RPAP3 (RNA polymerase II associated protein 3)

Gene

• Entrez ID: 79657
• Gene name: RNA polymerase II associated protein 3
• Gene symbol: RPAP3
• Synonyms (NCBI Gene): Tah1, hSpagh
• Chromosome: 12
• Chromosome location: 12q13.11
• Summary: This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT026636	hsa-miR-192-5p	Microarray	19074876
MIRT1315484	hsa-miR-194	CLIP-seq
MIRT1315485	hsa-miR-3074-5p	CLIP-seq
MIRT1315486	hsa-miR-3124-3p	CLIP-seq
MIRT1315487	hsa-miR-3163	CLIP-seq
MIRT1315488	hsa-miR-3201	CLIP-seq
MIRT1315489	hsa-miR-3647-3p	CLIP-seq
MIRT1315490	hsa-miR-370	CLIP-seq
MIRT1315491	hsa-miR-380	CLIP-seq
MIRT1315492	hsa-miR-409-3p	CLIP-seq
MIRT1315493	hsa-miR-410	CLIP-seq
MIRT1315494	hsa-miR-4475	CLIP-seq
MIRT1315495	hsa-miR-4495	CLIP-seq
MIRT1315496	hsa-miR-4540	CLIP-seq
MIRT1315497	hsa-miR-4662a-3p	CLIP-seq
MIRT1315498	hsa-miR-4791	CLIP-seq
MIRT1315499	hsa-miR-4802-3p	CLIP-seq
MIRT1315500	hsa-miR-490-5p	CLIP-seq
MIRT1315501	hsa-miR-548c-3p	CLIP-seq
MIRT1315502	hsa-miR-1179	CLIP-seq
MIRT1315503	hsa-miR-1229	CLIP-seq
MIRT1315504	hsa-miR-1289	CLIP-seq
MIRT1315505	hsa-miR-1299	CLIP-seq
MIRT1315506	hsa-miR-1825	CLIP-seq
MIRT1315507	hsa-miR-2392	CLIP-seq
MIRT1315508	hsa-miR-3143	CLIP-seq
MIRT1315509	hsa-miR-3150a-3p	CLIP-seq
MIRT1315510	hsa-miR-3175	CLIP-seq
MIRT1315511	hsa-miR-3605-5p	CLIP-seq
MIRT1315512	hsa-miR-3614-5p	CLIP-seq
MIRT1315513	hsa-miR-3662	CLIP-seq
MIRT1315514	hsa-miR-374c	CLIP-seq
MIRT1315515	hsa-miR-3908	CLIP-seq
MIRT1315516	hsa-miR-3942-3p	CLIP-seq
MIRT1315517	hsa-miR-3942-5p	CLIP-seq
MIRT1315518	hsa-miR-4277	CLIP-seq
MIRT1315519	hsa-miR-4282	CLIP-seq
MIRT1315520	hsa-miR-4422	CLIP-seq
MIRT1315521	hsa-miR-4666-3p	CLIP-seq
MIRT1315522	hsa-miR-4666-5p	CLIP-seq
MIRT1315523	hsa-miR-4699-5p	CLIP-seq
MIRT1315524	hsa-miR-4703-5p	CLIP-seq
MIRT1315525	hsa-miR-4766-3p	CLIP-seq
MIRT1315526	hsa-miR-4782-5p	CLIP-seq
MIRT1315527	hsa-miR-4797-5p	CLIP-seq
MIRT1315528	hsa-miR-4799-5p	CLIP-seq
MIRT1315499	hsa-miR-4802-3p	CLIP-seq
MIRT1315529	hsa-miR-513a-3p	CLIP-seq
MIRT1315530	hsa-miR-516b	CLIP-seq
MIRT1315531	hsa-miR-520d-5p	CLIP-seq
MIRT1315532	hsa-miR-520f	CLIP-seq
MIRT1315533	hsa-miR-524-5p	CLIP-seq
MIRT1315534	hsa-miR-543	CLIP-seq
MIRT1315535	hsa-miR-582-3p	CLIP-seq
MIRT1315536	hsa-miR-582-5p	CLIP-seq
MIRT1315537	hsa-miR-600	CLIP-seq
MIRT1315538	hsa-miR-655	CLIP-seq
MIRT1315539	hsa-miR-765	CLIP-seq
MIRT1315540	hsa-miR-939	CLIP-seq
MIRT2093865	hsa-miR-548ag	CLIP-seq
MIRT2093866	hsa-miR-548ai	CLIP-seq
MIRT2093867	hsa-miR-548m	CLIP-seq
MIRT2318376	hsa-miR-19a	CLIP-seq
MIRT2318377	hsa-miR-19b	CLIP-seq
MIRT2318378	hsa-miR-3663-3p	CLIP-seq
MIRT2318379	hsa-miR-455-5p	CLIP-seq
MIRT1315531	hsa-miR-520d-5p	CLIP-seq
MIRT1315533	hsa-miR-524-5p	CLIP-seq
MIRT1315514	hsa-miR-374c	CLIP-seq
MIRT1315515	hsa-miR-3908	CLIP-seq
MIRT1315517	hsa-miR-3942-5p	CLIP-seq
MIRT1315524	hsa-miR-4703-5p	CLIP-seq
MIRT1315525	hsa-miR-4766-3p	CLIP-seq
MIRT1315538	hsa-miR-655	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	18538670, 19875381, 20864032, 21044950, 21078300, 21360678, 24794838, 24965446, 25036637, 25544563, 28561026, 33961781, 35271311
GO:0005829	Component	Cytosol	IDA
GO:0005929	Component	Cilium	IDA
GO:0036064	Component	Ciliary basal body	IDA
GO:0050821	Process	Protein stabilization	NAS	29662061, 29844425, 31738558
GO:0097255	Component	R2TP complex	IDA	26711270
GO:0097255	Component	R2TP complex	IPI	29662061
GO:0101031	Component	Protein folding chaperone complex	IPI	29844425
GO:1990062	Component	RPAP3/R2TP/prefoldin-like complex	IPI	31738558

Other IDs

• MIM: 611477
• HGNC: 26151
• e!Ensembl: ENSG00000005175

Protein

• UniProt ID: Q9H6T3
• Protein name: RNA polymerase II-associated protein 3
• Protein function: Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.
• PDB: 4CGV, 4CGW, 6EZ4, 6FD7, 6FDP, 6FDT, 6FM8, 6FO1, 6GXZ, 6ZBK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00515	TPR_1	133 → 166	Tetratricopeptide repeat	Repeat
  PF00515	TPR_1	201 → 234	Tetratricopeptide repeat	Repeat
  PF13176	TPR_7	288 → 317	Tetratricopeptide repeat	Repeat
  PF13181	TPR_8	320 → 349	Tetratricopeptide repeat	Repeat
  PF13877	RPAP3_C	545 → 636	Potential Monad-binding region of RPAP3	Domain

• Sequence:

  MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGN
  FRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESE
  SEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRL
  KKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNE
  LRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYER
  AIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTAR
  TFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELIEKGHWDDVFLDSTQRQNVVKPI
  DNPPHPGSTKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNS
  SQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATT
  VLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHD
  FYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELK
  KRYGG

• Sequence length: 665

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations