LRRC31 (leucine rich repeat containing 31)

Gene

• Entrez ID: 79782
• Gene name: Leucine rich repeat containing 31
• Gene symbol: LRRC31
• Synonyms (NCBI Gene): HEL-S-293
• Chromosome: 3
• Chromosome location: 3q26.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT707462	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT551418	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT551417	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT551416	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT551415	hsa-miR-6504-3p	HITS-CLIP	21572407
MIRT551414	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT551413	hsa-miR-3924	HITS-CLIP	21572407
MIRT551418	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551417	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT551416	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551415	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT551414	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT551413	hsa-miR-3924	PAR-CLIP	21572407
MIRT707462	hsa-miR-5580-3p	HITS-CLIP	21572407
MIRT551418	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT551417	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT551416	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT551415	hsa-miR-6504-3p	HITS-CLIP	21572407
MIRT551414	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT551413	hsa-miR-3924	HITS-CLIP	21572407
MIRT551418	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT551417	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT551416	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT551415	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT551414	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT551413	hsa-miR-3924	PAR-CLIP	21572407
MIRT1119464	hsa-miR-124	CLIP-seq
MIRT1119465	hsa-miR-203	CLIP-seq
MIRT1119466	hsa-miR-3136-3p	CLIP-seq
MIRT1119467	hsa-miR-3163	CLIP-seq
MIRT1119468	hsa-miR-4694-3p	CLIP-seq
MIRT1119469	hsa-miR-506	CLIP-seq
MIRT1119470	hsa-miR-522	CLIP-seq
MIRT1119471	hsa-miR-548an	CLIP-seq
MIRT1119472	hsa-miR-577	CLIP-seq
MIRT2264194	hsa-miR-329	CLIP-seq
MIRT2264195	hsa-miR-362-3p	CLIP-seq
MIRT2264196	hsa-miR-3941	CLIP-seq
MIRT2264197	hsa-miR-466	CLIP-seq
MIRT2264198	hsa-miR-4672	CLIP-seq
MIRT2264199	hsa-miR-4789-3p	CLIP-seq
MIRT2264200	hsa-miR-603	CLIP-seq

Other IDs

• MIM: 620925
• HGNC: 26261
• e!Ensembl: ENSG00000114248

Protein

• UniProt ID: Q6UY01
• Protein name: Leucine-rich repeat-containing protein 31
• Sequence:

  MSQTRKKTSSEGETKPQTSTVNKFLRGSNAESRKEDNDLKTSDSQPSDWIQKTATSETAK
  PLSSEMEWRSSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELD
  ISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWN
  SKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIV
  GSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFE
  DSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLS
  RLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKL
  SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVRFL
  KELIELDISLRPSNFRDCGQWFRHLLYAVTKLPQITEIGMKRWILPASQEEELECFDQDK
  KRSIHFDHGGFQ

• Sequence length: 552

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
URINARY BLADDER CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	28413214	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	37487414	Associate	★☆☆☆☆ Found in Text Mining only
Central Nervous System Neoplasms	Central Nervous System Neoplasms	GWASCAT_DG	24908248		★☆☆☆☆ Found in Text Mining only
Central Nervous System Neoplasms	Central Nervous System Neoplasms	GWASDB_DG	24908248		★☆☆☆☆ Found in Text Mining only
Coronary Disease	Coronary artery disease	Pubtator	24349443	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	24349443, 26720590, 32296102	Associate	★☆☆☆☆ Found in Text Mining only
Eosinophilia	Eosinophilia	BEFREE	26462420		★☆☆☆☆ Found in Text Mining only
Eosinophilia	Eosinophilia	Pubtator	26462420	Associate	★☆☆☆☆ Found in Text Mining only
Eosinophilic esophagitis	Eosinophilia	BEFREE	26462420		★☆☆☆☆ Found in Text Mining only
Eosinophilic Esophagitis	Eosinophilia	Pubtator	26462420	Stimulate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	GWASCAT_DG	24908248		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	GWASDB_DG	24908248		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma	Glioma	Pubtator	24908248	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypoalphalipoproteinemias	Hypoalphalipoproteinemia	Pubtator	26720590	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	GWASDB_DG	23955597		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	28413214		★☆☆☆☆ Found in Text Mining only