Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	79663
Gene name	HSPB1 associated protein 1
Gene symbol	HSPBAP1
Synonyms (NCBI Gene)	PASS1
Chromosome	3
Chromosome location	3q21.1
Summary	This gene encodes a protein that binds to one of the small heat shock proteins, specifically hsp27. Hsp27 is involved with cell growth and differentiation. This encoded protein was found to be abnormally expressed in patients with intractable epilepsy, al

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024673	hsa-miR-215-5p	Microarray	19074876
MIRT026793	hsa-miR-192-5p	Microarray	19074876
MIRT1056599	hsa-miR-1	CLIP-seq
MIRT1056600	hsa-miR-1276	CLIP-seq
MIRT1056601	hsa-miR-206	CLIP-seq
MIRT1056602	hsa-miR-2278	CLIP-seq
MIRT1056603	hsa-miR-3125	CLIP-seq
MIRT1056604	hsa-miR-3187-3p	CLIP-seq
MIRT1056605	hsa-miR-380	CLIP-seq
MIRT1056606	hsa-miR-3916	CLIP-seq
MIRT1056607	hsa-miR-3926	CLIP-seq
MIRT1056608	hsa-miR-4435	CLIP-seq
MIRT1056609	hsa-miR-4676-5p	CLIP-seq
MIRT1056610	hsa-miR-4701-5p	CLIP-seq
MIRT1056611	hsa-miR-4798-5p	CLIP-seq
MIRT1056612	hsa-miR-548s	CLIP-seq
MIRT1056613	hsa-miR-575	CLIP-seq
MIRT1056614	hsa-miR-583	CLIP-seq
MIRT1056615	hsa-miR-588	CLIP-seq
MIRT1056616	hsa-miR-613	CLIP-seq
MIRT2245233	hsa-miR-1304	CLIP-seq
MIRT2245234	hsa-miR-133a	CLIP-seq
MIRT2245235	hsa-miR-133b	CLIP-seq
MIRT2245236	hsa-miR-2467-5p	CLIP-seq
MIRT2245237	hsa-miR-3188	CLIP-seq
MIRT2245238	hsa-miR-3975	CLIP-seq
MIRT2245239	hsa-miR-4281	CLIP-seq
MIRT2245240	hsa-miR-4292	CLIP-seq
MIRT2245241	hsa-miR-4308	CLIP-seq
MIRT2245242	hsa-miR-485-5p	CLIP-seq
MIRT2245243	hsa-miR-518a-5p	CLIP-seq
MIRT2245244	hsa-miR-527	CLIP-seq
MIRT2245245	hsa-miR-548a-5p	CLIP-seq
MIRT2245246	hsa-miR-548ab	CLIP-seq
MIRT2245247	hsa-miR-548ak	CLIP-seq
MIRT2245248	hsa-miR-548b-5p	CLIP-seq
MIRT2245249	hsa-miR-548c-5p	CLIP-seq
MIRT2245250	hsa-miR-548d-5p	CLIP-seq
MIRT2245251	hsa-miR-548h	CLIP-seq
MIRT2245252	hsa-miR-548i	CLIP-seq
MIRT2245253	hsa-miR-548j	CLIP-seq
MIRT2245254	hsa-miR-548n	CLIP-seq
MIRT2245255	hsa-miR-548w	CLIP-seq
MIRT2245256	hsa-miR-548y	CLIP-seq
MIRT2245257	hsa-miR-559	CLIP-seq
MIRT2245258	hsa-miR-563	CLIP-seq
MIRT1056599	hsa-miR-1	CLIP-seq
MIRT2548418	hsa-miR-1255a	CLIP-seq
MIRT2548419	hsa-miR-1255b	CLIP-seq
MIRT1056600	hsa-miR-1276	CLIP-seq
MIRT2548420	hsa-miR-138	CLIP-seq
MIRT2548421	hsa-miR-19a	CLIP-seq
MIRT2548422	hsa-miR-19b	CLIP-seq
MIRT1056601	hsa-miR-206	CLIP-seq
MIRT1056602	hsa-miR-2278	CLIP-seq
MIRT1056603	hsa-miR-3125	CLIP-seq
MIRT1056604	hsa-miR-3187-3p	CLIP-seq
MIRT1056605	hsa-miR-380	CLIP-seq
MIRT1056606	hsa-miR-3916	CLIP-seq
MIRT1056607	hsa-miR-3926	CLIP-seq
MIRT2548423	hsa-miR-3928	CLIP-seq
MIRT1056608	hsa-miR-4435	CLIP-seq
MIRT2548424	hsa-miR-4438	CLIP-seq
MIRT1056609	hsa-miR-4676-5p	CLIP-seq
MIRT1056610	hsa-miR-4701-5p	CLIP-seq
MIRT2548425	hsa-miR-4712-3p	CLIP-seq
MIRT1056611	hsa-miR-4798-5p	CLIP-seq
MIRT2548426	hsa-miR-520d-5p	CLIP-seq
MIRT2548427	hsa-miR-524-5p	CLIP-seq
MIRT2548428	hsa-miR-548l	CLIP-seq
MIRT2245254	hsa-miR-548n	CLIP-seq
MIRT1056612	hsa-miR-548s	CLIP-seq
MIRT2548429	hsa-miR-548t	CLIP-seq
MIRT1056613	hsa-miR-575	CLIP-seq
MIRT1056614	hsa-miR-583	CLIP-seq
MIRT1056615	hsa-miR-588	CLIP-seq
MIRT1056616	hsa-miR-613	CLIP-seq
MIRT2548430	hsa-miR-642b	CLIP-seq
MIRT2548418	hsa-miR-1255a	CLIP-seq
MIRT2548419	hsa-miR-1255b	CLIP-seq
MIRT1056600	hsa-miR-1276	CLIP-seq
MIRT2548420	hsa-miR-138	CLIP-seq
MIRT2548421	hsa-miR-19a	CLIP-seq
MIRT2548422	hsa-miR-19b	CLIP-seq
MIRT1056602	hsa-miR-2278	CLIP-seq
MIRT1056603	hsa-miR-3125	CLIP-seq
MIRT1056604	hsa-miR-3187-3p	CLIP-seq
MIRT1056605	hsa-miR-380	CLIP-seq
MIRT1056606	hsa-miR-3916	CLIP-seq
MIRT1056607	hsa-miR-3926	CLIP-seq
MIRT2548423	hsa-miR-3928	CLIP-seq
MIRT1056608	hsa-miR-4435	CLIP-seq
MIRT2548424	hsa-miR-4438	CLIP-seq
MIRT1056609	hsa-miR-4676-5p	CLIP-seq
MIRT1056610	hsa-miR-4701-5p	CLIP-seq
MIRT2548425	hsa-miR-4712-3p	CLIP-seq
MIRT1056611	hsa-miR-4798-5p	CLIP-seq
MIRT2548426	hsa-miR-520d-5p	CLIP-seq
MIRT2548427	hsa-miR-524-5p	CLIP-seq
MIRT2548428	hsa-miR-548l	CLIP-seq
MIRT2245254	hsa-miR-548n	CLIP-seq
MIRT1056612	hsa-miR-548s	CLIP-seq
MIRT2548429	hsa-miR-548t	CLIP-seq
MIRT1056613	hsa-miR-575	CLIP-seq
MIRT1056614	hsa-miR-583	CLIP-seq
MIRT1056615	hsa-miR-588	CLIP-seq
MIRT2548430	hsa-miR-642b	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24981860, 25416956, 28514442, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0016706	Function	2-oxoglutarate-dependent dioxygenase activity	IBA

MIM	HGNC	e!Ensembl
608263	16389	ENSG00000169087

Q96EW2

Protein name

HSPB1-associated protein 1 (27 kDa heat shock protein-associated protein 1) (Protein associated with small stress protein 1)

Protein function

May play a role in cellular stress response.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13621	Cupin_8	30 → 279	Cupin-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11978969}.

Sequence

MAAGSEATTPVIVAAGAGGEEGEHVKPFKPEKAKEIIMSLQQPAIFCNMVFDWPARHWNA
KYLSQVLHGKQIRFRMGMKSMSTVPQFETTCNYVEATLEEFLTWNCDQSSISGPFRDYDH
SKFWAYADYKYFVSLFEDKTDLFQDVKWSDFGFPGRNGQESTLWIGSLGAHTPCHLDSYG
CNLVFQVQGRKRWHLFPPEDTPFLYPTRIPYEESSVFSKINVVNPDLKRFPQFRKAQRHA
VTLSPGQVLFVPRHWWHYVESIDPVTVSINSWIELEEDHLARVEEAITRMLVCALKTAEN
PQNTRAWLNPTEVEETSHAVNCCYLNAAVSAFFDRCRTSEVVEIQALRTDGEHMKKEELN
VCNHMEVGQTGSQNLTTGTDKPEAASPFGPDLVPVAQRSEEPPSERGGIFGSDGKDFVDK
DGEHFGKLHCAKRQQIMSNSENAIEEQIASNTTTTPQTFISTDDLLDCLVNPQVTRIVAQ
LLIQGRSL

Sequence length

488

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL HEART SEPTAL DEFECT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART SEPTAL DEFECT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	25798051	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	30524971		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	17568411		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	LHGDN	17568411		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary clear cell renal cell carcinoma	Hereditary Renal Carcinoma	ORPHANET_DG	12939738		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary clear cell renal cell carcinoma	Hereditary Renal Carcinoma	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	25359680		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	25359680		★★★★★ ★☆☆☆☆ Found in Text Mining only

HSPBAP1 (HSPB1 associated protein 1)