UGT2A3 (UDP glucuronosyltransferase family 2 member A3)

Gene

• Entrez ID: 79799
• Gene name: UDP glucuronosyltransferase family 2 member A3
• Gene symbol: UGT2A3
• Synonyms (NCBI Gene): -
• Chromosome: 4
• Chromosome location: 4q13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1473615	hsa-miR-3074-3p	CLIP-seq
MIRT1473616	hsa-miR-3178	CLIP-seq
MIRT1473617	hsa-miR-365	CLIP-seq
MIRT1473618	hsa-miR-4263	CLIP-seq
MIRT1473619	hsa-miR-4659a-5p	CLIP-seq
MIRT1473620	hsa-miR-4659b-5p	CLIP-seq
MIRT1473621	hsa-miR-4733-3p	CLIP-seq
MIRT1473617	hsa-miR-365	CLIP-seq
MIRT2142608	hsa-miR-4528	CLIP-seq
MIRT1473619	hsa-miR-4659a-5p	CLIP-seq
MIRT1473620	hsa-miR-4659b-5p	CLIP-seq
MIRT2363089	hsa-miR-3978	CLIP-seq
MIRT2363090	hsa-miR-4452	CLIP-seq
MIRT2363091	hsa-miR-4635	CLIP-seq
MIRT2363092	hsa-miR-526b	CLIP-seq
MIRT2363093	hsa-miR-578	CLIP-seq
MIRT2462868	hsa-miR-539	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0006805	Process	Xenobiotic metabolic process	IDA	19858781
GO:0008194	Function	UDP-glycosyltransferase activity	IEA
GO:0015020	Function	Glucuronosyltransferase activity	IBA
GO:0015020	Function	Glucuronosyltransferase activity	IDA	19858781
GO:0015020	Function	Glucuronosyltransferase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA

Other IDs

• MIM: 616382
• HGNC: 28528
• e!Ensembl: ENSG00000135220

Protein

• UniProt ID: Q6UWM9
• Protein name: UDP-glucuronosyltransferase 2A3 (UDPGT 2A3) (EC 2.4.1.17)
• Protein function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00201	UDPGT	24 → 525	UDP-glucoronosyl and UDP-glucosyl transferase	Family

• Sequence:

  MRSDKSALVFLLLQLFCVGCGFCGKVLVWPCDMSHWLNVKVILEELIVRGHEVTVLTHSK
  PSLIDYRKPSALKFEVVHMPQDRTEENEIFVDLALNVLPGLSTWQSVIKLNDFFVEIRGT
  LKMMCESFIYNQTLMKKLQETNYDVMLIDPVIPCGDLMAELLAVPFVLTLRISVGGNMER
  SCGKLPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYDYHFWEEFYSKALGR
  PTTLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKEMENFVQSSGED
  GIVVFSLGSLFQNVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQNDL
  LGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTS
  EDLLRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHD
  LTWFQHYSIDVIGFLLACVATAIFLFTKCFLFSCQKFNKTRKIEKRE

• Sequence length: 527

Pathways

KEGG:

Pentose and glucuronate interconversions
Ascorbate and aldarate metabolism
Steroid hormone biosynthesis
Retinol metabolism
Porphyrin metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Biosynthesis of cofactors
Bile secretion
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation

Reactome:

Glucuronidation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	28745433, 36855796	Associate	★☆☆☆☆ Found in Text Mining only