FN3KRP (fructosamine 3 kinase related protein)

Gene

• Entrez ID: 79672
• Gene name: Fructosamine 3 kinase related protein
• Gene symbol: FN3KRP
• Synonyms (NCBI Gene): FN3KL
• Chromosome: 17
• Chromosome location: 17q25.3
• Summary: A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphor

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043690	hsa-miR-342-3p	CLASH	23622248
MIRT518828	hsa-miR-302f	PAR-CLIP	20371350
MIRT518827	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT518826	hsa-miR-1225-3p	PAR-CLIP	20371350
MIRT518825	hsa-miR-1233-3p	PAR-CLIP	20371350
MIRT518822	hsa-miR-658	PAR-CLIP	20371350
MIRT518821	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT518820	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT518819	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT518818	hsa-miR-1273e	PAR-CLIP	20371350
MIRT518828	hsa-miR-302f	PAR-CLIP	20371350
MIRT518827	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT518826	hsa-miR-1225-3p	PAR-CLIP	20371350
MIRT518825	hsa-miR-1233-3p	PAR-CLIP	20371350
MIRT518822	hsa-miR-658	PAR-CLIP	20371350
MIRT518821	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT518820	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT518819	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT518818	hsa-miR-1273e	PAR-CLIP	20371350
MIRT518828	hsa-miR-302f	PAR-CLIP	21572407
MIRT518827	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT518826	hsa-miR-1225-3p	PAR-CLIP	21572407
MIRT518825	hsa-miR-1233-3p	PAR-CLIP	21572407
MIRT518821	hsa-miR-25-5p	PAR-CLIP	21572407
MIRT518820	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT518819	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT518818	hsa-miR-1273e	PAR-CLIP	21572407
MIRT540738	hsa-miR-4318	PAR-CLIP	21572407
MIRT540737	hsa-miR-449b-3p	PAR-CLIP	21572407
MIRT540736	hsa-miR-4252	PAR-CLIP	21572407
MIRT540735	hsa-miR-4662a-5p	PAR-CLIP	21572407
MIRT518828	hsa-miR-302f	PAR-CLIP	23446348
MIRT518827	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT518826	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT518825	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT518824	hsa-miR-1273c	PAR-CLIP	23446348
MIRT518823	hsa-miR-3683	PAR-CLIP	23446348
MIRT518822	hsa-miR-658	PAR-CLIP	23446348
MIRT518821	hsa-miR-25-5p	PAR-CLIP	23446348
MIRT518820	hsa-miR-580-3p	PAR-CLIP	23446348
MIRT518819	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT518818	hsa-miR-1273e	PAR-CLIP	23446348
MIRT460722	hsa-miR-191-5p	PAR-CLIP	23592263
MIRT460721	hsa-miR-596	PAR-CLIP	23592263
MIRT460720	hsa-miR-7160-3p	PAR-CLIP	23592263
MIRT460719	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT460718	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT460717	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT460716	hsa-miR-4734	PAR-CLIP	23592263
MIRT460715	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT460714	hsa-miR-1286	PAR-CLIP	23592263
MIRT460713	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT460712	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT460711	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT460710	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT460709	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT079465	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT079466	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT540736	hsa-miR-4252	PAR-CLIP	27292025
MIRT540736	hsa-miR-4252	PAR-CLIP	27292025
MIRT540736	hsa-miR-4252	PAR-CLIP	27292025
MIRT540738	hsa-miR-4318	PAR-CLIP	27292025
MIRT540738	hsa-miR-4318	PAR-CLIP	27292025
MIRT540738	hsa-miR-4318	PAR-CLIP	27292025
MIRT540737	hsa-miR-449b-3p	PAR-CLIP	27292025
MIRT540737	hsa-miR-449b-3p	PAR-CLIP	27292025
MIRT540737	hsa-miR-449b-3p	PAR-CLIP	27292025
MIRT540735	hsa-miR-4662a-5p	PAR-CLIP	27292025
MIRT540735	hsa-miR-4662a-5p	PAR-CLIP	27292025
MIRT540735	hsa-miR-4662a-5p	PAR-CLIP	27292025
MIRT518828	hsa-miR-302f	PAR-CLIP	20371350
MIRT518827	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT518826	hsa-miR-1225-3p	PAR-CLIP	20371350
MIRT518825	hsa-miR-1233-3p	PAR-CLIP	20371350
MIRT518822	hsa-miR-658	PAR-CLIP	20371350
MIRT518821	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT518820	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT518819	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT518818	hsa-miR-1273e	PAR-CLIP	20371350
MIRT518828	hsa-miR-302f	PAR-CLIP	20371350
MIRT518827	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT518826	hsa-miR-1225-3p	PAR-CLIP	20371350
MIRT518825	hsa-miR-1233-3p	PAR-CLIP	20371350
MIRT518822	hsa-miR-658	PAR-CLIP	20371350
MIRT518821	hsa-miR-25-5p	PAR-CLIP	20371350
MIRT518820	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT518819	hsa-miR-6807-5p	PAR-CLIP	20371350
MIRT518818	hsa-miR-1273e	PAR-CLIP	20371350
MIRT518828	hsa-miR-302f	PAR-CLIP	21572407
MIRT518827	hsa-miR-219b-3p	PAR-CLIP	21572407
MIRT518826	hsa-miR-1225-3p	PAR-CLIP	21572407
MIRT518825	hsa-miR-1233-3p	PAR-CLIP	21572407
MIRT518821	hsa-miR-25-5p	PAR-CLIP	21572407
MIRT518820	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT518819	hsa-miR-6807-5p	PAR-CLIP	21572407
MIRT518818	hsa-miR-1273e	PAR-CLIP	21572407
MIRT540738	hsa-miR-4318	PAR-CLIP	21572407
MIRT540737	hsa-miR-449b-3p	PAR-CLIP	21572407
MIRT540736	hsa-miR-4252	PAR-CLIP	21572407
MIRT540735	hsa-miR-4662a-5p	PAR-CLIP	21572407
MIRT518828	hsa-miR-302f	PAR-CLIP	23446348
MIRT518827	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT518826	hsa-miR-1225-3p	PAR-CLIP	23446348
MIRT518825	hsa-miR-1233-3p	PAR-CLIP	23446348
MIRT518824	hsa-miR-1273c	PAR-CLIP	23446348
MIRT518823	hsa-miR-3683	PAR-CLIP	23446348
MIRT518822	hsa-miR-658	PAR-CLIP	23446348
MIRT518821	hsa-miR-25-5p	PAR-CLIP	23446348
MIRT518820	hsa-miR-580-3p	PAR-CLIP	23446348
MIRT518819	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT518818	hsa-miR-1273e	PAR-CLIP	23446348
MIRT460722	hsa-miR-191-5p	PAR-CLIP	23592263
MIRT460721	hsa-miR-596	PAR-CLIP	23592263
MIRT460720	hsa-miR-7160-3p	PAR-CLIP	23592263
MIRT460719	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT460718	hsa-miR-1915-3p	PAR-CLIP	23592263
MIRT460717	hsa-miR-6764-5p	PAR-CLIP	23592263
MIRT460716	hsa-miR-4734	PAR-CLIP	23592263
MIRT460715	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT460714	hsa-miR-1286	PAR-CLIP	23592263
MIRT460713	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT460712	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT460711	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT460710	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT460709	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT999881	hsa-miR-1178	CLIP-seq
MIRT999882	hsa-miR-1321	CLIP-seq
MIRT999883	hsa-miR-1539	CLIP-seq
MIRT999884	hsa-miR-15a	CLIP-seq
MIRT999885	hsa-miR-15b	CLIP-seq
MIRT999886	hsa-miR-16	CLIP-seq
MIRT999887	hsa-miR-1827	CLIP-seq
MIRT999888	hsa-miR-191	CLIP-seq
MIRT999889	hsa-miR-1915	CLIP-seq
MIRT999890	hsa-miR-195	CLIP-seq
MIRT999891	hsa-miR-19a	CLIP-seq
MIRT999892	hsa-miR-19b	CLIP-seq
MIRT999893	hsa-miR-2113	CLIP-seq
MIRT999894	hsa-miR-2278	CLIP-seq
MIRT999895	hsa-miR-2682	CLIP-seq
MIRT999896	hsa-miR-34a	CLIP-seq
MIRT999897	hsa-miR-34c-5p	CLIP-seq
MIRT999898	hsa-miR-3612	CLIP-seq
MIRT999899	hsa-miR-3669	CLIP-seq
MIRT999900	hsa-miR-3671	CLIP-seq
MIRT999901	hsa-miR-371b-3p	CLIP-seq
MIRT999902	hsa-miR-3978	CLIP-seq
MIRT999903	hsa-miR-424	CLIP-seq
MIRT999904	hsa-miR-4270	CLIP-seq
MIRT999905	hsa-miR-4272	CLIP-seq
MIRT999906	hsa-miR-433	CLIP-seq
MIRT999907	hsa-miR-4441	CLIP-seq
MIRT999908	hsa-miR-4468	CLIP-seq
MIRT999909	hsa-miR-4488	CLIP-seq
MIRT999910	hsa-miR-449a	CLIP-seq
MIRT999911	hsa-miR-449b	CLIP-seq
MIRT999912	hsa-miR-449c	CLIP-seq
MIRT999913	hsa-miR-450b-5p	CLIP-seq
MIRT999914	hsa-miR-4519	CLIP-seq
MIRT999915	hsa-miR-4532	CLIP-seq
MIRT999916	hsa-miR-4695-5p	CLIP-seq
MIRT999917	hsa-miR-4697-5p	CLIP-seq
MIRT999918	hsa-miR-4701-5p	CLIP-seq
MIRT999919	hsa-miR-4708-3p	CLIP-seq
MIRT999920	hsa-miR-4739	CLIP-seq
MIRT999921	hsa-miR-4756-5p	CLIP-seq
MIRT999922	hsa-miR-497	CLIP-seq
MIRT999923	hsa-miR-499a-5p	CLIP-seq
MIRT999924	hsa-miR-518a-5p	CLIP-seq
MIRT999925	hsa-miR-527	CLIP-seq
MIRT999926	hsa-miR-548m	CLIP-seq
MIRT999927	hsa-miR-556-5p	CLIP-seq
MIRT999928	hsa-miR-588	CLIP-seq
MIRT999929	hsa-miR-607	CLIP-seq
MIRT999930	hsa-miR-650	CLIP-seq
MIRT999931	hsa-miR-765	CLIP-seq
MIRT999889	hsa-miR-1915	CLIP-seq
MIRT999891	hsa-miR-19a	CLIP-seq
MIRT999892	hsa-miR-19b	CLIP-seq
MIRT999893	hsa-miR-2113	CLIP-seq
MIRT1996353	hsa-miR-3185	CLIP-seq
MIRT1996354	hsa-miR-338-3p	CLIP-seq
MIRT1996355	hsa-miR-3607-5p	CLIP-seq
MIRT1996356	hsa-miR-3611	CLIP-seq
MIRT1996357	hsa-miR-4426	CLIP-seq
MIRT1996358	hsa-miR-4530	CLIP-seq
MIRT1996359	hsa-miR-4647	CLIP-seq
MIRT1996360	hsa-miR-4662b	CLIP-seq
MIRT999924	hsa-miR-518a-5p	CLIP-seq
MIRT999925	hsa-miR-527	CLIP-seq
MIRT999881	hsa-miR-1178	CLIP-seq
MIRT2230330	hsa-miR-1252	CLIP-seq
MIRT2230331	hsa-miR-1264	CLIP-seq
MIRT999883	hsa-miR-1539	CLIP-seq
MIRT999888	hsa-miR-191	CLIP-seq
MIRT999889	hsa-miR-1915	CLIP-seq
MIRT999891	hsa-miR-19a	CLIP-seq
MIRT999892	hsa-miR-19b	CLIP-seq
MIRT999893	hsa-miR-2113	CLIP-seq
MIRT2230332	hsa-miR-2355-5p	CLIP-seq
MIRT2230333	hsa-miR-24	CLIP-seq
MIRT2230334	hsa-miR-2467-5p	CLIP-seq
MIRT2230335	hsa-miR-3148	CLIP-seq
MIRT2230336	hsa-miR-3188	CLIP-seq
MIRT2230337	hsa-miR-3618	CLIP-seq
MIRT999899	hsa-miR-3669	CLIP-seq
MIRT999900	hsa-miR-3671	CLIP-seq
MIRT2230338	hsa-miR-3679-3p	CLIP-seq
MIRT2230339	hsa-miR-3691-3p	CLIP-seq
MIRT999901	hsa-miR-371b-3p	CLIP-seq
MIRT2230340	hsa-miR-3975	CLIP-seq
MIRT2230341	hsa-miR-4291	CLIP-seq
MIRT2230342	hsa-miR-431	CLIP-seq
MIRT2230343	hsa-miR-4310	CLIP-seq
MIRT2230344	hsa-miR-4328	CLIP-seq
MIRT999906	hsa-miR-433	CLIP-seq
MIRT1996357	hsa-miR-4426	CLIP-seq
MIRT2230345	hsa-miR-4476	CLIP-seq
MIRT999909	hsa-miR-4488	CLIP-seq
MIRT2230346	hsa-miR-4517	CLIP-seq
MIRT999914	hsa-miR-4519	CLIP-seq
MIRT999915	hsa-miR-4532	CLIP-seq
MIRT2230347	hsa-miR-4533	CLIP-seq
MIRT1996359	hsa-miR-4647	CLIP-seq
MIRT1996360	hsa-miR-4662b	CLIP-seq
MIRT999917	hsa-miR-4697-5p	CLIP-seq
MIRT999918	hsa-miR-4701-5p	CLIP-seq
MIRT2230348	hsa-miR-4709-5p	CLIP-seq
MIRT2230349	hsa-miR-4753-3p	CLIP-seq
MIRT2230350	hsa-miR-485-5p	CLIP-seq
MIRT999923	hsa-miR-499a-5p	CLIP-seq
MIRT999924	hsa-miR-518a-5p	CLIP-seq
MIRT999925	hsa-miR-527	CLIP-seq
MIRT2230351	hsa-miR-582-5p	CLIP-seq
MIRT999928	hsa-miR-588	CLIP-seq
MIRT2230352	hsa-miR-593	CLIP-seq
MIRT2230353	hsa-miR-600	CLIP-seq
MIRT999929	hsa-miR-607	CLIP-seq
MIRT2230354	hsa-miR-654-3p	CLIP-seq
MIRT2230355	hsa-miR-759	CLIP-seq
MIRT2230356	hsa-miR-934	CLIP-seq
MIRT999924	hsa-miR-518a-5p	CLIP-seq
MIRT999925	hsa-miR-527	CLIP-seq
MIRT2534217	hsa-miR-10a	CLIP-seq
MIRT2534218	hsa-miR-10b	CLIP-seq
MIRT2534219	hsa-miR-1283	CLIP-seq
MIRT2534220	hsa-miR-142-3p	CLIP-seq
MIRT2534221	hsa-miR-3124-3p	CLIP-seq
MIRT2534222	hsa-miR-3138	CLIP-seq
MIRT2534223	hsa-miR-4323	CLIP-seq
MIRT2534224	hsa-miR-4474-3p	CLIP-seq
MIRT2534225	hsa-miR-4758-3p	CLIP-seq
MIRT2534226	hsa-miR-4796-3p	CLIP-seq
MIRT2534227	hsa-miR-520d-5p	CLIP-seq
MIRT2534228	hsa-miR-520g	CLIP-seq
MIRT2534229	hsa-miR-520h	CLIP-seq
MIRT2534230	hsa-miR-524-5p	CLIP-seq
MIRT2534231	hsa-miR-642a	CLIP-seq
MIRT2534232	hsa-miR-644	CLIP-seq
MIRT2534233	hsa-miR-648	CLIP-seq
MIRT2534234	hsa-miR-767-3p	CLIP-seq
MIRT2534217	hsa-miR-10a	CLIP-seq
MIRT2534218	hsa-miR-10b	CLIP-seq
MIRT2681069	hsa-miR-1238	CLIP-seq
MIRT2534219	hsa-miR-1283	CLIP-seq
MIRT2534220	hsa-miR-142-3p	CLIP-seq
MIRT2534221	hsa-miR-3124-3p	CLIP-seq
MIRT2534222	hsa-miR-3138	CLIP-seq
MIRT2534223	hsa-miR-4323	CLIP-seq
MIRT2534224	hsa-miR-4474-3p	CLIP-seq
MIRT2534225	hsa-miR-4758-3p	CLIP-seq
MIRT2534226	hsa-miR-4796-3p	CLIP-seq
MIRT2534227	hsa-miR-520d-5p	CLIP-seq
MIRT2534228	hsa-miR-520g	CLIP-seq
MIRT2534229	hsa-miR-520h	CLIP-seq
MIRT2534230	hsa-miR-524-5p	CLIP-seq
MIRT2534231	hsa-miR-642a	CLIP-seq
MIRT2534232	hsa-miR-644	CLIP-seq
MIRT2534233	hsa-miR-648	CLIP-seq
MIRT2681070	hsa-miR-656	CLIP-seq
MIRT2534234	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016301	Function	Kinase activity	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016301	Function	Kinase activity	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0043687	Process	Post-translational protein modification	TAS
GO:0102193	Function	Protein-ribulosamine 3-kinase activity	IEA

Other IDs

• MIM: 611683
• HGNC: 25700
• e!Ensembl: ENSG00000141560

Protein

• UniProt ID: Q9HA64
• Protein name: Ketosamine-3-kinase (EC 2.7.1.172) (Fructosamine-3-kinase-related protein) (FN3K-RP) (FN3K-related protein) (Protein-psicosamine 3-kinase FN3KRP) (EC 2.7.1.-)
• Protein function: Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively (PubMed:14633848, PubMe
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03881	Fructosamin_kin	2 → 309	Fructosamine kinase	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed; except in skeletal muscle where it is expressed at very low level (PubMed:15331600). Expressed in erythrocytes (PubMed:15137908). {ECO:0000269|PubMed:15137908, ECO:0000269|PubMed:15331600}.
• Sequence:

  MEELLRRELGCSSVRATGHSGGGCISQGRSYDTDQGRVFVKVNPKAEARRMFEGEMASLT
  AILKTNTVKVPKPIKVLDAPGGGSVLVMEHMDMRHLSSHAAKLGAQLADLHLDNKKLGEM
  RLKEAGTVGRGGGQEERPFVARFGFDVVTCCGYLPQVNDWQEDWVVFYARQRIQPQMDMV
  EKESGDREALQLWSALQLKIPDLFRDLEIIPALLHGDLWGGNVAEDSSGPVIFDPASFYG
  HSEYELAIAGMFGGFSSSFYSAYHGKIPKAPGFEKRLQLYQLFHYLNHWNHFGSGYRGSS
  LNIMRNLVK

• Sequence length: 309

Pathways

Reactome:

Gamma carboxylation, hypusine formation and arylsulfatase activation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Obesity	Obesity	BEFREE	27193597		★☆☆☆☆ Found in Text Mining only