IPO4 (importin 4)

Gene

• Entrez ID: 79711
• Gene name: Importin 4
• Gene symbol: IPO4
• Synonyms (NCBI Gene): Imp4
• Chromosome: 14
• Chromosome location: 14q12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT001620	hsa-let-7b-5p	pSILAC	18668040
MIRT001450	hsa-miR-16-5p	pSILAC	18668040
MIRT001450	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT001620	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT001620	hsa-let-7b-5p	CLASH	23622248
MIRT048945	hsa-miR-92a-3p	CLASH	23622248
MIRT048945	hsa-miR-92a-3p	CLASH	23622248
MIRT041255	hsa-miR-193b-3p	CLASH	23622248
MIRT037189	hsa-miR-877-3p	CLASH	23622248
MIRT036612	hsa-miR-940	CLASH	23622248
MIRT1068739	hsa-miR-498	CLIP-seq
MIRT1068740	hsa-miR-570	CLIP-seq
MIRT2016712	hsa-miR-124	CLIP-seq
MIRT2016713	hsa-miR-1266	CLIP-seq
MIRT2016714	hsa-miR-1285	CLIP-seq
MIRT2016715	hsa-miR-146b-3p	CLIP-seq
MIRT2016716	hsa-miR-149	CLIP-seq
MIRT2016717	hsa-miR-1587	CLIP-seq
MIRT2016718	hsa-miR-3151	CLIP-seq
MIRT2016719	hsa-miR-3155	CLIP-seq
MIRT2016720	hsa-miR-3155b	CLIP-seq
MIRT2016721	hsa-miR-3187-5p	CLIP-seq
MIRT2016722	hsa-miR-323-5p	CLIP-seq
MIRT2016723	hsa-miR-3545-3p	CLIP-seq
MIRT2016724	hsa-miR-3714	CLIP-seq
MIRT2016725	hsa-miR-378g	CLIP-seq
MIRT2016726	hsa-miR-3910	CLIP-seq
MIRT2016727	hsa-miR-4270	CLIP-seq
MIRT2016728	hsa-miR-4283	CLIP-seq
MIRT2016729	hsa-miR-4441	CLIP-seq
MIRT2016730	hsa-miR-4489	CLIP-seq
MIRT2016731	hsa-miR-4492	CLIP-seq
MIRT2016732	hsa-miR-4498	CLIP-seq
MIRT2016733	hsa-miR-4506	CLIP-seq
MIRT2016734	hsa-miR-4518	CLIP-seq
MIRT2016735	hsa-miR-4539	CLIP-seq
MIRT2016736	hsa-miR-4656	CLIP-seq
MIRT2016737	hsa-miR-4675	CLIP-seq
MIRT2016738	hsa-miR-4724-5p	CLIP-seq
MIRT2016739	hsa-miR-4741	CLIP-seq
MIRT2016740	hsa-miR-4753-5p	CLIP-seq
MIRT2016741	hsa-miR-484	CLIP-seq
MIRT2016742	hsa-miR-506	CLIP-seq
MIRT2016743	hsa-miR-612	CLIP-seq
MIRT2016744	hsa-miR-661	CLIP-seq
MIRT2016745	hsa-miR-762	CLIP-seq
MIRT2248805	hsa-miR-101	CLIP-seq
MIRT2248806	hsa-miR-1272	CLIP-seq
MIRT2248807	hsa-miR-1322	CLIP-seq
MIRT2248808	hsa-miR-144	CLIP-seq
MIRT2248809	hsa-miR-194	CLIP-seq
MIRT2248810	hsa-miR-2964a-5p	CLIP-seq
MIRT2016724	hsa-miR-3714	CLIP-seq
MIRT2248811	hsa-miR-579	CLIP-seq
MIRT2248812	hsa-miR-582-5p	CLIP-seq
MIRT2016712	hsa-miR-124	CLIP-seq
MIRT2016724	hsa-miR-3714	CLIP-seq
MIRT2016726	hsa-miR-3910	CLIP-seq
MIRT2016731	hsa-miR-4492	CLIP-seq
MIRT2016732	hsa-miR-4498	CLIP-seq
MIRT2016742	hsa-miR-506	CLIP-seq
MIRT2016745	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	14718166
GO:0005515	Function	Protein binding	IPI	17616579, 20805509, 22022502, 25959826, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0006606	Process	Protein import into nucleus	IBA
GO:0006606	Process	Protein import into nucleus	IDA	11823430, 16207705, 17682055
GO:0006606	Process	Protein import into nucleus	IEA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0008139	Function	Nuclear localization sequence binding	IBA
GO:0008139	Function	Nuclear localization sequence binding	IDA	17682055
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0031267	Function	Small GTPase binding	IEA
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0034504	Process	Protein localization to nucleus	IDA	14718166
GO:0061608	Function	Nuclear import signal receptor activity	IBA
GO:0061608	Function	Nuclear import signal receptor activity	IDA	16207705, 17682055

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8TEX9
• Protein name: Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)
• Protein function: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524). Serves as receptor for nuclear localization signals (NLS) in cargo s
• PDB: 5XAH, 5XBK, 7UNK, 8DYO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03810	IBN_N	24 → 90	Importin-beta N-terminal domain	Family
  PF02985	HEAT	395 → 425	HEAT repeat	Repeat
  PF13513	HEAT_EZ	913 → 968		Repeat

• Sequence:

  MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVL
  TRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLL
  QLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYS
  LRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVIT
  PYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVA
  AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA
  LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ
  FSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPEL
  MECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPV
  QIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEG
  LAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEI
  SGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEA
  LGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLR
  SCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIP
  ALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRL
  LPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDN
  ICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVA
  PELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGL
  S

• Sequence length: 1081

Pathways

KEGG:

Nucleocytoplasmic transport

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
FOCAL SEGMENTAL GLOMERULOSCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOUTH DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	CTD_human_DG	27602772		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30861176		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30861176		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30861176		★☆☆☆☆ Found in Text Mining only