Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	79642
Gene name	Arylsulfatase family member J
Gene symbol	ARSJ
Synonyms (NCBI Gene)	ASJ
Chromosome	4
Chromosome location	4q26
Summary	Sulfatases (EC 3.1.5.6), such as ARSJ, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027478	hsa-miR-98-5p	Microarray	19088304
MIRT027943	hsa-miR-93-5p	Sequencing	20371350
MIRT524830	hsa-miR-3121-3p	PAR-CLIP	20371350
MIRT524829	hsa-miR-3163	PAR-CLIP	20371350
MIRT524828	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT524827	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT524825	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT524824	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT559453	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT559452	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT559451	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT559450	hsa-miR-4262	PAR-CLIP	21572407
MIRT559449	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT027943	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT559448	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT559447	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT559446	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT559445	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT559444	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT559443	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT559442	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT559441	hsa-miR-3609	PAR-CLIP	21572407
MIRT559440	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT559439	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT559438	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT559436	hsa-miR-4289	PAR-CLIP	21572407
MIRT559437	hsa-miR-628-3p	PAR-CLIP	21572407
MIRT559435	hsa-miR-325	PAR-CLIP	21572407
MIRT559433	hsa-miR-4417	PAR-CLIP	21572407
MIRT559434	hsa-miR-22-5p	PAR-CLIP	21572407
MIRT559432	hsa-miR-4265	PAR-CLIP	21572407
MIRT559431	hsa-miR-4296	PAR-CLIP	21572407
MIRT559430	hsa-miR-4322	PAR-CLIP	21572407
MIRT559429	hsa-miR-6796-5p	PAR-CLIP	21572407
MIRT559428	hsa-miR-6759-5p	PAR-CLIP	21572407
MIRT559427	hsa-miR-4659a-3p	PAR-CLIP	21572407
MIRT559426	hsa-miR-4659b-3p	PAR-CLIP	21572407
MIRT524830	hsa-miR-3121-3p	PAR-CLIP	23446348
MIRT524829	hsa-miR-3163	PAR-CLIP	23446348
MIRT524828	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT524827	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT524826	hsa-miR-494-3p	PAR-CLIP	23446348
MIRT524825	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524824	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT524830	hsa-miR-3121-3p	PAR-CLIP	20371350
MIRT524829	hsa-miR-3163	PAR-CLIP	20371350
MIRT524828	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT524827	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT524825	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT524824	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT559453	hsa-miR-181a-5p	PAR-CLIP	21572407
MIRT559452	hsa-miR-181b-5p	PAR-CLIP	21572407
MIRT559451	hsa-miR-181d-5p	PAR-CLIP	21572407
MIRT559450	hsa-miR-4262	PAR-CLIP	21572407
MIRT559449	hsa-miR-181c-5p	PAR-CLIP	21572407
MIRT027943	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT559448	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT559447	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT559446	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT559445	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT559444	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT559443	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT559442	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT559441	hsa-miR-3609	PAR-CLIP	21572407
MIRT559440	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT559439	hsa-miR-4796-3p	PAR-CLIP	21572407
MIRT559438	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT559436	hsa-miR-4289	PAR-CLIP	21572407
MIRT559437	hsa-miR-628-3p	PAR-CLIP	21572407
MIRT559435	hsa-miR-325	PAR-CLIP	21572407
MIRT559433	hsa-miR-4417	PAR-CLIP	21572407
MIRT559434	hsa-miR-22-5p	PAR-CLIP	21572407
MIRT559432	hsa-miR-4265	PAR-CLIP	21572407
MIRT559431	hsa-miR-4296	PAR-CLIP	21572407
MIRT559430	hsa-miR-4322	PAR-CLIP	21572407
MIRT559429	hsa-miR-6796-5p	PAR-CLIP	21572407
MIRT559428	hsa-miR-6759-5p	PAR-CLIP	21572407
MIRT559427	hsa-miR-4659a-3p	PAR-CLIP	21572407
MIRT559426	hsa-miR-4659b-3p	PAR-CLIP	21572407
MIRT524830	hsa-miR-3121-3p	PAR-CLIP	23446348
MIRT524829	hsa-miR-3163	PAR-CLIP	23446348
MIRT524828	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT524827	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT524826	hsa-miR-494-3p	PAR-CLIP	23446348
MIRT524825	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524824	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1545579	hsa-miR-1245b-5p	CLIP-seq
MIRT1545580	hsa-miR-1304	CLIP-seq
MIRT1545581	hsa-miR-3136-5p	CLIP-seq
MIRT1545582	hsa-miR-3142	CLIP-seq
MIRT1545583	hsa-miR-3922-5p	CLIP-seq
MIRT1545584	hsa-miR-4439	CLIP-seq
MIRT1545585	hsa-miR-642b	CLIP-seq
MIRT1545586	hsa-miR-943	CLIP-seq
MIRT2176417	hsa-miR-106a	CLIP-seq
MIRT2176418	hsa-miR-106b	CLIP-seq
MIRT2176419	hsa-miR-1193	CLIP-seq
MIRT2176420	hsa-miR-154	CLIP-seq
MIRT2176421	hsa-miR-17	CLIP-seq
MIRT2176422	hsa-miR-181a	CLIP-seq
MIRT2176423	hsa-miR-181b	CLIP-seq
MIRT2176424	hsa-miR-181c	CLIP-seq
MIRT2176425	hsa-miR-181d	CLIP-seq
MIRT2176426	hsa-miR-203	CLIP-seq
MIRT2176427	hsa-miR-20a	CLIP-seq
MIRT2176428	hsa-miR-20b	CLIP-seq
MIRT2176429	hsa-miR-2116	CLIP-seq
MIRT1545581	hsa-miR-3136-5p	CLIP-seq
MIRT2176430	hsa-miR-34a	CLIP-seq
MIRT2176431	hsa-miR-34c-5p	CLIP-seq
MIRT2176432	hsa-miR-3616-3p	CLIP-seq
MIRT2176433	hsa-miR-371-5p	CLIP-seq
MIRT2176434	hsa-miR-4266	CLIP-seq
MIRT2176435	hsa-miR-4293	CLIP-seq
MIRT2176436	hsa-miR-4302	CLIP-seq
MIRT2176437	hsa-miR-4327	CLIP-seq
MIRT1545584	hsa-miR-4439	CLIP-seq
MIRT2176438	hsa-miR-449a	CLIP-seq
MIRT2176439	hsa-miR-449b	CLIP-seq
MIRT2176440	hsa-miR-4661-3p	CLIP-seq
MIRT2176441	hsa-miR-4677-5p	CLIP-seq
MIRT2176442	hsa-miR-4754	CLIP-seq
MIRT2176443	hsa-miR-4760-3p	CLIP-seq
MIRT2176444	hsa-miR-519d	CLIP-seq
MIRT2176445	hsa-miR-543	CLIP-seq
MIRT2176446	hsa-miR-548ah	CLIP-seq
MIRT2176447	hsa-miR-570	CLIP-seq
MIRT1545585	hsa-miR-642b	CLIP-seq
MIRT2176448	hsa-miR-648	CLIP-seq
MIRT2176449	hsa-miR-664	CLIP-seq
MIRT2176450	hsa-miR-93	CLIP-seq
MIRT1545586	hsa-miR-943	CLIP-seq
MIRT2479668	hsa-miR-1295	CLIP-seq
MIRT2479669	hsa-miR-138	CLIP-seq
MIRT2479670	hsa-miR-197	CLIP-seq
MIRT2479671	hsa-miR-299-5p	CLIP-seq
MIRT1545581	hsa-miR-3136-5p	CLIP-seq
MIRT2479672	hsa-miR-3664-3p	CLIP-seq
MIRT2479673	hsa-miR-3938	CLIP-seq
MIRT2479674	hsa-miR-4436a	CLIP-seq
MIRT1545584	hsa-miR-4439	CLIP-seq
MIRT2479675	hsa-miR-4496	CLIP-seq
MIRT2479676	hsa-miR-4519	CLIP-seq
MIRT2479677	hsa-miR-4659a-5p	CLIP-seq
MIRT2479678	hsa-miR-4659b-5p	CLIP-seq
MIRT2479679	hsa-miR-4717-5p	CLIP-seq
MIRT2479680	hsa-miR-4776-3p	CLIP-seq
MIRT2479681	hsa-miR-510	CLIP-seq
MIRT2176445	hsa-miR-543	CLIP-seq
MIRT2479682	hsa-miR-642a	CLIP-seq
MIRT2479683	hsa-miR-651	CLIP-seq
MIRT2479684	hsa-miR-656	CLIP-seq
MIRT1545586	hsa-miR-943	CLIP-seq
MIRT2176417	hsa-miR-106a	CLIP-seq
MIRT2176418	hsa-miR-106b	CLIP-seq
MIRT2675468	hsa-miR-1245b-3p	CLIP-seq
MIRT2675469	hsa-miR-1282	CLIP-seq
MIRT2479668	hsa-miR-1295	CLIP-seq
MIRT2479669	hsa-miR-138	CLIP-seq
MIRT2176421	hsa-miR-17	CLIP-seq
MIRT2176422	hsa-miR-181a	CLIP-seq
MIRT2176423	hsa-miR-181b	CLIP-seq
MIRT2176424	hsa-miR-181c	CLIP-seq
MIRT2176425	hsa-miR-181d	CLIP-seq
MIRT2675470	hsa-miR-196a	CLIP-seq
MIRT2675471	hsa-miR-196b	CLIP-seq
MIRT2479670	hsa-miR-197	CLIP-seq
MIRT2675472	hsa-miR-200b	CLIP-seq
MIRT2675473	hsa-miR-200c	CLIP-seq
MIRT2176426	hsa-miR-203	CLIP-seq
MIRT2176427	hsa-miR-20a	CLIP-seq
MIRT2176428	hsa-miR-20b	CLIP-seq
MIRT2176429	hsa-miR-2116	CLIP-seq
MIRT2675474	hsa-miR-299-3p	CLIP-seq
MIRT2479671	hsa-miR-299-5p	CLIP-seq
MIRT1545581	hsa-miR-3136-5p	CLIP-seq
MIRT2675475	hsa-miR-3151	CLIP-seq
MIRT2675476	hsa-miR-3170	CLIP-seq
MIRT2176430	hsa-miR-34a	CLIP-seq
MIRT2176431	hsa-miR-34c-5p	CLIP-seq
MIRT2675477	hsa-miR-3662	CLIP-seq
MIRT2479672	hsa-miR-3664-3p	CLIP-seq
MIRT2675478	hsa-miR-369-3p	CLIP-seq
MIRT2176433	hsa-miR-371-5p	CLIP-seq
MIRT2479673	hsa-miR-3938	CLIP-seq
MIRT2675479	hsa-miR-4261	CLIP-seq
MIRT2675480	hsa-miR-4279	CLIP-seq
MIRT2675481	hsa-miR-429	CLIP-seq
MIRT2176436	hsa-miR-4302	CLIP-seq
MIRT2479674	hsa-miR-4436a	CLIP-seq
MIRT1545584	hsa-miR-4439	CLIP-seq
MIRT2675482	hsa-miR-4447	CLIP-seq
MIRT2675483	hsa-miR-4472	CLIP-seq
MIRT2479675	hsa-miR-4496	CLIP-seq
MIRT2176438	hsa-miR-449a	CLIP-seq
MIRT2176439	hsa-miR-449b	CLIP-seq
MIRT2479676	hsa-miR-4519	CLIP-seq
MIRT2479677	hsa-miR-4659a-5p	CLIP-seq
MIRT2479678	hsa-miR-4659b-5p	CLIP-seq
MIRT2176441	hsa-miR-4677-5p	CLIP-seq
MIRT2479679	hsa-miR-4717-5p	CLIP-seq
MIRT2675484	hsa-miR-4757-3p	CLIP-seq
MIRT2479680	hsa-miR-4776-3p	CLIP-seq
MIRT2675485	hsa-miR-491-5p	CLIP-seq
MIRT2479681	hsa-miR-510	CLIP-seq
MIRT2176444	hsa-miR-519d	CLIP-seq
MIRT2176445	hsa-miR-543	CLIP-seq
MIRT2176446	hsa-miR-548ah	CLIP-seq
MIRT2675486	hsa-miR-548m	CLIP-seq
MIRT2479682	hsa-miR-642a	CLIP-seq
MIRT1545585	hsa-miR-642b	CLIP-seq
MIRT2176448	hsa-miR-648	CLIP-seq
MIRT2479684	hsa-miR-656	CLIP-seq
MIRT2176449	hsa-miR-664	CLIP-seq
MIRT2176450	hsa-miR-93	CLIP-seq
MIRT1545586	hsa-miR-943	CLIP-seq

Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004065	Function	Arylsulfatase activity	IEA
GO:0004065	Function	Arylsulfatase activity	TAS	16174644
GO:0005576	Component	Extracellular region	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0008484	Function	Sulfuric ester hydrolase activity	IBA
GO:0008484	Function	Sulfuric ester hydrolase activity	IEA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
610010	26286	ENSG00000180801

Q5FYB0

Protein name

Arylsulfatase J (ASJ) (EC 3.1.6.-)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00884	Sulfatase	76 → 390	Sulfatase	Family

Sequence

MAPRGCAGHPPPPSPQACVCPGKMLAMGALAGFWILCLLTYGYLSWGQALEEEEEGALLA
QAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQP
ICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLG
FYRKECMPTRRGFDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYSTQ
MYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCL
DEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRAVGFVH
SPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILH
NIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRW
HNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRRLSQFNKTAVPVRYPPKDP
RSNPRLNGGVWGPWYKEETKKKKPSKNQAEKKQKKSKKKKKKQQKAVSGSTCHSGVTCG

Sequence length

599

Interactions

View interactions

	Reactome
			Glycosphingolipid metabolism The activation of arylsulfatases

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHRONIC LYMPHOCYTIC LEUKEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINAL DEGENERATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UROLITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34965262	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	34326372	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ARSJ (arylsulfatase family member J)