Gene Gene information from NCBI Gene database.
Entrez ID 79723
Gene name SUV39H2 histone lysine methyltransferase
Gene symbol SUV39H2
Synonyms (NCBI Gene)
KMT1B
Chromosome 10
Chromosome location 10p13
miRNA miRNA information provided by mirtarbase database.
233
miRTarBase ID miRNA Experiments Reference
MIRT560846 hsa-miR-6768-3p PAR-CLIP 20371350
MIRT560845 hsa-miR-3156-5p PAR-CLIP 20371350
MIRT560844 hsa-miR-181a-5p PAR-CLIP 20371350
MIRT560843 hsa-miR-181b-5p PAR-CLIP 20371350
MIRT560842 hsa-miR-181c-5p PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
38
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 21402781
GO:0000775 Component Chromosome, centromeric region IEA
GO:0000785 Component Chromatin IDA 10949293
GO:0000785 Component Chromatin IEA
GO:0000976 Function Transcription cis-regulatory region binding ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
606503 17287 ENSG00000152455
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9H5I1
Protein name Histone-lysine N-methyltransferase SUV39H2 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 2) (H3-K9-HMTase 2) (Lysine N-methyltransferase 1B) (Suppressor of variegation 3-9 homolog 2) (Su(var)3-9 homolog 2)
Protein function Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,
PDB 2R3A , 6P0R
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00385 Chromo 47 96 Chromo (CHRromatin Organisation MOdifier) domain Domain
PF05033 Pre-SET 145 242 Pre-SET motif Family
PF00856 SET 262 373 SET domain Family
Sequence
Sequence length 410
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Lysine degradation
Metabolic pathways
  PKMTs methylate histone lysines
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MIGRAINE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SUV39H2-related disorder Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 30348215
★☆☆☆☆
Found in Text Mining only
Adult Hepatocellular Carcinoma Liver carcinoma BEFREE 30719171
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 30719171
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 24966962 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 16774942, 17693662, 30719171
★☆☆☆☆
Found in Text Mining only
Childhood Hepatocellular Carcinoma Liver carcinoma BEFREE 30719171
★☆☆☆☆
Found in Text Mining only
Chronic Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 28833505
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 29458143, 30719171
★☆☆☆☆
Found in Text Mining only
Congenital chromosomal disease Congenital Chromosomal Disease BEFREE 28833505
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus BEFREE 21896933
★☆☆☆☆
Found in Text Mining only