Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79668
Gene name	Poly(ADP-ribose) polymerase family member 8
Gene symbol	PARP8
Synonyms (NCBI Gene)	ARTD16pART16
Chromosome	5
Chromosome location	5q11.1

138

Show/Hide all (138)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000732	hsa-miR-145-5p	Review	19574400
MIRT1214591	hsa-miR-1231	CLIP-seq
MIRT1214592	hsa-miR-1286	CLIP-seq
MIRT1214593	hsa-miR-1323	CLIP-seq
MIRT1214594	hsa-miR-1324	CLIP-seq
MIRT1214595	hsa-miR-2276	CLIP-seq
MIRT1214596	hsa-miR-28-3p	CLIP-seq
MIRT1214597	hsa-miR-3129-3p	CLIP-seq
MIRT1214598	hsa-miR-3148	CLIP-seq
MIRT1214599	hsa-miR-3149	CLIP-seq
MIRT1214600	hsa-miR-3188	CLIP-seq
MIRT1214601	hsa-miR-346	CLIP-seq
MIRT1214602	hsa-miR-3655	CLIP-seq
MIRT1214603	hsa-miR-3662	CLIP-seq
MIRT1214604	hsa-miR-376a	CLIP-seq
MIRT1214605	hsa-miR-376b	CLIP-seq
MIRT1214606	hsa-miR-3908	CLIP-seq
MIRT1214607	hsa-miR-3942-5p	CLIP-seq
MIRT1214608	hsa-miR-4288	CLIP-seq
MIRT1214609	hsa-miR-4446-3p	CLIP-seq
MIRT1214610	hsa-miR-4656	CLIP-seq
MIRT1214611	hsa-miR-4659a-3p	CLIP-seq
MIRT1214612	hsa-miR-4659b-3p	CLIP-seq
MIRT1214613	hsa-miR-4680-3p	CLIP-seq
MIRT1214614	hsa-miR-4703-5p	CLIP-seq
MIRT1214615	hsa-miR-4722-5p	CLIP-seq
MIRT1214616	hsa-miR-4766-3p	CLIP-seq
MIRT1214617	hsa-miR-4772-3p	CLIP-seq
MIRT1214618	hsa-miR-548n	CLIP-seq
MIRT1214619	hsa-miR-548o	CLIP-seq
MIRT1214620	hsa-miR-578	CLIP-seq
MIRT1214621	hsa-miR-583	CLIP-seq
MIRT1214622	hsa-miR-632	CLIP-seq
MIRT1214623	hsa-miR-664	CLIP-seq
MIRT1214624	hsa-miR-1238	CLIP-seq
MIRT1214625	hsa-miR-1277	CLIP-seq
MIRT1214626	hsa-miR-141	CLIP-seq
MIRT1214627	hsa-miR-1972	CLIP-seq
MIRT1214628	hsa-miR-198	CLIP-seq
MIRT1214629	hsa-miR-200a	CLIP-seq
MIRT1214630	hsa-miR-216a	CLIP-seq
MIRT1214631	hsa-miR-297	CLIP-seq
MIRT1214632	hsa-miR-3121-3p	CLIP-seq
MIRT1214633	hsa-miR-3153	CLIP-seq
MIRT1214634	hsa-miR-3657	CLIP-seq
MIRT1214603	hsa-miR-3662	CLIP-seq
MIRT1214635	hsa-miR-371-5p	CLIP-seq
MIRT1214636	hsa-miR-371b-5p	CLIP-seq
MIRT1214637	hsa-miR-374a	CLIP-seq
MIRT1214638	hsa-miR-374b	CLIP-seq
MIRT1214604	hsa-miR-376a	CLIP-seq
MIRT1214605	hsa-miR-376b	CLIP-seq
MIRT1214639	hsa-miR-4275	CLIP-seq
MIRT1214640	hsa-miR-4277	CLIP-seq
MIRT1214641	hsa-miR-4330	CLIP-seq
MIRT1214642	hsa-miR-4648	CLIP-seq
MIRT1214643	hsa-miR-4654	CLIP-seq
MIRT1214644	hsa-miR-4668-5p	CLIP-seq
MIRT1214645	hsa-miR-4669	CLIP-seq
MIRT1214646	hsa-miR-4698	CLIP-seq
MIRT1214647	hsa-miR-4712-5p	CLIP-seq
MIRT1214648	hsa-miR-4769-5p	CLIP-seq
MIRT1214649	hsa-miR-4775	CLIP-seq
MIRT1214650	hsa-miR-4778-3p	CLIP-seq
MIRT1214651	hsa-miR-520d-5p	CLIP-seq
MIRT1214652	hsa-miR-524-5p	CLIP-seq
MIRT1214653	hsa-miR-549	CLIP-seq
MIRT1214654	hsa-miR-567	CLIP-seq
MIRT1214655	hsa-miR-590-3p	CLIP-seq
MIRT1214656	hsa-miR-606	CLIP-seq
MIRT1214657	hsa-miR-770-5p	CLIP-seq
MIRT2061763	hsa-let-7a	CLIP-seq
MIRT2061764	hsa-let-7b	CLIP-seq
MIRT2061765	hsa-let-7c	CLIP-seq
MIRT2061766	hsa-let-7d	CLIP-seq
MIRT2061767	hsa-let-7e	CLIP-seq
MIRT2061768	hsa-let-7f	CLIP-seq
MIRT2061769	hsa-let-7g	CLIP-seq
MIRT2061770	hsa-let-7i	CLIP-seq
MIRT2061771	hsa-miR-105	CLIP-seq
MIRT2061772	hsa-miR-1206	CLIP-seq
MIRT2061773	hsa-miR-1262	CLIP-seq
MIRT2061774	hsa-miR-142-3p	CLIP-seq
MIRT2061775	hsa-miR-196a	CLIP-seq
MIRT2061776	hsa-miR-196b	CLIP-seq
MIRT2061777	hsa-miR-202	CLIP-seq
MIRT2061778	hsa-miR-3127-3p	CLIP-seq
MIRT2061779	hsa-miR-3145-5p	CLIP-seq
MIRT2061780	hsa-miR-369-3p	CLIP-seq
MIRT1214635	hsa-miR-371-5p	CLIP-seq
MIRT1214636	hsa-miR-371b-5p	CLIP-seq
MIRT1214637	hsa-miR-374a	CLIP-seq
MIRT1214638	hsa-miR-374b	CLIP-seq
MIRT2061781	hsa-miR-374c	CLIP-seq
MIRT2061782	hsa-miR-376c	CLIP-seq
MIRT2061783	hsa-miR-4255	CLIP-seq
MIRT2061784	hsa-miR-4259	CLIP-seq
MIRT2061785	hsa-miR-4274	CLIP-seq
MIRT2061786	hsa-miR-4279	CLIP-seq
MIRT2061787	hsa-miR-4280	CLIP-seq
MIRT2061788	hsa-miR-431	CLIP-seq
MIRT2061789	hsa-miR-4455	CLIP-seq
MIRT2061790	hsa-miR-4458	CLIP-seq
MIRT2061791	hsa-miR-4500	CLIP-seq
MIRT2061792	hsa-miR-4519	CLIP-seq
MIRT1214611	hsa-miR-4659a-3p	CLIP-seq
MIRT1214612	hsa-miR-4659b-3p	CLIP-seq
MIRT1214613	hsa-miR-4680-3p	CLIP-seq
MIRT2061793	hsa-miR-4701-3p	CLIP-seq
MIRT1214649	hsa-miR-4775	CLIP-seq
MIRT1214650	hsa-miR-4778-3p	CLIP-seq
MIRT2061794	hsa-miR-4793-5p	CLIP-seq
MIRT2061795	hsa-miR-511	CLIP-seq
MIRT2061796	hsa-miR-526b	CLIP-seq
MIRT2061797	hsa-miR-576-3p	CLIP-seq
MIRT2061798	hsa-miR-579	CLIP-seq
MIRT2061799	hsa-miR-609	CLIP-seq
MIRT2061800	hsa-miR-655	CLIP-seq
MIRT2061801	hsa-miR-656	CLIP-seq
MIRT2061802	hsa-miR-885-5p	CLIP-seq
MIRT2061803	hsa-miR-942	CLIP-seq
MIRT2061804	hsa-miR-98	CLIP-seq
MIRT2290149	hsa-miR-3163	CLIP-seq
MIRT2290150	hsa-miR-4699-3p	CLIP-seq
MIRT1214651	hsa-miR-520d-5p	CLIP-seq
MIRT1214652	hsa-miR-524-5p	CLIP-seq
MIRT2290151	hsa-miR-1914	CLIP-seq
MIRT1214607	hsa-miR-3942-5p	CLIP-seq
MIRT1214639	hsa-miR-4275	CLIP-seq
MIRT2290152	hsa-miR-4684-3p	CLIP-seq
MIRT1214614	hsa-miR-4703-5p	CLIP-seq
MIRT2290153	hsa-miR-657	CLIP-seq
MIRT2455941	hsa-miR-138	CLIP-seq
MIRT2290149	hsa-miR-3163	CLIP-seq
MIRT2455942	hsa-miR-3650	CLIP-seq
MIRT2455943	hsa-miR-3688-5p	CLIP-seq
MIRT2455944	hsa-miR-548c-3p	CLIP-seq
MIRT2455945	hsa-miR-644	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IBA
GO:0003950	Function	NAD+ poly-ADP-ribosyltransferase activity	IEA
GO:0005635	Component	Nuclear envelope	IBA
GO:0016020	Component	Membrane	IBA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0016779	Function	Nucleotidyltransferase activity	IEA
GO:0019900	Function	Kinase binding	IBA
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IBA
GO:0043539	Function	Protein serine/threonine kinase activator activity	IBA
GO:0070213	Process	Protein auto-ADP-ribosylation	IDA	25043379
GO:0071782	Component	Endoplasmic reticulum tubular network	IBA
GO:0140803	Function	NAD+-protein-cysteine ADP-ribosyltransferase activity	IEA
GO:1990404	Function	NAD+-protein mono-ADP-ribosyltransferase activity	IDA	25043379

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8N3A8

Protein name

Protein mono-ADP-ribosyltransferase PARP8 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 16) (ARTD16) (Poly [ADP-ribose] polymerase 8) (PARP-8)

Protein function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00644	PARP	675 → 817	Poly(ADP-ribose) polymerase catalytic domain	Family

Sequence

MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYVGGPRSVSYSVHVSEDY
PDNTYVSSSENDEDVLVTTEPIPVIFHRIATELRKTNDINCCLSIKSKLQKENGEESRQN
STVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSAVREIYGPHAVSLREYGAIDD
VDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQYLNGPVPTVDVFQISTKERFGL
GHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKVKSPLHLFSTLRRSPSYPPPGCGKS
KSKLKSEQDGISKTHKLLRRTCSSTVKTDDVCVTKSHRTFGRSLSSDPRAEQAMTAIKSH
KLLNRPCPAAVKSEECLTLKSHRLLTRSCSGDPRCEHNTNLKPHKLLSRSYSSNLRMEEL
YGLKNHKLLSKSYSSAPKSSKTELFKEPNAEGRRLSLTSGLIGILTPSSSSSSQLAPNGA
KCIPVRDRGFLVQTIEFAEQRIPVLNEYCVVCDEPHVFQNGPMLRPTVCERELCVFAFQT
LGVMNEAADEIATGAQVVDLLVSMCRSALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKK
NYDRVMKALDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQ
LKFMHTPHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRL
QLHGAMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKSSNTSQSQKKGQQSQFL
QSRNLKCIALCEVITSSDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIH
KEILRVIGNQTATG

Sequence length

854

Interactions

View interactions

	Reactome
			Nicotinamide salvaging

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMBLYOPIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPEROPIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROBLASTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	GWASCAT_DG	29059683		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	37239316	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal melanoma	Pubtator	37033251, 37142279	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PARP8 (poly(ADP-ribose) polymerase family member 8)