Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79777
Gene name	Acyl-CoA binding domain containing 4
Gene symbol	ACBD4
Synonyms (NCBI Gene)	HMFT0700
Chromosome	17
Chromosome location	17q21.31
Summary	This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent li

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miRTarBase ID	miRNA	Experiments	Reference
MIRT036775	hsa-miR-760	CLASH	23622248
MIRT762069	hsa-miR-3591-5p	CLIP-seq
MIRT762070	hsa-miR-3606	CLIP-seq
MIRT762071	hsa-miR-921	CLIP-seq
MIRT762072	hsa-miR-1273e	CLIP-seq
MIRT762073	hsa-miR-1827	CLIP-seq
MIRT762074	hsa-miR-2964a-3p	CLIP-seq
MIRT762075	hsa-miR-302f	CLIP-seq
MIRT762076	hsa-miR-3122	CLIP-seq
MIRT762077	hsa-miR-3123	CLIP-seq
MIRT762078	hsa-miR-323-5p	CLIP-seq
MIRT762079	hsa-miR-3665	CLIP-seq
MIRT762080	hsa-miR-3689a-3p	CLIP-seq
MIRT762081	hsa-miR-3689c	CLIP-seq
MIRT762082	hsa-miR-3913-5p	CLIP-seq
MIRT762083	hsa-miR-3919	CLIP-seq
MIRT762084	hsa-miR-3929	CLIP-seq
MIRT762085	hsa-miR-4419b	CLIP-seq
MIRT762086	hsa-miR-4433	CLIP-seq
MIRT762087	hsa-miR-4459	CLIP-seq
MIRT762088	hsa-miR-4478	CLIP-seq
MIRT762089	hsa-miR-4532	CLIP-seq
MIRT762090	hsa-miR-4649-3p	CLIP-seq
MIRT762091	hsa-miR-4728-5p	CLIP-seq
MIRT762092	hsa-miR-4768-3p	CLIP-seq
MIRT762093	hsa-miR-485-5p	CLIP-seq
MIRT762094	hsa-miR-566	CLIP-seq
MIRT762073	hsa-miR-1827	CLIP-seq
MIRT762076	hsa-miR-3122	CLIP-seq
MIRT2443017	hsa-miR-3613-3p	CLIP-seq
MIRT2443018	hsa-miR-3622b-5p	CLIP-seq
MIRT762079	hsa-miR-3665	CLIP-seq
MIRT762080	hsa-miR-3689a-3p	CLIP-seq
MIRT762081	hsa-miR-3689c	CLIP-seq
MIRT762082	hsa-miR-3913-5p	CLIP-seq
MIRT2443019	hsa-miR-4253	CLIP-seq
MIRT2443020	hsa-miR-4426	CLIP-seq
MIRT2443021	hsa-miR-4647	CLIP-seq
MIRT2443022	hsa-miR-4662b	CLIP-seq
MIRT2443023	hsa-miR-4684-5p	CLIP-seq
MIRT762091	hsa-miR-4728-5p	CLIP-seq
MIRT2443024	hsa-miR-4736	CLIP-seq
MIRT2443025	hsa-miR-548c-3p	CLIP-seq
MIRT2443026	hsa-miR-940	CLIP-seq
MIRT2443017	hsa-miR-3613-3p	CLIP-seq
MIRT2443018	hsa-miR-3622b-5p	CLIP-seq
MIRT2443019	hsa-miR-4253	CLIP-seq
MIRT2443023	hsa-miR-4684-5p	CLIP-seq
MIRT2443025	hsa-miR-548c-3p	CLIP-seq
MIRT762073	hsa-miR-1827	CLIP-seq
MIRT762076	hsa-miR-3122	CLIP-seq
MIRT762078	hsa-miR-323-5p	CLIP-seq
MIRT2443017	hsa-miR-3613-3p	CLIP-seq
MIRT2443018	hsa-miR-3622b-5p	CLIP-seq
MIRT762080	hsa-miR-3689a-3p	CLIP-seq
MIRT762081	hsa-miR-3689c	CLIP-seq
MIRT762082	hsa-miR-3913-5p	CLIP-seq
MIRT2443019	hsa-miR-4253	CLIP-seq
MIRT2443020	hsa-miR-4426	CLIP-seq
MIRT2443021	hsa-miR-4647	CLIP-seq
MIRT2443022	hsa-miR-4662b	CLIP-seq
MIRT2443023	hsa-miR-4684-5p	CLIP-seq
MIRT762091	hsa-miR-4728-5p	CLIP-seq
MIRT2443024	hsa-miR-4736	CLIP-seq
MIRT2468506	hsa-miR-541	CLIP-seq
MIRT2443025	hsa-miR-548c-3p	CLIP-seq
MIRT2468507	hsa-miR-654-5p	CLIP-seq
MIRT2468508	hsa-miR-876-3p	CLIP-seq
MIRT2443026	hsa-miR-940	CLIP-seq
MIRT762073	hsa-miR-1827	CLIP-seq
MIRT762076	hsa-miR-3122	CLIP-seq
MIRT762078	hsa-miR-323-5p	CLIP-seq
MIRT2443017	hsa-miR-3613-3p	CLIP-seq
MIRT2443018	hsa-miR-3622b-5p	CLIP-seq
MIRT762080	hsa-miR-3689a-3p	CLIP-seq
MIRT762081	hsa-miR-3689c	CLIP-seq
MIRT762082	hsa-miR-3913-5p	CLIP-seq
MIRT2443019	hsa-miR-4253	CLIP-seq
MIRT2443020	hsa-miR-4426	CLIP-seq
MIRT2443021	hsa-miR-4647	CLIP-seq
MIRT2443022	hsa-miR-4662b	CLIP-seq
MIRT2443023	hsa-miR-4684-5p	CLIP-seq
MIRT762091	hsa-miR-4728-5p	CLIP-seq
MIRT2443024	hsa-miR-4736	CLIP-seq
MIRT2468506	hsa-miR-541	CLIP-seq
MIRT2443025	hsa-miR-548c-3p	CLIP-seq
MIRT2468507	hsa-miR-654-5p	CLIP-seq
MIRT2468508	hsa-miR-876-3p	CLIP-seq
MIRT2443026	hsa-miR-940	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000062	Function	Fatty-acyl-CoA binding	IBA
GO:0000062	Function	Fatty-acyl-CoA binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0006631	Process	Fatty acid metabolic process	IBA
GO:0008289	Function	Lipid binding	IEA

MIM	HGNC	e!Ensembl
619968	23337	ENSG00000181513

Q8NC06

Protein name

Acyl-CoA-binding domain-containing protein 4

Protein function

Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.

PDB

2WH5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00887	ACBP	13 → 97	Acyl CoA binding protein	Domain

Sequence

MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPG
FWDPIGRYKWDAWNSLGKMSREEAMSAYITEMKLVAQKVIDTVPLGEVAEDMFGYFEPLY
QVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVF
CDSLEQLEPELSSGQHLEESVIPGTAPCPPQRKRGCGAARRGPRSWTCGCWGQFEHYRRA
CRRCRRGCRAWRACPGPLSSLTLSVRLE

Sequence length

268

Interactions

View interactions

	Reactome
			Peroxisomal lipid metabolism

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	38186579	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	20111712	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ACBD4 (acyl-CoA binding domain containing 4)