KLHL36 (kelch like family member 36)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 79786
Gene name Kelch like family member 36
Gene symbol KLHL36
Synonyms (NCBI Gene)
C16orf44
Chromosome 16
Chromosome location 16q24.1
miRNA miRNA information provided by mirtarbase database.
452
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (452)
miRTarBase ID miRNA Experiments Reference
MIRT049740 hsa-miR-92a-3p CLASH 23622248
MIRT712680 hsa-miR-6823-5p HITS-CLIP 19536157
MIRT712679 hsa-miR-371b-5p HITS-CLIP 19536157
MIRT712678 hsa-miR-373-5p HITS-CLIP 19536157
MIRT712677 hsa-miR-616-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
4
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (4)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 28514442, 32814053, 33961781
GO:0016567 Process Protein ubiquitination IEA
GO:0097602 Function Cullin family protein binding IBA
GO:0097602 Function Cullin family protein binding IPI 14528312
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N4N3
Protein name Kelch-like protein 36
Protein function Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 36 → 143 BTB/POZ domain Domain
PF07707 BACK 148 → 250 BTB And C-terminal Kelch Domain
PF01344 Kelch_1 334 → 384 Kelch motif Repeat
PF01344 Kelch_1 386 → 431 Kelch motif Repeat
PF01344 Kelch_1 483 → 533 Kelch motif Repeat
PF01344 Kelch_1 535 → 582 Kelch motif Repeat
Sequence
Sequence length 616
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (2)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
LATE-ONSET ALZHEIMER'S DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Lung cancer Uncertain significance ClinVar
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (2)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Autistic Disorder Autism Pubtator 37794117 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Schizophrenia Schizophrenia Pubtator 37794117 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only