Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79710
Gene name	MORC family CW-type zinc finger 4
Gene symbol	MORC4
Synonyms (NCBI Gene)	ZCW4ZCWCC2dJ75H8.2
Chromosome	X
Chromosome location	Xq22.3
Summary	In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stra

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016607	hsa-miR-193b-3p	Microarray	20304954
MIRT023049	hsa-miR-124-3p	Microarray	18668037
MIRT030017	hsa-miR-26b-5p	Microarray	19088304
MIRT498680	hsa-miR-6863	HITS-CLIP	23824327
MIRT661454	hsa-miR-1321	HITS-CLIP	23824327
MIRT661455	hsa-miR-4739	HITS-CLIP	23824327
MIRT661453	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT661452	hsa-miR-3126-5p	HITS-CLIP	23824327
MIRT661450	hsa-miR-6875-5p	HITS-CLIP	23824327
MIRT661451	hsa-miR-4419a	HITS-CLIP	23824327
MIRT661449	hsa-miR-4510	HITS-CLIP	23824327
MIRT661448	hsa-miR-6127	HITS-CLIP	23824327
MIRT661447	hsa-miR-6129	HITS-CLIP	23824327
MIRT661446	hsa-miR-6130	HITS-CLIP	23824327
MIRT661445	hsa-miR-6133	HITS-CLIP	23824327
MIRT661444	hsa-miR-6834-5p	HITS-CLIP	23824327
MIRT498680	hsa-miR-6863	PAR-CLIP	24398324
MIRT498679	hsa-miR-6804-5p	PAR-CLIP	24398324
MIRT498678	hsa-miR-4710	PAR-CLIP	24398324
MIRT661454	hsa-miR-1321	PAR-CLIP	27292025
MIRT661454	hsa-miR-1321	PAR-CLIP	27292025
MIRT661454	hsa-miR-1321	PAR-CLIP	27292025
MIRT661452	hsa-miR-3126-5p	PAR-CLIP	27292025
MIRT661452	hsa-miR-3126-5p	PAR-CLIP	27292025
MIRT661452	hsa-miR-3126-5p	PAR-CLIP	27292025
MIRT661451	hsa-miR-4419a	PAR-CLIP	27292025
MIRT661451	hsa-miR-4419a	PAR-CLIP	27292025
MIRT661451	hsa-miR-4419a	PAR-CLIP	27292025
MIRT661449	hsa-miR-4510	PAR-CLIP	27292025
MIRT661449	hsa-miR-4510	PAR-CLIP	27292025
MIRT661449	hsa-miR-4510	PAR-CLIP	27292025
MIRT661455	hsa-miR-4739	PAR-CLIP	27292025
MIRT661455	hsa-miR-4739	PAR-CLIP	27292025
MIRT661455	hsa-miR-4739	PAR-CLIP	27292025
MIRT661453	hsa-miR-4756-5p	PAR-CLIP	27292025
MIRT661453	hsa-miR-4756-5p	PAR-CLIP	27292025
MIRT661453	hsa-miR-4756-5p	PAR-CLIP	27292025
MIRT661448	hsa-miR-6127	PAR-CLIP	27292025
MIRT661448	hsa-miR-6127	PAR-CLIP	27292025
MIRT661448	hsa-miR-6127	PAR-CLIP	27292025
MIRT661447	hsa-miR-6129	PAR-CLIP	27292025
MIRT661447	hsa-miR-6129	PAR-CLIP	27292025
MIRT661447	hsa-miR-6129	PAR-CLIP	27292025
MIRT661446	hsa-miR-6130	PAR-CLIP	27292025
MIRT661446	hsa-miR-6130	PAR-CLIP	27292025
MIRT661446	hsa-miR-6130	PAR-CLIP	27292025
MIRT661445	hsa-miR-6133	PAR-CLIP	27292025
MIRT661445	hsa-miR-6133	PAR-CLIP	27292025
MIRT661445	hsa-miR-6133	PAR-CLIP	27292025
MIRT661444	hsa-miR-6834-5p	PAR-CLIP	27292025
MIRT661444	hsa-miR-6834-5p	PAR-CLIP	27292025
MIRT661444	hsa-miR-6834-5p	PAR-CLIP	27292025
MIRT498680	hsa-miR-6863	PAR-CLIP	27292025
MIRT498680	hsa-miR-6863	PAR-CLIP	27292025
MIRT498680	hsa-miR-6863	PAR-CLIP	27292025
MIRT661450	hsa-miR-6875-5p	PAR-CLIP	27292025
MIRT661450	hsa-miR-6875-5p	PAR-CLIP	27292025
MIRT661450	hsa-miR-6875-5p	PAR-CLIP	27292025
MIRT661454	hsa-miR-1321	HITS-CLIP	27418678
MIRT661454	hsa-miR-1321	HITS-CLIP	27418678
MIRT661452	hsa-miR-3126-5p	HITS-CLIP	27418678
MIRT661452	hsa-miR-3126-5p	HITS-CLIP	27418678
MIRT661451	hsa-miR-4419a	HITS-CLIP	27418678
MIRT661451	hsa-miR-4419a	HITS-CLIP	27418678
MIRT661449	hsa-miR-4510	HITS-CLIP	27418678
MIRT661449	hsa-miR-4510	HITS-CLIP	27418678
MIRT661455	hsa-miR-4739	HITS-CLIP	27418678
MIRT661455	hsa-miR-4739	HITS-CLIP	27418678
MIRT661453	hsa-miR-4756-5p	HITS-CLIP	27418678
MIRT661453	hsa-miR-4756-5p	HITS-CLIP	27418678
MIRT661448	hsa-miR-6127	HITS-CLIP	27418678
MIRT661448	hsa-miR-6127	HITS-CLIP	27418678
MIRT661447	hsa-miR-6129	HITS-CLIP	27418678
MIRT661447	hsa-miR-6129	HITS-CLIP	27418678
MIRT661446	hsa-miR-6130	HITS-CLIP	27418678
MIRT661446	hsa-miR-6130	HITS-CLIP	27418678
MIRT661445	hsa-miR-6133	HITS-CLIP	27418678
MIRT661445	hsa-miR-6133	HITS-CLIP	27418678
MIRT661444	hsa-miR-6834-5p	HITS-CLIP	27418678
MIRT661444	hsa-miR-6834-5p	HITS-CLIP	27418678
MIRT498680	hsa-miR-6863	HITS-CLIP	27418678
MIRT498680	hsa-miR-6863	HITS-CLIP	27418678
MIRT661450	hsa-miR-6875-5p	HITS-CLIP	27418678
MIRT661450	hsa-miR-6875-5p	HITS-CLIP	27418678
MIRT498680	hsa-miR-6863	HITS-CLIP	23824327
MIRT661454	hsa-miR-1321	HITS-CLIP	23824327
MIRT661455	hsa-miR-4739	HITS-CLIP	23824327
MIRT661453	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT661452	hsa-miR-3126-5p	HITS-CLIP	23824327
MIRT661450	hsa-miR-6875-5p	HITS-CLIP	23824327
MIRT661451	hsa-miR-4419a	HITS-CLIP	23824327
MIRT661449	hsa-miR-4510	HITS-CLIP	23824327
MIRT661448	hsa-miR-6127	HITS-CLIP	23824327
MIRT661447	hsa-miR-6129	HITS-CLIP	23824327
MIRT661446	hsa-miR-6130	HITS-CLIP	23824327
MIRT661445	hsa-miR-6133	HITS-CLIP	23824327
MIRT661444	hsa-miR-6834-5p	HITS-CLIP	23824327
MIRT498680	hsa-miR-6863	PAR-CLIP	24398324
MIRT498679	hsa-miR-6804-5p	PAR-CLIP	24398324
MIRT498678	hsa-miR-4710	PAR-CLIP	24398324
MIRT1155461	hsa-miR-1253	CLIP-seq
MIRT1155462	hsa-miR-3154	CLIP-seq
MIRT1155463	hsa-miR-4299	CLIP-seq
MIRT1155464	hsa-miR-4456	CLIP-seq
MIRT1155465	hsa-miR-548q	CLIP-seq
MIRT1155466	hsa-miR-622	CLIP-seq
MIRT1155467	hsa-miR-124	CLIP-seq
MIRT1155468	hsa-miR-185	CLIP-seq
MIRT1155469	hsa-miR-3545-3p	CLIP-seq
MIRT1155470	hsa-miR-3646	CLIP-seq
MIRT1155471	hsa-miR-3647-3p	CLIP-seq
MIRT1155472	hsa-miR-3650	CLIP-seq
MIRT1155473	hsa-miR-3667-3p	CLIP-seq
MIRT1155474	hsa-miR-3714	CLIP-seq
MIRT1155475	hsa-miR-3910	CLIP-seq
MIRT1155476	hsa-miR-3942-3p	CLIP-seq
MIRT1155477	hsa-miR-4297	CLIP-seq
MIRT1155463	hsa-miR-4299	CLIP-seq
MIRT1155464	hsa-miR-4456	CLIP-seq
MIRT1155478	hsa-miR-4766-5p	CLIP-seq
MIRT1155479	hsa-miR-502-5p	CLIP-seq
MIRT1155480	hsa-miR-506	CLIP-seq
MIRT1155481	hsa-miR-548an	CLIP-seq
MIRT1155482	hsa-miR-548m	CLIP-seq
MIRT1155465	hsa-miR-548q	CLIP-seq
MIRT1155483	hsa-miR-889	CLIP-seq
MIRT1155484	hsa-miR-940	CLIP-seq
MIRT1155471	hsa-miR-3647-3p	CLIP-seq
MIRT1155483	hsa-miR-889	CLIP-seq
MIRT1155471	hsa-miR-3647-3p	CLIP-seq
MIRT2572503	hsa-miR-3187-3p	CLIP-seq
MIRT1155469	hsa-miR-3545-3p	CLIP-seq
MIRT1155472	hsa-miR-3650	CLIP-seq
MIRT1155473	hsa-miR-3667-3p	CLIP-seq
MIRT1155477	hsa-miR-4297	CLIP-seq
MIRT1155463	hsa-miR-4299	CLIP-seq
MIRT2572504	hsa-miR-4302	CLIP-seq
MIRT1155464	hsa-miR-4456	CLIP-seq
MIRT2572505	hsa-miR-4503	CLIP-seq
MIRT2572506	hsa-miR-4529-5p	CLIP-seq
MIRT2572507	hsa-miR-4645-3p	CLIP-seq
MIRT2572508	hsa-miR-4775	CLIP-seq
MIRT1155479	hsa-miR-502-5p	CLIP-seq
MIRT1155465	hsa-miR-548q	CLIP-seq
MIRT2572509	hsa-miR-644	CLIP-seq
MIRT2572510	hsa-miR-663b	CLIP-seq
MIRT2572503	hsa-miR-3187-3p	CLIP-seq
MIRT2572505	hsa-miR-4503	CLIP-seq
MIRT2572506	hsa-miR-4529-5p	CLIP-seq
MIRT2572510	hsa-miR-663b	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21988832
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0140002	Function	Histone H3K4me3 reader activity	IDA	26933034

MIM	HGNC	e!Ensembl
300970	23485	ENSG00000133131

Q8TE76

Protein name

MORC family CW-type zinc finger protein 4 (Zinc finger CW-type coiled-coil domain protein 2) (Zinc finger CW-type domain protein 4)

Protein function

Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4

PDB

7K7T

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13589	HATPase_c_3	47 → 182		Domain
PF17942	Morc6_S5	266 → 400	Morc6 ribosomal protein S5 domain 2-like	Family
PF07496	zf-CW	425 → 470	CW-type Zinc Finger	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas. {ECO:0000269|PubMed:17608765}.

Sequence

MLLYRGAPAGPGAPGCGLARPGGGPQAFGIRLSTMSPRYLQSNSSSHTRPFSAIAELLDN
AVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGV
FGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMII
TEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQY
DILVSDFDTEEKMTGGVTSELPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIAKSLA
NVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRGEGVG
VIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFETSTVARPIPK
VPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQELTDEDLCLS
KAKKQEQTVEEKKKMPMENENHQVFSNPPKILTVQEMAGLNNKTIGYEGIHSPSVLPSGG
EESRSPSLQLKPLDSSVLQFSSKYKWILGEEPVEKRRRLQNEMTTPSLDYSMPAPYRRVE
APVAYPEGENSHDKSSSERSTPPYLFPEYPEASKNTGQNREVSILYPGAKDQRQGSLLPE
ELEDQMPRLVAEESNRGSTTINKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAE
RRKAVESWNPVPYSVASAAIPAAAIGEKARGYEESEGHNTPKLKNQRELEELKRTTEKLE
RVLAERNLFQQKVEELEQERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQ
ILKAELERTKEEKQELKEKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTRLRIHVS
YLLTSVLPHLELREIGYDSEQVDGILYTVLEANHILD

Sequence length

937

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Abnormality of the face	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLELITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clinodactyly	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Macrocephaly	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Moderate intellectual disability	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANCREATITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Short 5th metacarpal	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute pancreatitis	Pancreatitis	BEFREE	29884332, 31163246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Hodgkin Lymphoma	Hodgkin Lymphoma	BEFREE	17608765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30320920		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	23946598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	23946598	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	17608765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Graft vs Host Disease	Graft-versus-host disease	Pubtator	26827181	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	17608765		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	23946598		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	23946598	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	17608765	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30320920		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obstructive azoospermia	Obstructive azoospermia	CLINVAR_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis	Pancreatitis	GWASDB_DG	23143602		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatitis	Pancreatitis	BEFREE	31163246		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatitis	Pancreatitis	Pubtator	33122719	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatitis Chronic	Pancreatitis	Pubtator	26820620, 28754779	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis, Chronic	Pancreatitis	BEFREE	25253127, 26820620, 28913878, 29884332		★★★★★ ★☆☆☆☆ Found in Text Mining only

MORC4 (MORC family CW-type zinc finger 4)