576	hsa-miR-370	CLIP-seq
MIRT1185577	hsa-miR-3921	CLIP-seq
MIRT1185578	hsa-miR-3926	CLIP-seq
MIRT2053783	hsa-miR-3944-5p	CLIP-seq
MIRT2053784	hsa-miR-4265	CLIP-seq
MIRT2053785	hsa-miR-4271	CLIP-seq
MIRT2053786	hsa-miR-4296	CLIP-seq
MIRT1185579	hsa-miR-4307	CLIP-seq
MIRT2053787	hsa-miR-4312	CLIP-seq
MIRT2053788	hsa-miR-4322	CLIP-seq
MIRT2053789	hsa-miR-4326	CLIP-seq
MIRT1185581	hsa-miR-4434	CLIP-seq
MIRT2053790	hsa-miR-4447	CLIP-seq
MIRT2053791	hsa-miR-4455	CLIP-seq
MIRT2053792	hsa-miR-4472	CLIP-seq
MIRT1185582	hsa-miR-4516	CLIP-seq
MIRT1185583	hsa-miR-4652-3p	CLIP-seq
MIRT1185584	hsa-miR-4653-5p	CLIP-seq
MIRT2053793	hsa-miR-4675	CLIP-seq
MIRT1185585	hsa-miR-4682	CLIP-seq
MIRT2053794	hsa-miR-4685-5p	CLIP-seq
MIRT1185586	hsa-miR-4719	CLIP-seq
MIRT2053795	hsa-miR-4725-3p	CLIP-seq
MIRT1185587	hsa-miR-4735-3p	CLIP-seq
MIRT2053796	hsa-miR-4739	CLIP-seq
MIRT2053797	hsa-miR-4741	CLIP-seq
MIRT2053798	hsa-miR-4756-5p	CLIP-seq
MIRT1185589	hsa-miR-4775	CLIP-seq
MIRT1185590	hsa-miR-4786-3p	CLIP-seq
MIRT2053799	hsa-miR-4794	CLIP-seq
MIRT2053800	hsa-miR-491-5p	CLIP-seq
MIRT1185591	hsa-miR-543	CLIP-seq
MIRT1185592	hsa-miR-548s	CLIP-seq
MIRT1185593	hsa-miR-567	CLIP-seq
MIRT2053801	hsa-miR-577	CLIP-seq
MIRT1185594	hsa-miR-590-3p	CLIP-seq
MIRT2053802	hsa-miR-592	CLIP-seq
MIRT2053803	hsa-miR-597	CLIP-seq
MIRT1185595	hsa-miR-642b	CLIP-seq
MIRT1185596	hsa-miR-663b	CLIP-seq
MIRT1185597	hsa-miR-760	CLIP-seq
MIRT1185598	hsa-miR-99a	CLIP-seq
MIRT1185599	hsa-miR-99b	CLIP-seq
MIRT1185567	hsa-miR-100	CLIP-seq
MIRT2282955	hsa-miR-106a	CLIP-seq
MIRT2282956	hsa-miR-106b	CLIP-seq
MIRT2053771	hsa-miR-1321	CLIP-seq
MIRT2282957	hsa-miR-17	CLIP-seq
MIRT1185570	hsa-miR-19a	CLIP-seq
MIRT1185571	hsa-miR-19b	CLIP-seq
MIRT2282958	hsa-miR-20a	CLIP-seq
MIRT2282959	hsa-miR-20b	CLIP-seq
MIRT2053773	hsa-miR-2110	CLIP-seq
MIRT1185573	hsa-miR-297	CLIP-seq
MIRT1185575	hsa-miR-3117-5p	CLIP-seq
MIRT2053776	hsa-miR-3151	CLIP-seq
MIRT2053777	hsa-miR-3162-5p	CLIP-seq
MIRT2282960	hsa-miR-3164	CLIP-seq
MIRT2053778	hsa-miR-337-3p	CLIP-seq
MIRT2053779	hsa-miR-33a	CLIP-seq
MIRT2053780	hsa-miR-33b	CLIP-seq
MIRT2282961	hsa-miR-3609	CLIP-seq
MIRT1185578	hsa-miR-3926	CLIP-seq
MIRT2053785	hsa-miR-4271	CLIP-seq
MIRT1185579	hsa-miR-4307	CLIP-seq
MIRT2053789	hsa-miR-4326	CLIP-seq
MIRT1185581	hsa-miR-4434	CLIP-seq
MIRT2053790	hsa-miR-4447	CLIP-seq
MIRT2053791	hsa-miR-4455	CLIP-seq
MIRT2053792	hsa-miR-4472	CLIP-seq
MIRT1185582	hsa-miR-4516	CLIP-seq
MIRT1185583	hsa-miR-4652-3p	CLIP-seq
MIRT2053794	hsa-miR-4685-5p	CLIP-seq
MIRT1185586	hsa-miR-4719	CLIP-seq
MIRT2053795	hsa-miR-4725-3p	CLIP-seq
MIRT2053796	hsa-miR-4739	CLIP-seq
MIRT2053798	hsa-miR-4756-5p	CLIP-seq
MIRT1185590	hsa-miR-4786-3p	CLIP-seq
MIRT2282962	hsa-miR-4796-3p	CLIP-seq
MIRT2282963	hsa-miR-4802-3p	CLIP-seq
MIRT2053800	hsa-miR-491-5p	CLIP-seq
MIRT2282964	hsa-miR-519d	CLIP-seq
MIRT1185591	hsa-miR-543	CLIP-seq
MIRT2282965	hsa-miR-548ah	CLIP-seq
MIRT1185592	hsa-miR-548s	CLIP-seq
MIRT1185593	hsa-miR-567	CLIP-seq
MIRT1185595	hsa-miR-642b	CLIP-seq
MIRT1185596	hsa-miR-663b	CLIP-seq
MIRT2282966	hsa-miR-93	CLIP-seq
MIRT1185598	hsa-miR-99a	CLIP-seq
MIRT1185599	hsa-miR-99b	CLIP-seq
MIRT1185567	hsa-miR-100	CLIP-seq
MIRT2282955	hsa-miR-106a	CLIP-seq
MIRT2282956	hsa-miR-106b	CLIP-seq
MIRT2053771	hsa-miR-1321	CLIP-seq
MIRT2282957	hsa-miR-17	CLIP-seq
MIRT1185570	hsa-miR-19a	CLIP-seq
MIRT1185571	hsa-miR-19b	CLIP-seq
MIRT2282958	hsa-miR-20a	CLIP-seq
MIRT2282959	hsa-miR-20b	CLIP-seq
MIRT2053773	hsa-miR-2110	CLIP-seq
MIRT1185573	hsa-miR-297	CLIP-seq
MIRT1185575	hsa-miR-3117-5p	CLIP-seq
MIRT2053776	hsa-miR-3151	CLIP-seq
MIRT2053777	hsa-miR-3162-5p	CLIP-seq
MIRT2282961	hsa-miR-3609	CLIP-seq
MIRT1185578	hsa-miR-3926	CLIP-seq
MIRT2053785	hsa-miR-4271	CLIP-seq
MIRT1185579	hsa-miR-4307	CLIP-seq
MIRT1185581	hsa-miR-4434	CLIP-seq
MIRT2053790	hsa-miR-4447	CLIP-seq
MIRT2053791	hsa-miR-4455	CLIP-seq
MIRT2053792	hsa-miR-4472	CLIP-seq
MIRT1185582	hsa-miR-4516	CLIP-seq
MIRT1185583	hsa-miR-4652-3p	CLIP-seq
MIRT2053794	hsa-miR-4685-5p	CLIP-seq
MIRT2053795	hsa-miR-4725-3p	CLIP-seq
MIRT2053796	hsa-miR-4739	CLIP-seq
MIRT2053798	hsa-miR-4756-5p	CLIP-seq
MIRT1185590	hsa-miR-4786-3p	CLIP-seq
MIRT2282962	hsa-miR-4796-3p	CLIP-seq
MIRT2053800	hsa-miR-491-5p	CLIP-seq
MIRT2282964	hsa-miR-519d	CLIP-seq
MIRT2282965	hsa-miR-548ah	CLIP-seq
MIRT1185592	hsa-miR-548s	CLIP-seq
MIRT1185593	hsa-miR-567	CLIP-seq
MIRT1185596	hsa-miR-663b	CLIP-seq
MIRT2282966	hsa-miR-93	CLIP-seq
MIRT1185598	hsa-miR-99a	CLIP-seq
MIRT1185599	hsa-miR-99b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0015095	Function	Magnesium ion transmembrane transporter activity	IEA
GO:0015693	Process	Magnesium ion transport	IBA
GO:0015693	Process	Magnesium ion transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:1903830	Process	Magnesium ion transmembrane transport	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9H841
• Protein name: NIPA-like protein 2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05653	Mg_trans_NIPA	45 → 332	Magnesium transporter NIPA	Family

• Sequence:

  MAAVAPAGPGDSASAALDELSLNFTYGAPGAGNGSLSGDWYRRNQIHLFGVLLAILGNLV
  ISISLNIQKYSHLQLAQQEHPRPYFKSVLWWGGVLLMAVGETGNFAAYGFAPITLIAPLG
  CVSVTGSAIISVTFLKDNLRASDLLGTTLAFAGTYLLVNFAPNITQAISARTVQYYLVGW
  QFLIYVILEILIFCILLYFYKRKGMKHMVILLTLVAILASLTVISVKAVSGMITFSVMDK
  MQLTYPIFYIMFIIMIASCVFQVKFLNQATKLYNTTTVVPVNHIFFTISAIIAGIIFYQE
  FLGAPFLTVFIYLFGCFLSFLGVFLVTRNREKEHLQQSYIDFGNIPGKQMLDKIQPDSHS
  LSYGTLPDGSDSTKSQSGEKKEV

• Sequence length: 383

Pathways

Reactome:

Miscellaneous transport and binding events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STEVENS-JOHNSON SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOXIC EPIDERMAL NECROLYSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UROLITHIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations