HHIPL2 (HHIP like 2)

Gene

• Entrez ID: 79802
• Gene name: HHIP like 2
• Gene symbol: HHIPL2
• Synonyms (NCBI Gene): KIAA1822L
• Chromosome: 1
• Chromosome location: 1q41

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1045033	hsa-miR-10a	CLIP-seq
MIRT1045034	hsa-miR-10b	CLIP-seq
MIRT1045035	hsa-miR-150	CLIP-seq
MIRT1045036	hsa-miR-188-3p	CLIP-seq
MIRT1045037	hsa-miR-1915	CLIP-seq
MIRT1045038	hsa-miR-217	CLIP-seq
MIRT1045039	hsa-miR-3120-3p	CLIP-seq
MIRT1045040	hsa-miR-411	CLIP-seq
MIRT1045041	hsa-miR-4263	CLIP-seq
MIRT1045042	hsa-miR-4270	CLIP-seq
MIRT1045043	hsa-miR-4441	CLIP-seq
MIRT1045044	hsa-miR-451b	CLIP-seq
MIRT1045045	hsa-miR-4713-5p	CLIP-seq
MIRT1045046	hsa-miR-4726-3p	CLIP-seq
MIRT1045047	hsa-miR-4797-5p	CLIP-seq
MIRT1045048	hsa-miR-499a-5p	CLIP-seq
MIRT1045049	hsa-miR-532-3p	CLIP-seq
MIRT1045050	hsa-miR-936	CLIP-seq
MIRT1549490	hsa-miR-1226	CLIP-seq
MIRT1549491	hsa-miR-1273d	CLIP-seq
MIRT1045046	hsa-miR-4726-3p	CLIP-seq
MIRT1549492	hsa-miR-634	CLIP-seq
MIRT1549493	hsa-miR-764	CLIP-seq
MIRT1549494	hsa-miR-767-5p	CLIP-seq
MIRT1549490	hsa-miR-1226	CLIP-seq
MIRT2545874	hsa-miR-3192	CLIP-seq
MIRT2545875	hsa-miR-3201	CLIP-seq
MIRT2545876	hsa-miR-4314	CLIP-seq
MIRT2545877	hsa-miR-4646-5p	CLIP-seq
MIRT2545878	hsa-miR-4791	CLIP-seq
MIRT1549492	hsa-miR-634	CLIP-seq
MIRT1549494	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 25910212
GO:0005576	Component	Extracellular region	IEA

Other IDs

• MIM: 620214
• HGNC: 25842
• e!Ensembl: ENSG00000143512

Protein

• UniProt ID: Q6UWX4
• Protein name: HHIP-like protein 2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03024	Folate_rec	44 → 206	Folate receptor family	Domain
  PF07995	GSDH	216 → 552	Glucose / Sorbosone dehydrogenase	Domain

• Sequence:

  MLRTSTPNLCGGLHCRAPWLSSGILCLCLIFLLGQVGLLQGHPQCLDYGPPFQPPLHLEF
  CSDYESFGCCDQHKDRRIAARYWDIMEYFDLKRHELCGDYIKDILCQECSPYAAHLYDAE
  NTQTPLRNLPGLCSDYCSAFHSNCHSAISLLTNDRGLQESHGRDGTRFCHLLDLPDKDYC
  FPNVLRNDYLNRHLGMVAQDPQGCLQLCLSEVANGLRNPVSMVHAGDGTHRFFVAEQVGV
  VWVYLPDGSRLEQPFLDLKNIVLTTPWIGDERGFLGLAFHPKFRHNRKFYIYYSCLDKKK
  VEKIRISEMKVSRADPNKADLKSERVILEIEEPASNHNGGQLLFGLDGYMYIFTGDGGQA
  GDPFGLFGNAQNKSSLLGKVLRIDVNRAGSHGKRYRVPSDNPFVSEPGAHPAIYAYGIRN
  MWRCAVDRGDPITRQGRGRIFCGDVGQNRFEEVDLILKGGNYGWRAKEGFACYDKKLCHN
  ASLDDVLPIYAYGHAVGKSVTGGYVYRGCESPNLNGLYIFGDFMSGRLMALQEDRKNKKW
  KKQDLCLGSTTSCAFPGLISTHSKFIISFAEDEAGELYFLATSYPSAYAPRGSIYKFVDP
  SRRAPPGKCKYKPVPVRTKSKRIPFRPLAKTVLDLLKEQSEKAARKSSSATLASGPAQGL
  SEKGSSKKLASPTSSKNTLRGPGTKKKARVGPHVRQGKRRKSLKSHSGRMRPSAEQKRAG
  RSLP

• Sequence length: 724

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MYOCARDIAL INFARCTION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinogenesis	Carcinogenesis	Pubtator	20187983	Associate	★☆☆☆☆ Found in Text Mining only
Iron Overload	Iron Overload	BEFREE	22237814		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	20187983	Associate	★☆☆☆☆ Found in Text Mining only